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Prealdonil Tablet is used to treat neuropathic pain. It contains Pregabalin and Epalrestat which work by changing the way in which nerves send messages to your brain and blocking the accumulation of sorbitol in the nerve, which causes diabetic nerve disease. This medicine may sometimes cause side effects such as weight gain, sleepiness/drowsiness, dry mouth, blurred vision, weight gain, and urine discolouration. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Manufacturer/Marketer :

Zydus Cadila

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Prealdonil Tablet

Prealdonil Tablet is an oral medicine primarily prescribed to manage diabetic neuropathy, which is nerve damage that can occur in people with diabetes. It targets the underlying metabolic causes of nerve damage while also relieving the burning, shooting, or stabbing pain associated with this condition.

To get the best results, you must take this medication consistently every day at the same times as prescribed by your doctor. It can be taken with or without food, but taking it with a meal may help if you experience a mild upset stomach. Alongside this treatment, managing your blood sugar levels through a balanced diet and regular physical activity is crucial for protecting your nerves.

While taking Prealdonil Tablet , some people may experience common, mild side effects such as dizziness, sleepiness, or dry mouth. However, you must consult your doctor immediately if you experience serious side effects like severe skin rashes, swelling of the face or throat, or unexplained muscle pain.

Talk to your doctor or pharmacist before starting this medicine if you have a history of kidney disease, liver issues, heart failure, or mood disorders like depression. Do not take this if you have a known allergy to any of its active components.

This medication can interact with alcohol, sleeping pills, and certain pain relievers, which may cause excessive sleepiness or breathing difficulties. If you are pregnant, planning to become pregnant, breastfeeding, or are an elderly individual, consult your doctor or pharmacist to ensure this medicine is safe for your specific situation.

Uses of Prealdonil Tablet

Prealdonil Tablet is used in the treatment of diabetic neuropathy. The detailed uses of Prealdonil Tablet are as follows:

  • Diabetic Neuropathy: Prealdonil Tablet helps manage the chronic nerve pain, burning sensations, numbness, and tingling in the hands and feet caused by diabetes-related nerve damage. It also works to slow down the progression of this nerve damage over time.

Key Benefits

Prealdonil Tablet provides comprehensive relief by targeting both the symptoms and the underlying progression of nerve damage. This dual action helps restore physical comfort and daily function.

Benefits may include:

  • It significantly reduces the intense, burning, or shooting pain in the limbs, allowing you to move more freely and comfortably.
  • By calming overactive nerves, this medicine helps reduce nighttime pain that can disrupt your sleep pattern.
  • It helps slow down the metabolic processes that cause physical damage to nerve cells, helping preserve long-term nerve health.

Directions for Use

  • Prealdonil Tablet can be taken with or without food as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Prealdonil Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Prealdonil Tablet Works

Prealdonil Tablet contains Epalrestat and Pregabalin, which work in different ways to protect your nerves and relieve pain. Epalrestat is an aldose reductase inhibitor. In diabetic patients, high blood sugar levels cause an excess buildup of a sugar called sorbitol in the nerves, which damages them. Epalrestat works by blocking the enzyme that creates sorbitol, thereby protecting the nerve fibres from structural damage and maintaining normal nerve conduction. Pregabalin is an alpha-2-delta ligand. It acts on the calcium channels in the central nervous system to reduce the release of specific chemical messengers that transmit pain signals. This action calms overactive nerve cells, significantly reducing the intensity of the pain signals sent to the brain.
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Alcohol

Caution

It is unsafe to consume alcohol since it may worsen the side effects like dizziness and sleepiness.

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Pregnancy

Caution

Prealdonil Tablet is a category C pregnancy drug. Please consult your doctor. Your doctor will weigh the benefits and potential risks before prescribing Prealdonil Tablet .

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Breast Feeding

Caution

The safe use of Prealdonil Tablet in breastfeeding mothers has not yet been established. So, it should be used in breastfeeding women only when prescribed by a doctor. Your doctor will weigh the benefits and potential risks before prescribing Prealdonil Tablet .

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Driving

Caution

Do not drive or operate machinery if you experience dizziness or drowsiness while using Prealdonil Tablet . Prealdonil Tablet can also sometimes cause blurry/double vision, hence avoid driving in such situations. Seek medical attention if the symptoms persist longer.

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Liver

Caution

Take Prealdonil Tablet with caution, especially if you have or had a history of liver disease/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Prealdonil Tablet with caution, especially if you have or had a history of kidney disease/conditions. The dose may be adjusted by your doctor as required.

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Children

Unsafe

Prealdonil Tablet is not recommended for children below the age of 18 years. The safety and efficacy of Prealdonil Tablet have not established. children.

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Heart

Caution

Prealdonil Tablet should be taken with caution in patients with heart problems. Therefore, please inform your doctor before using Prealdonil Tablet .

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Geriatrics

Caution

Prealdonil Tablet should be used under caution in geriatric patients. Please consult your physician.

What if I have taken an overdose of Prealdonil Tablet

In case of an accidental overdose, seek immediate medical attention or contact a poison control centre right away. Symptoms of an overdose may include severe sleepiness, confusion, agitation, or a rapid heart rate.

Diet & Lifestyle Advise

Managing diabetic neuropathy requires a comprehensive approach. These evidence-based lifestyle changes can support your treatment and improve nerve health:

  • Monitor blood sugar levels closely: Keeping your blood glucose within your target range is the most effective way to prevent further nerve damage.
  • Inspect your feet daily: Look for cuts, blisters, sores, or red spots. Because nerve damage can reduce pain sensation in your feet, you might not feel minor injuries that could lead to infections.
  • Exercise regularly: Engage in gentle physical activities like walking, swimming, or cycling. This improves blood circulation to your nerves and helps manage blood sugar.
  • Avoid alcohol entirely: Alcohol toxicities can worsen nerve damage and interact dangerously with your medication to cause severe drowsiness.
  • Quit smoking: Smoking constricts blood vessels, reducing nutrient-rich blood supply to your nerves, which can worsen neuropathic symptoms.
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How Soon It Starts Working

The time required for Prealdonil Tablet to start to work: The time required for Prealdonil Tablet to show its action is unknown. The time for which the effects of Prealdonil Tablet last: The duration of action for Prealdonil Tablet is clinically unknown.

What if you forget to take Prealdonil Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Storage

• Store this medicine at room temperature, ideally between 15°C and 30°C (59°F to 86°F).

Drug Warnings

  • Avoid Driving or Machinery: Do not drive, ride a bicycle, or operate heavy machinery after taking this medicine, as it can make you feel very dizzy and sleepy.
  • Do Not Stop Suddenly: If you need to stop taking this medicine, consult your doctor first. They will guide you on a gradually decreasing dose over at least a week to prevent withdrawal symptoms like insomnia, headache, or anxiety.
  • Monitor Your Mental Health: Pay close attention to your mental health. Report any sudden mood swings, worsening depression, or unusual thoughts to your doctor immediately.
  • Check your weight regularly: If you notice rapid, unexplained weight gain or swelling in your lower limbs, notify your doctor, as this may indicate fluid retention.
  • Inform Healthcare Providers: Inform any doctor or dentist treating you that you are taking Prealdonil Tablet , especially before undergoing any surgical procedures.

Drug-Drug Interactions

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  • Central Nervous System Depressants: Taking this medicine with anxiety medications, sleeping pills, muscle relaxants, or narcotic pain relievers can cause extreme sleepiness, dizziness, and slow down your breathing.
  • Certain Blood Pressure Medications: Combining this with ACE inhibitors may increase the risk of swelling (angioedema) in your face, lips, or throat.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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Alcohol: Avoid alcohol completely while taking this medicine. It can compound the sedative effects, leading to severe dizziness, sleepiness, and compromised coordination.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTICONVULSANT]

FAQs

Prealdonil Tablet is used to treat neuropathic pain. It is also used to treat diabetic neuropathy (nerve damage due to diabetes).
Prealdonil Tablet contains Pregabalin and Epalrestat. Prealdonil Tablet is a combination of two drugs: Pregabalin (anti-convulsant) and Epalrestat (carboxylic acid derivative). Pregabalin works by changing the way in which nerves send messages to your brain. Epalrestat is an aldose reductase inhibitor. It blocks the accumulation of sorbitol in the nerve, which causes diabetic nerve disease by inhibiting aldose reductase. It relieves the symptoms of neuropathic pain include numbness and pain of the hands, feet, leg cramps, etc. Together, Prealdonil Tablet helps to treat neuropathic pain (pain due to nerve damage) especially treat nerve damage due to diabetes mellitus.
Dry mouth could be a side-effect of Prealdonil Tablet . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.
No, you are not recommended to take Prealdonil Tablet with tramadol as co-administration of these medicines may cause breathing problems, drowsiness and even lead to a stage of coma. So, before using Prealdonil Tablet with pain killers like oxycodone or any other opioids analgesics, you are advised to contact your doctor so that the dosage may be adjusted accordingly to use safely.
People taking Prealdonil Tablet should be closely monitored for suicidal thoughts or behavior. Do not be reluctant to speak with your doctor immediately if you experience suicidal tendencies.
Prealdonil Tablet is used to treat neuropathic pain due to diabetic neuropathy. Diabetic neuropathy is a condition in which nerve damage occurs due to high blood glucose levels. It mostly damages the nerves in legs and feet.
No, you should not stop taking Prealdonil Tablet suddenly, even if your pain improves. Stopping it abruptly can cause withdrawal symptoms such as sleep problems, headaches, nausea, and anxiety, or cause your nerve pain to return. If you need to stop, your doctor will guide you on a gradual decrease in dose. Talk to your doctor before making any changes.
Yes, some individuals may experience weight gain or fluid retention while taking this medication. This is a recognised effect of one of its active components. If you notice rapid, unexpected weight gain or swelling in your hands or feet, talk to your doctor.
No, you should avoid drinking alcohol while taking this medicine. Alcohol can severely increase the drowsiness, dizziness, and lightheadedness caused by the medication, and it can also worsen diabetic nerve damage. Talk to your doctor if you have concerns about alcohol use.
Blurred vision is a common and usually temporary side effect as your body adjusts to the medication. However, if you experience any sudden changes in your vision or if the blurriness persists, contact your doctor immediately for an eye examination. Talk to your doctor if you have any vision concerns.
This medicine is generally not recommended during pregnancy or breastfeeding unless your doctor decides that the benefits outweigh the potential risks to the baby. Effective contraception is advised for women of childbearing age while taking this drug. Talk to your doctor to understand your options safely.
Yes, you can take this medication with or without food. However, taking it at the same time every day is highly recommended to keep the level of medicine in your body consistent. If it causes minor stomach upset, taking it with a meal can help. Talk to your doctor or pharmacist if you experience stomach discomfort.
No, this medication does not cure diabetic neuropathy. Instead, it effectively manages the chronic nerve pain associated with the condition and helps protect the nerves from further physical damage by regulating harmful metabolic processes. Talk to your doctor to learn more about a comprehensive management plan for diabetes.

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Country of origin

India

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads,Ahmedabad – 380015 Gujarat, India.
Other Info - PRE0754
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