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compositionComposition:NORTRIPTYLINE-10MG+PREGABALIN-75MG
prescription
Prescription Medicine
info
Pregain-NT 75 mg Tablet 10's
Pregain-NT 75 mg Tablet 10's

Pregain-Nt 75mg Tablet is used for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, spinal cord injury, etc. It contains Pregabalin and Nortriptyline, which affects the chemicals in the brain that send pain signals across the nervous system. Also, it increases nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. In some cases, you may experience certain common side effects such as dizziness, sleepiness, nausea, blurred vision, peripheral oedema (swelling of lower legs and hands), weight gain and dry mouth. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

NORTRIPTYLINE-10MG+PREGABALIN-75MG

Manufacturer/Marketer :

Ultra Drugs Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Pregain-Nt 75mg Tablet

Pregain-Nt 75mg Tablet is a combination medicine indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, spinal cord injury, etc. Neuropathic pain is a chronic progressive nerve disease which causes nerve pain due to nerve damage or a malfunctioning nervous system.

Pregain-Nt 75mg Tablet is a combination of two drugs: Pregabalin (anti-convulsant) and Nortriptyline (antidepressant). Pregabalin affects the chemicals in the brain that send pain signals across the nervous system. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Together, Pregain-Nt 75mg Tablet helps to treat neuropathic pain.

In some cases, you may experience certain common side-effects such as dizziness, sleepiness, nausea, blurred vision, peripheral oedema (swelling of lower legs and hands), weight gain and dry mouth. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

Consult your doctor if you are pregnant or breastfeeding. Pregain-Nt 75mg Tablet may cause drowsiness and dizziness, so drive only if you are alert. Pregain-Nt 75mg Tablet should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with Pregain-Nt 75mg Tablet as it could lead to increased dizziness and sleepiness. Keep your doctor informed about your health condition and medicines to rule out any side-effects.

Uses of Pregain-Nt 75mg Tablet

Pregain-Nt 75mg Tablet is used in the treatment of neuropathic pain. The detailed uses of Pregain-Nt 75mg Tablet are as follows:

  • Neuropathic Pain Management: Pregain-Nt 75mg Tablet is commonly prescribed to help alleviate pain caused by nerve damage or neuropathy, which can result from conditions such as diabetes or shingles.
  • Management of Epilepsy: Pregain-Nt 75mg Tablet may be used as part of the treatment plan for patients with epilepsy, specifically for controlling certain types of seizures.
  • Anxiety Disorder Treatment: Pregain-Nt 75mg Tablet can assist in managing generalized anxiety disorder, providing relief from excessive worry and improving overall emotional well-being.
  • Fibromyalgia Treatment: Pregain-Nt 75mg Tablet is often utilized to help reduce aches, pain, and discomfort associated with fibromyalgia, enhancing patient’s quality of life.

Key Benefits

Pregain-Nt 75mg Tablet is a combination of two medicines, namely: Pregabalin and Nortriptyline. Pregain-Nt 75mg Tablet is indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, spinal cord injury, etc. Pregabalin is an anti-convulsant which affects the chemicals in the brain that send pain signals across the nervous system. Nortriptyline is an antidepressant which works by increasing the levels of nerve transmitters (serotonin and noradrenaline) in the brain, thereby reduces the pain messages arriving in the brain. Together, Pregain-Nt 75mg Tablet helps to treat neuropathic pain (pain due to nerve damage).

Directions for Use

  • Take Pregain-Nt 75mg Tablet with or without food or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.
  • Swallow the medicine as a whole with glass of water.
  • Do not crush, break, or chew it.

How Pregain-Nt 75mg Tablet Works

Pregain-Nt 75mg Tablet is a combination of two drugs: Pregabalin (anti-convulsant) and Nortriptyline (antidepressant). Pregabalin affects the chemicals in the brain that send pain signals across the nervous system. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Together, Pregain-Nt 75mg Tablet helps to treat neuropathic pain.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Pregain-Nt 75mg Tablet as it may cause increased drowsiness and sleepiness.

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Pregnancy

Caution

Please consult your doctor if you have any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor before taking Pregain-Nt 75mg Tablet ; your doctor will decide whether Pregain-Nt 75mg Tablet can be taken by breastfeeding mothers or not.

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Driving

Unsafe

Pregain-Nt 75mg Tablet may cause drowsiness, sleepiness and blurred vision. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Pregain-Nt 75mg Tablet should not be given to children as safety and efficacy have not been established.

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Heart

Consult your doctor

Please inform your doctor if you have any pre-existing heart problems

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Geriatrics

Consult your doctor

Limited information available for use of Pregain-Nt 75mg Tablet in elderly patients. Please consult your doctor.

What if I have taken an overdose of Pregain-Nt 75mg Tablet

Do not take more than the prescribed dose of Pregain-Nt 75mg Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Include food rich in vitamin B and D in your diet.
  • Include cayenne pepper in your diet as it can help in lowering neuropathic pain.
  • Exercising regularly helps in improving overall health and combating pain.
  • Rest well, get plenty of sleep.
  • Try taking a warm bath as it can be soothing.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower the stress, decrease pain sensitivity and improves coping skills.
  • Acupuncture can be helpful by stimulating pressure points.
  • Using essential oils for massages can help increase circulation.

Have a query?

How Soon It Starts Working

The time required for Pregain-Nt 75mg Tablet to start to work: The time required for Pregain-Nt 75mg Tablet to show its action is unknown. The time for which the effects of Pregain-Nt 75mg Tablet last: The duration of action for Pregain-Nt 75mg Tablet is unknown.

What if you forget to take Pregain-Nt 75mg Tablet

If you miss a dose of Pregain-Nt 75mg Tablet , take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

Do not take Pregain-Nt 75mg Tablet if you are allergic to any of its contents. Inform your doctor before taking Pregain-Nt 75mg Tablet if you have or had heart problems, bipolar syndrome, severe liver disease or if you have taken MAO inhibitors in the last 14 days. Consult your doctor before taking cough-cold medicines containing adrenaline-like drugs such as ephedrine, phenylpropanolamine, isoprenaline, noradrenaline or phenylephrine. Consult your doctor if you are pregnant or breastfeeding. Pregain-Nt 75mg Tablet may cause drowsiness and dizziness, so drive only if you are alert. Pregain-Nt 75mg Tablet should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with Pregain-Nt 75mg Tablet as it could lead to increased drowsiness and sleepiness.

Drug-Drug Interactions

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Drug-Drug Interactions: Pregain-Nt 75mg Tablet may interact with antidepressants (amitriptyline, duloxetine, mirtazapine, fluoxetine, sertraline, citalopram, escitalopram, bupropion), pain killer (codeine, fentanyl, hydrocodone, morphine, oxycodone, tramadol, acetaminophen), anti-convulsant (gabapentin, phenobarbital, phenytoin, clonazepam, topiramate), anti-anxiety (diazepam, alprazolam), sedative-hypnotics (zolpidem), antihistamine (diphenhydramine, cetirizine), muscle relaxant (cyclobenzaprine), antiemetic (ondansetron).

Drug-Food Interactions: Avoid alcohol consumption while taking Pregain-Nt 75mg Tablet as it might cause increased drowsiness and sleepiness.

Drug-Disease Interactions: Inform your doctor if you have angioedema, creatine kinase elevations, heart problems, depression, fits, pheochromocytoma (tumour of the adrenal gland), bone marrow suppression, tardive dyskinesia (involuntary facial movements), glaucoma, schizophrenia, bipolar disorder, thyroid problems, urinary retention, kidney and liver problems.

No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[MISCELLANEOUS]

FAQs

Pregain-Nt 75mg Tablet is used to treat neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, spinal cord injury, etc.
Pregain-Nt 75mg Tablet affects the chemicals in the brain that send pain signals across the nervous system. It increases nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain.
Dry mouth could be a side-effect of Pregain-Nt 75mg Tablet . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.
To treat your condition effectually, continue taking Pregain-Nt 75mg Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Pregain-Nt 75mg Tablet .
Pregain-Nt 75mg Tablet is used to treat nerve pain due to diabetic neuropathy. Diabetic neuropathy is a condition in which nerve damage occurs due to high blood glucose levels. It mostly damages the nerves in the legs and feet.
Pregain-Nt 75mg Tablet may cause peripheral oedema. Peripheral oedema is the swelling of hands and lower legs. Avoid sitting or standing for too long. Raise your legs by putting a pillow under the legs while lying down.
Pregain-Nt 75mg Tablet may cause weight gain due to an increase in appetite. Maintain a healthy weight by regular exercise and following a proper diet.
Pregain-Nt 75mg Tablet is a combination of two drugs: Pregabalin (anti-convulsant) and Nortriptyline (antidepressant). Pregabalin affects the chemicals in the brain that send pain signals across the nervous system. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Together, they help treat neuropathic pain.
When taking Pregain-Nt 75mg Tablet , you must be mindful of your diet and lifestyle to maintain a healthy weight. This medication combination can increase your appetite, leading to weight gain. Focus on nutrient-dense foods, be mindful of your portion sizes, and avoid high-calorie snacks like crisps, cakes, biscuits, and sweets. Instead, opt for fresh fruits and vegetables, low-calorie foods, whole grains, and lean protein sources. Regular exercise will also help stabilize your weight and support overall health and well-being.
Pregain-Nt 75mg Tablet causes sleepiness or drowsiness as a common side effect. Because Pregain-Nt 75mg Tablet is a tricyclic antidepressant that increases the levels of certain neurotransmitters (serotonin and noradrenaline) in the brain and works by modulating calcium channel activity in nerve cells, which can lead to drowsiness as a side effect, this side effect does not require medical attention and will resolve gradually over time. It's essential to be cautious when engaging in activities that require alertness, such as driving or operating heavy machinery. However, you are advised to talk to your doctor if you experience these side effects persistently.
Taking Pregain-Nt 75mg Tablet can affect your sexual life. You might experience lower sex drive, erectile dysfunction, or problems with ejaculation or orgasm. If you notice any of these changes, it's important to tell your doctor. They can help you find solutions or adjust your medication to minimize these effects. Remember, being open and honest about your sexual health is crucial in managing potential side effects and finding the best treatment for you.
Most common side effects of Pregain-Nt 75mg Tablet tend to subside as your body adapts to the medication. However, in rare cases, you may experience severe reactions, including allergic responses, significant mood changes (such as suicidal ideation), seizures, or irregular heartbeats. If you encounter any of these symptoms, seek medical attention immediately. Prompt treatment can help address these issues and ensure your safety. Remember, it's always best to consult with your healthcare provider if you have concerns.
The time it takes for Pregain-Nt 75mg Tablet to take effect can vary considerably from person to person. While some people may start feeling better after a couple of weeks, it may take up to 4-6 weeks to experience the full benefits. The exact duration of treatment will depend on your individual medical condition, and your doctor will provide personalized guidance on the recommended course of treatment.
If you forget to take Pregain-Nt 75mg Tablet , take it as soon as you remember. A small variation in time may not show much effect. If it is too late, continue taking the next dose as indicated, But never take a double dose in your next dose. Consult your doctor if you are uncomfortable or experiencing symptoms.
Never use a greater quantity of medicine than prescribed. Pregain-Nt 75mg Tablet may cause serious side effects such as abnormal heartbeat, seizures, allergic reactions, and suicidal ideation. Please inform your doctor and get medical assistance as soon as possible to avoid major complications.
Taking more than the recommended dosage does not provide additional relief and can increase the risk of adverse effects and long-term health complications.
While taking Pregain-Nt 75mg Tablet , it's crucial to be mindful of potential interactions and risks. Avoid excessive alcohol consumption, as it may intensify side effects, and refrain from driving or operating heavy machinery until you understand how the medication affects you. Additionally, consult your doctor before taking other medications or supplements to prevent interactions, and limit grapefruit or grapefruit juice intake, as it may impact absorption. Sudden changes in diet or exercise routines should also be avoided. Furthermore, exercise caution when taking medications containing opioids, as they may interact with Pregain-Nt 75mg Tablet . By following your doctor's guidance and being aware of these potential interactions, you can minimize risks and ensure the medication works effectively for you.
Regular check-ins with your doctor are crucial when receiving medical treatment to monitor your progress and address any concerns. The frequency of visits may vary depending on your individual situation, but typically, you can expect to see your doctor regularly during the initial treatment phase to adjust treatment plans and monitor side effects. During maintenance, periodic check-ins will also help track your progress and address any concerns.
Storage: Store the Pregain-Nt 75mg Tablet in its original container to protect it from the external environment. Keep the medication out of reach of children. Store in a cool and dry place away from sunlight.Disposal: Do not consume it after the expiration date.Check the expiration date, remove the label, keep it in a plastic bag, and throw it in household trash. Do not flush the medication down the toilet or sink.
No, Pregain-Nt 75mg Tablet is not an OTC drug; it cannot be given directly without a registered medical practitioner prescription.
The most common side effects of the Pregain-Nt 75mg Tablet are blurred vision, dizziness, dry mouth, peripheral oedema (swelling of lower legs and hands), nausea, sleepiness, and weight gain. These side effects may not cause many complications but gradually decrease over time. If you feel any discomfort, contact your doctor; you may get guidance to suppress your discomfort.
Pregain-Nt 75mg Tablet may interact with antidepressants (amitriptyline, duloxetine, mirtazapine, fluoxetine, sertraline, citalopram, escitalopram, bupropion), pain killer (codeine, fentanyl, hydrocodone, morphine, oxycodone, tramadol, acetaminophen), anti-convulsant (gabapentin, phenobarbital, phenytoin, clonazepam, topiramate), anti-anxiety (diazepam, alprazolam), sedative-hypnotics (zolpidem), antihistamine (diphenhydramine, cetirizine), muscle relaxant (cyclobenzaprine), antiemetic (ondansetron). So, please confirm with your doctor about pre-existing diseases and your present medication. Your doctor will weigh the risks and suggest the medication to avoid drug interactions.
While using Pregain-Nt 75mg Tablet , following a healthy diet and lifestyle is essential to maximize the medication's effectiveness and minimize potential side effects. Eat a balanced diet rich in whole foods, fruits, vegetables, and whole grains, and stay hydrated by drinking plenty of water. Limit your intake of processed and high-sugar foods, and exercise regularly with activities like walking or light physical activity to maintain overall health. Aim for 7-8 hours of sleep per night to help your body recover and manage stress through relaxation techniques like meditation or deep breathing. Additionally, avoid excessive alcohol consumption and smoking. Following these guidelines and consulting your doctor for personalized advice can optimize your treatment and improve your overall well-being.
The most crucial advice while using any medication is to prioritize your mental health and safety. If you're using a medication that can increase the risk of suicidal thoughts or behaviour, it's essential to be closely monitored by your healthcare provider. If you experience any thoughts or feelings of self-harm, it's vital to seek help immediately. Don't hesitate to reach out to your doctor or a crisis helpline for support. Remember, your well-being is the top priority; timely intervention can make a significant difference.
Pregain-Nt 75mg Tablet can be taken with or without food. Swallow it as a whole with a glass of water, do not chew or break it. Always follow your physician's instructions for how much and how many doses to take. Also, inform your doctor if you are having any discomfort; they will guide you in managing it.
Before using this medication, you should inform your doctor about your medical history, including any ongoing medicines, to avoid potential interactions and minimize side effects.
There have been no long-term side effects reported as of now. If you experience any side effects that persist, please stop taking the medication and consult the doctor immediately.
Pregain-Nt 75mg Tablet is a combination of two drugs: Pregabalin (anti-convulsant) and Nortriptyline (antidepressant).
Pregain-Nt 75mg Tablet should not be given to children as safety and efficacy have not been established. Please reach out to the doctor for more assistance.

Disclaimer

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Reference

  1. Drugs.com Clinical Review Team. Pregabalin Drug Interactions Reference. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  2. Drugs.com Clinical Review Team. Nortriptyline Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  3. Electronic Medicines Compendium (EMC). Pil.5044 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  4. Electronic Medicines Compendium (EMC). Pil.7057 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  5. Pregabalin [Prescribing Information]. 2009. [Accessed on 22 Apr. 2019] Check here
  6. Pregabalin [Prescribing Information]. 2011. [Accessed on 22 Apr. 2019] Check here
  7. Nortriptyline [Prescribing Information]. 2025. [Accessed on 14 Apr. 2025]Check here

Country of origin

India

Manufacturer/Marketer address

Baddi, Nalagarh Bypass Rd, Manpura, Himachal Pradesh 174102
Other Info - PRE1264

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