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  3. Posanat 300 mg Injection 16.7 ml

Posanat 300 mg Injection 16.7 ml, Pack of 1 INJECTION
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Posanat 300 mg Injection 16.7 ml is used to prevent and treat fungal infections. It contains a medicine called posaconazole. It is a triazole antifungal agent and exerts its antifungal activity through the blockage of certain enzymes (P-450 dependent enzyme, sterol 14α-demethylase). This leads to inhibiting the synthesis of ergosterol, a key component of the fungal cell membrane, and the accumulation of methylated sterol precursors. This results in the inhibition of fungal cell growth and cell death. Thus, it treats infections.
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Composition :

POSACONAZOLE-18MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Posanat 300 mg Injection 16.7 ml

Posanat 300 mg Injection 16.7 ml is in a class of medications called azole antifungals. It is used to prevent and treat fungal infections in adults and children two years of age and older with a weakened ability to fight infection. Besides this, it is also used to treat invasive aspergillosis (a serious fungal infection that begins in the lungs and spreads through the bloodstream to other organs) in adults and teenagers 13 years of age and older. Any disease caused by a fungus is known as a fungal infection.

Posanat 300 mg Injection 16.7 ml contains a medicine called posaconazole. It is a triazole antifungal agent and exerts its antifungal activity through the blockage of certain enzymes (P-450 dependent enzyme, sterol 14α-demethylase). This leads to inhibiting the synthesis of ergosterol, a key component of the fungal cell membrane, and the accumulation of methylated sterol precursors. This results in the inhibition of fungal cell growth and cell death. Thus, it treats infections.

Posanat 300 mg Injection 16.7 ml will be administered by a qualified healthcare professional. You may sometimes experience injection site reactions, fever, headache, chills or shaking, stomach pain, constipation, diarrhoea, nosebleeds and coughing. Most of these side effects of Posanat 300 mg Injection 16.7 ml do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Inform your doctor if you are allergic or hypersensitive to any component present in Posanat 300 mg Injection 16.7 ml or if you are pregnant, suspect you are pregnant, plan to have a baby or are breastfeeding; your doctor will prescribe Posanat 300 mg Injection 16.7 ml only if the benefits outweigh the risk. Before taking the Posanat 300 mg Injection 16.7 ml, inform your doctor about your medical history and ongoing therapies to rule out any potential adverse effects or interactions.

Uses of Posanat 300 mg Injection 16.7 ml

Treatment of Fungal infections

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Directions for Use

• Your doctor will determine the dosage and frequency depending on your condition.• Posanat 300 mg Injection 16.7 ml will be administered by a healthcare professional.• Do not self-administer.

Medicinal Benefits

It is used to prevent and treat fungal infections in adults and children two years of age and older with a weakened ability to fight infection. It is also used to treat invasive aspergillosis (a serious fungal infection that begins in the lungs and spreads through the bloodstream to other organs) in adults and teenagers 13 years of age and older. Posanat 300 mg Injection 16.7 ml contains a medicine called posaconazole. It is a triazole antifungal agent and exerts its antifungal activity through the blockage of certain enzymes (P-450 dependent enzyme, sterol 14α-demethylase). This leads to inhibiting the synthesis of ergosterol, a key component of the fungal cell membrane, and the accumulation of methylated sterol precursors. This results in the inhibition of fungal cell growth and cell death. Thus, it treats infections.

How Posanat 300 mg Injection 16.7 ml Works

Posanat 300 mg Injection 16.7 ml contains a medicine called posaconazole. It is a triazole antifungal agent and exerts its antifungal activity through the blockage of certain enzymes (P-450 dependent enzyme, sterol 14α-demethylase). This leads to inhibiting the synthesis of ergosterol, a key component of the fungal cell membrane, and the accumulation of methylated sterol precursors. This results in the inhibition of fungal cell growth and cell death. Thus, it treats infections.

Storage

• Store in a cool and dry place away from sunlight.
• Keep Posanat 300 mg Injection 16.7 ml out of the sight and reach of children.
• Cold chain - To be stored in cold places at 2ºC to 8ºC.
Side effects of Posanat 300 mg Injection 16.7 ml
  • Avoid alcohol as it may be harmful and worsen certain condition.
  • Take nutritional supplements only as advised by your doctor.
  • Limit sodium intake.
  • Consult your doctor for medications to treat your condition effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

What if I have taken an overdose of Posanat 300 mg Injection 16.7 ml

Since Posanat 300 mg Injection 16.7 ml is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.

Drug Warnings

Keep your doctor informed about your health condition and medicines to rule out any side effects. Posanat 300 mg Injection 16.7 ml is restricted to people sensitive to product constituents or other antifungal medicines. During pregnancy and lactation, posaconazole should only be used after careful risk/benefit considerations, so before taking Posanat 300 mg Injection 16.7 ml, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. It is unknown whether it is safe to consume alcohol with Posanat 300 mg Injection 16.7 ml. However, as a precautionary measure, it is advisable not to take or limit alcohol.

Drug-Drug Interactions

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PosaconazoleConivaptan
Critical
PosaconazoleTolvaptan
Critical

Drug-Drug Interactions

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PosaconazoleConivaptan
Critical
How does the drug interact with Posanat 300 mg Injection 16.7 ml:
When Posanat 300 mg Injection 16.7 ml is taken with Conivaptan, it can increase the blood levels and effects of conivaptan.

How to manage the interaction:
Although there is an interaction between Posanat 300 mg Injection 16.7 ml and conivaptan, they can be taken together if prescribed by a doctor. However, contact a doctor if you experience difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, or mood changes. Do not discontinue any medications without consulting a doctor.
PosaconazoleTolvaptan
Critical
How does the drug interact with Posanat 300 mg Injection 16.7 ml:
Taking Tolvaptan and Posanat 300 mg Injection 16.7 ml together results in an increase in the levels and effects of Tolvaptan.

How to manage the interaction:
Although there is an interaction between Tolvaptan and Posanat 300 mg Injection 16.7 ml, it can be taken if prescribed by a doctor. However, consult a doctor if you experience difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, or seizures (fits). Do not stop using any medications without a doctor's advice.
PosaconazoleEplerenone
Critical
How does the drug interact with Posanat 300 mg Injection 16.7 ml:
Coadministration of Posanat 300 mg Injection 16.7 ml with eplerenone can increase the blood levels of eplerenone. This can increase the risk of serious side effects, including hyperkalemia (high blood potassium).

How to manage the interaction:
Although there is an interaction between Posanat 300 mg Injection 16.7 ml and eplerenone, it can be taken if a doctor has advised it. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PosaconazolePimozide
Critical
How does the drug interact with Posanat 300 mg Injection 16.7 ml:
Taking pimozide with Posanat 300 mg Injection 16.7 ml can increase the levels of pimozide in the blood, which can lead to an increased risk of abnormal heart rhythm.

How to manage the interaction:
Although there is an interaction between Posanat 300 mg Injection 16.7 ml and pimozide, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience severe or prolonged diarrhea, vomiting dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
PosaconazoleDronedarone
Critical
How does the drug interact with Posanat 300 mg Injection 16.7 ml:
When Dronedarone is taken with Posanat 300 mg Injection 16.7 ml, can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Posanat 300 mg Injection 16.7 ml with Dronedarone is not recommended, please consult your doctor before taking it. They can be taken together if advised by your doctor. However, contact your doctor if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop taking any medications without consulting a doctor.
PosaconazoleCerivastatin
Critical
How does the drug interact with Posanat 300 mg Injection 16.7 ml:
Taking cerivastatin with Posanat 300 mg Injection 16.7 ml can increase the blood levels of cerivastatin.

How to manage the interaction:
Although there is an interaction between Posanat 300 mg Injection 16.7 ml and cerivastatin, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, dark-colored urine, and yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
PosaconazoleEliglustat
Critical
How does the drug interact with Posanat 300 mg Injection 16.7 ml:
Taking eliglustat with Posanat 300 mg Injection 16.7 ml can increase the levels of eliglustat in the blood.

How to manage the interaction:
Although there is an interaction between Posanat 300 mg Injection 16.7 ml and eliglustat, they can be taken together if prescribed by a doctor. However, contact a doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, a slow heart rate, or a weak pulse. Do not discontinue any medications without consulting a doctor.
PosaconazoleSilodosin
Critical
How does the drug interact with Posanat 300 mg Injection 16.7 ml:
Coadministration of silodosin and Posanat 300 mg Injection 16.7 ml may significantly increase the blood levels and effects of silodosin.

How to manage the interaction:
Although there is an interaction between Posanat 300 mg Injection 16.7 ml and Silodosin, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, nasal congestion, and headache. Do not discontinue any medications without consulting a doctor.
PosaconazoleLurasidone
Critical
How does the drug interact with Posanat 300 mg Injection 16.7 ml:
Taking lurasidone together with Posanat 300 mg Injection 16.7 ml may result in significantly higher lurasidone blood levels.

How to manage the interaction:
Although there is an interaction between lurasidone and Posanat 300 mg Injection 16.7 ml, they can be used if prescribed by a doctor. However, consult a doctor if you have any abnormal muscle activity, dizziness, lightheadedness, headache, flushing, or fainting. Do not discontinue any medications without consulting a doctor.
PosaconazoleRanolazine
Critical
How does the drug interact with Posanat 300 mg Injection 16.7 ml:
When Posanat 300 mg Injection 16.7 ml is taken with Ranolazine, may significantly increase the blood levels and effects of Ranolazine.

How to manage the interaction:
Although there is an interaction between Posanat 300 mg Injection 16.7 ml and ranolazine, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Take the medication as directed by the doctor and at regular intervals if you take Posanat 300 mg Injection 16.7 ml for more than one day.
  • Do not use other over-the-counter medications, herbal or vitamin supplements without informing your pharmacist or doctor when you take Posanat 300 mg Injection 16.7 ml.
  • Continue taking your normal regular diet unless your doctor prescribes a specific diet.
  • It is advisable to follow a candida diet during yeast infections. This diet excludes sugar, gluten, certain dairy products, and alcoholic beverages and switches to low-sugar fruits, non-starchy vegetables, and gluten-free foods.
  • A very high sugar or high-carbohydrate diet may increase the count of Candida in some people. It is better to avoid or limit alcohol and caffeine intake during the Posanat 300 mg Injection 16.7 ml treatment to enhance a healthy lifestyle practice.

Habit Forming

No

Therapeutic Class

ANTIFUNGALS

Posanat 300 mg Injection 16.7 ml Substitute

Substitutes safety advice
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Alcohol

Caution

Limit or avoid consumption of alcohol while on treatment with Posanat 300 mg Injection 16.7 ml as it may increase the risk of serious side effects.

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Pregnancy

Caution

Posanat 300 mg Injection 16.7 ml is not recommended for use in pregnancy unless clearly necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Posanat 300 mg Injection 16.7 ml.

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Breast Feeding

Caution

There is no substantial research yet on using Posanat 300 mg Injection 16.7 ml in breastfeeding women. Inform your doctor if you are a nursing mother before taking Posanat 300 mg Injection 16.7 ml; your doctor will decide whether Posanat 300 mg Injection 16.7 ml can be taken by breastfeeding mothers.

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Driving

Caution

It is unknown whether Posanat 300 mg Injection 16.7 ml alters the ability to drive, so do not drive or operate machinery if you experience any symptoms affecting your ability to concentrate and react.

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Liver

Caution

Inform your doctor before receiving the Posanat 300 mg Injection 16.7 ml if you have a liver impairment/disorder history. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Kidney

Caution

Inform your doctor before receiving the Posanat 300 mg Injection 16.7 ml if you have a kidney impairment/disorder history. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Consult your doctor

Please consult your doctor. Your doctor will prescribe a suitable dose based on your child's age and condition.

FAQs

Posanat 300 mg Injection 16.7 ml is used to treat Fungal infections.

Posanat 300 mg Injection 16.7 ml contains a medicine called posaconazole. It is a triazole antifungal agent and exerts its antifungal activity through the blockage of certain enzymes (P-450 dependent enzyme, sterol 14α-demethylase). This leads to inhibiting the synthesis of ergosterol, a key component of the fungal cell membrane, and the accumulation of methylated sterol precursors. This results in inhibiting fungal cell growth and, ultimately, cell death. Thus, it treats infections.

Posanat 300 mg Injection 16.7 ml is not recommended for coadministration with anticoagulants, So if you are under anticoagulant therapy, inform your doctor before prescribing Posanat 300 mg Injection 16.7 ml.

If you are allergic to posaconazole or similar antifungals such as fluconazole, itraconazole, ketoconazole, or voriconazole, you should not use it. When combined with certain medications, posaconazole can have unfavourable or dangerous side effects.

Posanat 300 mg Injection 16.7 ml may cause side effects like injection site reactions, diarrhoea, nausea, fever, vomiting, headache and coughing, although not everybody gets them. Most of these side effects of Posanat 300 mg Injection 16.7 ml do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

In some cases, using Posanat 300 mg Injection 16.7 ml may lead to nosebleeds as a side effect. It does not require medical attention and gradually resolves over time. However, if the side effects persist or worsen, please consult your doctor.

Posanat 300 mg Injection 16.7 ml will be administered by a qualified healthcare professional. Please do not self-administer.

Yes, Posanat 300 mg Injection 16.7 ml is effective in the treatment of fungal infections and prevention of invasive aspergillosis (a serious fungal infection that begins in the lungs and spreads through the bloodstream to other organs).

Country of origin

INDIA

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - POS0079

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 9:23 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://medlineplus.gov/druginfo/meds/a616017.html
  2. https://www.drugs.com/drug-interactions/posaconazole.html
  3. https://pubmed.ncbi.nlm.nih.gov/16961575/#:~:text=Posaconazole%2C%20a%20new%20triazole%20antifungal,fungi%20except%20Pneumocystis%20and%20Pythium.
  4. https://go.drugbank.com/drugs/DB01263
  5. https://mft.nhs.uk/app/uploads/sites/10/2021/11/Posaconazole-NAC-PIL.pdf

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