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compositionComposition:PEMETREXED-500MG
prescription
Prescription Medicine
info
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Phenat Injection is used to treat Non-small cell lung cancer and malignant pleural mesothelioma. It contains Pemetrexed, which treats cancer by blocking the action of substances that may help the cancer cells multiply. Do not use this medication if you are pregnant or breastfeeding. Women and men should use effective contraception during treatment with Phenat Injection and for 6 and 3 months afterwards. It is not recommended for children below 18 years.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PEMETREXED-500MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Phenat Injection

Phenat Injection is an injection used to treat certain types of cancers, such as non-small cell lung cancer and malignant pleural mesothelioma. It is a medical treatment designed to slow down or stop the growth of cancer cells in the body. By targeting these abnormal cells, the medicine helps manage the disease and prevent it from spreading further.

This medicine is given as an infusion into a vein on a schedule determined by your doctor, usually once every three weeks. Because it is given in a clinical setting by healthcare professionals, maintaining your scheduled appointments is vital for consistent results. Staying well-hydrated and eating balanced, small meals during your treatment cycle can support your body through therapy.

Common side effects of this treatment include fatigue, nausea, and low blood cell counts. You must contact your doctor immediately if you develop signs of an infection, such as a fever, or experience unusual bleeding and bruising. Your healthcare team will monitor your blood counts regularly to ensure it is safe for you to continue treatment.

Before you begin taking Phenat Injection, tell your doctor if you have kidney disease, as this condition can affect how your body clears the medicine. Do not take this if you have had a severe allergic reaction to this medicine or any of its ingredients. It is also important to share your complete medical history with your oncologist before your first session.

Certain medicines, such as nonsteroidal anti-inflammatory drugs (NSAIDs), can interact with Phenat Injection and increase your risk of severe side effects. Avoid alcohol and smoking during treatment, as they can place extra strain on your liver and worsen fatigue. If you are pregnant, planning to become pregnant, or breastfeeding, you should not take this medicine, and elderly patients may require closer monitoring of their kidney function.

Uses of Phenat Injection

Phenat Injection is used to treat certain types of cancers. The detailed uses of Phenat Injection are as follows:

  • Non-small cell lung cancer: Phenat Injection helps by stopping the division and growth of cancer cells in patients with advanced non-squamous non-small cell lung cancer.
  • Malignant pleural mesothelioma: Phenat Injection is used in combination with other chemotherapy drugs to treat this rare cancer of the lung lining, helping to control tumour growth.

Key Benefits

Phenat Injection helps treat certain types of cancer by slowing the growth and spread of cancer cells. With regular use as prescribed, it helps control disease progression, relieve tumour-related symptoms, and support long-term treatment outcomes.

  • Helps Control Cancer Progression: By slowing the growth or stabilising tumours, this medicine helps manage the disease and delay its progression.
  • Relieves Cancer-Related Symptoms: As tumour growth is controlled, this medicine may help reduce persistent coughing, chest pain, breathing difficulties, and other symptoms caused by cancer, improving daily comfort.
  • Supports Long-Term Disease Management: When used as maintenance therapy after initial treatment, this medicine helps delay the return of cancer, prolong disease control, and support better quality of life and overall treatment outcomes.
Side effects of Phenat Injection
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Phenat Injection will be administered by a nurse or doctor.
  • Do not self-administer.

How Phenat Injection Works

Phenat Injection contains pemetrexed, which is a folate antimetabolite that works by disrupting the replication process of cancer cells. Cancer cells require certain natural substances, including folate, to synthesise DNA and RNA so they can grow and divide. This medicine acts as an impostor, blocking the specific enzymes that use folate to build genetic material. Without the necessary building blocks for DNA, the cancer cells are unable to replicate and eventually die. Because cancer cells divide much faster than most healthy cells, they are highly sensitive to this blockage, which helps limit the spread of the disease throughout your body.
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Alcohol

Consult your doctor

It is not known if alcohol affects Phenat Injection. Please consult your doctor.

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Pregnancy

Unsafe

Pemetrexed belongs to pregnancy category D. The use of Phenat Injection should be avoided during pregnancy as it might harm the unborn baby.

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Breast Feeding

Unsafe

Breastfeeding must be discontinued during treatment with Phenat Injection.

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Driving

Caution

Phenat Injection may cause tiredness. Caution is advised while driving or operating heavy machinery.

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Liver

Consult your doctor

If you have a history of liver disease, inform your doctor before receiving Phenat Injection.

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Kidney

Caution

Dose adjustment may be needed. If you have a history of kidney disease, inform your doctor before receiving Phenat Injection.

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Children

Unsafe

Phenat Injection is not recommended for children below 18 years as safety and effectiveness have not been established.

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Heart

Consult your doctor

Please consult your doctor if you have any heart problems before taking Phenat Injection.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Phenat Injection to geriatric patients. Your doctor will prescribe Phenat Injection if the benefits outweigh the risks.

What if I have taken an overdose of Phenat Injection

An overdose is highly unlikely because a trained medical professional prepares and injects your dose. However, if you suspect an error or experience severe symptoms after your session, seek immediate medical attention.

Diet & Lifestyle Advise

  • Take your prescribed supplements: Always take your folic acid and vitamin B12 supplements exactly as directed to help protect your healthy blood cells from the medicine.
  • Stay well-hydrated: Drink plenty of water and clear fluids, especially on the days surrounding your treatment, to help support your kidney function.
  • Eat small, frequent meals: If you experience nausea or a loss of appetite, eating smaller portions five to six times a day can help maintain your nutrition.
  • Avoid infections: Wash your hands frequently, practice good personal hygiene, and avoid close contact with anyone who is currently sick.
health query

Have a query?

How Soon It Starts Working

The time required for Phenat Injection to start to work: The time required for Phenat Injection to show its action is not clinically established. The time for which the effects of Phenat Injection last: The effect of Phenat Injection lasts for 6 to 9 hours.

What if you forget to take Phenat Injection

Since this medicine is given by a healthcare professional at scheduled clinical visits, missing a dose is unlikely. If you miss an appointment, contact your clinic immediately to reschedule your infusion.

Storage

• Unopened vials of Phenat Injection dry powder should be stored at room temperature, between 20°C to 25°C (68°F to 77°F).

Drug Warnings

  • Check the solution: If you observe your treatment being prepared, ensure the liquid is clear, colourless to light yellow, and free of visible particles before it is injected.
  • Monitor your temperature: Keep a reliable digital thermometer at home and check your temperature immediately if you feel warm, cold, or unwell.
  • Avoid certain pain relievers: Do not take ibuprofen, naproxen, or other NSAIDs for a few days before and after your infusion without consulting your doctor first, as they can increase the medicine's toxicity.
  • Protect your skin: Use gentle, fragrance-free moisturisers and wear sunscreen when outdoors, as your skin may become highly sensitive during treatment.

Drug-Drug Interactions

verifiedApollotooltip

  • Nonsteroidal anti-inflammatory drugs (NSAIDs): Medicines like ibuprofen or naproxen can slow down the removal of Phenat Injection from your body, increasing the risk of severe side effects.
  • Kidney-damaging medicines: Other medications that can strain the kidneys may increase the toxicity of Phenat Injection if used at the same time.
PemetrexedCladribine
Severe
PemetrexedTofacitinib
Severe

Drug-Drug Interactions

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PemetrexedCladribine
Severe
How does the drug interact with Phenat Injection:
Taking Cladribine with Phenat Injection can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Cladribine and Phenat Injection together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
PemetrexedTofacitinib
Severe
How does the drug interact with Phenat Injection:
Taking Tofacitinib with Phenat Injection may increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Phenat Injection and Tofacitinib, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without first consulting your doctor.
PemetrexedBaricitinib
Severe
How does the drug interact with Phenat Injection:
Coadministration of Phenat Injection with Baricitinib can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Phenat Injection and Baricitinib together can cause an interaction, it can be taken if your doctor has suggested it. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate. Do not stop using any medications without a doctor's advice.
PemetrexedEtanercept
Severe
How does the drug interact with Phenat Injection:
When Etanercept is used with Phenat Injection, the likelihood or severity of infection may increase.

How to manage the interaction:
Although taking Phenat Injection and Etanercept together can cause an interaction, it can be taken if a doctor has suggested it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
PemetrexedMeloxicam
Severe
How does the drug interact with Phenat Injection:
Co-administration of Meloxicam and Phenat Injection together may increase the levels of Phenat Injection in the blood.

How to manage the interaction:
Co-administration of Meloxicam with Phenat Injection can possibly result in an interaction, but it can be taken if a doctor has advised it. If you notice symptoms like fever, chills, flu-like symptoms, mouth sores, severe diarrhea, or any injuries, call a doctor right away. Do not discontinue any medications without consulting a doctor.
PemetrexedInfliximab
Severe
How does the drug interact with Phenat Injection:
When Phenat Injection is taken with Infliximab, it can enhance the metabolism of Phenat Injection. This can reduce the treatment outcome and can increase the risk or severity of developing serious infections.

How to manage the interaction:
Taking Phenat Injection with Infliximab together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PemetrexedClozapine
Severe
How does the drug interact with Phenat Injection:
Combining Phenat Injection with Clozapine can increase the risk of infection.

How to manage the interaction:
Co-administration of Phenat Injection with Clozapine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
PemetrexedThalidomide
Severe
How does the drug interact with Phenat Injection:
Taking thalidomide together with Phenat Injection may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Phenat Injection together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No clinically significant food interactions are known with Phenat Injection when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

Your doctor may prescribe folic acid and vitamin B12 before and during treatment with Phenat Injection to help protect healthy cells and reduce the risk and severity of certain side effects, particularly blood-related and gastrointestinal side effects. Take these supplements exactly as directed by your doctor.
Hair thinning or mild hair loss can occur during treatment with Phenat Injection, although complete hair loss is less common than with many other chemotherapy medicines. Speak with your doctor if you are concerned or if hair loss becomes troublesome.
This medicine can cause severe fatigue, dizziness, or weakness. Avoid driving or operating machinery until you know how the treatment affects you. Talk to your doctor.
No, this medicine can cause severe harm to an unborn baby. Both men and women should use highly effective birth control during treatment and for several months afterwards. Talk to your doctor.
The medicine is typically given once every three weeks, but your oncologist will determine the exact schedule based on your response to the therapy. Talk to your doctor.
It is best to avoid alcohol, as it can worsen liver strain, dehydration, and fatigue associated with your treatment. Talk to your doctor.
You should avoid live vaccines because your immune system may be weakened by the treatment, which could make the vaccine unsafe. Talk to your doctor.
Skin rashes are a known side effect. Your doctor may prescribe steroid tablets to take before your injection to prevent this, but you should report any new skin changes immediately. Talk to your doctor.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - PHE0084
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