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compositionComposition:SPIRONOLACTONE-50MG+TORSEMIDE-20MG
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Prescription Medicine
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Plextor Plus 20/50 Tablet 10's is used to treat Oedema. It contains Spirolactone and Torsemide, which work by increasing the amount of urine that is passed out from the kidneys. In some cases, you may experience side effects such as dehydration, electrolyte disturbances (potassium and sodium), headache, nausea, or dizziness. Before starting this medicine, inform your doctor if you are pregnant, breastfeeding, taking any other medicines or have pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

SPIRONOLACTONE-50MG+TORSEMIDE-20MG

Manufacturer/Marketer :

Plexcure Healthcare Pvt Ltd

Consume Type :

Oral

Return Policy :

Not Returnable

About Plextor Plus 20/50 Tablet 10's

Plextor Plus 20/50 Tablet 10's is a prescription oral medication primarily used to manage fluid retention, also known as oedema. It is prescribed to treat swelling in the tissues caused by serious underlying medical conditions such as heart failure, liver disease, or kidney disorders. By helping your body eliminate excess fluid, this medication reduces swelling and relieves pressure on your cardiovascular system.

To achieve the best clinical outcomes, you must take Plextor Plus 20/50 Tablet 10's consistently every single day, exactly as directed by your healthcare provider. This oral tablet is typically taken once daily in the morning, and it can be taken with or without food. Combining this treatment with a low-sodium diet and daily monitoring of your weight can significantly enhance its effectiveness.

While taking Plextor Plus 20/50 Tablet 10's, you might experience mild, common side effects such as an increased need to urinate, mild dizziness, or lightheadedness. However, you should contact your doctor immediately if you experience severe symptoms like extreme muscle weakness, irregular heartbeat, or severe cramps, which could indicate a serious imbalance in your blood minerals.

Talk to your doctor before starting this medication if you have a history of liver damage, diabetes, or gout, as these conditions may require careful monitoring. You should not take Plextor Plus 20/50 Tablet 10's if you have severe kidney failure, are completely unable to urinate, or have dangerously high levels of potassium in your blood.

This medication can interact with other blood pressure drugs, potassium supplements, and alcohol, potentially causing dangerously low blood pressure or disrupting safe mineral balances. If you are pregnant, breastfeeding, or are an elderly individual, you should consult your healthcare provider to discuss the safety and risks of using this medication.

Uses of Plextor Plus 20/50 Tablet 10's

Plextor Plus 20/50 Tablet 10's is used to manage oedema. The detailed uses of Plextor Plus 20/50 Tablet 10's are as follows:

  • Fluid retention (Oedema): Plextor Plus 20/50 Tablet 10's helps remove excess water and salt from your body tissues, reducing swelling in your legs, ankles, feet, or abdomen.
  • Congestive Heart Failure: By lowering the total fluid volume in your blood vessels, it makes it easier for your heart to pump blood, reducing physical strain.
  • Liver Cirrhosis Support: It helps safely drain fluid buildup in the abdominal cavity that commonly occurs when liver damage impairs normal circulation.
     

Key Benefits

Plextor Plus 20/50 Tablet 10's helps manage fluid retention by increasing the removal of excess water and salt from the body. This action helps reduce swelling and supports the proper functioning of the heart, lungs, and blood vessels, improving overall comfort and well-being.

  • Helps Reduce Swelling and Fluid Build-Up: By removing excess fluid from the body, Plextor Plus 20/50 Tablet 10's helps relieve swelling in the legs, ankles, and other affected areas, making movement more comfortable and reducing feelings of heaviness or tightness.
  • Supports Easier Breathing: Reducing excess fluid can decrease the strain on the heart and lungs, helping relieve shortness of breath and improving comfort during physical activity and rest.
  • Helps Maintain Potassium Balance: The formulation is designed to help remove excess fluid while reducing the risk of low potassium levels. Maintaining healthy potassium levels supports normal muscle, nerve, and heart function during treatment.
     

Directions for Use

Follow these step-by-step instructions to take this oral medication safely and effectively:

  • Swallow the tablet whole with a full glass of water.
  • Do not crush, chew, or break the tablet, as this can affect how the medicine is absorbed in your body.
  • Take this medication at the same time every day, ideally in the morning, to avoid having to wake up during the night to urinate.
  • You can take this medicine with or without food, but be consistent with how you take it each day.
  • Always follow your doctor's exact instructions regarding your dose and schedule.
     

How Plextor Plus 20/50 Tablet 10's Works

As a combination oral medication, Plextor Plus 20/50 Tablet 10's works by targeting your kidneys in two distinct ways to promote fluid loss while maintaining mineral balance. The first active component in this medicine, torsemide, is a loop diuretic that acts on a part of the kidney called the loop of Henle. It blocks the reabsorption of sodium and chloride, causing your body to eliminate excess salt and water through the urine. Torsemide also increases the excretion of potassium and magnesium, which can contribute to mineral imbalances during treatment. This process rapidly decreases the volume of fluid circulating in your bloodstream, relieving pressure in swollen tissues. The second active component, spironolactone, is a potassium-sparing diuretic and aldosterone receptor blocker. When your body flushes out salt and water, it naturally risks losing too much potassium, an essential mineral for heart function. By blocking aldosterone receptors in the kidneys, spironolactone helps the body retain potassium while still allowing excess sodium and water to be eliminated. This complements the action of torsemide and helps reduce the risk of low potassium levels during treatment. Working together, these two ingredients safely relieve swelling while helping maintain mineral balance.
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Alcohol

Caution

You are recommended not to consume alcohol along with Plextor Plus 20/50 Tablet 10's to avoid unpleasant side-effects.

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Pregnancy

Unsafe

Plextor Plus 20/50 Tablet 10's must not be taken during pregnancy.

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Breast Feeding

Unsafe

Breastfeeding must be avoided during treatment with Plextor Plus 20/50 Tablet 10's.

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Driving

Caution

It is not recommended to drive after taking Plextor Plus 20/50 Tablet 10's as it may occasionally cause drowsiness due to orthostatic hypotension (sudden drop in blood pressure on standing from lying position).

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Liver

Caution

Plextor Plus 20/50 Tablet 10's to be taken with caution, especially if you have a history of liver problems. Your doctor may adjust your dose depending on your current kidney conditions.

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Kidney

Caution

Plextor Plus 20/50 Tablet 10's to be taken with caution, especially if you have a history of kidney problems. Your doctor may adjust your dose depending on your current kidney conditions.

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Children

Unsafe

Plextor Plus 20/50 Tablet 10's is not recommended for children below 12 years of age.

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Heart

Safe if prescribed

Plextor Plus 20/50 Tablet 10's is safe for use in heart patients if recommended by the physician.

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Geriatrics

Caution

Plextor Plus 20/50 Tablet 10's should be used with caution in geriatric patients as it can cause side effects, including increased potassium levels in some cases. Please consult your physician.

What if I have taken an overdose of Plextor Plus 20/50 Tablet 10's

Do not take more than the prescribed dose of Plextor Plus 20/50 Tablet 10's as it may cause serious side effects. If you suspect you have taken an overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Limit sodium intake: Reduce your daily consumption of table salt, processed foods, canned soups, and salty snacks. High sodium intake causes your body to hold onto water, directly fighting against the therapeutic effects of Plextor Plus 20/50 Tablet 10's.
  • Monitor your weight daily: Weigh yourself every morning at the same time, wearing similar clothing, after urinating but before eating. Report any sudden weight gain (such as 2-3 pounds in a single day or 5 pounds in a week) to your doctor immediately, as this is a primary sign of fluid accumulation.
  • Avoid potassium-rich salt substitutes: Do not use salt substitutes containing potassium chloride, and talk to your doctor before eating large amounts of high-potassium foods (like bananas or spinach), as this medicine causes your body to retain potassium.
  • Track your daily fluid intake: If your doctor has put you on a fluid restriction, keep a precise log of everything you drink to avoid overloading your system.
     
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How Soon It Starts Working

  • The time required for Plextor Plus 20/50 Tablet 10's to start to work: Plextor Plus 20/50 Tablet 10's ideally shows its action within 1 hour after administration.
  • The time for which the effects of Plextor Plus 20/50 Tablet 10's last: The effect of Plextor Plus 20/50 Tablet 10's lasts for 2 to 3 days.

What if you forget to take Plextor Plus 20/50 Tablet 10's

If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and take the next dose at the scheduled time. Do not take a double dose.

Storage

Store Plextor Plus 20/50 Tablet 10's tablets at controlled room temperature, ideally between 20°C and 25°C (68°F to 77°F). •Keep the medication in its original container, tightly closed, to protect it from direct light, moisture, and extreme heat.

Drug Warnings

  • Stand up slowly: To prevent dizziness or fainting caused by a sudden drop in blood pressure, take your time when rising from a sitting or lying position.
  • Schedule regular blood tests: Attend all scheduled medical appointments for blood tests to check your kidney function and blood potassium levels.
  • Monitor your blood pressure: Keep a regular log of your blood pressure readings at home and share them with your doctor during your visits.
  • Limit alcohol consumption: Drinking alcohol while taking Plextor Plus 20/50 Tablet 10's can worsen side effects like dizziness, drowsiness, and dangerously low blood pressure.
  • Avoid prolonged sun exposure: Some patients may experience increased skin sensitivity to sunlight while taking this medication. Consider using sunscreen and wearing protective clothing when spending extended periods outdoors, particularly if you notice increased skin sensitivity.
     

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Drug-Drug Interactions

  • Potassium supplements and potassium-sparing pills: May cause dangerously high levels of potassium in your blood, which can lead to life-threatening heart rhythm problems.
  • ACE inhibitors and ARBs (blood pressure medications): Taking these alongside Plextor Plus 20/50 Tablet 10's increases the risk of high blood potassium levels and kidney strain.
  • Nonsteroidal Anti-inflammatory Drugs (NSAIDs like ibuprofen): May reduce the effectiveness of this medication and significantly increase the risk of kidney damage.
  • Lithium: This medicine can decrease the clearance of lithium from your body, raising the risk of severe lithium toxicity.


Drug-Food Interactions

  • Salt substitutes: Avoid salt alternatives that contain potassium, as they can lead to an unsafe accumulation of potassium in your body.
  • Liquorice root: Consuming natural liquorice can counteract the therapeutic effects of Plextor Plus 20/50 Tablet 10's and worsen fluid retention.


Drug-Disease Interactions

  • Severe kidney disease: If your kidneys are failing or you cannot pass urine, taking this medication can cause severe, life-threatening mineral imbalances and fluid retention.
  • Liver damage (Cirrhosis): Sudden changes in fluid and mineral balance can trigger a serious brain condition called hepatic encephalopathy; use with extreme caution.
  • Diabetes: This medication may alter blood sugar control, requiring closer monitoring of your glucose levels and potential adjustments to your diabetes medications.
  • Gout: This medicine can raise uric acid levels in your blood, potentially triggering painful gout attacks.
     

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[DIURETIC]

FAQs

Plextor Plus 20/50 Tablet 10's is primarily used to treat oedema. It also maintains the bloodstream potassium level and prevents hypertension (high blood pressure due to oedema (fluid retention).
Plextor Plus 20/50 Tablet 10's works by increasing the amount of urine that is passed out from the kidneys. It effectively reduces excess fluid levels in the body and treats oedema (swelling) associated with heart, liver, kidney, or lung disease. This reduces the heart workload and makes the heart more efficient at pumping blood throughout the body. Thus, it also helps lower high blood pressure, reducing the chances of any future heart attack, stroke, or angina (chest pain).
It is a medical term for fluid retention or overload. Due to oedema, the legs, hands, and other body parts start swelling, increasing blood pressure. If it does not subside, please consult your doctor immediately.
The main side effect of Plextor Plus 20/50 Tablet 10's is peeing (urination) more often than normal. Most people need to pee about 30 minutes after taking Plextor Plus 20/50 Tablet 10's, and again within a few hours. Do not take Plextor Plus 20/50 Tablet 10's before going to bed, or you may have to wake in the night to urinate frequently.
Yes, Plextor Plus 20/50 Tablet 10's is known to cause dehydration (excessive loss of fluids). The patient may experience dry mouth, decreased urine output, excessive thirst and hypotension (decreased blood pressure). Therefore, please increase your fluid intake to prevent excessive dehydration.
Yes, Plextor Plus 20/50 Tablet 10's can cause increased potassium level (hyperkalemia), especially in patients with kidney problems or if you are taking potassium supplements along with Plextor Plus 20/50 Tablet 10's. Please monitor your electrolyte level regularly to avoid an increase in blood potassium level.
Plextor Plus 20/50 Tablet 10's may cause orthostatic hypotension. This is low blood pressure that makes you feel dizzy or lightheaded when you stand up after sitting or lying down. This may be more common after just starting this drug. You can avoid this by standing up slowly. If the symptoms persists, consult your doctor.
Plextor Plus 20/50 Tablet 10's should be swallowed as a whole with water; do not crush or chew it. Take it preferably in the daytime to avoid frequent urination in the nighttime.
Plextor Plus 20/50 Tablet 10's contains torsemide which may increase the levels of uric acid, leading to gout. Consult the doctor if you experience severe pain, tenderness, or swelling, often in the big toe.
Plextor Plus 20/50 Tablet 10's is not recommended for people allergic to any of its components, have low blood pressure (less than 90 mm of Hg), have had a heart attack, or have kidney disease (with creatinine clearance less than 30 mL/min), or liver disease. Besides this, it is contraindicated in low blood pressure (hypotension), cardiogenic shock (sudden stopping of blood flow to the heart), and aortic stenosis (heart valve problem).
Store Plextor Plus 20/50 Tablet 10's at room temperature, in a dry place. Keep out of sight and reach of children.
Plextor Plus 20/50 Tablet 10's is a combination medication containing Spironolactone and Torsemide.
Yes, it is safe to use Plextor Plus 20/50 Tablet 10's if taken in the dose and duration prescribed by the doctor.
Plextor Plus 20/50 Tablet 10's may cause side effects like dehydration, electrolyte disturbances (potassium and sodium), headache, nausea, or dizziness. If the side effects are persistent, reach out to your doctor.
Because Plextor Plus 20/50 Tablet 10's contains an ingredient that helps your body retain potassium, eating excessive amounts of potassium-rich foods like bananas, oranges, or spinach can lead to dangerously high blood potassium levels. You do not need to avoid them entirely, but you should consume them in moderation. Talk to your doctor.
It is highly advised to limit or avoid alcohol while taking Plextor Plus 20/50 Tablet 10's. Alcohol can worsen the blood pressure-lowering effects of this medicine, leading to severe dizziness, lightheadedness, and an increased risk of fainting. Talk to your doctor.
Yes, this medication can sometimes affect blood sugar levels and may make it slightly more difficult to manage diabetes. If you have diabetes, you should monitor your blood glucose levels more closely while taking this medicine. Talk to your doctor.
No, you should avoid taking nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen without consulting a healthcare professional first. These painkillers can reduce the effectiveness of Plextor Plus 20/50 Tablet 10's and increase your risk of severe kidney damage. Talk to your doctor.
Yes, your doctor will require regular blood tests to monitor your kidney function and check the levels of electrolytes, particularly potassium, in your blood. This is essential to ensure the medicine is working safely and effectively. Talk to your doctor.

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While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

315, Golden Square, Kalyan Chok, Near Nikol fire station, Nikol, Ahmedabad—382350, Gujarat, India.
Other Info - PLE0187
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