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compositionComposition:PRAMIPEXOLE-0.125MG
prescription
Prescription Medicine
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Pramiset-0.125 Tablet is used to treat the symptoms of Parkinson's disease and moderate to severe Willis-Ekbom disease (restless legs syndrome) in adults. It contains Pramipexole, which mimics the action of dopamine, a natural substance found in the brain that helps control body movement. In some cases, you may experience side effects such as sleepiness, nausea, constipation, dizziness, fatigue, hallucinations, dry mouth, muscle spasms, and peripheral oedema (leg swelling due to fluid overload). Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PRAMIPEXOLE-0.125MG

Manufacturer/Marketer :

Mesmer Pharmaceuticals

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Pramiset-0.125 Tablet

Pramiset-0.125 Tablet is a prescription tablet used to manage the symptoms of Parkinson's disease and moderate-to-severe Restless Legs Syndrome (RLS). It helps ease physical difficulties such as muscle stiffness, tremors, and the uncontrollable urge to move your limbs. By helping restore a natural chemical balance in the brain, it allows for smoother and more comfortable movement throughout the day.

To achieve the best results, you must take Pramiset-0.125 Tablet consistently and exactly as prescribed by your doctor. You can take this medicine with or without food, though taking it with a meal can help reduce feelings of nausea. Combining your medical treatment with daily habits like gentle stretching and a structured sleep schedule can further improve your symptoms.

While taking Pramiset-0.125 Tablet , you may experience mild, common side effects such as nausea, dizziness, or sleepiness. However, you must contact your doctor immediately if you experience serious issues, such as sudden, uncontrollable sleepiness during daytime activities or unusual changes in your behaviour.

Do not take this if you have had a severe allergic reaction to this medication in the past. Before starting Pramiset-0.125 Tablet , speak with your doctor if you have kidney disease, low blood pressure, or a history of sleep disorders.

This medicine can interact with alcohol, sleeping pills, or other medications that cause drowsiness, significantly increasing your risk of falling asleep unexpectedly. If you are pregnant, planning to become pregnant, breastfeeding, or are an elderly individual, consult your doctor to ensure this medicine is safe for your specific situation.

Uses of Pramiset-0.125 Tablet

Pramiset-0.125 Tablet may be prescribed for the following conditions: 

  • Parkinson's disease: Pramiset-0.125 Tablet helps relieve physical symptoms such as tremors, stiffness, slow movement, and poor muscle control caused by this progressive nervous system disorder.
  • Restless Legs Syndrome (RLS): Pramiset-0.125 Tablet reduces the uncomfortable pulling or crawling sensations in the legs and the irresistible urge to move them, which commonly occur during rest or bedtime.

Key Benefits

Pramiset-0.125 Tablet helps improve movement and reduce symptoms associated with Parkinson's disease and Restless Legs Syndrome. By acting on dopamine receptors in the brain, it supports better motor control and physical comfort.

  • Improves Movement Control: Helps reduce movement-related symptoms and supports better coordination during daily activities.
  • Reduces Tremors and Stiffness: Helps relieve shaking, muscle stiffness, and slowed movements, making routine tasks easier to perform.
  • Enhances Daily Functioning: May improve mobility and independence, allowing greater participation in everyday activities.
  • Relieves Restless Legs Symptoms: Helps reduce the uncomfortable sensations and irresistible urge to move the legs associated with Restless Legs Syndrome.
  • Supports Better Sleep: By relieving nighttime leg discomfort, it may help promote more restful and uninterrupted sleep.
Side effects of Pramiset-0.125 Tablet
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
  • Uncontrolled and involuntary movements need immediate medical attention.
  • Observe your movements and try to understand and control the particular movement.
  • Regularly do strengthening exercises to improve blood flow throughout the body and avoid involuntary movements.
  • Implement massage techniques to enhance blood flow to organs.
  • Take a balanced diet and quit smoking.
  • Practice yoga and meditation to improve thought processes and reduce uncontrolled and involuntary movements.
  • Hallucination is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control hallucinations. You can share what is being seen with a therapist to know whether they are real or imaginary.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your imagination.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes of hallucinations.
  • Talk to your dietician and consume food that can improve your mental health.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Do not stand up suddenly. Lie down and get up slowly only when you feel better.
  • Avoid alcohol and large meals.
  • Drink enough water before standing for long periods.
  • Exercise regularly; however, avoid exercising in extreme heat.
  • Eat small, low-carb meals.
  • Wear compression stockings.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Directions for Use

To use Pramiset-0.125 Tablet safely and effectively, follow these instructions: 

  • Swallow the tablet whole with a full glass of water.
  • Do not crush, chew, or break the tablet, as this can change how the medicine is absorbed into your body.
  • You may take this medicine with or without food. If you experience an upset stomach, taking your dose with a light meal or snack can help.

Always take Pramiset-0.125 Tablet exactly as your doctor has instructed. Do not change your dose or stop taking it without consulting your healthcare provider first.

How Pramiset-0.125 Tablet Works

The brain relies on a natural chemical messenger called dopamine to coordinate smooth, purposeful muscle movements. In conditions like Parkinson's disease and Restless Legs Syndrome, the brain suffers from a lack of active dopamine. The primary component in Pramiset-0.125 Tablet , pramipexole, acts directly on dopamine receptors in the brain, mimicking the effects of natural dopamine. By stimulating these receptors, the medication helps restore the balance of chemical signals in your nervous system. This direct action successfully calms overactive muscles, reduces tremors, and relieves the sensory discomfort associated with restless limbs.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Pramiset-0.125 Tablet as it may cause increased dizziness.

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Pregnancy

Caution

Please consult your doctor if you have any concerns regarding this; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Unsafe

Do not take Pramiset-0.125 Tablet if you are breastfeeding. Pramiset-0.125 Tablet may reduce the production of breast milk. Also, it can pass into breast milk. If taking Pramiset-0.125 Tablet is unavoidable, stop breastfeeding.

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Driving

Unsafe

Pramiset-0.125 Tablet may cause dizziness, sleepiness and hallucinations. Avoid driving and handling machinery if you experience these symptoms.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Pramiset-0.125 Tablet is not recommended for use in children below 18years.

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Heart

Consult your doctor

Please consult your doctor before using Pramiset-0.125 Tablet if you have pre-existing heart problems. Your doctor will prescribe Pramiset-0.125 Tablet if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Please consult a doctor before giivng Pramiset-0.125 Tablet to geriatric patients. Your doctor will prescribe Pramiset-0.125 Tablet if the benefits outweigh the risks.

What if I have taken an overdose of Pramiset-0.125 Tablet

Do not take more than the prescribed dose of Pramiset-0.125 Tablet as it may cause an overdose. The symptoms of overdose include a fast heart rate. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Stand up slowly: To prevent dizziness and fainting caused by a sudden drop in blood pressure, take your time when moving from a lying or sitting position to standing.
  • Adjust your evening routine: If you are taking this medication for Restless Legs Syndrome, avoid caffeine, alcohol, and nicotine in the evening, as these substances can worsen leg restlessness.
  • Increase dietary fibre: To combat medication-induced constipation, drink plenty of water throughout the day and eat foods high in fibre, such as whole grains, fruits, and vegetables.
  • Engage in gentle exercise: Regular, low-impact activities like walking, swimming, or light stretching can help maintain muscle flexibility and improve overall mobility.
health query

Have a query?

How Soon It Starts Working

The time required for Pramiset-0.125 Tablet to start to work: The time required for Pramiset-0.125 Tablet to show its action is unknown.

The time for which the effects of Pramiset-0.125 Tablet last: The duration of action for Pramiset-0.125 Tablet is unknown.

What if you forget to take Pramiset-0.125 Tablet

If you miss a dose of Pramiset-0.125 Tablet , take it as soon as you remember. However, if it is almost time for the next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Storage

•Store Pramiset-0.125 Tablet at room temperature between 20°C and 25°C (68°F to 77°F). •Keep the tablets in their original packaging to protect them from direct light and moisture.

Drug Warnings

  • Use Caution During Activities: Do not drive, operate machinery, or perform hazardous tasks until you know how Pramiset-0.125 Tablet affects you, as it may cause sudden sleep episodes or drowsiness.
  • Monitor Behavioural Changes: Ask family members or caregivers to watch for unusual behaviours, such as compulsive gambling, excessive spending, overeating, or other impulse-control problems.
  • Do Not Stop Treatment Suddenly: Do not discontinue Pramiset-0.125 Tablet abruptly, as this may lead to withdrawal symptoms. Your doctor will advise you on gradually reducing the dose if needed.
  • Monitor Blood Pressure: Check your blood pressure regularly, especially when starting treatment or adjusting the dose, as this medicine may cause sudden drops in blood pressure.
  • Monitor Restless Legs Symptoms: If you are taking Pramiset-0.125 Tablet for Restless Legs Syndrome and notice your symptoms starting earlier in the day, becoming more intense, or spreading to other parts of your body, inform your doctor. This may be a sign of augmentation, a recognised complication of long-term treatment

Drug-Drug Interactions

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Drug-Drug Interactions

Inform your doctor if you are taking any of the following medicines, as they may interact with Pramiset-0.125 Tablet : 

  • Cimetidine: Can increase the levels of Pramiset-0.125 Tablet in your body, raising the risk of side effects.
  • Metoclopramide: May block the dopamine receptors in your brain, making Pramiset-0.125 Tablet less effective.
  • edatives or sleeping pills: Can cause extreme drowsiness and increase the risk of sudden daytime sleep when combined with this medicine.

Drug-Food Interactions

Certain foods and beverages may affect treatment with Pramiset-0.125 Tablet :

  • Alcohol: Can significantly worsen drowsiness, dizziness, and the risk of suddenly falling asleep. Avoid consuming alcohol during your treatment.

Drug-Disease Interactions

Inform your doctor if you have a history of the following conditions before taking Pramiset-0.125 Tablet , as dose adjustments or additional monitoring may be required: 

  • Kidney disease: Your body may clear this medicine more slowly, requiring your doctor to adjust your dose.
  • Low blood pressure: This medication can lower blood pressure further upon standing, increasing your risk of fainting.
  • Mental health disorders: If you have a history of hallucinations, confusion, or schizophrenia, this medicine may worsen your symptoms.
PramipexoleOlanzapine
Critical
PramipexoleRisperidone
Critical

Drug-Drug Interactions

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PramipexoleOlanzapine
Critical
How does the drug interact with Pramiset-0.125 Tablet:
Taking Olanzapine with Pramiset-0.125 Tablet can increase the risk and severity of side effects and reduce the effectiveness of Pramiset-0.125 Tablet.

How to manage the interaction:
Co-administration of Olanzapine and Pramiset-0.125 Tablet is not recommended as it leads to an interaction, it can be taken if advised by a doctor. If you experience any symptoms such as drowsiness, dizziness, and lightheadedness, contact a doctor immediately. Avoid driving or operating dangerous machinery, and be careful while getting up from a sitting or lying position. Do not discontinue any medications without consulting a doctor.
PramipexoleRisperidone
Critical
How does the drug interact with Pramiset-0.125 Tablet:
Taking Risperidone with Pramiset-0.125 Tablet may reduce the effectiveness of Pramiset-0.125 Tablet.

How to manage the interaction:
Taking Risperidone with Pramiset-0.125 Tablet is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience drowsiness, dizziness, and lightheadedness contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PramipexoleEsketamine
Severe
How does the drug interact with Pramiset-0.125 Tablet:
Combining Esketamine with Pramiset-0.125 Tablet may increase side effects

How to manage the interaction:
Although taking Pramiset-0.125 Tablet and Esketamine together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience any symptoms like drowsiness, confusion, difficulty concentrating, and impairment in thinking, judgment, reaction speed, and motor coordination, consult a doctor. Do not discontinue the medication without consulting a doctor.
PramipexoleSodium oxybate
Severe
How does the drug interact with Pramiset-0.125 Tablet:
Taking Sodium oxybate with Pramiset-0.125 Tablet may increase he risk of side effects.

How to manage the interaction:
Taking Pramiset-0.125 Tablet with Sodium oxybate together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience drowsiness, dizziness, lightheadedness, confusion, depression, low blood pressure, slow or shallow breathing, and impairment in thinking, judgment, and motor coordination, consult a doctor. Do not discontinue any medications without a doctor's advice.
PramipexoleAmisulpride
Severe
How does the drug interact with Pramiset-0.125 Tablet:
Taking Amisulpride with Pramiset-0.125 Tablet may decrease the efficacy of both medications.

How to manage the interaction:
Although taking amisulpride along with Pramiset-0.125 Tablet can result in an interaction, it can be taken if a doctor has advised it. Avoid jobs that demand mental awareness and exercise caution while rising from a sitting or sleeping posture. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIPARKINSON AGENTS]

FAQs

Pramiset-0.125 Tablet is used to treat Parkinson's disease and Willis-Ekbom disease (restless legs syndrome).
Pramiset-0.125 Tablet works by acting like dopamine and triggering the nerve impulses in the brain that control our body movements, like restless leg syndrome and Parkinson's.
Pramiset-0.125 Tablet may lower the blood pressure than normal, leading to hypotension (low blood pressure), especially during the initial days of treatment. Do not stand up suddenly; rise slowly to avoid a sudden drop in blood pressure. Regularly monitor your blood pressure levels while taking Pramiset-0.125 Tablet .
Dry mouth could be a side effect of Pramiset-0.125 Tablet . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevent drying of the mouth.
Pramiset-0.125 Tablet may cause peripheral oedema (swelling of lower legs and hands due to fluid overload). So, avoid sitting or standing for too long.
Hallucination is a medical condition in which the person may feel, hear or believe things that are not true, see things that are not there, or feel unusually suspicious or confused. If you experience hallucinations, please talk to your doctor immediately.
Pramiset-0.125 Tablet may be indicated in the treatment of restless leg syndrome. It should be taken 2-3 hours before bedtime or as advised by the doctor.
The most common side effects of Pramiset-0.125 Tablet that may occur in some individuals are sleepiness, nausea, constipation, dizziness, fatigue, hallucinations, dry mouth, muscle spasms, and peripheral oedema (leg swelling due to fluid overload). Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
Medications such as antipsychotics (haloperidol, risperidone), medications for mental illness (chlorpromazine, droperidol, fluphenazine) should not be taken along with Pramiset-0.125 Tablet as these may interact with it and potentially decrease its effectiveness. Hence, inform your doctor about all your medications and health issues before taking Pramiset-0.125 Tablet to avoid negative interactions. Your doctor will suggest a suitable treatment. Please note that this is not an exhaustive list, and it's essential to consult your doctor or pharmacist for a complete list of medications to avoid when taking Pramiset-0.125 Tablet .
No, Pramiset-0.125 Tablet is not a muscle relaxer. It is a dopamine agonist used to treat symptoms of Parkinson's disease, restless legs syndrome (RLS), and other conditions.
Pramiset-0.125 Tablet may not cause weight gain, but some individuals might experience changes in their weight, either gaining or losing it, due to its side effects. It is a good idea to consult your doctor if you notice significant weight fluctuations or have any concerns about your weight for proper management.
Yes, Pramiset-0.125 Tablet can cause sleepiness in some individuals as a common side effect. It may also lead to sudden sleep attacks without warning. To ensure safety, avoid driving or activities requiring mental alertness unless you're fully alert. Consult your doctor if this effect is causing you more difficulty in relief.
Pramiset-0.125 Tablet works by stimulating dopamine receptors in the brain to help regulate movement and relieve symptoms of restless legs syndrome, such as itching, tingling, or burning, in the legs.
Swallow a whole Pramiset-0.125 Tablet with water; do not crush, break or chew it.
While Pramiset-0.125 Tablet is generally well-tolerated, some rare but potentially serious side effects may occur. If you experience hallucinations, confusion, unusual behaviour, vision changes, or muscle issues, don't hesitate to reach out to your healthcare team for guidance and support.
No, you should avoid alcohol while taking Pramiset-0.125 Tablet . Alcohol can greatly increase your risk of severe drowsiness, dizziness, and falling asleep suddenly during routine daily activities. Talk to your doctor if you have concerns.
No, Pramiset-0.125 Tablet does not cure Parkinson's disease. Instead, it helps manage and control your symptoms, such as tremors and stiffness, so you can move more easily. Talk to your doctor about your long-term treatment plan.
No, you should never stop taking Pramiset-0.125 Tablet suddenly, even if you feel completely better. Stopping abruptly can cause withdrawal symptoms such as anxiety, restlessness, sweating, fatigue, depressed mood, or a rapid heartbeat. Your doctor will provide instructions on gradually decreasing the dose safely.
It may take several weeks of gradually increasing the dose before you notice a significant improvement in your symptoms. Be patient and continue taking the medication exactly as prescribed. Talk to your doctor if you do not see improvements.
Yes, in some cases, Pramiset-0.125 Tablet can cause intense, uncontrollable urges, such as compulsive gambling, eating, spending, or sexual urges. If you or your family notice any unusual behavioural changes, contact your doctor right away.
You can take Pramiset-0.125 Tablet either with or without food. However, if you experience nausea or an upset stomach when taking it, swallowing the tablet with a meal or snack can help ease these symptoms. Talk to your doctor or pharmacist for personalised advice.
The safety of Pramiset-0.125 Tablet during pregnancy is not fully established. If you are pregnant, planning to become pregnant, or breastfeeding, you must discuss the potential risks and benefits with your doctor before starting this medication.
In some people taking Pramiset-0.125 Tablet for Restless Legs Syndrome, symptoms may gradually begin earlier in the day, become more severe, or affect additional body parts. This phenomenon is called augmentation. If you notice these changes, contact your doctor, as your treatment plan may need to be reviewed or adjusted.

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While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

16Th Floor, Godrej Bkc, Plot C, G Block, Bandra-Kurla Complex, Bandra (East), Mumbai 400 051, India.
Other Info - PRA0416

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