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  3. Pramiprex 0.5 Tablet 10's

Pramiprex 0.5 Tablet 10's, Pack of 10 TABLETS
Pramiprex 0.5 Tablet 10's, Pack of 10 TABLETS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Pramiprex 0.5 Tablet is used to treat the symptoms of Parkinson's disease and moderate to severe Willis-Ekbom disease (restless legs syndrome) in adults. It contains Pramipexole, which works by mimicking the action of dopamine (acting in place of dopamine), a natural substance found in the brain needed to control body movement. This triggers the nerve impulses in the brain that control body movements. In some cases, you may experience certain common side effects such as sleepiness, nausea, constipation, dizziness, fatigue, hallucinations, dry mouth, muscle spasms, and peripheral oedema (leg swelling due to fluid overload). Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

PRAMIPEXOLE-0.5MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Pramiprex 0.5 Tablet

Pramiprex 0.5 Tablet belongs to a group of antiparkinson agents or dopamine agonists used to treat the symptoms of Parkinson’s disease and moderate to severe Willis-Ekbom disease (restless legs syndrome) in adults. Parkinson’s disease is a progressive neurological disorder in which the first signs are problems with movements. Willis-Ekbom disease is a condition which causes the uncontrollable urge to move the legs.

Pramiprex 0.5 Tablet contains 'Pramipexole' that works by mimicking the action of dopamine (acting in place of dopamine), a natural substance found in the brain needed to control body movement. This triggers the nerve impulses in the brain that control body movements.

In some cases, you may experience certain common side-effects such as sleepiness, nausea, constipation, dizziness, fatigue, hallucinations, dry mouth, muscle spasms, and peripheral oedema (leg swelling due to fluid overload). Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

Do not discontinue Pramiprex 0.5 Tablet on your own. Consult your doctor if you are pregnant or breastfeeding. Pramiprex 0.5 Tablet may cause drowsiness and dizziness, do not drive unless you are alert. Pramiprex 0.5 Tablet should not be used in children below 18 years. Avoid consuming alcohol along with Pramiprex 0.5 Tablet as it could lead to increased drowsiness and dizziness. Rise slowly from sitting or lying position as Pramiprex 0.5 Tablet may cause orthostatic hypotension (sudden lowering in blood pressure leading to dizziness on standing). 

Uses of Pramiprex 0.5 Tablet

Pramiprex 0.5 Tablet is used in the treatment of Parkinson's disease, Willis-Ekbom disease (restless legs syndrome). The detailed uses of Pramiprex 0.5 Tablet are as follows:<br/>• Parkinson's Disease Treatment: Pramiprex 0.5 Tablet treats symptoms of Parkinson's disease, such as tremors, stiffness, and slow movement, by mimicking dopamine in the brain, improving motor function and mobility.<br/>• Restless Legs Syndrome (RLS) Treatment: Pramiprex 0.5 Tablet helps to alleviate symptoms of RLS, by reducing uncomfortable sensations and the urge to move the legs, improving sleep and quality of life.<br/>

Directions for Use

• Take Pramiprex 0.5 Tablet with or without food as advised by your doctor.• It is advised to take Pramiprex 0.5 Tablet 3 times daily; however, follow your doctor’s recommendation regarding the dosage and duration.• Swallow Pramiprex 0.5 Tablet as a whole with a glass of water.• Do not crush, break, or chew it.

Medicinal Benefits

Pramiprex 0.5 Tablet belongs to a group of antiparkinson agents called dopamine agonists used to treat the symptoms of Parkinson’s disease and moderate to severe Willis-Ekbom disease (restless legs syndrome) in adults. Pramiprex 0.5 Tablet binds to the dopamine receptor and mimics its action. Dopamine is a naturally-occurring neurotransmitter in the brain. Dopamine is absent or reduced in people with Parkinson’s disease. Pramiprex 0.5 Tablet works by stimulating the dopamine receptors in the brain. This triggers the nerve impulses in the brain that control body movements. Pramiprex 0.5 Tablet helps in relieving the symptoms of Parkinson’s disease, such as muscle spasms, tremors, stiffness, and poor muscle control.

How Pramiprex 0.5 Tablet Works

Pramiprex 0.5 Tablet contains 'Pramipexole' that works by mimicking the action of dopamine (acting in place of dopamine), a natural substance found in the brain needed to control body movement. This triggers the nerve impulses in the brain that control body movements.

Storage

Keep Pramiprex 0.5 Tablet out of reach and sight of children.
Side effects of Pramiprex 0.5 Tablet
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
  • Uncontrolled and involuntary movements need immediate medical attention.
  • Observe your movements and try to understand and control the particular movement.
  • Regularly do strengthening exercises to improve blood flow throughout the body and avoid involuntary movements.
  • Implement massage techniques to enhance blood flow to organs.
  • Take a balanced diet and quit smoking.
  • Practice yoga and meditation to improve thought processes and reduce uncontrolled and involuntary movements.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
  • Do not stand up suddenly. Lie down and get up slowly only when you feel better.
  • Avoid alcohol and large meals.
  • Drink enough water before standing for long periods.
  • Exercise regularly; however, avoid exercising in extreme heat.
  • Eat small, low-carb meals.
  • Wear compression stockings.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.

What if I have taken an overdose of Pramiprex 0.5 Tablet

Do not take more than the prescribed dose of Pramiprex 0.5 Tablet as it may cause overdose. The symptoms of overdose include fast heart rate. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Pramiprex 0.5 Tablet if you are allergic to any of its contents. Talk to your doctor before taking Pramiprex 0.5 Tablet if you have kidney problems, hallucinations, dyskinesia (abnormal limb movements), dystonia (inability to keep the neck straight), sleepiness or suddenly falling asleep, psychosis, vision impairment, severe heart or blood vessel disease, or augmentation (symptoms start earlier). Inform your doctor if you experience symptoms such as apathy, anxiety, depression, fatigue, sweating or pain after dose reduction or stopping Pramiprex 0.5 Tablet . Pramiprex 0.5 Tablet may cause intense urges such as increased sex drive, gambling, overeating and wasting money. Consult your doctor if you are pregnant or breastfeeding. Pramiprex 0.5 Tablet may cause drowsiness and dizziness, do not drive unless you are alert. Pramiprex 0.5 Tablet should not be given to children below 18 years. Avoid consuming alcohol along with Pramiprex 0.5 Tablet as it could lead to increased drowsiness and dizziness. Rise slowly from sitting or lying position as Pramiprex 0.5 Tablet causes orthostatic hypotension (sudden lowering in blood pressure leading to dizziness on standing). 

Drug-Drug Interactions

verifiedApollotooltip
PramipexoleRisperidone
Critical
PramipexoleOlanzapine
Critical

Drug-Drug Interactions

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PramipexoleRisperidone
Critical
How does the drug interact with Pramiprex 0.5 Tablet:
Taking Risperidone with Pramiprex 0.5 Tablet may reduce the effectiveness of Pramiprex 0.5 Tablet.

How to manage the interaction:
Taking Risperidone with Pramiprex 0.5 Tablet is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience drowsiness, dizziness, and lightheadedness contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PramipexoleOlanzapine
Critical
How does the drug interact with Pramiprex 0.5 Tablet:
Taking Olanzapine with Pramiprex 0.5 Tablet can increase the risk and severity of side effects and reduce the effectiveness of Pramiprex 0.5 Tablet.

How to manage the interaction:
Co-administration of Olanzapine and Pramiprex 0.5 Tablet is not recommended as it leads to an interaction, it can be taken if advised by a doctor. If you experience any symptoms such as drowsiness, dizziness, and lightheadedness, contact a doctor immediately. Avoid driving or operating dangerous machinery, and be careful while getting up from a sitting or lying position. Do not discontinue any medications without consulting a doctor.
PramipexoleSodium oxybate
Severe
How does the drug interact with Pramiprex 0.5 Tablet:
Taking Sodium oxybate with Pramiprex 0.5 Tablet may increase he risk of side effects.

How to manage the interaction:
Taking Pramiprex 0.5 Tablet with Sodium oxybate together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience drowsiness, dizziness, lightheadedness, confusion, depression, low blood pressure, slow or shallow breathing, and impairment in thinking, judgment, and motor coordination, consult a doctor. Do not discontinue any medications without a doctor's advice.
PramipexoleEsketamine
Severe
How does the drug interact with Pramiprex 0.5 Tablet:
Combining Esketamine with Pramiprex 0.5 Tablet may increase side effects

How to manage the interaction:
Although taking Pramiprex 0.5 Tablet and Esketamine together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience any symptoms like drowsiness, confusion, difficulty concentrating, and impairment in thinking, judgment, reaction speed, and motor coordination, consult a doctor. Do not discontinue the medication without consulting a doctor.
PramipexoleAmisulpride
Severe
How does the drug interact with Pramiprex 0.5 Tablet:
Taking Amisulpride with Pramiprex 0.5 Tablet may decrease the efficacy of both medications.

How to manage the interaction:
Although taking amisulpride along with Pramiprex 0.5 Tablet can result in an interaction, it can be taken if a doctor has advised it. Avoid jobs that demand mental awareness and exercise caution while rising from a sitting or sleeping posture. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a healthy diet and exercise regularly.

  • Include a diet rich in iron, folate and magnesium. 

  • Regularly attend therapy sessions.

  • Perform meditation and yoga.

  • Follow a regular sleep pattern.

  • Avoid smoking and alcohol consumption.

  • Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

Habit Forming

No

Therapeutic Class

ANTIPARKINSON AGENTS

Pramiprex 0.5 Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Pramiprex 0.5 Tablet as it may cause increased dizziness.

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Pregnancy

Caution

Please consult your doctor if you have any concerns regarding this; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Unsafe

Do not take Pramiprex 0.5 Tablet if you are breastfeeding. Pramiprex 0.5 Tablet may reduce the production of breast milk. Also, it can pass into breast milk. If taking Pramiprex 0.5 Tablet is unavoidable, stop breastfeeding.

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Driving

Unsafe

Pramiprex 0.5 Tablet may cause dizziness, sleepiness and hallucinations. Avoid driving and handling machinery if you experience these symptoms.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Pramiprex 0.5 Tablet is not recommended for use in children below 18years.

Have a query?

FAQs

Pramiprex 0.5 Tablet is used to treat Parkinson&amp;#039;s disease and Willis Ekbom disease (restless legs syndrome).

Pramiprex 0.5 Tablet works by acting like dopamine and triggering the nerve impulses in the brain that controls our body movements like restless leg syndrome and Parkinson&amp;#039;s.

Pramiprex 0.5 Tablet may lower the blood pressure than normal leading to hypotension (low blood pressure), especially during the initial days of treatment. Do not stand up suddenly, rise slowly to avoid a sudden drop in blood pressure. Regularly monitor your blood pressure levels while taking Pramiprex 0.5 Tablet .

Dry mouth could be a side-effect of Pramiprex 0.5 Tablet . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevents drying of the mouth.

Pramiprex 0.5 Tablet may cause peripheral oedema (swelling of lower legs and hands due to fluid overload). So, avoid sitting or standing for too long.

Hallucination is a medical condition in which the person may feel, hear or believe things that are not true, see things that are not there, feel unusually suspicious or confused. If you experience hallucinations, please talk to your doctor immediately.

Do not discontinue Pramiprex 0.5 Tablet without consulting your doctor, as it could lead to recurring symptoms. To treat your condition effectually, continue taking Pramiprex 0.5 Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Pramiprex 0.5 Tablet .

Pramiprex 0.5 Tablet may be indicated in the treatment of restless leg syndrome. It should be taken 2-3 hours before bedtime or as advised by the doctor.

The most common side effects of Pramiprex 0.5 Tablet that may occur in some individuals are sleepiness, nausea, constipation, dizziness, fatigue, hallucinations, dry mouth, muscle spasms, and peripheral oedema (leg swelling due to fluid overload). Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Medications such as antipsychotics (haloperidol, risperidone), medications for mental illness (chlorpromazine, droperidol, fluphenazine) should not be taken along with Pramiprex 0.5 Tablet as these may interact with it and potentially decrease its effectiveness. Hence, inform your doctor about all your medications and health issues before taking Pramiprex 0.5 Tablet to avoid negative interactions. Your doctor will suggest a suitable treatment. Please note that this is not an exhaustive list, and it's essential to consult your doctor or pharmacist for a complete list of medications to avoid when taking Pramiprex 0.5 Tablet .

No, Pramiprex 0.5 Tablet is not a muscle relaxer. It is a dopamine agonist used to treat symptoms of Parkinson's disease, restless legs syndrome (RLS), and other conditions.

Pramiprex 0.5 Tablet is not commonly involved in causing weight gain, some individuals might experience changes in their weight, either gaining or losing it due to its side effects. It is a good idea to consult your doctor if you notice significant weight fluctuations or have any concerns about your weight for proper management.

Yes, Pramiprex 0.5 Tablet can cause sleepiness in some individuals as a common side effect. It may also lead to sudden sleep attacks without warning. To ensure safety, avoid driving or activities requiring mental alertness unless you're fully alert. Consult your doctor if this effect is causing you more difficulty in relief.

Pramiprex 0.5 Tablet works by stimulating dopamine receptors in the brain to help regulate movement and relieve symptoms of restless legs syndrome, such as itching, tingling, or burning, in the legs.

Swallow a whole Pramiprex 0.5 Tablet with water; do not crush, break or chew it.

While Pramiprex 0.5 Tablet is generally well-tolerated, some rare but potentially serious side effects may occur. If you experience hallucinations, confusion, unusual behaviour, vision changes, or muscle issues, don't hesitate to reach out to your healthcare team for guidance and support.

In rare cases, Pramiprex 0.5 Tablet may cause some impulse control disorders in some individuals, including eating too much or losing control of eating, changes in sex drive (too high or too low), and compulsive gambling. These problems can be serious, so it is important to monitor your or your loved one's behaviour closely. Tell your doctor if you notice any unusual changes.

Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - PRA0010

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:35 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/022421s003lbl.pdfhttp://mri.cts-mrp.eu/download/AT_H_0314_005_FinalPL.pdf
  2. https://www.ema.europa.eu/en/documents/product-information/pramipexole-accord-epar-product-information_en.pdf
  3. https://www.drugs.com/mtm/pramipexole.html

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