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  1. Home
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  3. Pramee 0.25 Tablet 10's

Prescription drug
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Pramee 0.25 Tablet 10's, Pack of 10
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Extra 15% Off with Bank Offers

Composition :

PRAMIPEXOLE-0.25MG

Manufacturer/Marketer :

Integrity Pharmaceutical Corp

Consume Type :

ORAL

Return Policy :

Not Returnable

About Pramee 0.25 Tablet 10's

Pramee 0.25 Tablet 10's belongs to a group of antiparkinson agents or dopamine agonists used to treat the symptoms of Parkinson’s disease and moderate to severe Willis-Ekbom disease (restless legs syndrome) in adults.

Pramee 0.25 Tablet 10's contains 'Pramipexole' that works by mimicking the action of dopamine, a natural substance found in the brain. This triggers the nerve impulses in the brain that control body movements.

In some cases, you may experience side effects such as sleepiness, nausea, constipation, dizziness, fatigue, hallucinations, dry mouth, muscle spasms, and peripheral oedema (leg swelling due to fluid overload). Talk to your doctor if you experience the side effects persist or worsen.

Consult your doctor if you are pregnant or breastfeeding. Pramee 0.25 Tablet 10's may cause drowsiness and dizziness, do not drive unless you are alert. Keep your doctor informed about your health condition and medications to prevent any interactions.

Uses of Pramee 0.25 Tablet 10's

Pramee 0.25 Tablet 10's is used in the treatment of Parkinson’s disease, Willis-Ekbom disease (restless legs syndrome). The detailed uses of Pramee 0.25 Tablet 10's are as follows:

  • Parkinson’s Disease Treatment: Pramee 0.25 Tablet 10's treats symptoms of Parkinson’s disease, such as tremors, stiffness, and slow movement, by mimicking dopamine in the brain, improving motor function and mobility.
  • Restless Legs Syndrome (RLS) Treatment: Pramee 0.25 Tablet 10's helps to alleviate symptoms of RLS, by reducing uncomfortable sensations and the urge to move the legs, improving sleep and quality of life.

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Directions for Use

  • Take Pramee 0.25 Tablet 10's with or without food as advised by your doctor.
  • It is advised to take Pramee 0.25 Tablet 10's 3 times daily; however, follow your doctor’s recommendation regarding the dosage and duration.
  • Swallow Pramee 0.25 Tablet 10's as a whole with a glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

  • Pramee 0.25 Tablet 10's is used to treat the symptoms of Parkinson’s disease, such as tremors, stiffness, muscle spasms, and poor muscle control.
  • It helps restore the balance of dopamine activity in the brain, which is reduced in patients with Parkinson’s disease.
  • Pramee 0.25 Tablet 10's acts as a dopamine agonist, meaning it binds to and stimulates dopamine receptors, mimicking the natural effects of dopamine.
  • Pramee 0.25 Tablet 10's improves motor function and coordination, making body movements smoother and more controlled.
  • It is also used to treat moderate to severe Willis–Ekbom disease (restless legs syndrome) by reducing uncomfortable sensations and the urge to move the legs.
  • It helps reduce symptom severity, enhance mobility, and improve quality of life in affected individuals.
  • Pramee 0.25 Tablet 10's provides effective relief from movement-related symptoms and supports better daily functioning in patients with Parkinson’s disease or restless legs syndrome.

How Pramee 0.25 Tablet 10's Works

Pramee 0.25 Tablet 10's contains 'Pramipexole' that works by mimicking the action of dopamine (acting in place of dopamine), a natural substance found in the brain needed to control body movement. This triggers the nerve impulses in the brain that control body movements.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Pramee 0.25 Tablet
  • Hallucination is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control hallucinations. You can share what is being seen with a therapist to know whether they are real or imaginary.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your imagination.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes of hallucinations.
  • Talk to your dietician and consume food that can improve your mental health.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
  • Uncontrolled and involuntary movements need immediate medical attention.
  • Observe your movements and try to understand and control the particular movement.
  • Regularly do strengthening exercises to improve blood flow throughout the body and avoid involuntary movements.
  • Implement massage techniques to enhance blood flow to organs.
  • Take a balanced diet and quit smoking.
  • Practice yoga and meditation to improve thought processes and reduce uncontrolled and involuntary movements.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
  • Do not stand up suddenly. Lie down and get up slowly only when you feel better.
  • Avoid alcohol and large meals.
  • Drink enough water before standing for long periods.
  • Exercise regularly; however, avoid exercising in extreme heat.
  • Eat small, low-carb meals.
  • Wear compression stockings.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

What if I have taken an overdose of Pramee 0.25 Tablet 10's

Do not take more than the prescribed dose of Pramee 0.25 Tablet 10's as it may cause an overdose. The symptoms of overdose include a fast heart rate. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

  • Do not take Pramee 0.25 Tablet 10's if you are allergic to any of its contents.
  • Talk to your doctor before taking Pramee 0.25 Tablet 10's if you have kidney problems, hallucinations, dyskinesia (abnormal limb movements), dystonia (inability to keep the neck straight), sleepiness or suddenly falling asleep, psychosis, vision impairment, severe heart or blood vessel disease, or augmentation (symptoms start earlier).
  • Inform your doctor if you experience symptoms such as apathy, anxiety, depression, fatigue, sweating or pain after dose reduction or stopping Pramee 0.25 Tablet 10's.
  • Pramee 0.25 Tablet 10's may cause intense urges such as increased sex drive, gambling, overeating and wasting money. Talk to your doctor if you have any concerns.
  • Consult your doctor if you are pregnant or breastfeeding.
  • Pramee 0.25 Tablet 10's may cause drowsiness and dizziness, do not drive unless you are alert.
  • Pramee 0.25 Tablet 10's is not recommended for children below 18 years.
  • Avoid consuming alcohol along with Pramee 0.25 Tablet 10's as it could lead to increased drowsiness and dizziness.
  • Rise slowly from sitting or lying position as Pramee 0.25 Tablet 10's causes orthostatic hypotension (sudden lowering in blood pressure leading to dizziness on standing).
  • Let your doctor know if you are taking any other medicines, including supplements and herbal products.

Drug-Drug Interactions

verifiedApollotooltip
PramipexoleRisperidone
Critical
PramipexoleOlanzapine
Critical

Drug-Drug Interactions

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PramipexoleRisperidone
Critical
How does the drug interact with Pramee 0.25 Tablet:
Taking Risperidone with Pramee 0.25 Tablet may reduce the effectiveness of Pramee 0.25 Tablet.

How to manage the interaction:
Taking Risperidone with Pramee 0.25 Tablet is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience drowsiness, dizziness, and lightheadedness contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PramipexoleOlanzapine
Critical
How does the drug interact with Pramee 0.25 Tablet:
Taking Olanzapine with Pramee 0.25 Tablet can increase the risk and severity of side effects and reduce the effectiveness of Pramee 0.25 Tablet.

How to manage the interaction:
Co-administration of Olanzapine and Pramee 0.25 Tablet is not recommended as it leads to an interaction, it can be taken if advised by a doctor. If you experience any symptoms such as drowsiness, dizziness, and lightheadedness, contact a doctor immediately. Avoid driving or operating dangerous machinery, and be careful while getting up from a sitting or lying position. Do not discontinue any medications without consulting a doctor.
PramipexoleEsketamine
Severe
How does the drug interact with Pramee 0.25 Tablet:
Combining Esketamine with Pramee 0.25 Tablet may increase side effects

How to manage the interaction:
Although taking Pramee 0.25 Tablet and Esketamine together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience any symptoms like drowsiness, confusion, difficulty concentrating, and impairment in thinking, judgment, reaction speed, and motor coordination, consult a doctor. Do not discontinue the medication without consulting a doctor.
PramipexoleSodium oxybate
Severe
How does the drug interact with Pramee 0.25 Tablet:
Taking Sodium oxybate with Pramee 0.25 Tablet may increase he risk of side effects.

How to manage the interaction:
Taking Pramee 0.25 Tablet with Sodium oxybate together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience drowsiness, dizziness, lightheadedness, confusion, depression, low blood pressure, slow or shallow breathing, and impairment in thinking, judgment, and motor coordination, consult a doctor. Do not discontinue any medications without a doctor's advice.
PramipexoleAmisulpride
Severe
How does the drug interact with Pramee 0.25 Tablet:
Taking Amisulpride with Pramee 0.25 Tablet may decrease the efficacy of both medications.

How to manage the interaction:
Although taking amisulpride along with Pramee 0.25 Tablet can result in an interaction, it can be taken if a doctor has advised it. Avoid jobs that demand mental awareness and exercise caution while rising from a sitting or sleeping posture. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a healthy diet and exercise regularly.
  • Include a diet rich in iron, folate and magnesium.
  • Regularly attend therapy sessions.
  • Perform meditation and yoga.
  • Follow a regular sleep pattern.
  • Avoid smoking and alcohol consumption.
  • Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

Habit Forming

No

Therapeutic Class

ANTIPARKINSON AGENTS

Pramee 0.25 Tablet 10's Substitute

Substitutes safety advice
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Pramee 0.25 Tablet 10's as it may cause increased dizziness.

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Pregnancy

Caution

Please consult your doctor if you have any concerns regarding this; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Unsafe

Do not take Pramee 0.25 Tablet 10's if you are breastfeeding. Pramee 0.25 Tablet 10's may reduce the production of breast milk. Also, it can pass into breast milk. If taking Pramee 0.25 Tablet 10's is unavoidable, stop breastfeeding.

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Driving

Unsafe

Pramee 0.25 Tablet 10's may cause dizziness, sleepiness and hallucinations. Avoid driving and handling machinery if you experience these symptoms.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Pramee 0.25 Tablet 10's is not recommended for use in children below 18years.

FAQs

Pramee 0.25 Tablet 10's is used to treat Parkinson's disease and Willis-Ekbom disease (restless legs syndrome).

Pramee 0.25 Tablet 10's works by acting like dopamine and triggering the nerve impulses in the brain that control our body movements, like restless leg syndrome and Parkinson's.

Pramee 0.25 Tablet 10's may lower the blood pressure than normal, leading to hypotension (low blood pressure), especially during the initial days of treatment. Do not stand up suddenly; rise slowly to avoid a sudden drop in blood pressure. Regularly monitor your blood pressure levels while taking Pramee 0.25 Tablet 10's.

Dry mouth could be a side effect of Pramee 0.25 Tablet 10's. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevent drying of the mouth.

Pramee 0.25 Tablet 10's may cause peripheral oedema (swelling of lower legs and hands due to fluid overload). So, avoid sitting or standing for too long.

Hallucination is a medical condition in which the person may feel, hear or believe things that are not true, see things that are not there, or feel unusually suspicious or confused. If you experience hallucinations, please talk to your doctor immediately.

Do not discontinue Pramee 0.25 Tablet 10's without consulting your doctor, as it could lead to recurring symptoms. To treat your condition effectually, continue taking Pramee 0.25 Tablet 10's for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Pramee 0.25 Tablet 10's.

Pramee 0.25 Tablet 10's may be indicated in the treatment of restless leg syndrome. It should be taken 2-3 hours before bedtime or as advised by the doctor.

The most common side effects of Pramee 0.25 Tablet 10's that may occur in some individuals are sleepiness, nausea, constipation, dizziness, fatigue, hallucinations, dry mouth, muscle spasms, and peripheral oedema (leg swelling due to fluid overload). Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Medications such as antipsychotics (haloperidol, risperidone), medications for mental illness (chlorpromazine, droperidol, fluphenazine) should not be taken along with Pramee 0.25 Tablet 10's as these may interact with it and potentially decrease its effectiveness. Hence, inform your doctor about all your medications and health issues before taking Pramee 0.25 Tablet 10's to avoid negative interactions. Your doctor will suggest a suitable treatment. Please note that this is not an exhaustive list, and it's essential to consult your doctor or pharmacist for a complete list of medications to avoid when taking Pramee 0.25 Tablet 10's.

No, Pramee 0.25 Tablet 10's is not a muscle relaxer. It is a dopamine agonist used to treat symptoms of Parkinson's disease, restless legs syndrome (RLS), and other conditions.

Pramee 0.25 Tablet 10's may not cause weight gain, but some individuals might experience changes in their weight, either gaining or losing it, due to its side effects. It is a good idea to consult your doctor if you notice significant weight fluctuations or have any concerns about your weight for proper management.

Yes, Pramee 0.25 Tablet 10's can cause sleepiness in some individuals as a common side effect. It may also lead to sudden sleep attacks without warning. To ensure safety, avoid driving or activities requiring mental alertness unless you're fully alert. Consult your doctor if this effect is causing you more difficulty in relief.

Pramee 0.25 Tablet 10's works by stimulating dopamine receptors in the brain to help regulate movement and relieve symptoms of restless legs syndrome, such as itching, tingling, or burning, in the legs.

Swallow a whole Pramee 0.25 Tablet 10's with water; do not crush, break or chew it.

While Pramee 0.25 Tablet 10's is generally well-tolerated, some rare but potentially serious side effects may occur. If you experience hallucinations, confusion, unusual behaviour, vision changes, or muscle issues, don't hesitate to reach out to your healthcare team for guidance and support.

In rare cases, Pramee 0.25 Tablet 10's may cause some impulse control disorders in some individuals, including eating too much or losing control of eating, changes in sex drive (too high or too low), and compulsive gambling. These problems can be serious, so it is important to monitor your or your loved one's behaviour closely. Tell your doctor if you notice any unusual changes.

Country of origin

India

Manufacturer/Marketer address

678, Sharnam Avenue, Panchvati, Gorwa, Vadodara, Gujarat, 391310
Other Info - PRA0474

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Nov 4, 2025 | 1:18 PM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/022421s003lbl.pdfhttp://mri.cts-mrp.eu/download/AT_H_0314_005_FinalPL.pdf
  2. https://www.ema.europa.eu/en/documents/product-information/pramipexole-accord-epar-product-information_en.pdf
  3. https://www.drugs.com/mtm/pramipexole.html
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