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compositionComposition:NORTRIPTYLINE-10MG+PREGABALIN-75MG
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Prescription Medicine
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Pregasim-NT Capsule 10's is used for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, spinal cord injury, etc. It contains Pregabalin and Nortriptyline, which affects the chemicals in the brain that send pain signals across the nervous system. Also, it increases nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. In some cases, you may experience certain common side effects such as dizziness, sleepiness, nausea, blurred vision, peripheral oedema (swelling of lower legs and hands), weight gain and dry mouth. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

NORTRIPTYLINE-10MG+PREGABALIN-75MG

Manufacturer/Marketer :

Orsim Pharma

Consume Type :

Oral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Pregasim-NT Capsule 10's

Pregasim-NT Capsule 10's is a prescription medication used to manage long-term nerve pain, also known as neuropathic pain. It is prescribed to treat pain caused by nerve damage due to conditions like diabetes, shingles, or spinal injuries. This medication combines two active ingredients that work together to calm hyperactive nerves and block pain signals from reaching your brain.

For the best results, you must take Pregasim-NT Capsule 10's regularly and exactly as your doctor directs, typically once daily before bedtime. You can take this medication with or without food, but keeping a consistent schedule daily is highly recommended. Combining this treatment with lifestyle adjustments, such as gentle physical activity and a balanced diet, can help improve your overall comfort and results.

While taking Pregasim-NT Capsule 10's, you may experience mild, common side effects like drowsiness, dry mouth, or mild dizziness. These usually improve as your body adjusts, but you must contact your doctor immediately if you experience serious issues, such as severe mood changes, thoughts of self-harm, or a rapid, irregular heartbeat.

Do not take this if you have recently had a heart attack or are currently taking monoamine oxidase inhibitors (MAOIs) for depression. Talk to your doctor before starting this medicine if you have a history of heart disease, kidney issues, glaucoma, or depression.

This medication can interact with alcohol, sleeping pills, or antihistamines, significantly increasing your risk of severe drowsiness and slow breathing. If you are pregnant, planning a pregnancy, breastfeeding, or are an older adult, consult your doctor or pharmacist to discuss whether this medicine is safe for you.

Uses of Pregasim-NT Capsule 10's

Pregasim-NT Capsule 10's is prescribed to help manage nerve pain and related conditions. Common uses include:

  • Neuropathic pain: Pregasim-NT Capsule 10's helps relieve chronic, burning, or shooting pain caused by damaged nerves from conditions like diabetes (diabetic neuropathy) or shingles (postherpetic neuralgia).
  • Fibromyalgia: In some cases, your doctor may prescribe Pregasim-NT Capsule 10's off-label to help manage widespread pain, improve sleep quality, and reduce discomfort. Always use this medicine only as directed by your doctor.
     

Key Benefits

Pregasim-NT Capsule 10's combines two medicines that work together to relieve neuropathic (nerve) pain. It helps reduce abnormal pain signals, improving comfort, sleep quality, and overall daily functioning.

  • Relieves Nerve Pain: Helps reduce burning, stabbing, tingling, and shooting pain caused by damaged or overactive nerves.
  • Reduces Pain Intensity: Acts on multiple pain pathways to provide more effective relief from chronic neuropathic pain.
  • Improves Sleep Quality: By reducing night-time nerve pain, it helps promote more restful and uninterrupted sleep.
  • Enhances Daily Functioning: Better pain control allows you to perform daily activities with greater comfort and improved mobility.
  • Improves Quality of Life: Regular use helps reduce the impact of chronic nerve pain, supporting better physical and emotional well-being.
     

Directions for Use

  • Take Pregasim-NT Capsule 10's with or without food or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.
  • Swallow the medicine as a whole with glass of water.
  • Do not crush, break, or chew it.

How Pregasim-NT Capsule 10's Works

Pregasim-NT Capsule 10's works through two different mechanisms to help relieve nerve pain. Each active ingredient targets pain signals in a different way, providing complementary relief. The first active component, pregabalin, belongs to a group of medicines called gabapentinoids, which help calm overactive nerve signals. It works by binding to the alpha-2-delta subunits of voltage-gated calcium channels, special sites on nerve cells that control the release of pain-signalling chemicals. This reduces the release of these chemicals, helping calm overactive nerves and relieve nerve pain. The second active component, nortriptyline, is a tricyclic antidepressant. In the treatment of nerve pain, it works mainly by blocking the reuptake (reabsorption) of norepinephrine, a natural chemical involved in controlling pain and mood, and to a lesser extent, serotonin. This increases the availability of these chemical messengers, strengthening the body's natural pain-control pathways and reducing the transmission of pain signals to the brain. Together, these two components work hand in hand to reduce abnormal nerve activity, interrupt pain signals, and provide effective relief from chronic nerve pain.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Pregasim-NT Capsule 10's as it may cause increased drowsiness and sleepiness.

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Pregnancy

Caution

Please consult your doctor if you have any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor before taking Pregasim-NT Capsule 10's; your doctor will decide whether Pregasim-NT Capsule 10's can be taken by breastfeeding mothers or not.

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Driving

Unsafe

Pregasim-NT Capsule 10's may cause drowsiness, sleepiness and blurred vision. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Pregasim-NT Capsule 10's should not be given to children as safety and efficacy have not been established.

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Heart

Consult your doctor

Please inform your doctor if you have any pre-existing heart problems

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Geriatrics

Consult your doctor

Limited information available for use of Pregasim-NT Capsule 10's in elderly patients. Please consult your doctor.

What if I have taken an overdose of Pregasim-NT Capsule 10's

If you suspect an overdose, seek emergency medical care or call a poison control centre immediately. Symptoms of an overdose may include severe drowsiness, confusion, rapid heart rate, or loss of consciousness.

Diet & Lifestyle Advise

  • Stay hydrated: Drink plenty of water throughout the day to help manage common side effects like dry mouth and constipation.
  • Eat a high-fibre diet: Incorporate vegetables, fruits, and whole grains into your meals to keep your digestion regular.
  • Manage your blood sugar: If your nerve pain is due to diabetes, closely monitoring and managing your blood sugar levels can prevent further nerve damage.
  • Engage in gentle exercise: Activities like walking, swimming, or stretching can improve blood circulation and reduce overall nerve sensitivity. Talk to your doctor before starting any new exercise routine.
  • Avoid alcohol: Alcohol can worsen nerve damage and significantly increase the drowsy side effects of Pregasim-NT Capsule 10's.
     
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How Soon It Starts Working

The time required for Pregasim-NT Capsule 10's to start to work: The time required for Pregasim-NT Capsule 10's to show its action is unknown. The time for which the effects of Pregasim-NT Capsule 10's last: The duration of action for Pregasim-NT Capsule 10's is unknown.

What if you forget to take Pregasim-NT Capsule 10's

If you miss a dose of Pregasim-NT Capsule 10's, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

•Store Pregasim-NT Capsule 10's according to the instructions on the product packaging, generally at room temperature, ideally between 15°C and 30°C (59°F and 86°F). •Keep the medication in its original packaging to protect it from excessive heat, moisture, and direct lig

Drug Warnings

  • Avoid driving: Do not drive, operate heavy machinery, or perform dangerous activities until you know how Pregasim-NT Capsule 10's affects your alertness, as it can cause significant drowsiness.
  • Do not stop suddenly: Do not stop taking Pregasim-NT Capsule 10's abruptly. Stopping suddenly can cause withdrawal symptoms like nausea, headaches, and trouble sleeping. Your doctor will help you by gradually decreasing the dose when it is time to stop.
  • Inspect your medication: Check the tablets or capsules before taking them; do not use them if they appear discoloured, chipped, or damaged.
  • Watch your mood: Pay close attention to any sudden changes in your mood, behaviour, or thoughts, and report them to a doctor immediately.
  • Inform your healthcare team: Tell any dentist, surgeon, or medical specialist that you are taking Pregasim-NT Capsule 10's before undergoing any procedure or medical test.
     

verifiedApollotooltip
  • Monoamine Oxidase Inhibitors (MAOIs): Taking Pregasim-NT Capsule 10's with MAOIs can cause dangerously high blood pressure and severe brain chemistry issues. Do not take this medicine within 14 days of stopping an MAOI.
  • CNS Depressants and Pain Relievers: Combining this medicine with sleeping pills, anxiety medications, muscle relaxants, or opioid pain relievers can cause extreme drowsiness and dangerous breathing difficulties.
  • Anticholinergic Drugs: Medicines for bladder control or allergies can worsen dry mouth, constipation, and blurred vision when taken with Pregasim-NT Capsule 10's.
     

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  • Alcohol: Drinking alcohol while taking this medicine can cause severe sleepiness, dizziness, and slow your coordination.
     

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[MISCELLANEOUS]

FAQs

Pregasim-NT Capsule 10's is used to treat neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, spinal cord injury, etc.
Pregasim-NT Capsule 10's affects the chemicals in the brain that send pain signals across the nervous system. It increases nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain.
Pregasim-NT Capsule 10's is used to treat nerve pain due to diabetic neuropathy. Diabetic neuropathy is a condition in which nerve damage occurs due to high blood glucose levels. It mostly damages the nerves in the legs and feet.
Pregasim-NT Capsule 10's may cause peripheral oedema. Peripheral oedema is the swelling of hands and lower legs. Avoid sitting or standing for too long. Raise your legs by putting a pillow under the legs while lying down.
Pregasim-NT Capsule 10's is a combination of two drugs: Pregabalin (anti-convulsant) and Nortriptyline (antidepressant). Pregabalin affects the chemicals in the brain that send pain signals across the nervous system. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Together, they help treat neuropathic pain.
When taking Pregasim-NT Capsule 10's, you must be mindful of your diet and lifestyle to maintain a healthy weight. This medication combination can increase your appetite, leading to weight gain. Focus on nutrient-dense foods, be mindful of your portion sizes, and avoid high-calorie snacks like crisps, cakes, biscuits, and sweets. Instead, opt for fresh fruits and vegetables, low-calorie foods, whole grains, and lean protein sources. Regular exercise will also help stabilize your weight and support overall health and well-being.
Taking Pregasim-NT Capsule 10's can affect your sexual life. You might experience lower sex drive, erectile dysfunction, or problems with ejaculation or orgasm. If you notice any of these changes, it's important to tell your doctor. They can help you find solutions or adjust your medication to minimize these effects. Remember, being open and honest about your sexual health is crucial in managing potential side effects and finding the best treatment for you.
Most common side effects of Pregasim-NT Capsule 10's tend to subside as your body adapts to the medication. However, in rare cases, you may experience severe reactions, including allergic responses, significant mood changes (such as suicidal ideation), seizures, or irregular heartbeats. If you encounter any of these symptoms, seek medical attention immediately. Prompt treatment can help address these issues and ensure your safety. Remember, it's always best to consult with your healthcare provider if you have concerns.
The time it takes for Pregasim-NT Capsule 10's to take effect can vary considerably from person to person. While some people may start feeling better after a couple of weeks, it may take up to 4-6 weeks to experience the full benefits. The exact duration of treatment will depend on your individual medical condition, and your doctor will provide personalized guidance on the recommended course of treatment.
If you forget to take Pregasim-NT Capsule 10's, take it as soon as you remember. A small variation in time may not show much effect. If it is too late, continue taking the next dose as indicated, But never take a double dose in your next dose. Consult your doctor if you are uncomfortable or experiencing symptoms.
Never use a greater quantity of medicine than prescribed. Pregasim-NT Capsule 10's may cause serious side effects such as abnormal heartbeat, seizures, allergic reactions, and suicidal ideation. Please inform your doctor and get medical assistance as soon as possible to avoid major complications.
Taking more than the recommended dosage does not provide additional relief and can increase the risk of adverse effects and long-term health complications.
While taking Pregasim-NT Capsule 10's, it's crucial to be mindful of potential interactions and risks. Avoid excessive alcohol consumption, as it may intensify side effects, and refrain from driving or operating heavy machinery until you understand how the medication affects you. Additionally, consult your doctor before taking other medications or supplements to prevent interactions, and limit grapefruit or grapefruit juice intake, as it may impact absorption. Sudden changes in diet or exercise routines should also be avoided. Furthermore, exercise caution when taking medications containing opioids, as they may interact with Pregasim-NT Capsule 10's. By following your doctor's guidance and being aware of these potential interactions, you can minimize risks and ensure the medication works effectively for you.
Regular check-ins with your doctor are crucial when receiving medical treatment to monitor your progress and address any concerns. The frequency of visits may vary depending on your individual situation, but typically, you can expect to see your doctor regularly during the initial treatment phase to adjust treatment plans and monitor side effects. During maintenance, periodic check-ins will also help track your progress and address any concerns.
Storage: Store the Pregasim-NT Capsule 10's in its original container to protect it from the external environment. Keep the medication out of reach of children. Store in a cool and dry place away from sunlight.Disposal: Do not consume it after the expiration date.Check the expiration date, remove the label, keep it in a plastic bag, and throw it in household trash. Do not flush the medication down the toilet or sink.
No, Pregasim-NT Capsule 10's is not an OTC drug; it cannot be given directly without a registered medical practitioner prescription.
The most common side effects of the Pregasim-NT Capsule 10's are blurred vision, dizziness, dry mouth, peripheral oedema (swelling of lower legs and hands), nausea, sleepiness, and weight gain. These side effects may not cause many complications but gradually decrease over time. If you feel any discomfort, contact your doctor; you may get guidance to suppress your discomfort.
Pregasim-NT Capsule 10's may interact with antidepressants (amitriptyline, duloxetine, mirtazapine, fluoxetine, sertraline, citalopram, escitalopram, bupropion), pain killer (codeine, fentanyl, hydrocodone, morphine, oxycodone, tramadol, acetaminophen), anti-convulsant (gabapentin, phenobarbital, phenytoin, clonazepam, topiramate), anti-anxiety (diazepam, alprazolam), sedative-hypnotics (zolpidem), antihistamine (diphenhydramine, cetirizine), muscle relaxant (cyclobenzaprine), antiemetic (ondansetron). So, please confirm with your doctor about pre-existing diseases and your present medication. Your doctor will weigh the risks and suggest the medication to avoid drug interactions.
While using Pregasim-NT Capsule 10's, following a healthy diet and lifestyle is essential to maximize the medication's effectiveness and minimize potential side effects. Eat a balanced diet rich in whole foods, fruits, vegetables, and whole grains, and stay hydrated by drinking plenty of water. Limit your intake of processed and high-sugar foods, and exercise regularly with activities like walking or light physical activity to maintain overall health. Aim for 7-8 hours of sleep per night to help your body recover and manage stress through relaxation techniques like meditation or deep breathing. Additionally, avoid excessive alcohol consumption and smoking. Following these guidelines and consulting your doctor for personalized advice can optimize your treatment and improve your overall well-being.
The most crucial advice while using any medication is to prioritize your mental health and safety. If you're using a medication that can increase the risk of suicidal thoughts or behaviour, it's essential to be closely monitored by your healthcare provider. If you experience any thoughts or feelings of self-harm, it's vital to seek help immediately. Don't hesitate to reach out to your doctor or a crisis helpline for support. Remember, your well-being is the top priority; timely intervention can make a significant difference.
Pregasim-NT Capsule 10's can be taken with or without food. Swallow it as a whole with a glass of water, do not chew or break it. Always follow your physician's instructions for how much and how many doses to take. Also, inform your doctor if you are having any discomfort; they will guide you in managing it.
Before using this medication, you should inform your doctor about your medical history, including any ongoing medicines, to avoid potential interactions and minimize side effects.
There have been no long-term side effects reported as of now. If you experience any side effects that persist, please stop taking the medication and consult the doctor immediately.
Pregasim-NT Capsule 10's is a combination of two drugs: Pregabalin (anti-convulsant) and Nortriptyline (antidepressant).
Pregasim-NT Capsule 10's should not be given to children as safety and efficacy have not been established. Please reach out to the doctor for more assistance.
No, you should not stop taking Pregasim-NT Capsule 10's suddenly, even if you feel better. Stopping the medicine abruptly can lead to withdrawal symptoms like headache, sleep troubles, and nausea. Your doctor will advise you on how to stop safely by gradually decreasing the dose. Talk to your doctor.
Yes, some people experience mild weight gain while taking this medication. This can happen due to an increased appetite or fluid retention. Eating a balanced diet and staying active can help manage this. Talk to your doctor.
No, you should avoid alcohol while taking this medicine. Alcohol can dangerously increase the drowsy and dizzy effects of the medication, making it unsafe to perform daily tasks. Talk to your doctor or pharmacist.
Dry mouth is a common side effect. You can manage this by sipping water regularly, chewing sugar-free gum, or sucking on sugar-free hard candies. If dry mouth persists or becomes severe, talk to your doctor or pharmacist.
Yes, drowsiness is a very common side effect, especially when you first start the medication. Taking the dose at bedtime can help reduce daytime sleepiness. Avoid driving or using machinery if you feel drowsy. Talk to your doctor.
Pregasim-NT Capsule 10's is generally not recommended during pregnancy unless your doctor decides the benefits outweigh the potential risks to the baby. If you are pregnant or planning to become pregnant, talk to your doctor.
Yes, in some cases, this medication can affect your heart rhythm or rate, particularly if you have pre-existing heart conditions. If you experience a pounding heartbeat, dizziness, or chest discomfort, seek medical attention immediately. Talk to your doctor.

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While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Drugs.com Clinical Review Team. Pregabalin Drug Interactions Reference. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Nortriptyline Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. Electronic Medicines Compendium (EMC). Pil.5044 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  4. Electronic Medicines Compendium (EMC). Pil.7057 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  5. Pregabalin [Prescribing Information]. 2009. [Accessed on 22 Apr. 2019]Check here
  6. Pregabalin [Prescribing Information]. 2011. [Accessed on 22 Apr. 2019]Check here
  7. Nortriptyline [Prescribing Information]. 2025. [Accessed on 14 Apr. 2025]Check here

Country of origin

India

Manufacturer/Marketer address

No 71, Dasappan Street, Rathinapuri, Coimbatore-641027, Tamilnadu, India
Other Info - PRE1550

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