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Tazar 4.5 gm Injection 1's

Tazar 4.5 gm Injection 1's

Prescription drug
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Manufacturer/Marketer

Lupin Ltd

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Jan-25

About Tazar 4.5 gm Injection 1's

Tazar 4.5 gm Injection 1's belongs to the 'Antibiotics' class of drugs, primarily used to treat bacterial infections. It is used to treat various hospital-acquired and ventilator-associated pneumonia, urinary tract infections, intra-abdominal infections, skin and soft tissue infections (like diabetic foot infections) and uterine infections. Bacterial infection occurs when harmful bacteria grow in the body and causes illness. It can infect any part of the body and multiply very quickly.

Tazar 4.5 gm Injection 1's contains two medicines, namely: Piperacillin (Penicillin antibiotic) and Tazobactam (beta-lactamase inhibitor). Piperacillin belongs to the class of 'Penicillin antibiotics.' It has bactericidal (ability to kill bacteria) activity against gram-positive and gram-negative aerobic (requires oxygen to survive) and anaerobic (survives with little or no oxygen) bacteria. Piperacillin acts by binding to the penicillin-binding proteins (PBPs) inside the bacterial cell wall and inhibits its cell wall synthesis. Tazobactam is a beta-lactamase inhibitor. Beta-lactamases are the enzymes produced by bacteria to gain multi-resistance to β-lactam antibiotics, such as penicillins and cephalosporins. Tazobactam prevents the breakdown of other antibiotics by beta-lactamase enzyme-producing organisms. In Tazar 4.5 gm Injection 1's, Tazobactam works by preventing bacteria from destroying Piperacillin.

Tazar 4.5 gm Injection 1's will be administered by a healthcare professional. Like all medicines, Tazar 4.5 gm Injection 1's also causes side effects, although not everybody gets them. Common side effects of Tazar 4.5 gm Injection 1's include nausea, constipation, diarrhoea, headache, and trouble sleeping. If any of these effects persist or worsen, seek medical advice promptly. 

Brief your medical history to the doctor if you have any allergic reactions to antibiotics. Please inform your doctor if you have any liver, kidney diseases, bleeding disorders, and fits before using Tazar 4.5 gm Injection 1's. Do not use Tazar 4.5 gm Injection 1's while having vaccinations with live bacterial vaccines (typhoid vaccine) since Tazar 4.5 gm Injection 1's may affect vaccines' activity. Tazar 4.5 gm Injection 1's should be used during pregnancy only if the doctor advises you. It is also excreted into breast milk in small amounts. Hence, it is recommended to consult your doctor if you are pregnant or breastfeeding before taking Tazar 4.5 gm Injection 1's. 

Uses of Tazar 4.5 gm Injection 1's

Treatment of Bacterial infections, hospital-acquired and ventilator-associated pneumonia, urinary tract infections, intra-abdominal infections, skin and soft tissue infections, and uterine infections.

Medicinal Benefits

Tazar 4.5 gm Injection 1's contains two medicines, namely: Piperacillin and Tazobactam. Piperacillin is a Penicillin antibiotic. It acts by binding to the penicillin-binding proteins (PBPs) inside the bacterial cell wall and inhibits its cell wall synthesis. Tazobactam is a beta-lactamase inhibitor that prevents the breakdown of other antibiotics by beta-lactamase enzyme-producing organisms. In Tazar 4.5 gm Injection 1's, Tazobactam works by preventing bacteria from destroying Piperacillin. Thus, Tazar 4.5 gm Injection 1's helps treat various bacterial infections of the stomach, lungs, skin and uterus.

Directions for Use

Tazar 4.5 gm Injection 1's will be administered by a healthcare professional; do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Tazar 4.5 gm Injection 1's

  • Nausea
  • Constipation
  • Diarrhoea
  • Headache
  • Trouble sleeping 

Drug Warnings

If you have a history of any cystic fibrosis (damaged lungs and digestive system), kidney disease, fits, colitis (inflammation of the colon), bleeding disorders, or heart or liver diseases, please inform your doctor before starting Tazar 4.5 gm Injection 1's. Please seek medical advice if you are pregnant or breastfeeding before taking Tazar 4.5 gm Injection 1's. Patients aged above 65 years are not at an increased risk of having side effects. However, the dosage should be adjusted if the patient has a history of renal impairment. Safety and efficacy of Tazar 4.5 gm Injection 1's in children less than two months of age have not been established.

Drug Interactions

Drug-Drug Interaction: Tazar 4.5 gm Injection 1's may interact with anticoagulants (heparin), anti-cancer drugs (methotrexate), antibiotics (tobramycin, vancomycin), gout medicines (probenecid), and anaesthetic drugs (vecuronium).

Drug-Food Interaction: Avoid alcohol consumption while taking Tazar 4.5 gm Injection 1's to prevent unpleasant side-effects, such as nausea and vomiting.

Drug-Disease Interaction: Before taking Tazar 4.5 gm Injection 1's, let your doctor know if you have cystic fibrosis, kidney disease, fits, colitis, bleeding disorders, heart or liver diseases, and are undergoing dialysis treatment.

Drug-Drug Interactions Checker List

  • HEPARIN
  • METHOTREXATE
  • TOBRAMYCIN
  • VANCOMYCIN
  • PROBENECID
  • VECURONIUM

Habit Forming

No

Diet & Lifestyle Advise

  • Include more fibre-enriched food in your diet, as it can be easily digested by your gut bacteria, which helps stimulate their growth. Thus, fibre foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains like whole-grain bread, and brown rice should be included in your diet. 
  • Eating grapefruit during antibiotics treatment can prevent the body from utilizing Tazar 4.5 gm Injection 1's properly. So, avoid intake of grapefruit or grapefruit juice with the antibiotic. 
  • Avoid intake of alcoholic beverages with Tazar 4.5 gm Injection 1's as it can make you dehydrated and affect your sleep. This can make it more challenging for your body to aid the Tazar 4.5 gm Injection 1's in fighting off infections.
  • Manage stress, eat healthily, drink plenty of water, exercise regularly, and get plenty of sleep.
  • Do not walk barefoot at places like gym showers to prevent bacterial infections. 

Special Advise

  • Renal, hepatic, and blood function tests are advised during prolonged therapy to rule out any toxicity caused due to overdose of Tazar 4.5 gm Injection 1's. 
  • Clostridium difficile-associated diarrhoea (CDAD) is reported during the usage of antibiotics like Tazar 4.5 gm Injection 1's. Please see your doctor if you experience prolonged diarrhoea.
  • Penicillin antibiotics are easily removed during dialysis; hence let your doctor know if you are undergoing dialysis treatment so that the dose can be scheduled after the dialysis.
  • Tazar 4.5 gm Injection 1's may also affect urine glucose tests; hence inform your doctor beforehand if you are using Tazar 4.5 gm Injection 1's.

Disease/Condition Glossary

Bacterial infection occurs when harmful bacteria grow in the body and causes illness. It can infect any part of the body and multiply very quickly. Bacteria occur in three basic shapes: spherical, rod and spiral-shaped. Bacteria may be gram-positive (have thick cell wall) or gram-negative (do not have a cell wall). Some common symptoms of a bacterial infection include cough, fever and tiredness. 

Hospital-acquired pneumonia/ nosocomial pneumonia: It is a lower respiratory infection of the lungs that occurs during a hospital stay.

Ventilator-associated pneumonia: A lung infection occurs in people who are on mechanical ventilation breathing machines in hospitals.

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Alcohol

Caution

Avoid alcohol consumption while taking Tazar 4.5 gm Injection 1's to prevent unpleasant side-effects, such as nausea and vomiting.

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Pregnancy

Caution

Tazar 4.5 gm Injection 1's should be used with caution during pregnancy since it crosses the placenta in humans. Please consult your doctor before taking Tazar 4.5 gm Injection 1's if you are pregnant or planning to conceive.

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Breast Feeding

Caution

There is limited data on how Tazar 4.5 gm Injection 1's affects breastfed infants. Tazar 4.5 gm Injection 1's is excreted into breast milk. Please consult your doctor before taking Tazar 4.5 gm Injection 1's if you are breastfeeding.

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Driving

Caution

It is unknown whether Tazar 4.5 gm Injection 1's affects your ability to drive and operating machinery. Drive only if you are physically stable and mentally focussed. If you experience dizziness or fatigue after taking Tazar 4.5 gm Injection 1's, do not drive or operate any machinery.

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Liver

Caution

Let your doctor know if you have any history of liver diseases before taking Tazar 4.5 gm Injection 1's. Your doctor will prescribe Tazar 4.5 gm Injection 1's only if the benefits outweigh the risk.

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Kidney

Caution

Penicillin antibiotics are easily removed by dialysis. Beta-lactam antibiotics like Tazobactam should be cautiously administered in patients with renal impairment. Prolonged use of Tazar 4.5 gm Injection 1's may cause nephrotoxicity and alterations in renal function, hence please let your doctor know if you have any history of kidney diseases before taking Tazar 4.5 gm Injection 1's. Your doctor will prescribe Tazar 4.5 gm Injection 1's only if the benefits outweigh the risk.

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Children

Caution

Safety and efficacy of Tazar 4.5 gm Injection 1's in children less than two months of age have not been established.

Country of origin

India

Manufacturer/Marketer address

Lupin Ltd, 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India.
Other Info -

FAQs

Tazar 4.5 gm Injection 1's contains Piperacillin and Tazobactam. Piperacillin inhibits bacterial cell wall synthesis, and Tazobactam prevents the bacteria from gaining resistance against Piperacillin. Thus Tazar 4.5 gm Injection 1's helps in treating various bacterial infections.
Tazar 4.5 gm Injection 1's should be used with proper caution and doctor consultation if you have any cystic fibrosis (damaged lungs and digestive system), kidney disease, fits, colitis (inflammation of the colon), bleeding disorders, heart or liver diseases and undergoing dialysis.
Tazar 4.5 gm Injection 1's can affect live vaccines like typhoid vaccine and decrease their effectiveness. Please consult a doctor before you start Tazar 4.5 gm Injection 1's if you are undergoing any vaccinations.
It is recommended to complete the course of Tazar 4.5 gm Injection 1's even if you feel better as it is an antibiotic, and stopping it midway may lead to recurring infections. Continue taking Tazar 4.5 gm Injection 1's for as long as your doctor has prescribed to treat your condition effectually.

Disclaimer

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