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compositionComposition:FLUPIRTINE-100MG+PARACETAMOL-325MG
prescription
Prescription Medicine
info
Pirineu P Tablet 10's
Pirineu P Tablet 10's
Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

FLUPIRTINE-100MG+PARACETAMOL-325MG

Manufacturer/Marketer :

Gladstone Pharma India Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Pirineu P Tablet

Living with moderate-to-severe pain can make everyday activities difficult and affect your quality of life. Pirineu P Tablet is a prescription oral medication primarily used for the short-term treatment of acute pain, particularly pain associated with musculoskeletal conditions such as muscle spasms and muscle-related discomfort. In selected cases, a doctor may consider its use for other painful conditions based on individual clinical assessment. 

For optimal results, you should take Pirineu P Tablet consistently at the exact times prescribed by your doctor. It can be taken with or without food, though taking it with a meal or a glass of water can help prevent minor stomach upset. Incorporating gentle, low-impact daily movement and maintaining proper hydration will also support your body's healing process.

While taking Pirineu P Tablet , you may experience mild, common side effects like drowsiness, dizziness, or a dry mouth. However, you must stop taking the medication and seek urgent medical attention immediately if you notice serious symptoms such as severe upper stomach pain, yellowing of your skin or eyes, dark-coloured urine, pale stools, or unusual fatigue, as these may be signs of liver damage. 
Before starting this medication, it is vital to discuss your medical history with your doctor. Do not take this if you have active liver disease, a history of severe alcohol abuse, or conditions causing extreme muscle weakness. Your doctor will need to evaluate your health to ensure this medication is safe for you.

This medicine can interact with other treatments, so always share a complete list of your current drugs with your pharmacist. Specifically, avoid drinking alcohol while on Pirineu P Tablet , as this combination significantly increases the risk of severe liver damage. If you are pregnant, breastfeeding, or managing health conditions as an older adult, consult your doctor before taking this medicine.

Flupirtine was withdrawn from the European Union market in 2018 following recommendations by regulatory authorities due to the risk of serious liver injury. However, flupirtine-containing medicines remain available in some countries, including India, where their use is subject to local regulatory guidance and prescribing restrictions. Availability and approved uses may vary between countries, and additional monitoring may be recommended in certain settings. 
 

Uses of Pirineu P Tablet

Your doctor may prescribe Pirineu P Tablet for the short-term management of selected acute pain conditions. Appropriate use depends on the underlying cause of the pain and individual patient factors, including liver health and overall medical history. 

  • Acute muscle spasms: Pirineu P Tablet helps relax tight, contracted muscle fibres and reduces localised pain.
  • Nerve-related pain: In selected patients, a doctor may prescribe Pirineu P Tablet to help manage certain types of nerve-related pain. The suitability of this treatment depends on the underlying cause and individual patient factors.
  • Post-surgical pain: It manages moderate to severe discomfort following surgical operations to help you recover more comfortably.
  • Joint and musculoskeletal pain: Your doctor may prescribe Pirineu P Tablet for short-term relief of certain acute musculoskeletal pain conditions when clinically appropriate. 
     

Key Benefits

Pirineu P Tablet provides multi-action relief to help you feel better and recover your quality of life. The primary benefits include:

  • Rapid pain relief: By blocking pain pathways quickly, this medication helps ease sharp or persistent aching so you can return to your normal daily activities without constant discomfort.
  • Improved mobility: Because it relaxes stiff, spasming muscles, Pirineu P Tablet makes movement easier, allowing you to participate in physical therapy or gentle daily exercise with less resistance.
  • Enhanced rest and recovery: Unmanaged pain often disrupts sleep. By soothing both nerve and muscle pain, this medication helps you rest more deeply, which is essential for your body's natural healing process.
Side effects of Pirineu P Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Consume more fruits, vegetables, and cruciferous foods like cabbage, kale, and broccoli.
  • Reduced alcohol intake can enhance liver enzyme function.
  • Oxidative stress can be managed by eating foods rich in antioxidants, such as vitamins C and E.
  • Liver function tests regularly can help manage increased levels of AST.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.

Directions for Use

To ensure you get the maximum benefit from Pirineu P Tablet while staying safe, follow these steps:

  • Swallow the tablet whole with a full glass of water.
  • Do not chew, crush, or break the tablet, as this can cause the medicine to release too quickly into your system, increasing the risk of side effects.
  • You can take this medicine with or without food, but taking it with food can protect your stomach if you are prone to indigestion.
    Always take this medication exactly as prescribed by your doctor. Do not increase your dose or take it for longer than recommended.
     

How Pirineu P Tablet Works

Pirineu P Tablet is a combination medication that uses two distinct active components working together in the body to manage pain and muscle tension. The first active component acts on the nervous system as a neuronal potassium channel opener. By opening these channels in nerve cells, it helps stabilise nerve membranes and reduce the transmission of pain signals. It may also indirectly influence NMDA receptor activity involved in pain processing, which could contribute to its overall pain-relieving effects. Although the exact mechanisms are not fully understood, its primary action is believed to involve modulation of neuronal potassium channels. The second active component is a widely trusted pain reliever and fever reducer. It works by blocking the production of specific chemical messengers in the brain, known as prostaglandins, which are responsible for signaling pain and inflammation. Together, these two components provide a dual-action mechanism that addresses both the physical tension in the muscles and the transmission of pain signals to the brain.
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Alcohol

Unsafe

Consuming alcohol with Pirineu P Tablet is not advisable as it may cause unpleasant side effects, or you may become more sensitive to the effects of alcohol.

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Pregnancy

Consult your doctor

Pirineu P Tablet is not recommended during pregnancy. However, your doctor may prescribe it for you during pregnancy if he/she feels the benefit outweighs the risk.

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Breast Feeding

Consult your doctor

According to the studies available to date, a small percentage of flupirtine maleate passes into breast milk. Therefore, flupirtine maleate must not be administered during lactation unless necessary.

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Driving

Unsafe

Avoid driving or operating heavy machinery after taking Pirineu P Tablet , as it may cause dizziness.

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Liver

Unsafe

Pirineu P Tablet can cause liver toxicity. So, it should be avoided in patients with liver diseases. However, dose adjustments and close monitoring are necessary if it is used in patients with liver diseases.

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Kidney

Consult your doctor

In patients with kidney problems, dose adjustments of Pirineu P Tablet are required. Therefore, use Pirineu P Tablet only when prescribed by a doctor.

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Children

Consult your doctor

It is recommended to consult a doctor before using Pirineu P Tablet in children below six years.

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Heart

Caution

Pirineu P Tablet should be used under extreme caution in heart patients as it can cause potential risk in some patients.

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Geriatrics

Unsafe

Pirineu P Tablet should be avoided in geriatric patients, as it can cause serious adverse effects like liver/kidney damage, dizziness or drowsiness.

What if I have taken an overdose of Pirineu P Tablet

Do not take more than the prescribed dose of Pirineu P Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Avoid alcohol completely: Alcohol places severe stress on your liver and, when combined with Pirineu P Tablet , greatly increases the risk of severe liver damage.
  • Drink plenty of water: Staying well-hydrated supports your kidneys and liver as they process and clear the medication from your system.
  • Eat a liver-friendly diet: Focus on eating fresh fruits, vegetables, whole grains, and lean proteins while limiting heavy, fatty, or highly processed foods that strain your digestive organs.
  • Practice gentle mobility: If you are recovering from a muscle strain or spasm, engage in gentle stretching or short walks to maintain blood circulation, but avoid heavy lifting or high-impact workouts until your doctor clears you.
  • Keep a symptom diary: Note down when you take Pirineu P Tablet and any side effects you experience, which can help your doctor monitor your progress and liver health.
     

Have a query?

How Soon It Starts Working

The time required for Pirineu P Tablet to start to work: The time required for Pirineu P Tablet to show its action is not clinically established. 

The time for which the effects of Pirineu P Tablet last: The duration of action for Pirineu P Tablet is not clinically established.

What if you forget to take Pirineu P Tablet

If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and take the next dose at the scheduled time. Do not take a double dose.

Storage

• Store the tablets at room temperature, ideally between 15°C and 30°C (59°F to 86°F). • Keep the tablets in their original blister packaging to protect them from direct light, heat, and moisture.

Drug Warnings

  • Check packaging integrity: Always inspect the blister pack before use; do not take any tablet if the foil is torn, punctured, or showing signs of tampering.
  • Watch your other medications: Carefully read the labels of any over-the-counter cough, cold, or pain remedies to ensure they do not contain paracetamol, as taking them together can cause a dangerous overdose.
  • Do not drive or operate machinery: Because Pirineu P Tablet can cause drowsiness and slow your reaction times, avoid driving or operating tools until you are certain how the medicine affects your alertness.
  • Monitor your skin and eyes: Perform a daily self-check for signs of yellowing in your eyes or skin, which requires immediate medical intervention.
  • Limit your treatment period: Do not use this medication for longer than your doctor has prescribed, as prolonged use significantly increases the risk of liver damage.
     

Drug-Drug Interactions

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Drug-Drug Interactions

Pirineu P Tablet may interact with certain medications and increase the risk of side effects or reduce treatment effectiveness, including:

  • Other paracetamol-containing products: Taking these together increases the concentration of the active ingredients in your body, risking severe liver damage.
  • Blood thinners (like warfarin): Regular use of Pirineu P Tablet can enhance the effect of blood thinners, which may increase your risk of bleeding.
  • Seizure medications: These medicines can increase the activity of certain liver enzymes, which may reduce flupirtine levels and potentially decrease its effectiveness. They may also increase the risk of liver toxicity associated with paracetamol, particularly when high doses are used or when other liver risk factors are present.
  • Sedatives or sleeping pills: Combining these with Pirineu P Tablet can cause dangerous drowsiness, slow breathing, and poor muscle coordination.


Drug-Food Interactions

Certain foods and beverages may affect the safety of Pirineu P Tablet . For example:

  • Alcohol: Drinking alcohol while taking Pirineu P Tablet is highly dangerous as it severely increases the risk of acute liver failure.


Drug-Disease Interactions

Pirineu P Tablet may not be suitable for people with certain medical conditions, such as:

  • Liver disease: Do not take Pirineu P Tablet if you have liver impairment, cirrhosis, or hepatitis, as it can worsen liver function and lead to liver failure.
  • Myasthenia gravis: This medicine can cause further muscle relaxation, which may dangerously worsen symptoms of severe muscle weakness.
  • Kidney impairment: If your kidneys are not fully functional, Pirineu P Tablet can accumulate in your body, requiring your doctor to adjust your dose carefully.
Flupirtine + ParacetamolTeriflunomide
Severe
Flupirtine + ParacetamolLeflunomide
Severe

Drug-Drug Interactions

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Flupirtine + ParacetamolTeriflunomide
Severe
How does the drug interact with Pirineu P Tablet:
Co-administration of Pirineu P Tablet with Teriflunomide can lead to severe liver problems.

How to manage the interaction:
Although there is a possible interaction between Pirineu P Tablet and Teriflunomide, it can be taken if prescribed by a doctor. In case you experience any side effects like fever, chills, swollen or painful joints, severe tiredness or weakness, unusual bleeding or bruises, itchy or rashy skin, reduced hunger, nausea, vomiting, or yellowing of the skin or whites of the eyes, consult a doctor. Do not stop taking any medications without a doctor's advice.
Flupirtine + ParacetamolLeflunomide
Severe
How does the drug interact with Pirineu P Tablet:
Co-administration of Pirineu P Tablet with Leflunomide can lead to severe liver problems.

How to manage the interaction:
Although there is a possible interaction between Pirineu P Tablet and Leflunomide, it can be taken if prescribed by a doctor. In case you experience any side effects like fever, chills, swollen or painful joints, severe tiredness or weakness, unusual bleeding or bruises, itchy or rashy skin, reduced hunger, nausea, vomiting, or yellowing of the skin or whites of the eyes, consult a doctor. Do not stop taking any medications without a doctor's advice.
Flupirtine + ParacetamolLomitapide
Severe
How does the drug interact with Pirineu P Tablet:
Co-administration of Pirineu P Tablet with Lomitapide can lead to severe liver problems.

How to manage the interaction:
Although there is a possible interaction between Pirineu P Tablet and Lomitapide, it can be taken if prescribed by a doctor. In case you experience any side effects like fever, chills, swollen or painful joints, severe tiredness or weakness, unusual bleeding or bruises, itchy or rashy skin, reduced hunger, nausea, vomiting, or yellowing of the skin or whites of the eyes, consult a doctor. Do not stop taking any medications without a doctor's advice.
Flupirtine + ParacetamolEthanol
Severe
How does the drug interact with Pirineu P Tablet:
Co-administration of Pirineu P Tablet with Ethanol can lead to severe liver problems.

How to manage the interaction:
Although there is a possible interaction between Pirineu P Tablet and Ethanol, it can be taken if prescribed by a doctor. In case you experience any side effects like fever, chills, swollen or painful joints, severe tiredness or weakness, unusual bleeding or bruises, itchy or rashy skin, reduced hunger, nausea, vomiting, or yellowing of the skin or whites of the eyes, consult a doctor. Do not stop taking any medications without a doctor's advice.
Flupirtine + ParacetamolKetoconazole
Severe
How does the drug interact with Pirineu P Tablet:
Co-administration of Pirineu P Tablet with Ketoconazole can lead to severe liver problems.

How to manage the interaction:
Although there is a possible interaction between Pirineu P Tablet and Ketoconazole, it can be taken if prescribed by a doctor. In case you experience any side effects like fever, chills, swollen or painful joints, severe tiredness or weakness, unusual bleeding or bruises, itchy or rashy skin, reduced hunger, nausea, vomiting, or yellowing of the skin or whites of the eyes, consult a doctor. Do not stop taking any medications without a doctor's advice.
Flupirtine + ParacetamolMipomersen
Severe
How does the drug interact with Pirineu P Tablet:
Co-administration of Pirineu P Tablet with Mipomersen can lead to severe liver problems.

How to manage the interaction:
Although there is a possible interaction between Pirineu P Tablet and Mipomersen, it can be taken if prescribed by a doctor. In case you experience any side effects like fever, chills, swollen or painful joints, severe tiredness or weakness, unusual bleeding or bruises, itchy or rashy skin, reduced hunger, nausea, vomiting, or yellowing of the skin or whites of the eyes, consult a doctor. Do not stop taking any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANALGESIC AND ANTIPYRETIC AGENT]

FAQs

Pirineu P Tablet is widely used in the treatment of acute and chronic pain, fever, headache, joint pains, dysmenorrhea (period pain), postoperative pain, toothache after dental extraction, and myalgia (muscle pain).

Pirineu P Tablet contains flupirtine (non-opioid analgesic) and paracetamol (analgesic and antipyretic). Flupirtine works by blocking‚ the glutamate receptors that are involved in producing pain signals. Paracetamol acts as an analgesic and antipyretic by inhibiting the release of prostaglandins (chemical mediators) that cause pain, inflammation, and fever. Altogether provide relief from pain.

No, Pirineu P Tablet provides pain relief from menstrual pain (dysmenorrheal). It may not affect on periods. Please consult the doctor if you have any concerns regarding this.

Yes, Pirineu P Tablet can be used to treat pain associated with osteoarthritis. But, you should take it as advised by your doctor.

Pirineu P Tablet contains Paracetamol, known to cause liver damage when you take large dosages. Often, stop consuming alcohol when taking this drug, as this can further increase the risk of liver damage. The use of this drug in patients with underlying liver disease should preferably be avoided.

Usually, Pirineu P Tablet is used for a short period of time and can be stopped when the pain is relieved. It should be continued, however, if you are instructed to do so by your doctor.

The common side effects of Pirineu P Tablet include nausea, vomiting, wind, abdominal discomfort, diarrhoea, constipation, heartburn, drowsiness, dizziness, headache, and depression. Most of these side effects of Pirineu P Tablet are temporary, do not require medical attention, and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

No, do not take a higher than the recommended dose of Pirineu P Tablet as it may lead to unpleasant side effects/overdose. Take it as per the dose advised by the doctor.

Store Pirineu P Tablet at room temperature, in a dry place. Keep it out of sight and reach of children.

No, you must completely avoid alcohol while taking Pirineu P Tablet . Combining alcohol with this medication severely increases the risk of liver damage and can make you extremely drowsy. Talk to your doctor if you have questions about managing this safely.

Pirineu P Tablet is generally intended for short-term use and is often limited to a maximum of two weeks due to the risk of liver injury. Your doctor may recommend liver function monitoring during treatment. Always follow the duration prescribed by your healthcare provider.

Yes, drowsiness and dizziness are common side effects of Pirineu P Tablet . Avoid driving, operating machinery, or performing any task that requires concentration until you know how this medication affects you. Talk to your doctor if these symptoms do not improve.

You must stop taking Pirineu P Tablet immediately and seek urgent medical attention. Yellowing of the skin or eyes is a primary sign of liver damage. Talk to your doctor right away if you notice this, dark urine, or severe stomach pain.

You should consult your healthcare provider before taking any other pain or cold medications. Never take other products containing paracetamol, as this can cause a serious and dangerous overdose. Talk to your doctor or pharmacist to confirm what is safe.

This medication is generally not recommended during pregnancy or while breastfeeding unless your doctor decides it is absolutely necessary. There is not enough safety data to guarantee it will not harm the baby. Talk to your doctor to discuss safer alternatives.

Older adults can take Pirineu P Tablet , but they must do so with caution. The elderly are more susceptible to side effects like dizziness, falls, and liver strain. Talk to your doctor about starting with a lower dose and undergoing regular health monitoring.

Pirineu P Tablet may be prescribed in selected cases of nerve-related pain, depending on the underlying condition and your doctor's clinical judgement. Its primary approved use in many markets has been for acute pain, particularly musculoskeletal pain. Talk to your doctor to determine whether it is appropriate for your specific condition.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

INDIA

Manufacturer/Marketer address

Gladstone Pharma India Pvt.Ltd., Plot No. 274/4, Natesh Nagar, Second Cross, Virugambakkam, Chennai., PO BOX 600 092
Other Info - PIR0136

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