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  3. Piptaz 4.5gm Injection

Piptaz 4.5gm Injection, Pack of 1 INJECTION
Piptaz 4.5gm Injection, Pack of 1 INJECTION
Piptaz 4.5gm Injection, Pack of 1 INJECTION
Piptaz 4.5gm Injection, Pack of 1 INJECTION
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Composition :

PIPERACILLIN-4000MG + TAZOBACTAM-500MG

Manufacturer/Marketer :

Genetic Pharma

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About Piptaz 4.5gm Injection

Piptaz 4.5gm Injection belongs to the 'Antibiotics' class of drugs, primarily used to treat bacterial infections. It is used to treat various hospital-acquired and ventilator-associated pneumonia, urinary tract infections, intra-abdominal infections, skin and soft tissue infections (like diabetic foot infections) and uterine infections. Bacterial infection occurs when harmful bacteria grow in the body and causes illness. It can infect any part of the body and multiply very quickly.

Piptaz 4.5gm Injection contains two medicines, namely: Piperacillin (Penicillin antibiotic) and Tazobactam (beta-lactamase inhibitor). Piperacillin belongs to the class of 'Penicillin antibiotics.' It has bactericidal (ability to kill bacteria) activity against gram-positive and gram-negative aerobic (requires oxygen to survive) and anaerobic (survives with little or no oxygen) bacteria. Piperacillin acts by binding to the penicillin-binding proteins (PBPs) inside the bacterial cell wall and inhibits its cell wall synthesis. Tazobactam is a beta-lactamase inhibitor. Beta-lactamases are the enzymes produced by bacteria to gain multi-resistance to β-lactam antibiotics, such as penicillins and cephalosporins. Tazobactam prevents the breakdown of other antibiotics by beta-lactamase enzyme-producing organisms. In Piptaz 4.5gm Injection, Tazobactam works by preventing bacteria from destroying Piperacillin.

Piptaz 4.5gm Injection will be administered by a healthcare professional. Like all medicines, Piptaz 4.5gm Injection also causes side effects, although not everybody gets them. Common side effects of Piptaz 4.5gm Injection include nausea, constipation, diarrhoea, headache, and trouble sleeping. If any of these effects persist or worsen, seek medical advice promptly. 

Brief your medical history to the doctor if you have any allergic reactions to antibiotics. Please inform your doctor if you have any liver, kidney diseases, bleeding disorders, and fits before using Piptaz 4.5gm Injection. Do not use Piptaz 4.5gm Injection while having vaccinations with live bacterial vaccines (typhoid vaccine) since Piptaz 4.5gm Injection may affect vaccines' activity. Piptaz 4.5gm Injection should be used during pregnancy only if the doctor advises you. It is also excreted into breast milk in small amounts. Hence, it is recommended to consult your doctor if you are pregnant or breastfeeding before taking Piptaz 4.5gm Injection. 

Uses of Piptaz 4.5gm Injection

Piptaz 4.5gm Injection is used to treat bacterial infections, hospital-acquired and ventilator-associated pneumonia, urinary tract infections, intra-abdominal infections, skin and soft tissue infections, and uterine infections. The detailed uses of Piptaz 4.5gm Injection are as follows:
•Treatment of Intra-Abdominal Infections: Piptaz 4.5gm Injection treats serious intra-abdominal infections by targeting the bacteria that cause them.
•Respiratory Tract Infections: Piptaz 4.5gm Injection is used to treat severe respiratory infections, including pneumonia.
•Skin and Soft Tissue Infections: Piptaz 4.5gm Injection treats complicated skin and soft tissue infections, including those from surgical wounds, bites, or diabetic foot infections.
•Urinary tract infections: Piptaz 4.5gm Injection is also effective in treating urinary tract infections, helping to eliminate the bacteria that cause these infections.
•Gynecological Infections: Piptaz 4.5gm Injection is used to treat severe infections in women, including pelvic inflammatory disease and endometritis, by targeting a broad range of bacteria.

Directions for Use

Piptaz 4.5gm Injection will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Piptaz 4.5gm Injection contains two medicines, namely: Piperacillin and Tazobactam. Piperacillin is a Penicillin antibiotic. It acts by binding to the penicillin-binding proteins (PBPs) inside the bacterial cell wall and inhibits its cell wall synthesis. Tazobactam is a beta-lactamase inhibitor that prevents the breakdown of other antibiotics by beta-lactamase enzyme-producing organisms. In Piptaz 4.5gm Injection, Tazobactam works by preventing bacteria from destroying Piperacillin. Thus, Piptaz 4.5gm Injection helps treat various bacterial infections of the stomach, lungs, skin and uterus.

How Piptaz 4.5gm Injection Works

Piptaz 4.5gm Injection contains two medicines, namely: Piperacillin (Penicillin antibiotic) and Tazobactam (beta-lactamase inhibitor). Piperacillin belongs to the class of 'Penicillin antibiotics.' It has bactericidal (ability to kill bacteria) activity against gram-positive and gram-negative aerobic (requires oxygen to survive) and anaerobic (survives with little or no oxygen) bacteria. Piperacillin acts by binding to the penicillin-binding proteins (PBPs) inside the bacterial cell wall and inhibits its cell wall synthesis. Tazobactam is a beta-lactamase inhibitor. Beta-lactamases are the enzymes produced by bacteria to gain multi-resistance to β-lactam antibiotics, such as penicillins and cephalosporins. Tazobactam prevents the breakdown of other antibiotics by beta-lactamase enzyme-producing organisms. In Piptaz 4.5gm Injection, Tazobactam works by preventing bacteria from destroying Piperacillin.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Piptaz 4.5gm Injection

The overdose of Piptaz 4.5gm Injection is unlikely as it is administered by a doctor. However, in case of overdose, it may cause vomiting, nausea and diarrhoea. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

If you have a history of any cystic fibrosis (damaged lungs and digestive system), kidney disease, fits, colitis (inflammation of the colon), bleeding disorders, or heart or liver diseases, please inform your doctor before starting Piptaz 4.5gm Injection. Please seek medical advice if you are pregnant or breastfeeding before taking Piptaz 4.5gm Injection. Patients aged above 65 years are not at an increased risk of having side effects. However, the dosage should be adjusted if the patient has a history of renal impairment. Safety and efficacy of Piptaz 4.5gm Injection in children less than two months of age have not been established.

Drug-Drug Interactions

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PiperacillinHeparin
Severe
PiperacillinVancomycin
Severe

Drug-Drug Interactions

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PiperacillinHeparin
Severe
How does the drug interact with Piptaz 4.5gm Injection:
When used together Piptaz 4.5gm Injection will raise the amount of anticoagulant(blood thinners, are chemical substances that prevent or reduce clotting of blood) effect of heparin.

How to manage the interaction:
Although there is a possible interaction between Piptaz 4.5gm Injection and Heparin, you can take these medicines together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
PiperacillinVancomycin
Severe
How does the drug interact with Piptaz 4.5gm Injection:
Coadministration of Vancomycin with Piptaz 4.5gm Injection can increase the risk or severity of kidney problems.

How to manage the interaction:
Taking Vancomycin with Piptaz 4.5gm Injection may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include more fibre-enriched food in your diet, as it can be easily digested by your gut bacteria, which helps stimulate their growth. Thus, fibre foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains like whole-grain bread, and brown rice should be included in your diet. 
  • Eating grapefruit during antibiotics treatment can prevent the body from utilizing Piptaz 4.5gm Injection properly. So, avoid intake of grapefruit or grapefruit juice with the antibiotic. 
  • Avoid intake of alcoholic beverages with Piptaz 4.5gm Injection as it can make you dehydrated and affect your sleep. This can make it more challenging for your body to aid the Piptaz 4.5gm Injection in fighting off infections.
  • Manage stress, eat healthily, drink plenty of water, exercise regularly, and get plenty of sleep.
  • Do not walk barefoot at places like gym showers to prevent bacterial infections. 

Habit Forming

No

Therapeutic Class

ANTIBIOTIC COMBINATION

Piptaz 4.5gm Injection Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

Avoid alcohol consumption while taking Piptaz 4.5gm Injection to prevent unpleasant side-effects, such as nausea and vomiting.

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Pregnancy

Caution

Piptaz 4.5gm Injection should be used with caution during pregnancy since it crosses the placenta in humans. Please consult your doctor before taking Piptaz 4.5gm Injection if you are pregnant or planning to conceive.

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Breast Feeding

Caution

There is limited data on how Piptaz 4.5gm Injection affects breastfed infants. Piptaz 4.5gm Injection is excreted into breast milk. Please consult your doctor before taking Piptaz 4.5gm Injection if you are breastfeeding.

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Driving

Caution

It is unknown whether Piptaz 4.5gm Injection affects your ability to drive and operating machinery. Drive only if you are physically stable and mentally focussed. If you experience dizziness or fatigue after taking Piptaz 4.5gm Injection, do not drive or operate any machinery.

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Liver

Caution

Let your doctor know if you have any history of liver diseases before taking Piptaz 4.5gm Injection. Your doctor will prescribe Piptaz 4.5gm Injection only if the benefits outweigh the risk.

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Kidney

Caution

Penicillin antibiotics are easily removed by dialysis. Beta-lactam antibiotics like Tazobactam should be cautiously administered in patients with renal impairment. Prolonged use of Piptaz 4.5gm Injection may cause nephrotoxicity and alterations in renal function, hence please let your doctor know if you have any history of kidney diseases before taking Piptaz 4.5gm Injection. Your doctor will prescribe Piptaz 4.5gm Injection only if the benefits outweigh the risk.

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Children

Caution

Safety and efficacy of Piptaz 4.5gm Injection in children less than two months of age have not been established.

Have a query?

FAQs

Piptaz 4.5gm Injection is used to treat bacterial infections. It is used to treat various hospital-acquired and ventilator-associated pneumonia, urinary tract infections, intra-abdominal infections, skin and soft tissue infections (like diabetic foot infections) and uterine infections.

Piptaz 4.5gm Injection contains Piperacillin and Tazobactam. Piperacillin inhibits bacterial cell wall synthesis, and Tazobactam prevents the bacteria from gaining resistance against Piperacillin. Thus Piptaz 4.5gm Injection helps in treating various bacterial infections.

Piptaz 4.5gm Injection should be used with proper caution and doctor consultation if you have any cystic fibrosis (damaged lungs and digestive system), kidney disease, fits, colitis (inflammation of the colon), bleeding disorders, heart or liver diseases and undergoing dialysis.

Piptaz 4.5gm Injection can affect live vaccines like typhoid vaccine and decrease their effectiveness. Please consult a doctor before you start Piptaz 4.5gm Injection if you are undergoing any vaccinations.

It is recommended to complete the course of Piptaz 4.5gm Injection even if you feel better as it is an antibiotic, and stopping it midway may lead to recurring infections. Continue taking Piptaz 4.5gm Injection for as long as your doctor has prescribed to treat your condition effectually.

Piptaz 4.5gm Injection is used to treat bacterial infections, including hospital-acquired and ventilator-associated pneumonia, urinary tract infections, intra-abdominal infections, skin and soft tissue infections, and uterine infections.

Country of origin

India

Manufacturer/Marketer address

1098, G J Patel Estate, Bajwa, Vadodara - 391310, Near Government Hospital
Other Info - PIP0006

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Apr 10, 2025 | 9:11 AM IST

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Reference

  1. https://www.webmd.com/drugs/2/drug-16568/piperacillin-tazobactam-intravenous/details
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/050684s88s89s90_050750s37s38s39lbl.pdf
  3. https://www.medicines.org.uk/emc/product/6526/smpc#gref
  4. https://www.drugs.com/pregnancy/piperacillin-tazobactam.html

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