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compositionComposition:COLISTIMETHATE SODIUM
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Prescription Medicine
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Polyxx-E 2Miu Inj is used to treat bacterial infections. It contains Colistimethate Sodium.  It effectively solubilizes the bacterial cell membrane, resulting in bacterial cell death. As a result, it destroys the bacteria and successfully treats the infection. Common side effects of Polyxx-E 2Miu Inj may include injection site reactions, renal damage, visual disturbances, GI disturbances, dizziness, nausea, vomiting and muscle weakness.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

COLISTIMETHATE SODIUM

Manufacturer/Marketer :

Macleods Pharmaceuticals Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Polyxx-E 2Miu Inj

Polyxx-E 2Miu Inj is an injectable antibiotic used to treat serious bacterial infections, particularly those caused by hard-to-treat bacteria. It is prescribed for severe infections of the lungs, urinary tract, or blood when other standard antibiotics are not effective.

This medicine is injected regularly at set intervals to keep a constant level of the drug in your body. Because it is given as an injection, food does not affect how it works, but staying well-hydrated is crucial during treatment. Making small lifestyle adjustments, like drinking plenty of water and getting extra rest, can help your body recover faster.

While highly effective, some people may experience side effects such as tingling in the hands or feet, dizziness, or mild stomach upset. You must consult your doctor immediately if you experience serious symptoms like decreased urination, severe muscle weakness, or difficulty breathing.

Before starting treatment, tell your doctor if you have kidney disease or nerve disorders. Do not take this if you have had a severe allergic reaction to this medication or similar antibiotics in the past.

It can interact with other medicines, such as specific muscle relaxants or other antibiotics that can cause kidney strain, so always share your full medication list. If you are pregnant, breastfeeding, or an older adult, you should consult your healthcare provider, as your doctor may need to monitor your kidney function closely.

Uses of Polyxx-E 2Miu Inj

Polyxx-E 2Miu Inj is used in the treatment of bacterial infections. The detailed use of Polyxx-E 2Miu Inj is as follows:

  • Severe Gram-negative bacterial infections (a type of bacteria with a tough outer coating that makes them harder to kill): Polyxx-E 2Miu Inj helps clear severe infections in the lungs, urinary tract, or blood caused by these hard-to-treat bacteria.
  • Multidrug-resistant infections: Polyxx-E 2Miu Inj acts as an important treatment option when other standard antibiotics fail to clear resistant bacterial strains.

Key Benefits

$Name provides vital therapeutic relief for patients fighting severe, deep-seated infections. The following are the benefits of this medication:

  • Helps eliminate the bacteria responsible for severe infections.
  • Relieves symptoms such as fever, body pain, and fatigue as the infection improves.
  • Supports recovery and helps restore normal organ function in patients with severe lung or bloodstream infections.
  • Reduces the risk of the infection spreading to other parts of the body.
  • Provides an effective treatment option when other commonly used antibiotics are no longer effective against resistant bacteria.

Directions for Use

  • Your doctor will determine the dosage and frequency depending on your condition.
  • Polyxx-E 2Miu Inj will be administered by a healthcare professional.
  • Do not self-administer.

How Polyxx-E 2Miu Inj Works

Polyxx-E 2Miu Inj works by targeting and disrupting the outer protective barrier (the cell wall) of harmful bacteria. By damaging this membrane, it causes the essential contents of the bacterial cell to leak out, which quickly destroys the bacteria. This action stops the spread of the infection and allows your body's natural immune system to clear the remaining bacteria.
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Alcohol

Caution

Limit alcohol consumption while on treatment with this medicine as it may worsen drowsiness, dizziness or sleepiness.

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Pregnancy

Caution

Polyxx-E 2Miu Inj should not be used in pregnancy unless necessary. Hence, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Polyxx-E 2Miu Inj.

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Breast Feeding

Caution

Polyxx-E 2Miu Inj should not be used in nursing mothers unless necessary. So, inform your doctor if you are a breastfeeding mother. Your doctor will weigh the benefits and potential risks before prescribing Polyxx-E 2Miu Inj.

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Driving

Caution

You may have side effects like visual disturbances and dizziness after taking Polyxx-E 2Miu Inj that may make you unfit to drive or operate machinery. Hence, do not drive or operate machinery until you are feeling well.

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Liver

Safe if prescribed

Inform your doctor before receiving Polyxx-E 2Miu Inj if you have a liver impairment/disorder history. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Kidney

Caution

Caution should be exercised while using Polyxx-E 2Miu Inj in patients with severe kidney disease. Inform your doctor before receiving Polyxx-E 2Miu Inj if you have a kidney impairment/disorder history. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Consult your doctor

Please consult your doctor. Your doctor will decide the dose of this medicine based on the age and condition of your child.

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Heart

Caution

Polyxx-E 2Miu Inj should be used cautiously in heart patients due to risks like irregular heartbeat and neuromuscular effects. Always consult your doctor before use and ensure close monitoring during treatment.

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Geriatrics

Caution

Geriatric patients may receive Polyxx-E 2Miu Inj, but only with caution due to higher risk of kidney toxicity and nerve effects. Close monitoring is essential to ensure safe and effective treatment.

What if I have taken an overdose of Polyxx-E 2Miu Inj

If you suspect an overdose, seek immediate medical attention or call emergency services. Symptoms of an overdose may include severe dizziness, numbness, tingling, or breathing difficulties.

Diet & Lifestyle Advise

  • Stay hydrated: Drink plenty of water throughout the day to help your kidneys process and clear the medication safely.
  • Get plenty of rest: Allow your body time to heal and recover from the physical stress of a severe bacterial infection.
  • Avoid alcohol: Refrain from drinking alcohol during treatment to prevent dehydration and reduce stress on your kidneys and liver.
  • Eat simple meals: If you experience mild nausea, stick to bland, easy-to-digest foods to keep your stomach settled.
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Have a query?

How Soon It Starts Working

The time required for Polyxx-E 2Miu Inj to start to work: The exact onset time of Polyxx-E 2Miu Inj has not been clinically established. The time for which the effects of Polyxx-E 2Miu Inj last: The duration of Polyxx-E 2Miu Inj’s effect is clinically not established.

What if you forget to take Polyxx-E 2Miu Inj

If you miss a dose, inject it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not double the dose to make up for a missed one. If you are receiving this medicine in a hospital, notify your nurse or doctor if you think a dose was missed.

Storage

• Store dry vials of Polyxx-E 2Miu Inj according to the product label, generally at controlled room temperature (up to 25°C to 30°C, depending on the manufacturer), away from direct light, heat, and moisture.

Drug Warnings

  • Check the medicine before use: Inspect the prepared injection before use. Do not use it if the liquid is cloudy, has changed colour, or contains visible particles.
  • Rotate injection sites: If you are receiving injections into a muscle, use a different injection site each time as advised by your healthcare provider. This can help reduce soreness and irritation.
  • Attend regular blood and urine tests: Keep all scheduled blood and urine test appointments. These tests help your doctor monitor your kidney health during treatment.
  • Report nerve-related symptoms: Contact your doctor immediately if you develop slurred speech, vision changes, unusual drowsiness, confusion, severe dizziness, or worsening tingling or numbness. These may be signs of nerve-related side effects.
  • Attend blood level monitoring if advised: If you are receiving high doses, long-term treatment, or have kidney problems, your doctor may occasionally check the level of this medicine in your blood. This helps ensure your treatment is safe and effective.
  • Complete the full course: Continue taking this medicine exactly as prescribed, even if you feel better. Stopping treatment too early can cause the infection to return and make it harder to treat.
  • Avoid driving if affected: Do not drive or operate heavy machinery if you feel dizzy or notice tingling after receiving this medicine.
  • Avoid if you have a severe allergy: Do not use this medicine if you have had a serious allergic reaction to Polyxx-E 2Miu Inj, colistin, polymyxin B, or similar antibiotics. Tell your doctor about any previous allergies before treatment.

verifiedApollotooltip
  • Other kidney-straining drugs (e.g., gentamicin, amikacin, ibuprofen): Taking Polyxx-E 2Miu Inj alongside other antibiotics or certain pain relievers can increase the risk of kidney damage.
  • Muscle relaxants (e.g., vecuronium): Combining this medicine with muscle-relaxing medications can increase the risk of severe muscle weakness and breathing difficulties.

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verifiedApollotooltip
  • No clinically significant food interactions are known with Polyxx-E 2Miu Inj.

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTI- BACTERIALS]

FAQs

Polyxx-E 2Miu Inj contains Colistimethate Sodium. Colistimethate Sodium effectively solubilizes the bacterial cell membrane, resulting in bacterial cell death. As a result, Polyxx-E 2Miu Inj destroys the bacteria and successfully treats the infection.
Polyxx-E 2Miu Inj is contraindicated in people with Hypersensitivity to any component in Polyxx-E 2Miu Inj. Besides this, it is also contraindicated to use in people with myasthenia gravis (muscle disorder).
Polyxx-E 2Miu Inj contains Colistimethate Sodium. It is an antibiotic medication used when other drugs or therapy are ineffective. Colistimethate Sodium essentially solubilizes the bacterial cell membrane, resulting in bacterial cell death. As a result, Polyxx-E 2Miu Inj kills the bacteria and effectively treats the infection. In addition, it can also treat infectious diarrhoea and urinary tract infections.
Do not use anti diarrhoeal until the doctor has prescribed you. You can drink plenty of fluids (electrolytes) to avoid dehydration. Besides this, you can also take prebiotics or probiotics to manage diarrhoea as it may help increase the number of good bacteria in the intestine, which aids indigestion.
After taking an antibiotic, you may need to wait up to three hours to eat or drink dairy products, including milk and butter, yoghurt, and cheese. Grapefruit juice and dietary supplements containing minerals like calcium may also work to dampen the effect of antibiotics.
Before taking Polyxx-E 2Miu Inj, inform your doctor if you have a history of kidney problems, myasthenia gravis (a condition that causes muscle weakness), porphyria (a blood disorder), or asthma. These conditions may affect your treatment or require special monitoring.
Polyxx-E 2Miu Inj is safe when used as per the dose and duration advised by a doctor.
Polyxx-E 2Miu Inj is effective when taken as per the doses prescribed by your doctor. Polyxx-E 2Miu Inj should be administered under medical supervision for optimal results.
If you forget to take a dose of Polyxx-E 2Miu Inj consult your healthcare provider for advice. Your doctor will guide you on the appropriate steps, but do not administer an extra dose to make up for the missed one.
Polyxx-E 2Miu Inj causes side effects such as visual disturbances, dizziness, nausea, vomiting, confusion, muscle weakness, respiratory insufficiency, and kidney damage. Therefore, please contact a doctor if any of these side effects persist for longer durations.
Polyxx-E 2Miu Inj is an injectable antibiotic used to treat serious bacterial infections, including infections of the lungs, urinary tract, blood, and other difficult-to-treat infections caused by susceptible bacteria, especially when other antibiotics are not effective. It should only be used under the supervision of a healthcare professional.
It is given as an injection into a muscle (intramuscularly) or as an infusion into a vein (intravenously), usually by a healthcare professional in a hospital or clinic. Talk to your doctor if you are managing this at home.
Yes. Your doctor will usually monitor your kidney function with blood and urine tests during treatment. They will also watch for signs of nerve-related side effects, such as slurred speech, vision changes, confusion, or severe tingling. In some patients, especially those receiving prolonged treatment or with kidney problems, doctors may also check the level of the medicine in the blood to help choose the safest and most effective dose.
Yes, it can sometimes cause kidney strain. Your doctor will monitor your kidney function closely with regular blood and urine tests during your treatment. Talk to your doctor if you notice decreased urination.
Polyxx-E 2Miu Inj should be used during pregnancy only if your doctor believes the expected benefits outweigh the potential risks. It is generally reserved for serious or life-threatening infections when safer alternatives are not suitable. Consult your doctor if you are pregnant or planning pregnancy.
Tingling or numbness is a known side effect of this medicine. Tell your doctor as soon as possible if you notice these symptoms. They will decide whether any changes to your treatment are needed. Do not stop the medicine unless your doctor tells you to.
Stopping the medication early can allow surviving bacteria to multiply, causing the infection to return and become resistant to future antibiotic treatments. Talk to your doctor before stopping the medication.
Once mixed with liquid, it should be used immediately or stored in a refrigerator at 2°C to 8°C (36°F to 46°F) for no longer than 24 hours. Do not freeze it. Talk to your pharmacist for storage guidance.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, INDIA.
Other Info - POL0384
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