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  3. Piozide M 80mg/15mg/500mg Tablet

Piozide M 80mg/15mg/500mg Tablet, Pack of 1 Tablet
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Piozide M 80mg/15mg/500mg Tablet is used to treat Type 2 diabetes. It works by increasing the insulin released by the pancreas, lowers glucose production in the liver, delays glucose absorption from the intestines and increases the body's response to insulin. It may cause side effects such as nausea, taste change, weight gain, vomiting, diarrhoea, stomach ache, and respiratory infection. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

GLICLAZIDE-80MG + METFORMIN-500MG + PIOGLITAZONE-15MG

Manufacturer/Marketer :

Placker Life Sciences

Consume Type :

ORAL

Return Policy :

Not Returnable

About Piozide M 80mg/15mg/500mg Tablet

Piozide M 80mg/15mg/500mg Tablet is used to treat Type 2 diabetes. Type 2 diabetes is a chronic or lifelong condition affecting how your body processes glucose. People with type 2 diabetes either do not produce enough insulin or if at all the insulin is produced, it is unable to perform its function in the body (insulin resistance). Due to this, the blood glucose level increases and symptoms such as frequent urination increased thirst and increased hunger start. 

Piozide M 80mg/15mg/500mg Tablet contains Gliclazide, metformin and pioglitazone. Gliclazide works by increasing the insulin released by the pancreas. Metformin acts by lowering glucose production in the liver, delaying glucose absorption from the intestines and increasing the body's response to insulin. Pioglitazone works by decreasing the amount of glucose released by the liver and improving the sensitivity of tissues of muscles and fats towards insulin effects.

In some cases, Piozide M 80mg/15mg/500mg Tablet may cause side effects such as nausea, taste change, weight gain, vomiting, diarrhoea, stomach ache, and a respiratory infection. Most of these side effects may not require medical attention and resolve gradually overtime. However, talk to the doctor if the side effects persist or worsen.

Do not take Piozide M 80mg/15mg/500mg Tablet if you are allergic to any of its components, have diabetic ketoacidosis (excess acids in your blood), type 1 diabetes mellitus or severe kidney/liver disease. Please inform the doctor if you have heart disease, are pregnant, are planning to get pregnant or are breastfeeding. Piozide M 80mg/15mg/500mg Tablet may cause lactic acidosis (accumulation of lactic acid in the blood), which requires immediate medical attention. Do not consume alcohol (risk of lactic acidosis) or fast for prolonged periods (risk of hypoglycemia).

Uses of Piozide M 80mg/15mg/500mg Tablet

Treatment of Type 2 Diabetes Mellitus.

Directions for Use

• Take Piozide M 80mg/15mg/500mg Tablet with food to avoid stomach upset or as advised by a doctor.• Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.• Swallow the medicine as a whole with glass of water.• Do not crush, break, or chew it.

Medicinal Benefits

Piozide M 80mg/15mg/500mg Tablet contains Gliclazide, Metformin, and Pioglitazone. Gliclazide increases the production of insulin by acting on the pancreas. Metformin acts by decreasing liver glucose production and intestinal glucose uptake. Pioglitazone works by decreasing the amount of glucose released by the liver and improving the sensitivity of tissues of muscles and fats towards insulin effects. Together, Piozide M 80mg/15mg/500mg Tablet decreases the elevated blood sugar level after the meal, along with the recommended diet and exercise. Piozide M 80mg/15mg/500mg Tablet also helps to prevent serious complications of diabetes such as kidney damage (diabetic nephropathy), blindness (diabetic retinopathy), loss of sensation in your hands and feet (diabetic neuropathy) or even loss of the foot.

How Piozide M 80mg/15mg/500mg Tablet Works

Piozide M 80mg/15mg/500mg Tablet contains Gliclazide, metformin and pioglitazone. Gliclazide works by increasing the insulin released by the pancreas. Metformin acts by lowering glucose production in the liver, delaying glucose absorption from the intestines and increasing the body's response to insulin. Pioglitazone works by decreasing the amount of glucose released by the liver and improving the sensitivity of tissues of muscles and fats towards insulin effects.

Storage

stored at room temperature below 30°C
Side effects of Piozide M 80mg/15mg/500mg Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • If you experience low blood sugar levels, inform your doctor. They will assess the severity and make recommendations for the next actions.
  • Your doctor will assess your symptoms, blood sugar levels, and overall health before recommending the best course of action, which may include treatment, lifestyle modifications, or prescription adjustments.
  • Follow your doctor's instructions carefully to manage the episode and adjust your treatment plan.
  • Make medication adjustments as recommended by your doctor to prevent future episodes.
  • Implement diet and lifestyle modifications as your doctor advises to manage low blood sugar levels.
  • Monitor your blood sugar levels closely for patterns and changes.
  • Track your progress by recording your blood sugar levels, food intake, and physical activity.
  • Seek further guidance from your doctor if symptoms persist or worsen so that your treatment plan can be revised.
Managing Medication-Triggered Bronchitis (Inflammation of the bronchial tubes): A Step-by-Step Guide:
  • If you experience symptoms like coughing, wheezing, chest tightness, or difficulty breathing after taking medication, seek medical attention immediately.
  • Your healthcare provider will work with you to stop the medication causing the reaction, start alternative treatments, and provide supportive therapy.
  • To manage symptoms and prevent complications, follow your doctor's advice to use inhalers or nebulizers as prescribed, practice good hygiene, avoid irritants, stay hydrated, and get plenty of rest.
  • Regularly track your symptoms and report any changes or concerns to your healthcare provider.
  • Chest pain may last for a while and needs immediate medical attention as it is a significant health issue to be attended to.
  • Take rest and refrain from doing physical activity for a while, and restart after a few days.
  • Try applying an ice pack to the strained area for at least 20 minutes thrice a day. Ice pack thus helps reduce inflammation.
  • Sit upright and maintain proper posture if there is persistent chest pain. • Use extra pillows to elevate your position and prop your chest up while sleeping.

What if I have taken an overdose of Piozide M 80mg/15mg/500mg Tablet

Do not take more than the prescribed dose of Piozide M 80mg/15mg/500mg Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Piozide M 80mg/15mg/500mg Tablet may cause ‘lactic acidosis’ (buildup of lactic acid in the blood), characterized by abdominal pain, muscle cramps, vomiting, severe fatigue, and difficulty breathing. It is a life-threatening condition that requires immediate medical attention. Inform your doctor if you have any severe liver or kidney problems, as their normal functioning is required to eliminate excess lactic acid from the body.  Do not consume excess alcohol, as it increases the risk of lactic acidosis. It should be used with caution in patients with heart disease as it increases the risk of heart failure.

Drug-Drug Interactions

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MetforminIopromide
Critical
MetforminIopanoic acid
Critical

Drug-Drug Interactions

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MetforminIopromide
Critical
How does the drug interact with Piozide M 80mg/15mg/500mg Tablet:
Co-administration of Iopromide with Piozide M 80mg/15mg/500mg Tablet can increase the risk of lactic acidosis.

How to manage the interaction:
Taking Iopromide with Piozide M 80mg/15mg/500mg Tablet is not recommended, please consult a doctor before taking it. Do not discontinue the medication without consulting a doctor.
MetforminIopanoic acid
Critical
How does the drug interact with Piozide M 80mg/15mg/500mg Tablet:
Co-administration of Iopanoic acid with Piozide M 80mg/15mg/500mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Piozide M 80mg/15mg/500mg Tablet with Iopanoic acid is not recommended, please consult your doctor before taking it.
MetforminIoglicic acid
Critical
How does the drug interact with Piozide M 80mg/15mg/500mg Tablet:
Co-administration of Ioglicic acid with Piozide M 80mg/15mg/500mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Piozide M 80mg/15mg/500mg Tablet with Ioglicic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIohexol
Critical
How does the drug interact with Piozide M 80mg/15mg/500mg Tablet:
Co-administration of Iohexol with Piozide M 80mg/15mg/500mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Piozide M 80mg/15mg/500mg Tablet with Iohexol is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIopamidol
Critical
How does the drug interact with Piozide M 80mg/15mg/500mg Tablet:
Co-administration of Iopamidol with Piozide M 80mg/15mg/500mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Piozide M 80mg/15mg/500mg Tablet with Iopamidol is not recommended, please consult a doctor before taking it. Do not discontinue the medications without consulting a doctor.
MetforminIodamide
Critical
How does the drug interact with Piozide M 80mg/15mg/500mg Tablet:
Co-administration of Piozide M 80mg/15mg/500mg Tablet and Iodamide can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Piozide M 80mg/15mg/500mg Tablet with Iodamide is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIopydol
Critical
How does the drug interact with Piozide M 80mg/15mg/500mg Tablet:
Co-administration of Iopydol with Piozide M 80mg/15mg/500mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Piozide M 80mg/15mg/500mg Tablet with Iopydol is not recommended, please consult your doctor before taking it.
MetforminMetrizamide
Critical
How does the drug interact with Piozide M 80mg/15mg/500mg Tablet:
Co-administration of Piozide M 80mg/15mg/500mg Tablet with Metrizamide together can cause the risk of lactic acidosis (when the body produces too much lactic acid ).

How to manage the interaction:
Taking Piozide M 80mg/15mg/500mg Tablet with Metrizamide is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. However, if you experience headaches, muscle cramps or pain, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MetforminIocetamic acid
Critical
How does the drug interact with Piozide M 80mg/15mg/500mg Tablet:
Co-administration of Piozide M 80mg/15mg/500mg Tablet and Iocetamic acid can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Piozide M 80mg/15mg/500mg Tablet with Iocetamic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIobitridol
Critical
How does the drug interact with Piozide M 80mg/15mg/500mg Tablet:
Co-administration of Piozide M 80mg/15mg/500mg Tablet and Iobitridol can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Piozide M 80mg/15mg/500mg Tablet with Iobitridol is generally avoided as it can result in an interaction. Please consult your doctor before taking it.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat at regular intervals. Do not take the long gap between a meal or snack.
  • Monitor your blood sugar level regularly, especially when there are a lot of fluctuations.
  • Invest in at least 150 minutes of moderate-intensity physical activity and 15 minutes of high-intensity exercise weekly.
  • Lose weight gradually to achieve a healthy body mass index (18.5 to 24.9).
  • Replace refined carbohydrate-containing foods with whole grain foods and increase intake of fruits and veggies and other fibre-enriched foods.
  • Reduce saturated fat (or hidden fats) intake in food like chips, crisps, pastries, biscuits, and samosas. Choose omega-3 fatty acid-containing oils for daily cooking. For frying, you may use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil.
  • Do not take stress as it may elevate your blood sugar level. You may adopt stress management techniques like mindfulness, yoga, or meditation to control stress-related blood sugar changes.
  • Opt for low-fat dairy products (low-fat yoghurt, fat-free milk, cheese, etc.).
  • Keep your blood pressure as normal (120/80) as possible. As it reduces the risk of cardiovascular diseases in diabetes patients.

Habit Forming

No

Therapeutic Class

ANTIDIABETICS AND ANTIHYPERGLYCEMICS

Piozide M 80mg/15mg/500mg Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

Alcohol may increase the risk of side effects and worsen the condition.

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Pregnancy

Caution

If you are pregnant, consult your doctor before taking Piozide M 80mg/15mg/500mg Tablet. Your doctor may prescribe this medicine if the benefits outweigh the risks.

bannner image

Breast Feeding

Caution

If you are breastfeeding, consult your doctor before taking Piozide M 80mg/15mg/500mg Tablet. Your doctor may prescribe this medicine if the benefits outweigh the risks.

bannner image

Driving

Caution

Piozide M 80mg/15mg/500mg Tablet may cause vision problems. So, do not drive or operate heavy machinery if you have any problems with your vision while using Piozide M 80mg/15mg/500mg Tablet.

bannner image

Liver

Caution

Piozide M 80mg/15mg/500mg Tablet should be taken with caution, especially if you have a history of liver diseases/conditions. Your doctor may adjust the dose if required based on your condition.

bannner image

Kidney

Caution

Piozide M 80mg/15mg/500mg Tablet should be taken with caution in patients with kidney diseases. Your doctor may adjust the dose if required based on your condition.

bannner image

Children

Unsafe

Piozide M 80mg/15mg/500mg Tablet is not recommended for use in children below 18 years.

Have a query?

FAQs

Piozide M 80mg/15mg/500mg Tablet is used to treat type II diabetes, a chronic or lifelong condition affecting how your body processes glucose.

Piozide M 80mg/15mg/500mg Tablet works by increasing the production of insulin by acting on the pancreas, decreasing liver glucose production and intestinal glucose uptake. It also decreases the amount of glucose released by the liver.

Some patients may experience a decline in blood sugar levels lower than normal (hypoglycemia), resulting in sweating, dizziness, headache, confusion, feeling hungry, temporary changes in vision, uneasiness, irritability, and weakness. In such cases, seek medical attention immediately.

Piozide M 80mg/15mg/500mg Tablet may cause side effects such as nausea, taste change, weight gain, vomiting, diarrhoea, stomach ache, and a respiratory infection. Most of these side effects may not require medical attention and resolve gradually overtime. However, talk to the doctor if the side effects persist or worsen.

Symptoms of hypoglycaemia (low blood sugar) are feeling hungry, dizziness, irritability, sweating, tiredness, and palpitations. If you experience these symptoms consume glucose biscuits, sugar candy or fruit juice.

Include healthy food in your diet, exercise regularly, manage stress with relaxation techniques, and avoid smoking & alcohol consumption.

Country of origin

India

Manufacturer/Marketer address

A 407, Anjani Complex Chakla, Andheri East, Mumbai
Other Info - PI24358

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:44 AM IST

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Reference

  1. https://www.medicineindia.org/pharmacology-for-generic/3154/gliclazide-metformin-pioglitazone
  2. https://www.medicines.org.uk/emc/files/pil.4731.pdf
  3. https://mri.cts-mrp.eu/human/downloads/NL_H_1544_002_FinalPL_2of3.pdf
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