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compositionComposition:AMLODIPINE-5MG+HYDROCHLOROTHIAZIDE-12.5MG
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Prescription Medicine
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Prelo-H Tablet is used to treat hypertension (high blood pressure). It contains Amlodipine and Hydrochlorothiazide, which relax and widen blood vessels. Also, it helps to remove extra water and certain electrolytes from the body through urine. Thus, it lowers high blood pressure and reduces the chances of future heart attack and stroke. It may cause side effects such as glucose intolerance (low or high level of glucose), ankle swelling, sleepiness, headache, (sense of heat in the face, ears, neck, and trunk), flushing, tiredness, nausea, decreased potassium level in the blood, increased blood uric acid, and altered blood lipid level.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

AMLODIPINE-5MG+HYDROCHLOROTHIAZIDE-12.5MG

Manufacturer/Marketer :

Marsha Pharma Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Prelo-H Tablet

Prelo-H Tablet is a prescription oral medication used to treat high blood pressure (hypertension). By lowering elevated blood pressure, this medicine helps prevent serious cardiovascular events like strokes, heart attacks, and kidney problems.

To get the most benefit, you should take Prelo-H Tablet consistently at the same time every single day, exactly as prescribed by your doctor. You can take this tablet with or without food. Combining this medicine with a low-sodium diet, regular exercise, and maintaining a healthy weight will greatly support your treatment results.

While taking Prelo-H Tablet , some people may experience mild side effects like dizziness, lightheadedness, or mild ankle swelling. If you develop specific serious side effects, such as rapid heartbeats, severe muscle weakness, or signs of an allergic reaction, contact your doctor immediately.

Before starting Prelo-H Tablet , tell your doctor if you have a history of kidney disease, liver damage, gout, or severe dehydration. Do not take this medicine if you are unable to pass urine or if you have a known severe allergy to any of its components or sulphur-based drugs (sulfonamides).

Avoid drinking alcohol while taking Prelo-H Tablet , as it can excessively lower your blood pressure and cause severe dizziness. This medicine can also interact with other blood pressure drugs, lithium, and certain pain relievers, which can alter its effectiveness or increase side effects. If you are pregnant, planning to breastfeed, or an older adult, consult your doctor or pharmacist to ensure this medicine is safe for you.

Uses of Prelo-H Tablet

Prelo-H Tablet is used to treat high blood pressure (hypertension). The detailed uses of Prelo-H Tablet are as follows:

  • High blood pressure (hypertension): Prelo-H Tablet helps by relaxing the blood vessels and helping your body get rid of excess salt and water, which lowers your overall blood pressure.
  • Reducing cardiovascular risk: By maintaining a normal blood pressure level, this medicine lowers your risk of experiencing complications like strokes or heart attacks.

Key Benefits

Prelo-H Tablet helps manage high blood pressure effectively by combining two complementary medicines in a single tablet. With regular use, it supports stable blood pressure control, simplifies your treatment routine, and helps protect your heart, kidneys, and other vital organs from long-term damage.

  • Steady Blood Pressure Control: By combining two distinct actions in one tablet, Prelo-H Tablet provides consistent, round-the-clock blood pressure control. This helps keep your readings in a safe range throughout the day and night.
  • Convenience of a Combined Treatment: Instead of taking multiple separate pills, Prelo-H Tablet offers the convenience of a single daily tablet. This simplifies your daily routine and makes it much easier to stay on track with your treatment.
  • Long-Term Heart and Kidney Protection: Lowering your blood pressure helps protect your vital organs from strain. Over time, this decreases the likelihood of kidney failure, vision loss, and chronic heart failure, helping you maintain your long-term health and independence.
Side effects of Prelo-H Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Directions for Use

  • Prelo-H Tablet can be taken with or without food as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Prelo-H Tablet as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Prelo-H Tablet Works

Prelo-H Tablet is a combination of two active medicines that work in different ways to lower your blood pressure. The first active ingredient is a calcium channel blocker. It works by relaxing and widening your blood vessels. When your blood vessels are relaxed, blood can flow through them much more easily, which immediately reduces the workload on your heart. The second active ingredient is a diuretic, often referred to as a 'water pill'. It works on your kidneys to help your body eliminate extra water and salt through your urine. Reducing the overall volume of fluid circulating in your bloodstream naturally lowers the pressure inside your blood vessels. Together, these two mechanisms provide a synergistic effect, lowering your blood pressure more effectively than either medicine could when used alone.
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Alcohol

Unsafe

You are recommended not to consume alcohol along with Prelo-H Tablet to avoid unpleasant side-effects.

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Pregnancy

Caution

Prelo-H Tablet is not recommended during pregnancy unless your doctor considers it essential. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Breast Feeding

Caution

Prelo-H Tablet should not be used when breastfeeding unless clearly necessary. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

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Driving

Caution

Prelo-H Tablet may sometimes cause dizziness, nausea, tiredness or headache. Therefore, it is advised to drive only if you are alert after taking Prelo-H Tablet .

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Liver

Caution

Prelo-H Tablet to be taken with caution, especially if you have a history of liver diseases. Your doctor may adjust your dose depending on your current liver conditions.

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Kidney

Caution

Prelo-H Tablet to be taken with caution, especially if you have a history of kidney diseases. Your doctor may adjust your dose depending on your current kidney conditions.

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Children

Caution

Prelo-H Tablet to be taken with caution, especially if you are children below the age of 12. Your doctor may adjust your dose depending upon your age.

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Heart

Safe if prescribed

Prelo-H Tablet is safe for use in heart patients if recommended by the physician.

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Geriatrics

Caution

Prelo-H Tablet should be used under caution in geriatric patients. Please consult your physician.

What if I have taken an overdose of Prelo-H Tablet

If you accidentally take too much of Prelo-H Tablet , you may experience severe dizziness, fainting, a rapid heart rate, or extreme weakness. Seek immediate medical attention or contact a poison control centre right away.

Diet & Lifestyle Advise

  • Limit sodium intake: Avoid high-sodium foods like processed meats, canned soups, and fast food. Reducing salt in your diet directly helps lower blood pressure.
  • Eat potassium-rich foods: Diuretics can sometimes lower your potassium levels. Talk to your doctor about incorporating foods like bananas, spinach, and sweet potatoes into your diet or if you need to monitor your potassium intake.
  • Stay properly hydrated: While this medicine helps remove excess water, severe dehydration can be dangerous. Drink a moderate, healthy amount of water daily unless your doctor advises otherwise.
  • Limit alcohol and quit smoking: Alcohol can dangerously lower your blood pressure when combined with Prelo-H Tablet , while smoking damages blood vessels and raises your cardiovascular risks.
  • Stand up slowly: To prevent dizziness or fainting when getting up from a sitting or lying position, stand up slowly and steady yourself for a moment.
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How Soon It Starts Working

  • The time required for Prelo-H Tablet to start to work: The time required for Prelo-H Tablet to start to work is 2 hours after administration.
  • The time for which the effects of Prelo-H Tablet last: The effect of Prelo-H Tablet lasts for 24 hours.

What if you forget to take Prelo-H Tablet

If you miss a dose of Prelo-H Tablet , take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Storage

•Store Prelo-H Tablet tablets at controlled room temperature, ideally between 20°C and 25°C (68°F to 77°F). •Keep the tablets in their original packaging to protect them from light and moisture.

Drug Warnings

  • Monitor your blood pressure: Keep a daily log of your blood pressure readings at home and share it with your doctor during visits.
  • Avoid grapefruit products: Grapefruit and grapefruit juice can interact with this medicine, leading to higher levels of the medication in your blood and increasing the risk of side effects.
  • Protect your skin from the sun: This medicine can make your skin more sensitive to sunlight, increasing the risk of sunburns. Use sunscreen and wear protective clothing when outdoors.
  • Check other OTC medicines: Many over-the-counter medications, especially pain relievers like ibuprofen or cold medicines, can raise your blood pressure or interact with Prelo-H Tablet . Always consult your pharmacist before buying OTC remedies.
  • Schedule regular lab tests: Your doctor may order routine blood tests to check your kidney function and electrolyte levels (like potassium and sodium) while you are taking this medicine.

Drug-Drug Interactions

verifiedApollotooltip
  • Lithium: Taking Prelo-H Tablet with lithium can cause toxic levels of lithium to build up in your body.
  • Other blood pressure medications: Combining this medicine with other drugs that lower blood pressure can increase the risk of severely low blood pressure (hypotension).
  • NSAIDs (like ibuprofen or naproxen): These pain relievers can reduce the blood pressure-lowering effect of Prelo-H Tablet and increase the risk of kidney damage.
  • Potassium supplements: Taking potassium supplements or potassium-sparing water pills with this medicine requires close monitoring, as it can cause unsafe changes in your blood potassium levels.
Hydrochlorothiazide + AmlodipineDantrolene
Critical
Hydrochlorothiazide + AmlodipineCisapride
Critical

Drug-Drug Interactions

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Hydrochlorothiazide + AmlodipineDantrolene
Critical
How does the drug interact with Prelo-H Tablet:
Using Prelo-H Tablet together with dantrolene may increase the risk of hyperkalemia (high blood potassium).

How to manage the interaction:
Although taking Prelo-H Tablet with Dantrolene can cause an interaction, it can be taken if prescribed by a doctor. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.
Hydrochlorothiazide + AmlodipineCisapride
Critical
How does the drug interact with Prelo-H Tablet:
Taking Cisapride and Prelo-H Tablet can increase the risk of an irregular heart rhythm. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Combining Cisapride and Prelo-H Tablet is generally avoided as it can result in an interaction; it can be taken if your doctor advises. However, consult the doctor immediately if you experience dizziness, lightheadedness, fainting, or fast or pounding heartbeats. Do not stop using any medications without a doctor's advice.
Hydrochlorothiazide + AmlodipineDofetilide
Critical
How does the drug interact with Prelo-H Tablet:
Taking Dofetilide and Prelo-H Tablet can increase the risk of an irregular heart rhythm, which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Combining dofetilide and Prelo-H Tablet is not recommended as it can result in an interaction, but it can be taken if your doctor advises. However, contact your doctor immediately if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.
Hydrochlorothiazide + AmlodipineDolasetron
Severe
How does the drug interact with Prelo-H Tablet:
Co-administration of Dolasetron and Prelo-H Tablet can affect the rhythm of your heart, which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Dolasetron and Hydrochlorothiazide together is avoided as it can possibly result in an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like irregular heartbeat, chest tightness, blurred vision, nausea, and seizures, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
Hydrochlorothiazide + AmlodipineMitotane
Severe
How does the drug interact with Prelo-H Tablet:
Using Prelo-H Tablet and mitotane together may drastically lower amlodipine blood levels, which makes the medicine less effective.

How to manage the interaction:
Although co-administration of Prelo-H Tablet with mitotane can result in an interaction, it can be taken if a doctor has advised it. Consult your doctor if your symptoms do not improve. Do not discontinue any medications without consulting a doctor.
Hydrochlorothiazide + AmlodipineZiprasidone
Severe
How does the drug interact with Prelo-H Tablet:
Taking Ziprasidone and Prelo-H Tablet can increase the risk of an irregular heart rhythm which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Ziprasidone and Hydrochlorothiazide together is avoided as it can possibly result in an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
Hydrochlorothiazide + AmlodipineRifapentine
Severe
How does the drug interact with Prelo-H Tablet:
Coadministration of Prelo-H Tablet and Rifapentine may significantly reduce the blood levels of amlodipine, which may make the medication less effective.

How to manage the interaction:
There may be a possibility of interaction between Prelo-H Tablet and Rifapentine, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
Hydrochlorothiazide + AmlodipineFosphenytoin
Severe
How does the drug interact with Prelo-H Tablet:
When Prelo-H Tablet is taken with Fosphenytoin, it may decrease the blood levels of Amlodipine, which may make Amlodipine less effective.

How to manage the interaction:
Although taking Amlodipine and Fosphenytoin together can cause an interaction, it can be taken if a doctor has suggested it. Contact a doctor if your symptoms do not improve. Do not stop using any medications without a doctor's advice.
Hydrochlorothiazide + AmlodipinePhenobarbital
Severe
How does the drug interact with Prelo-H Tablet:
Using phenobarbital and Prelo-H Tablet may drastically lower amlodipine blood levels, which makes the medicine less effective.

How to manage the interaction:
Although co-administration of phenobarbital with amlodipine can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
Hydrochlorothiazide + AmlodipineNitisinone
Severe
How does the drug interact with Prelo-H Tablet:
Coadministration of Prelo-H Tablet and Nitisinone may increase the blood levels and effects of Nitisinone.

How to manage the interaction:
Taking Nitisinone with Amlodipine together can result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit and grapefruit juice: May increase the absorption of this medicine, causing your blood pressure to drop too low and increasing side effects like swelling and dizziness.
  • Alcohol: Can worsen dizziness, lightheadedness, and the blood pressure-lowering effects of the medication.
     
AMLODIPINE-5MG+HYDROCHLOROTHIAZIDE-12.5MGFruit juices, Fruits
Mild

Drug-Food Interactions

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AMLODIPINE-5MG+HYDROCHLOROTHIAZIDE-12.5MGFruit juices, Fruits
Mild
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consumption of grapefruit or grapefruit juice with Prelo-H Tablet increases the blood levels of amlodipine. Avoid or limit the consumption of grapefruit or grapefruit juice.

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Habit Forming

No

Therapeutic Class

[ANTI- HYPERTENSIVES]

FAQs

Prelo-H Tablet is used to treat hypertension (high blood pressure).
Yes, Prelo-H Tablet may cause dizziness. It is advised to avoid driving or operating any heavy machinery while taking Prelo-H Tablet . In case you feel dizzy or light-headed, it is advised to rest for some time until you feel better.
Prelo-H Tablet can be safely taken as long as your doctor has prescribed it to you. Conditions such as high blood pressure are lifelong conditions, and one should not abruptly discontinue them without discussing it with a doctor.
No, it is a prescribed drug given by a physician to prevent specific medical conditions. Taking it on your own can cause unwanted side effects.
While taking Prelo-H Tablet , consult your doctor before adding any supplements to control blood pressure. Supplements can interact with the medication or increase side effects. Always consult your doctor to make an informed decision and ensure safe usage. They will help you determine the best course of action.
If you feel nauseous after taking Prelo-H Tablet , it's a common side effect that usually goes away with time. If it persists or bothers you, consult your doctor. In the meantime, take the tablet with food and stay hydrated to help manage nausea.
While taking Prelo-H Tablet , monitoring your vital signs and health indicators is essential. This includes keeping track of your blood pressure to ensure the medication is effectively controlling your hypertension, as well as regular blood tests to check your kidney function, potassium levels, and blood sugar levels, especially if you have diabetes. Additionally, monitoring your electrolyte levels, including potassium, sodium, and chloride, will help detect any imbalances.
The key active components present in Prelo-H Tablet are Amlodipine and Hydrochlorothiazide, which are antihypertensive medicines. Amlodipine, a calcium channel blocker, relaxes blood vessels, improving blood flow and reducing blood pressure. Hydrochlorothiazide, a diuretic, helps remove excess fluid from the body, reducing blood volume and blood pressure. These two medicines work together synergistically to effectively manage hypertension (high blood pressure).
Common side effects of Prelo-H Tablet may include glucose intolerance (low or high level of glucose), ankle swelling, sleepiness, headache (sense of heat in the face, ears, neck, and trunk), flushing, tiredness, nausea, decreased potassium level in the blood, Increased blood uric acid, and altered blood lipid level. Most of these side effects of Prelo-H Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.
Avoid or limit alcohol consumption while taking Prelo-H Tablet . Alcohol can increase the blood pressure-lowering effect of the medication, leading to dizziness or fainting. It can also increase the risk of dehydration and electrolyte imbalances. If you do drink alcohol, do so in moderation and consult your doctor for personalized advice.
Prelo-H Tablet is not recommended during pregnancy unless your doctor considers it essential. Your doctor will weigh the benefits and potential risks before prescribing it.
Prelo-H Tablet should not be used when breastfeeding unless clearly necessary. Your doctor will weigh the benefits and potential risks before prescribing it. Please consult your doctor.
Yes, you can take Prelo-H Tablet at night, but it is generally recommended to take it in the morning. Because this medicine contains a diuretic ('water pill'), taking it close to bedtime may cause you to wake up during the night to urinate. Talk to your doctor or pharmacist to find the best dosing schedule for you.
Mild ankle or foot swelling is a known side effect of this medicine. However, you should still report this to your doctor, especially if it worsens or is accompanied by breathing difficulties. Do not stop taking your medication without consulting your doctor.
You may begin to see a drop in your blood pressure within a few days of starting Prelo-H Tablet , but it can take up to 2 to 4 weeks to reach its full therapeutic effect. Continue taking the medicine daily even if you feel well. Talk to your doctor if you do not see an improvement.
Caffeine can temporarily raise your blood pressure, which may counteract the effects of Prelo-H Tablet . It is usually safe to consume moderate amounts of caffeine, but you should discuss your daily caffeine intake with your doctor.
Prelo-H Tablet does not typically cause significant weight gain. If you notice a sudden, rapid increase in weight, it may be due to fluid retention (oedema), which is a possible side effect. If this happens, talk to your doctor right away.
This medicine can make your skin more sensitive to sunlight, making you sunburn more easily. You do not need to avoid the sun entirely, but you should apply high-SPF sunscreen, wear protective clothing, and avoid tanning beds. Talk to your doctor if you experience a severe sunburn or skin rash.
You should avoid taking ibuprofen or other nonsteroidal anti-inflammatory drugs (NSAIDs) regularly without consulting your doctor. NSAIDs can decrease the effectiveness of Prelo-H Tablet and increase your risk of kidney damage. Talk to your doctor or pharmacist about safer pain relief alternatives.
Stopping Prelo-H Tablet suddenly can cause your blood pressure to rise rapidly, increasing your risk of serious heart complications or stroke. If you need to stop this medication, your doctor will guide you on how to do so safely. Always talk to your doctor before making any changes.

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Country of origin

India

Manufacturer/Marketer address

5, ARAM APARTMENTS, 12 SAMPATRAO COLONY, B.P.C. ROAD. ALKAPURI, VADODARA – 390005
Other Info - PRE0519
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