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compositionComposition:CILOSTAZOLE-50MG
prescription
Prescription Medicine
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Pletoz 50 Tablet is used to treat pain in the legs due to insufficient blood flow (intermittent claudication). It contains Cilostazole, which works by widening the blood vessels and reducing the blood clotting time, thereby decreasing stickiness in blood vessels. In some cases, you may experience headaches, ankle swelling, diarrhoea, abnormal stools, vomiting, and nausea. Inform your doctor if you are taking any other medicines or have pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CILOSTAZOLE-50MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Pletoz 50 Tablet

Pletoz 50 Tablet is a prescription medication used to improve the symptoms of a condition called intermittent claudication. This condition causes painful muscle cramping in your legs during physical activity, such as walking, due to narrowed arteries that restrict blood flow. This medicine helps you walk longer distances before needing to stop and rest due to leg pain.

To get the best results, you must take Pletoz 50 Tablet consistently every day, usually twice a day. You should take this medicine on an empty stomach, at least 30 minutes before or 2 hours after your morning and evening meals. Combining this treatment with structured physical therapy and heart-healthy lifestyle habits can significantly enhance your physical mobility.

While taking Pletoz 50 Tablet , some people may experience mild side effects, such as headaches or runny nose. However, you should contact your doctor immediately if you notice more serious symptoms, including chest pain, an unusually fast or pounding heartbeat, or unexpected bruising and bleeding.

Do not take this medicine if you have heart failure of any severity, as it can worsen your condition. You should also avoid this medication if you currently have an active bleeding disorder, such as a bleeding stomach ulcer. If you have a history of liver damage or kidney disease, talk to your doctor or pharmacist before starting this treatment to ensure it is safe for you.

Pletoz 50 Tablet can interact with other substances, such as blood thinners, certain stomach acid medications, and grapefruit juice, which may increase the risk of side effects. It is also important to avoid smoking, as nicotine constricts blood vessels and reduces the effectiveness of the treatment. If you are pregnant, breastfeeding, or are an elderly individual, consult your healthcare provider before taking this medication.

Uses of Pletoz 50 Tablet

Pletoz 50 Tablet is primarily used to improve blood flow in people with circulation problems affecting the legs.

  • Intermittent claudication: Pletoz 50 Tablet helps reduce leg pain, cramping, numbness, and weakness that occur during walking or exercise due to reduced blood flow in the leg arteries. It improves circulation, allowing you to walk longer distances with less discomfort.

Key Benefits

Pletoz 50 Tablet helps improve mobility and quality of life by enhancing blood flow to the lower limbs.

  • Improves walking distance: By increasing blood circulation to the legs, Pletoz 50 Tablet can help you walk farther before experiencing pain or discomfort.
  • Reduces leg pain and cramping: Regular use may decrease the frequency and severity of muscle cramps, pain, and fatigue associated with intermittent claudication.
  • Enhances daily mobility: Improved circulation can make it easier to perform everyday activities, participate in social events, and engage in light physical exercise.
  • Supports a more active lifestyle: Better blood flow helps deliver oxygen and nutrients to leg muscles during movement, promoting greater comfort and endurance.
  • Improves overall quality of life: By reducing symptoms and increasing physical function, Pletoz 50 Tablet can help people maintain greater independence and confidence in their daily routines.
Side effects of Pletoz 50 Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Your doctor may adjust the dose of your medication, discontinue, or switch to alternative medicines to manage your symptoms.
  • Drink plenty of water and caffeine-free drinks.
  • Eat more fibre by consuming fruits, vegetables, and whole grains.
  • Avoid processed, spicy, or fatty foods.
  • Try not to skip meals, delay eating, or eat too quickly.
  • Regular exercise can help improve digestion and promote better stool movement.
  • Wash your hands regularly with soap and water or use a hand sanitizer to prevent the spread of infections.
  • Wear masks, gloves and other protective clothing.
  • Cover sneezes and coughs with a medical mask or tissue or your elbow.
  • Take vaccinations to enhance your immunity to specific diseases.
  • Clean your utensils, linen and surfaces regularly.
Managing Medication-Triggered Rhinitis (Stuffy Nose): A Step-by-Step Guide
  • Consult your doctor if you experience nasal congestion, runny nose, or sinus pressure after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your rhinitis symptoms.
  • If advised by your doctor, use nasal decongestants or saline nasal sprays to help relieve nasal congestion.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of water and other fluids to help thin out mucus and soothe your nasal passages.
  • Drink warm fluids such as warm water with honey, broth, soup or herbal tea to soothe sore throat.
  • Gargle with warm salt water.
  • Suck on lozenges to increase the production of saliva and soothe your throat.
  • Use a humidifier to soothe sore throat as it adds moisture to the air and makes breathing easier.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Directions for Use

To get the best results from Pletoz 50 Tablet , it is important to take the medication exactly as prescribed by your doctor.

  • Swallow the tablet whole with a full glass of water.
  • Do not crush, chew, or split the tablet unless your doctor specifically instructs you to do so.
  • Take Pletoz 50 Tablet on an empty stomach, either 30 minutes before meals or 2 hours after meals, as food can affect how the medication is absorbed.
  • Try to take your doses at the same times each day to maintain consistent levels of the medicine in your body.
  • Follow your doctor's prescribed treatment schedule carefully and attend any recommended follow-up appointments.
  • Do not stop taking the medication suddenly without consulting your doctor, as this may reduce its effectiveness in managing your symptoms.

How Pletoz 50 Tablet Works

Pletoz 50 Tablet works in two distinct ways to improve blood flow in your limbs. First, it acts as a vasodilator, which means it relaxes and widens the blood vessels. This relaxation allows blood to flow more easily through the narrowed arteries in your legs. Second, this medicine has antiplatelet properties. It prevents tiny blood cells called platelets from clumping together and forming blood clots inside your blood vessels. By keeping your blood flowing smoothly and preventing blockages, the medication ensures a steady oxygen supply to your leg muscles during activity.
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Alcohol

Safe if prescribed

No interaction found; in case of any discomfort, consult your doctor.

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Pregnancy

Caution

Pletoz 50 Tablet is not recommended during pregnancy unless your doctor considers it essential. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Breast Feeding

Unsafe

Pletoz 50 Tablet is not recommended for breastfeeding mothers as it may harm the baby.

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Driving

Caution

Drive with caution, Pletoz 50 Tablet may cause blurry vision and dizziness or weariness may occur.

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Liver

Caution

Pletoz 50 Tablet to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Pletoz 50 Tablet to be taken with caution, especially if you have a history of kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Unsafe

Pletoz 50 Tablet is not recommended for children. The safety and effectiveness of Pletoz 50 Tablet have not been established in children due to limited testing of this drug on children. If necessary, your doctor will decide whether to give Pletoz 50 Tablet or not.

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Heart

Unsafe

Pletoz 50 Tablet is not recommended for use in heart patients as it can lead to cardiovascular effects.

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Geriatrics

Caution

Pletoz 50 Tablet should be used under caution in geriatric patients. Please consult your physician.

What if I have taken an overdose of Pletoz 50 Tablet

If you suspect an overdose, seek immediate medical attention or contact your local emergency room. Symptoms of an overdose may include severe headaches, dizziness, a rapid heart rate, or low blood pressure.

Diet & Lifestyle Advise

  • Participate in a walking program: Engaging in a regular, structured walking routine can significantly improve the distance you can walk over time when combined with this medication.
  • Stop smoking: Tobacco smoke narrows your blood vessels and actively worsens peripheral arterial disease, counteracting the benefits of Pletoz 50 Tablet .
  • Eat a heart-healthy diet: Focus on foods low in saturated fats, trans fats, and cholesterol to prevent further buildup of plaque in your arteries.
  • Avoid grapefruit products: Do not consume grapefruit or grapefruit juice, as it can interfere with how your body processes this medicine.
health query

Have a query?

How Soon It Starts Working

  • The time required for Pletoz 50 Tablet to start to work: The time required for Pletoz 50 Tablet to show its action is not clinically established.
  • The time for which the effects of Pletoz 50 Tablet last: The duration of action for Pletoz 50 Tablet is not clinically established.

What if you forget to take Pletoz 50 Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store Pletoz 50 Tablet at room temperature, ideally between 20°C and 25°C (68°F and 77°F). • Keep the tablets in their original packaging to protect them from moisture and direct light.

Drug Warnings

  • Avoid taking this medicine with a high-fat meal: Never take this medication with a high-fat meal, as this can dramatically increase absorption and raise your risk of severe side effects.
  • Before surgery or dental procedures: If you need surgery or a dental procedure, inform your surgeon or dentist that you are taking Pletoz 50 Tablet , as you may need to stop taking it temporarily to prevent excess bleeding.
  • Take extra care to prevent injuries: Be cautious when using sharp objects, like razors or nail clippers, because this medicine makes you more prone to bleeding.
  • Monitor your heart rate regularly: Check your pulse regularly and notify your healthcare provider if you notice your heart beating much faster than usual.

Drug-Drug Interactions

verifiedApollotooltip

Pletoz 50 Tablet may interact with medications that affect blood clotting or alter how the drug is metabolised in the body.

  • Blood thinners and antiplatelet medicines: Taking these medications with Pletoz 50 Tablet may increase the risk of bleeding.
  • Omeprazole and similar stomach acid-reducing medicines: These can increase the levels of Pletoz 50 Tablet in the bloodstream, potentially increasing the risk of side effects.
  • Certain antibiotics and antifungal medications: These medicines may raise Pletoz 50 Tablet levels in the body, making adverse effects more likely.
CilostazolCisapride
Critical
CilostazolPimozide
Critical

Drug-Drug Interactions

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CilostazolCisapride
Critical
How does the drug interact with Pletoz 50 Tablet:
When Pletoz 50 Tablet is taken with Cisapride, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Using Cisapride and Pletoz 50 Tablet is not recommended, but it can be taken if prescribed by a doctor. If you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, call a doctor right away. Do not stop using any medications without a doctor's advice.
CilostazolPimozide
Critical
How does the drug interact with Pletoz 50 Tablet:
When Pletoz 50 Tablet is taken with Pimozide, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Using Pimozide with Pletoz 50 Tablet is not generally advised, but it can be taken if prescribed by a doctor. If you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, call a doctor right away. Do not stop using any medications without a doctor's advice.
CilostazolSparfloxacin
Critical
How does the drug interact with Pletoz 50 Tablet:
When Pletoz 50 Tablet is taken with Sparfloxacin, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
There may be a possibility of interaction between Sparfloxacin and Pletoz 50 Tablet, but it can be taken if prescribed by a doctor. If you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, call a doctor right away. Do not stop using any medications without a doctor's advice.
CilostazolThioridazine
Critical
How does the drug interact with Pletoz 50 Tablet:
When Pletoz 50 Tablet is taken with Thioridazine, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Using Thioridazine with Pletoz 50 Tablet is not recommended, but it can be taken if prescribed by a doctor. If you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, call a doctor right away. Do not stop using any medications without a doctor's advice.
CilostazolMesoridazine
Critical
How does the drug interact with Pletoz 50 Tablet:
When Mesoridazine is taken with Cisapride, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Using Mesoridazine with Pletoz 50 Tablet, is not recommended but it can be taken if prescribed by a doctor. If you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, call a doctor right away. Do not stop using any medications without a doctor's advice.
CilostazolZiprasidone
Critical
How does the drug interact with Pletoz 50 Tablet:
When Pletoz 50 Tablet is taken with Ziprasidone, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Using Ziprasidone and Pletoz 50 Tablet is not recommended, but it can be taken if prescribed by a doctor. If you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, call a doctor right away. Do not stop using any medications without a doctor's advice.
CilostazolDelavirdine
Severe
How does the drug interact with Pletoz 50 Tablet:
Co-administration of delavirdine with Pletoz 50 Tablet may increase the risk of side effects.

How to manage the interaction:
Taking delavirdine with Pletoz 50 Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, nausea, diarrhea, bleeding. Do not discontinue any medications without consulting a doctor.
CilostazolMoxifloxacin
Severe
How does the drug interact with Pletoz 50 Tablet:
Co-administration of Moxifloxacin with Pletoz 50 Tablet can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Moxifloxacin with Pletoz 50 Tablet together can result in an interaction, it can be taken if a doctor has advised it. However, contact a doctor immediately if you experience dizziness, shortness of breath, or rapid heartbeat. Do not discontinue any medications without consulting a doctor.
CilostazolApixaban
Severe
How does the drug interact with Pletoz 50 Tablet:
Coadministration of Pletoz 50 Tablet and Apixaban co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Pletoz 50 Tablet and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
CilostazolDasatinib
Severe
How does the drug interact with Pletoz 50 Tablet:
Co-administration of Dasatinib with Pletoz 50 Tablet can increase the risk of bleeding.

How to manage the interaction:
Taking Dasatinib with Pletoz 50 Tablet together can result in an interaction, it can be taken if a doctor has advised it. However, contact a doctor immediately if you experience any symptoms such as bruising, dizziness, red or black, tarry stools, severe headache, and weakness. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip

Certain foods and beverages can affect the absorption and metabolism of Pletoz 50 Tablet .

  • Grapefruit and grapefruit juice: These may increase the amount of Pletoz 50 Tablet in the bloodstream and raise the risk of side effects.
  • High-fat meals: Taking Pletoz 50 Tablet with high-fat meals can increase drug absorption and alter its effects. Follow your doctor's instructions regarding meal timing.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[CARDIOVASCULAR AGENTS]

FAQs

Pletoz 50 Tablet is used to treat intermittent claudication (pain in the legs due to insufficient blood flow). It also reduces cramping, numbness, or weakness in the legs when walking in such patients.
Pletoz 50 Tablet works by widening the blood vessels and reducing the blood clotting time, thereby decreasing stickiness in blood vessels. Hence, it increases the blood supply to the limbs. It can also increase the distance you can walk without pain since it improves your leg's blood circulation.
No, you should not stop taking Pletoz 50 Tablet even if you feel better, as the pain might come back and become even worse.
Yes, taking Pletoz 50 Tablet can increase bleeding risk as it contains cilostazole, which increases bleeding time. So, please be very cautious while shaving, cutting fingernails or toenails, or using sharp objects to avoid bleeding. Let your doctor know before undergoing any surgical procedure that you are taking Pletoz 50 Tablet .
No, it is a prescribed drug given by a physician for preventing specific medical conditions. Taking it on your own can cause unwanted side effects.
If you forget to take Pletoz 50 Tablet at any time, take it as soon as you remember, then continue to take it at the usual times. Do not take a double dose to make up for a forgotten dose.
Pletoz 50 Tablet may cause side effects like headaches, ankle swelling, diarrhoea, abnormal stools, vomiting, and nausea. Most of these side effects of Pletoz 50 Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.
Pletoz 50 Tablet might lower the blood pressure; taking Pletoz 50 Tablet with blood pressure-lowering medicines might further decrease the blood pressure. Therefore, please consult the doctor before taking Pletoz 50 Tablet with other blood pressure-lowering medicines.
No, do not smoke if you are taking Pletoz 50 Tablet , as smoking might affect the working of Pletoz 50 Tablet .
You are advised to take Pletoz 50 Tablet for the duration prescribed by the doctor. The duration of treatment will depend on your condition and response to the treatment.
Yes, you may need to stop taking Pletoz 50 Tablet a few days before surgery to avoid the increased risk of bleeding during the procedure. Let the doctor know if you are due to undergo surgery.
Pletoz 50 Tablet might lower the blood pressure as it widens the blood vessels. Therefore, if you have low blood pressure/high blood pressure or if you are taking blood pressure-lowering medicines, please consult a doctor.
No, you should take Pletoz 50 Tablet on an empty stomach, either 30 minutes before or 2 hours after breakfast and dinner. Taking it with food, especially high-fat meals, can cause too much of the drug to be absorbed. Talk to your doctor if you have trouble timing your doses.
Many patients begin to notice an improvement in their walking distance within 2 to 4 weeks, but it may take up to 12 weeks of consistent use to experience the full benefits. Talk to your doctor if your symptoms do not improve after 3 months.
This medication belongs to a class of drugs that can increase the risk of severe heart complications and mortality in patients with heart failure of any severity. Do not take this medicine if you have heart failure. Talk to your doctor for safer alternatives.
It is highly recommended to limit or avoid alcohol while taking Pletoz 50 Tablet . Alcohol can widen your blood vessels further, which may worsen side effects like dizziness, lightheadedness, and headaches. Talk to your doctor or pharmacist for personalised advice.
Headaches are a very common side effect when starting this medication and often improve as your body adjusts. However, if your headache is severe, persistent, or accompanied by vision changes, talk to your doctor or pharmacist immediately.
Taking aspirin with Pletoz 50 Tablet can increase your risk of bleeding because both medications reduce blood clotting. You should only take them together if your doctor specifically prescribes both and monitors your health closely. Talk to your doctor about all the medications you use.
Pletoz 50 Tablet is generally not recommended during pregnancy or breastfeeding due to a lack of safety data on how it affects developing babies. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor to explore safer treatment options.

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Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - PLE0008
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