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compositionComposition:AMITRIPTYLINE-10MG+PREGABALIN-50MG
prescription
Prescription Medicine
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Pregatex-AT Tablet is used for the management of neuropathic pain. It contains Pregabalin and Amitriptyline, which works by increasing the level of serotonin and noradrenaline, thereby decreasing the movement of pain receptors. Thus, helps in relieving nerve pain. It may cause common side effects such as weight gain, dry mouth, blurred vision, dizziness, tiredness, nausea, vomiting, diarrhoea, and constipation. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

AMITRIPTYLINE-10MG+PREGABALIN-50MG

Manufacturer/Marketer :

Zancortex Pharma

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Pregatex-AT Tablet

Pregatex-AT Tablet is a prescription oral medication primarily used to treat long-term nerve pain, also known as neuropathic pain, caused by conditions like diabetes or shingles. It works by calming hyperactive nerve cells and blocking pain signals traveling up the spinal cord to the brain.

To get the most benefit from this medicine, you must take it consistently at the same times every day, typically once daily in the evening. You can take it with or without food. Alongside your medication, incorporating light physical activity and managing daily stress can significantly improve your overall recovery and treatment results.

While taking Pregatex-AT Tablet , you might experience common side effects such as drowsiness, dizziness, or a dry mouth. Most of these symptoms are mild, but you must contact your doctor immediately if you notice serious issues like severe mood swings, swelling in your face or throat, or an irregular heartbeat.

Before you start taking this medicine, talk to your doctor if you have a history of heart issues, kidney disease, glaucoma, or depression. Do not take this if you have recently had a heart attack or if you have severe heart block.

This medicine can interact with alcohol, sleeping pills, and certain strong pain relievers, which can make you feel excessively drowsy and impair your coordination. If you are pregnant, planning to breastfeed, or are an older adult, consult your doctor or pharmacist to ensure this medicine is safe for your specific health needs.

Uses of Pregatex-AT Tablet

Pregatex-AT Tablet is used to manage nerve-related pain conditions. The detailed uses of Pregatex-AT Tablet are as follows:

  • Neuropathic Pain: Pregatex-AT Tablet helps relieve persistent burning, stabbing, or shooting pain caused by damaged nerves from conditions like diabetes, shingles, or spinal cord injuries.
  • Fibromyalgia: It assists in reducing widespread musculoskeletal pain, chronic fatigue, and muscle stiffness by calming the overactive pain pathways in the brain.

Key Benefits

Pregatex-AT Tablet helps relieve nerve-related pain and discomfort, allowing you to carry out daily activities with greater ease and comfort. By reducing persistent pain signals, it supports improved physical function and overall well-being. Benefits may include:

  • Helps reduce nerve pain, burning sensations, tingling, and discomfort.
  • Improves ability to perform daily activities with less pain.
  • Supports better mobility and physical functioning.
  • Helps reduce nighttime pain that may interfere with sleep.
  • Promotes more restful sleep and improved daytime energy levels.
  • Enhances overall quality of life by providing long-term relief from nerve-related symptoms.
Side effects of Pregatex-AT Tablet
  • Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
  • Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
  • Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
  • Gently massage the swollen area with firm but not painful pressure.
  • Keep the swollen area clean and moisturized to prevent injury and infection.
  • Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
  • If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Include fruits, vegetables, and whole grains in your diet.
  • Exercise regularly.
  • Quit smoking as it may increase the risk of neuropathy.
  • Getting massage therapy and acupuncture might help with pain.
  • Avoid massaging the bruise, as this might worsen the damage to the injured tissue.
  • Resting the affected area helps prevent more injury and aids healing.
  • Place a cloth-wrapped ice pack or cold compress on the affected area for 10 to 15 minutes.
  • If the bruise is extensive, severe, or accompanied by other symptoms like warmth, redness, or swelling, get medical help.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
  • Limit your intake of carbonated drinks, alcohol and caffeine as these substances can irritate your bladder.
  • Do Kegel exercises to strengthen pelvic floor muscles and improve bladder control.
  • Use absorbent pads or underwear to manage accidental urination.
  • If incontinence continues or worsens, see a doctor to check for underlying issues.
  • Uncoordinated muscle movements need immediate medical attention.
  • Observe your movements and try to understand and control the particular movement.
  • Regularly do strengthening exercises to improve blood flow throughout the body and avoid involuntary movements.
  • Implement massage techniques to enhance blood flow to organs.
  • Take a balanced diet and quit smoking.
  • Practice yoga and meditation to improve thought processes and reduce uncontrolled and involuntary movements.

Directions for Use

  • Swallow the tablet or capsule whole with a full glass of water. Do not crush, chew, or break the medicine.
  • Take the medicine at the same time each day, preferably in the evening, to help manage daytime sleepiness.
  • You can take this medication with or without food.
  • Always follow your doctor's exact instructions regarding how and when to take your medication, and do not change your dose without consulting them.

How Pregatex-AT Tablet Works

Pregatex-AT Tablet contains Pregabalin and Amitriptyline. • Pregabalin: It helps calm overactive nerves and reduces the pain signals sent to the brain. This helps relieve nerve-related pain, burning sensations, tingling, and discomfort. • Amitriptyline: It helps strengthen the body's natural pain-control system and reduces the perception of pain. It can also help improve sleep and overall comfort in people with nerve pain.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Pregatex-AT Tablet as it may increase drowsiness and sleepiness.

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Pregnancy

Caution

Please consult your doctor if you have any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor before taking Pregatex-AT Tablet ; your doctor will decide whether Pregatex-AT Tablet can be taken by breastfeeding mothers or not.

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Driving

Unsafe

Pregatex-AT Tablet may cause drowsiness, sleepiness and blurred vision. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Pregatex-AT Tablet should not be given to children as the safety and efficacy have not been established.

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Heart

Caution

Pregatex-AT Tablet should be taken with caution in patients with heart disease. Please consult your physician.

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Geriatrics

Caution

Pregatex-AT Tablet should be used in elderly patients only when prescribed by a doctor. If you have any concerns about using Pregatex-AT Tablet in older adults, please consult your doctor.

What if I have taken an overdose of Pregatex-AT Tablet

If you suspect an overdose, seek immediate emergency medical attention or contact a poison control center. Symptoms of an overdose may include extreme drowsiness, confusion, rapid heartbeat, or fits.

Diet & Lifestyle Advise

  • Sip water frequently: To combat dry mouth, carry a water bottle with you, suck on sugar-free hard candies, or chew sugar-free gum.
  • Stand up slowly: To prevent dizziness caused by sudden blood pressure changes, take your time when rising from a sitting or lying position.
  • Increase dietary fiber: Eat more fruits, vegetables, and whole grains to prevent constipation, which can sometimes be triggered by this medicine.
  • Stay active safely: Engage in low-impact activities like walking or swimming to keep muscles active and reduce chronic stiffness.
health query

Have a query?

How Soon It Starts Working

  • The time required for Pregatex-AT Tablet to start to work: The time required for Pregatex-AT Tablet to show its action is not clinically established.
  • The time for which the effects of Pregatex-AT Tablet last: The duration of action for Pregatex-AT Tablet is not clinically established.

What if you forget to take Pregatex-AT Tablet

If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Do not stop treatment abruptly: Do not stop taking Pregatex-AT Tablet suddenly without consulting your doctor, as this may cause withdrawal symptoms such as nausea, headache, sleep disturbances, or a return of your pain symptoms.
  • Use caution during activities requiring alertness: This medicine may cause drowsiness, dizziness, or reduced concentration. Avoid driving, operating heavy machinery, or performing hazardous tasks until you know how it affects you.
  • Monitor your mood and behavior closely: Watch for sudden changes in mood, anxiety, depression, unusual behavior, or thoughts of self-harm, especially during the first 4 to 8 weeks of treatment and after dose adjustments. Family members or caregivers should also help monitor for these changes.
  • Avoid alcohol during treatment: Alcohol can increase the sedative and dizzying effects of this medicine and may increase the risk of falls, accidents, and serious side effects.
  • Attend regular monitoring appointments: Your doctor may recommend monitoring kidney function, body weight, mood and behavior, and heart health, particularly in older adults, patients with kidney disease, or those with pre-existing heart conditions.
  • Inform healthcare providers before procedures: Tell your dentist, surgeon, or other healthcare professionals that you are taking this medicine before undergoing any medical or dental procedure.
  • Special Populations: Older adults may be more sensitive to side effects such as drowsiness, dizziness, confusion, blurred vision, constipation, and falls. Patients with kidney impairment may require lower doses because pregabalin is removed from the body through the kidneys. This medicine is generally not recommended for children unless specifically prescribed and monitored by a specialist.

Drug-Drug Interactions

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Drug-Drug Interactions

  • Central nervous system depressants (such as sleeping pills, muscle relaxants, and strong pain medications): May cause severe drowsiness, slowed breathing, or extreme fatigue when taken with Pregatex-AT Tablet .
  • Certain antidepressants (such as MAO inhibitors): Can lead to a dangerous reaction called serotonin syndrome, causing high blood pressure, rapid heart rate, and confusion. Do not take Pregatex-AT Tablet if you have taken an MAO inhibitor in the last 14 days.
  • Anticholinergic medications: May increase the risk of dry mouth, severe constipation, and blurred vision.

Drug-Food Interactions

  • Alcohol: Significantly increases drowsiness, dizziness, and coordination issues, raising the risk of falls and injury.

Drug-Disease Interactions

  • Heart conditions (including recent heart attacks or irregular rhythms): This medicine may affect heart rate and rhythm, worsening these issues.
  • Heart Conditions: Amitriptyline may affect electrical activity within the heart and can increase the risk of heart rhythm abnormalities, including QT prolongation, in susceptible individuals. Patients with heart disease should be monitored carefully.
  • Epilepsy or Seizure Disorders: Pregabalin is also used as an antiepileptic medicine. Abrupt discontinuation may increase seizure risk, particularly in people with epilepsy. Follow your doctor's tapering instructions carefully.
  • Kidney problems: The body may clear the medication more slowly, requiring your doctor to adjust your dose.
  • Glaucoma: May increase pressure inside the eyes, worsening certain types of glaucoma.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTICONVULSANT]

FAQs

Pregatex-AT Tablet is used for the management of neuropathic pain. Neuropathic pain is a chronic progressive nerve disease which causes nerve pain due to nerve damage or a malfunctioning nervous system.
Pregatex-AT Tablet may cause weight gain due to an increase in appetite. Maintain a healthy weight by regular exercise and following a proper diet.
To relieve dry mouth, try sipping water frequently, chewing sugar-free gum, or sucking on sugar-free candies. Maintaining excellent oral hygiene is also helpful to prevent tooth decay associated with dry mouth. Talk to your doctor if the dryness is severe.
No, you should never stop taking Pregatex-AT Tablet suddenly. Stopping abruptly can cause withdrawal symptoms like sleep issues, headaches, nausea, or a sudden return of severe pain. Your doctor will help you by gradually decreasing the dose.
Pregatex-AT Tablet is used to treat neuropathic pain due to diabetic neuropathy. Diabetic neuropathy is a condition in which nerve damage occurs due to high blood glucose levels. It mostly damages the nerves in legs and feet.
Pregatex-AT Tablet may cause sexual disturbances such as decreased sex drive and problems with erection. Consult your doctor if you have any concerns regarding this.
Pregatex-AT Tablet contains Pregabalin and Amitriptyline. Pregabalin works by binding to the specific site on voltage-gated calcium channels; this helps in relieving nerve pain. Amitriptyline increases the level of serotonin and noradrenaline, thereby decreasing the movement of pain receptors. Together, Pregatex-AT Tablet helps to treat neuropathic pain.
Pregatex-AT Tablet is a combination of two drugs: Pregabalin (anti-convulsant), and Amitriptyline (antidepressant). Helps in the management of neuropathic pain.
Yes, weight gain is a recognized side effect of Pregatex-AT Tablet due to potential changes in metabolism and increased appetite. Managing your diet and staying physically active can help control this. Talk to your doctor for advice.
Yes, feeling sleepy, tired, or dizzy is a common effect of this medication, especially when you first start taking it. It is usually recommended to take your dose in the evening. Talk to your doctor if the sleepiness interferes with your daily life.
The use of Pregatex-AT Tablet may rarely cause turn urine colour to blue or green. If you notice any unusual changes, inform your doctor.
In rare cases, some side effects of Pregatex-AT Tablet may become serious in some individuals including severe blurred vision, dizziness, stomach issues like nausea and vomiting, and unusual weight gain. If you experience any of these, seek medical help.
Some people may notice an improvement in their pain within a couple of weeks, but it can take several weeks of consistent use to feel the full therapeutic effect. Talk to your doctor if your symptoms do not improve.
If you forget a dose of Pregatex-AT Tablet , take it immediately when you remember. But, if your next dose is nearer, skip the missed dose and continue with your regular schedule. Never double dose to make up for a missed dose, as this may increase side effects.
If you take too much Pregatex-AT Tablet by mistake, please contact your doctor or emergency services immediately. Overdose symptoms may include drowsiness, confusion, and changes in heartbeat.
No, higher than the recommended dose of Pregatex-AT Tablet does not provide more effectiveness or additional relief. Instead, it may increase the risk of adverse effects.
When taking Pregatex-AT Tablet avoid drinking alcohol, driving if you are feeling dizzy or sleepy, and taking other medications without consulting your doctor. Always follow your doctor's instructions and don't increase the prescribed dose.
See your doctor as per your scheduled follow-up. The frequency of visits varies based on your health needs. If you are having any concerns or unusual symptoms, you can schedule a visit to discuss with your doctor.
Store Pregatex-AT Tablet in a cool dry place protected from sunlight and moisture. Keep them out of reach of children and pets. Regularly check the expiry date. To dispose of the medicine place it in a plastic bag, and throw it away in the household trash. Remember, never flush the medicine down the toilet or sink.
The common side effects of the Pregatex-AT Tablet , which may occur in some individuals are weight gain, dry mouth, blurred vision, dizziness, tiredness, nausea, vomiting, diarrhoea, and constipation. Most of these side effects will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects frequently.
You should avoid alcohol while taking Pregatex-AT Tablet . Alcohol can worsen drowsiness, cause severe dizziness, and increase the risk of accidents. Talk to your doctor if you have concerns.
Pregatex-AT Tablet is generally not recommended during pregnancy unless your doctor decides the benefits outweigh the risks. If you are pregnant or planning a pregnancy, talk to your doctor to discuss safer alternatives.
Some mild over-the-counter pain relievers can be taken with Pregatex-AT Tablet , but you should avoid combining it with strong prescription painkillers or muscle relaxants without professional advice. Talk to your doctor or pharmacist before starting any new medicines.
The duration of treatment depends on the cause and severity of your nerve pain. Some people may need treatment for several months, while others may require longer-term therapy. Your doctor will regularly review your symptoms and determine how long treatment should continue.
Stopping this medicine abruptly may cause withdrawal symptoms such as headache, nausea, anxiety, sleep disturbances, sweating, and a return or worsening of pain. In people with epilepsy or seizure disorders, sudden discontinuation may increase the risk of seizures. Your doctor will usually recommend gradually reducing the dose over several days or weeks, depending on your current dose, treatment duration, and medical condition.
Contact your doctor promptly if you experience severe dizziness, fainting, blurred vision that does not improve, swelling of the face or throat, difficulty breathing, significant mood changes, depression, thoughts of self-harm, rapid or irregular heartbeat, difficulty passing urine, sudden weight gain, or worsening pain despite treatment.

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Reference

  1. Electronic Medicines Compendium (EMC). Pil.7057 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Pil.5698 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Amitriptyline Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Drugs.com Clinical Review Team. Pregabalin Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  5. Thour A, Marwaha R Amitriptyline. [Updated 2023 Jul 18]. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024Check here
  6. Pregabalin [Prescribing Information]. 2018. [Accessed on 16 Sep. 2024]Check here

Country of origin

India

Manufacturer/Marketer address

H NO 9-8-161/2 BESIDE ANDHRA BANK SAROOR NAGAR HYDERABAD Ranga Reddy Telangana 500035
Other Info - PRE1819

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