EPLERENONE should not be given to the people allergic to EPLERENONE, have low blood pressure (less than 90 mm of Hg), have had a heart attack, kidney disease (with creatinine clearance less than 30 mL/min), liver disease, high serum potassium (hyperkalemia), diabetes mellitus type 2 and patients with nil urine output (anuria), pregnant women, planning to get pregnant and breastfeeding women. EPLERENONE can pass into breast milk, but its effect on the baby is unknown, so it is better to tell your doctor if you are taking EPLERENONE and breastfeeding. Dehydration with electrolyte and acid-base disturbances must be corrected before using EPLERENONE. Do not take extra potassium supplements or potassium-rich foods such as bananas and broccoli with EPLERENONE. It may lead to an excessive increase in blood potassium levels (hyperkalemia). Please take EPLERENONE at least 4 hours before sleeping to avoid frequent urination at night. Also, do not take EPLERENONE along with lithium to prevent serious side effects.

Drug-Drug Interactions: EPLERENONE may interact with other high blood pressure-lowering pills (metoprolol, ramipril, hydrochlorothiazide), blood thinners (aspirin, warfarin), anti-epilepsy medicines (carbamazepine, phenobarbital), immune-suppressing drugs (cyclosporine), painkillers (ibuprofen), anti-fungal medicines (itraconazole, ketoconazole), HIV medicines (ritonavir, nelfinavir), anti-bacterial medicines (clarithromycin, telithromycin), anti-depressants (lithium).

Drug-Food Interactions: You are recommended not to consume alcohol with EPLERENONE to avoid unpleasant side effects. Also, St. John's wort plant (natural remedy to treat depression) is known to interact with EPLERENONE.

Drug-Disease Interactions: EPLERENONE should not be given to people with low blood pressure (hypotension), coronary heart disease, liver or kidney disease, heart failure, high serum potassium (hyperkalemia), diabetes mellitus type 2 and patients with nil urine output (anuria).

• Consume antioxidant-rich food. Blueberries, cherries, tomatoes, squash, and bell peppers are highly antioxidants.
• Eat natural diuretic foods. Asparagus, beets, green beans, grapes, onion, leafy greens, pineapple, leeks, pumpkin, and garlic are all-natural diuretic foods.
• Use healthy cooking oils like soybean, olive, canola, and coconut oil.
• You should avoid refined foods such as white bread, spaghetti, sugar, and red meat.
• Reduce or eliminate Trans fatty acids, which are found in commercially baked items such as cookies, cakes, crackers, French fries, onion rings, doughnuts, and processed foods.
• Avoid the consumption of too much salt or salty food.
• Keep your weight under control with a BMI of 19.5-24.9.
• Regular physical activity or exercise like walking improves your blood flow.
• Elevate your legs or the swollen area on a chair or pillow.
• Avoid standing or sitting for extended periods.
• Avoid chronic stress, as it can raise your blood pressure.
• Spend time with your loved ones to cope with stress and practice mindfulness techniques.
• Quitting smoking and alcohol consumption is the best strategy to lower the risk of many health complications.

• Treatment with EPLERENONE requires regular monitoring of serum potassium and creatinine level.
• Monitor your blood pressure daily and if there is too much fluctuation, then immediately contact your doctor.
• Monitor your blood sugar level daily and if there is too much fluctuation, then immediately contact your doctor.