PIROX CAPSULE 20MG
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About PIROX CAPSULE 20MG
PIROX CAPSULE 20MG is used to relieve symptoms like pain, inflammation, and joint stiffness associated with rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. Osteoarthritis is a degenerative joint disease caused by the breakdown of cartilage (a protective covering) and the underlying bone.
PIROX CAPSULE 20MG contains Piroxicam, which works by blocking the effect of a chemical messenger in the body, known as cyclooxygenase (COX) enzymes, that produce another chemical, prostaglandins.
In some cases, you may experience common side effects, such as diarrhoea, stomach upset, headache, dizziness, ringing in the ears, heartburn, nausea, vomiting, and constipation. Most of these side effects do not require medical attention. However, speak to your doctor if you experience these side effects persistently.
Do not take PIROX CAPSULE 20MG if you are allergic to any of its ingredients or have a history of an asthma attack or severe allergic reaction to NSAIDs. Consult your doctor before taking PIROX CAPSULE 20MG if you are pregnant or planning to become pregnant. PIROX CAPSULE 20MG is not recommended for children under 18 years, as its safety and efficacy have not been established.
Uses of PIROX CAPSULE 20MG
PIROX CAPSULE 20MG is used to treat joint pain and inflammation associated with various conditions. The detailed uses of PIROX CAPSULE 20MG are as follows:
- Rheumatoid Arthritis: It helps reduce inflammation and joint damage caused by autoimmune activity.
- Osteoarthritis: It helps relieve joint pain, inflammation, and stiffness caused by cartilage wear and tear.
- Ankylosing Spondylitis: It helps alleviate spinal pain and stiffness associated with this chronic inflammatory disease.
- Menstrual Pain (Dysmenorrhea) Management: It can effectively relieve pain caused by menstrual cramps, providing comfort during menstruation (periods).
- Postoperative Pain Management: It is often prescribed for short-term pain and inflammation management following surgical procedures.
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Directions for Use
- PIROX CAPSULE 20MG can be taken with or without food. However, taking it after food may help reduce stomach upset.
- It is usually taken 1-2 times daily at the same time each day or as prescribed by your doctor.
- Swallow it as a whole with a glass of water.
- Do not crush, chew, break, or open the medication.
Key Benefits
- PIROX CAPSULE 20MG belongs to the group of painkillers known as NSAIDs (Non-Steroidal Anti-Inflammatory Drugs).
- PIROX CAPSULE 20MG is used to relieve symptoms associated with rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis, such as stiffness, swelling, and joint pain.
- PIROX CAPSULE 20MG contains Piroxicam, which works by blocking the effect of a chemical messenger in the body, known as cyclooxygenase (COX) enzymes, that produce another chemical, prostaglandins.
- Prostaglandins are produced at injury sites and cause pain and swelling.
- By blocking the effect of COX enzymes, fewer prostaglandins are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site.
How PIROX CAPSULE 20MG Works
Storage
- Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
- Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
- Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
- Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
- Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
- Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
- Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
- Drink water or other clear fluids.
- To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
- Include bland foods like rice, toast, crackers, and rice in your diet.
- Avoid lying down immediately after eating as it may cause indigestion or heartburn.
- Avoid acidic and spicy food as it may cause indigestion.
- Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
- Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
- Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
- Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
- Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
- Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
- Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
- Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
- Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
- Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
- Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
- Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
- Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
- Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
- Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
- Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
- Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
- Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
- Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
- Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
- Tell your doctor about your GAS symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
- To manage GAS symptoms, eat a balanced diet of fibre, vegetables, and fruits.
- Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
- Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
- Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
- Take medication for GAS symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
- If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.
What if I have taken an overdose of PIROX CAPSULE 20MG
Drug Warnings
- Do not take PIROX CAPSULE 20MG if you are allergic to any of its ingredients or have a history of an asthma attack or severe allergic reaction to NSAIDs.
- PIROX CAPSULE 20MG may increase the risk of serious heart-related problems, like heart attack and stroke.
- It may also cause stomach and intestinal bleeding/ulcers. So, inform your doctor if you have any heart or stomach problems before taking PIROX CAPSULE 20MG.
- Avoid taking PIROX CAPSULE 20MG if you have had heart bypass surgery or coronary artery bypass graft surgery (CABG), as it can increase your risk of a heart attack or stroke.
- Consult your doctor before taking PIROX CAPSULE 20MG if you are pregnant or planning to become pregnant.
- Avoid breastfeeding while taking PIROX CAPSULE 20MG, as it can pass into breast milk.
- PIROX CAPSULE 20MG is not recommended for children under 18 years, as its safety and efficacy have not been established.
- PIROX CAPSULE 20MG may cause drowsiness, dizziness, and vision problems, so drive with caution.
- Avoid consuming alcohol along with PIROX CAPSULE 20MG, as it may increase drowsiness and the risk of stomach bleeding.
- Inform your doctor before taking PIROX CAPSULE 20MG if you have asthma, water retention (oedema), hypertension (high blood pressure), diabetes (high blood sugar), high cholesterol, blood clots, or liver/kidney disease.
Drug-Drug Interactions
Drug-Drug Interactions
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Using ketorolac tromethamine together with Pirox Capsule 20mg may increase the risk of side effects.
How to manage the interaction:
Taking Pirox Capsule 20mg with Ketorolac tromethamine is not recommended as it can cause an interaction, it can be taken if prescribed by the doctor. Consult a doctor if you experience any unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop using any medications without talking to a doctor.
Co-administration of Cidofovir with Pirox Capsule 20mg can increase the risk of kidney problems.
How to manage the interaction:
Taking Pirox Capsule 20mg with Cidofovir is not recommended as it can cause an interaction, it can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
Taking Pirox Capsule 20mg with Rofecoxib together may lead to side effects such as inflammation(swelling with redness and pain), bleeding, ulceration.
How to manage the interaction:
Taking Pirox Capsule 20mg with Rofecoxib together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
Coadministration of Pirox Capsule 20mg and Tenofovir alafenamide can increase the risk of kidney damage.
How to manage the interaction:
Although taking Tenofovir alafenamide and Pirox Capsule 20mg together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, swelling, difficulty breathing, bone pain, muscle pain, dizziness, and irregular heartbeat, consult a doctor. Do not stop using any medications without consulting a doctor.
Using ibritumomab tiuxetan together with Pirox Capsule 20mg may increase the risk of bleeding.
How to manage the interaction:
Co-administration of Pirox Capsule 20mg with Ibritumomab tiuxetan (90y) can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without talking to a doctor.
Coadministration of Tolmetin with Pirox Capsule 20mg can increase the risk of side effects (inflammation, bleeding, ulceration, and rarely, perforation).
How to manage the interaction:
There may be a possibility of interaction between Pirox Capsule 20mg and Tolmetin, but it can be taken if prescribed by a doctor. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not discontinue any medication without consulting a doctor.
Using perindopril together with Pirox Capsule 20mg may reduce the effects of perindopril in lowering blood pressure, they may also increase the risk of kidney problems.
How to manage the interaction:
Co-administration of Pirox Capsule 20mg with Perindopril can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, swelling, breathing difficulty, muscle pain, and irregular heart rhythm, contact a doctor immediately. Do not stop using any medications without a doctor's advice.
Co-administration of Sirolimus with Pirox Capsule 20mg can increase the risk or severity of kidney damage.
How to manage the interaction:
Co-administration of Sirolimus with Pirox Capsule 20mg can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, fluid retention, swelling, difficulty breathing, bone pain, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, consult a doctor. Do not stop using any medication without consulting your doctor.
Coadministration of Pirox Capsule 20mg and Ketoconazole may increase the risk of liver injury.
How to manage the interaction:
Although taking Ketoconazole and Pirox Capsule 20mg together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of hunger, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
Coadministration of Pirox Capsule 20mg with Valdecoxib can increase the risk of side effects including inflammation(swelling with redness and pain), bleeding, ulceration.
How to manage the interaction:
Taking Pirox Capsule 20mg with Valdecoxib together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not discontinue any medication without consulting a doctor.
Drug-Food Interactions
Drug-Food Interactions
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Diet & Lifestyle Advise
- Physical activity helps strengthen muscles and relieve joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
- Performing yoga may also help improve joint flexibility and pain.
- Maintain a healthy weight by engaging in regular low-impact exercises and consuming a balanced diet.
- Get adequate sleep, as rest can help reduce inflammation and swelling.
- Follow heat or cold therapy, apply a cold or hot compress on the joints for 15-20minutes regularly.
- De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
- Acupuncture, massage, and physical therapy may also be helpful.
- Eat foods rich in antioxidants, such as berries, spinach, kidney beans, and dark chocolate.
- Foods containing flavonoids can help reduce inflammation. These include soy, berries, broccoli, grapes, and green tea.
- Avoid smoking and alcohol consumption.
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Alcohol
Safe if prescribed
Avoid alcohol consumption while taking PIROX CAPSULE 20MG, as it may cause increased dizziness and drowsiness. It may also cause an increase in the risk of stomach/intestinal ulcers and bleeding.
Pregnancy
Consult your doctor
Avoid taking PIROX CAPSULE 20MG if you are pregnant unless prescribed by the doctor. Please consult your doctor if you have any concerns regarding this; your doctor will prescribe PIROX CAPSULE 20MG only if the benefits outweigh the risks. Do not take PIROX CAPSULE 20MG in the last 20 weeks of pregnancy, as it may cause serious kidney and heart problems in the unborn baby and complications with the pregnancy.
Breast Feeding
Consult your doctor
PIROX CAPSULE 20MG can pass into breast milk. So, avoid breastfeeding while taking PIROX CAPSULE 20MG. Please consult your doctor if you have any concerns regarding this.
Driving
Safe if prescribed
PIROX CAPSULE 20MG may cause drowsiness, dizziness, and vision problems. Do not drive or operate heavy machinery unless you are alert.
Liver
Consult your doctor
Dose adjustment may be needed. PIROX CAPSULE 20MG should be used with caution in patients with liver impairment/liver disease.
Kidney
Consult your doctor
Dose adjustment may be needed. PIROX CAPSULE 20MG should be used with caution in patients with kidney impairment/kidney disease.
Children
Safe if prescribed
PIROX CAPSULE 20MG is not recommended for children under 18 years, as its efficacy and safety have not been established.
Heart
PIROX CAPSULE 20MG may increase the risk of heart attack or stroke. Do not use PIROX CAPSULE 20MG immediately before or after bypass surgery. Inform your doctor if you have a history of heart disease or other heart problems.
Geriatrics
Consult your doctor
PIROX CAPSULE 20MG may be used in geriatric patients, but only with caution and close medical supervision due to its long half-life and increased risk of serious side effects.
FAQs
PIROX CAPSULE 20MG is used to relieve symptoms like pain, inflammation, and joint stiffness associated with rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.
PIROX CAPSULE 20MG works by blocking the effect of chemical messengers (prostaglandin), thereby reducing joint pain, stiffness, swelling, and inflammation.
Diarrhoea might be a side effect of PIROX CAPSULE 20MG. Drink lots of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.
Do not take PIROX CAPSULE 20MG for longer durations or high doses as it may cause unpleasant side effects. Do not exceed the dose and duration prescribed by your doctor.
PIROX CAPSULE 20MG may increase the risk of heart attack or stroke. Do not use PIROX CAPSULE 20MG within 1 week before or after bypass surgery. Inform your doctor if you have a history of heart disease or other heart problems.
Consult your doctor before taking PIROX CAPSULE 20MG if you have diabetes, as PIROX CAPSULE 20MG might increase your blood sugar levels.
The common side effects of PIROX CAPSULE 20MG are diarrhoea, stomach upset, headache, dizziness, ringing in the ears, heartburn, nausea, vomiting, and constipation. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to speak to your doctor if you experience these side effects persistently.
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Reference
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/018147s029lbl.pdf
- https://www.nafdac.gov.ng/wp-content/uploads/Files/SMPC/a_v7/SmPc-PIROXICAM.pdf
- https://www.medicines.org.uk/emc/files/pil.14311.pdf
- https://www.drugs.com/mtm/piroxicam.html
- https://medlineplus.gov/druginfo/meds/a684045.html
- https://www.medindia.net/doctors/drug_information/piroxicam.htm
