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compositionComposition:METHYLCOBALAMIN-750MCG+PREGABALIN-75MG
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Prescription Medicine
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Preneurolin Plus Tablet is used in the treatment of neuropathic pain. It contains Pregabalin and Methylcobalamin, which decreases the pain signals and helps rejuvenate and protect damaged nerve cells. It may cause common side effects such as dizziness, drowsiness, headache, loss of appetite, nausea or vomiting, diarrhea, headache, vision problems, and sweating. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Composition :

METHYLCOBALAMIN-750MCG+PREGABALIN-75MG

Manufacturer/Marketer :

Theon Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Preneurolin Plus Tablet

Preneurolin Plus Tablet is a prescription oral medicine used to manage neuropathic pain, which is nerve pain caused by damage or injury to your nerves. It is commonly prescribed for conditions such as diabetic neuropathy, shingles pain (postherpetic neuralgia), or nerve pain from spinal cord injuries. By targeting overactive nerve pathways, this medication helps quiet down abnormal pain signals and supports natural nerve recovery.

For the best results, you should take Preneurolin Plus Tablet consistently at the same times every day as directed by your doctor. You can take this medication with or without food, swallowing the capsule or tablet whole with a glass of water. Making healthy lifestyle choices, such as maintaining stable blood sugar levels and staying physically active, can significantly improve your treatment results.

While using Preneurolin Plus Tablet , some people may experience mild side effects like drowsiness, dizziness, or dry mouth. However, you should consult your doctor immediately if you face more serious issues, such as unexplained muscle pain, sudden mood changes, or severe swelling in your hands or feet.

Talk to your doctor before starting this medicine if you have a history of kidney disease, heart failure, or severe allergies. Do not take this if you have had a severe allergic reaction to pregabalin, methylcobalamin, or any other ingredients in this formulation.

This medication can interact with other substances like alcohol, sleeping pills, or anxiety medicines, which can dangerously increase drowsiness. If you are pregnant, breastfeeding, planning to become pregnant, or are an elderly individual, consult your doctor or pharmacist before taking this medicine to ensure it is safe for you.

Uses of Preneurolin Plus Tablet

Doctors prescribe Preneurolin Plus Tablet to treat several conditions involving nerve discomfort and damage. Key uses include:

  • Diabetic Neuropathy: Preneurolin Plus Tablet helps relieve chronic, burning, or tingling pain in the hands and feet caused by nerve damage from high blood sugar.
  • Postherpetic Neuralgia: It provides relief from persistent nerve pain that can linger after a shingles infection has healed.
  • Spinal Cord Injury Pain: Preneurolin Plus Tablet helps manage chronic neuropathic pain resulting from spinal cord damage.
  • Fibromyalgia: It helps reduce widespread muscle pain, stiffness, and sensitivity throughout the body.
     

Key Benefits

Preneurolin Plus Tablet is designed to help you regain comfort and improve your overall quality of life. By addressing both the symptoms and the underlying health of your nerves, this medicine offers key physical benefits:

  • Effective Pain Relief: It works quickly to quiet constant burning, stabbing, or shooting nerve sensations, allowing for easier, pain-free movement during the day.
  • Better Sleep Quality: Nerve pain often worsens at night, making it difficult to rest. By calming overactive nerves, this medicine helps you sleep more soundly.
  • Nerve Repair Support: It contains vital nutrients that help rebuild the protective coating of damaged nerves, promoting gradual healing and long-term recovery.

 

 

Side effects of Preneurolin Plus Tablet
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

Directions for Use

  • Take Preneurolin Plus Tablet with or without food or as advised by a doctor.
  • Recommended to take the medicine twice a day, in the morning and evening or as advised by your doctor.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Preneurolin Plus Tablet Works

Preneurolin Plus Tablet combines two active ingredients that target nerve pain in complementary ways. Pregabalin belongs to a group of medicines called anticonvulsants. It works by binding to specific calcium channels in your brain and spinal cord. This action reduces the release of certain chemical messengers that carry pain signals through your nervous system, effectively turning down the 'volume' of the pain you feel. Methylcobalamin is a highly active form of vitamin B12. It plays a crucial role in producing myelin, which is the protective sheath that covers and insulates your nerve fibres. By supporting myelin production, it helps repair damaged nerve cells and restores proper nerve signal transmission.
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Alcohol

Caution

Alcohol may worsen the condition by increasing the risk of side-effects.

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Pregnancy

Unsafe

Preneurolin Plus Tablet is a category C medicine. It is not recommended for use in pregnant women unless the doctor thinks the benefits outweigh the risks.

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Breast Feeding

Caution

Preneurolin Plus Tablet should be used with caution in breastfeeding mothers unless the doctor thinks the benefits outweigh the risks.

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Driving

Caution

Preneurolin Plus Tablet may cause dizziness and drowsiness. So, avoid driving or operating heavy machinery while using Preneurolin Plus Tablet .

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Liver

Caution

Preneurolin Plus Tablet should be used with caution in patients with liver diseases. Dose adjustments may be necessary.

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Kidney

Caution

Preneurolin Plus Tablet should be used with caution in patients with kidney diseases. Dose adjustments may be necessary

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Children

Unsafe

Preneurolin Plus Tablet is not recommended for anyone below the age of 18 years.

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Heart

Consult your doctor

Please inform your doctor if you have any pre-existing heart problems

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Geriatrics

Consult your doctor

Limited information available for use of Preneurolin Plus Tablet in elderly patients. Please consult your doctor.

What if I have taken an overdose of Preneurolin Plus Tablet

If you take more than your prescribed dose of Preneurolin Plus Tablet , seek emergency medical help immediately. Overdose symptoms may include severe drowsiness, confusion, agitation, or restlessness.

Diet & Lifestyle Advise

To support your nerve recovery while taking Preneurolin Plus Tablet , consider these evidence-based lifestyle changes:

  • Control blood sugar: If you have diabetes, carefully monitor and manage your blood sugar levels to prevent further nerve damage.
  • Eat a nutrient-rich diet: Incorporate foods high in B-vitamins, such as eggs, lean meats, poultry, and fortified cereals, to naturally support nerve health.
  • Stay physically active: Engage in low-impact exercises like walking, swimming, or light stretching to improve blood circulation to your nerves.
  • Check your feet daily: Nerve damage can reduce pain sensation in your feet. Inspect them regularly for cuts, blisters, or infections that you might not feel.
  • Avoid smoking and limit alcohol: Smoking reduces blood flow to the nerves, and alcohol can worsen nerve pain. Avoiding both can speed up your recovery.

 

health query

Have a query?

How Soon It Starts Working

The time required for Preneurolin Plus Tablet to start to work: The time required for Preneurolin Plus Tablet to show its action is not clinically established. The time for which the effects of Preneurolin Plus Tablet last: The duration of action for Preneurolin Plus Tablet is not clinically established.

What if you forget to take Preneurolin Plus Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and return to your regular schedule. Do not take a double dose to make up for a missed one.

Storage

•Store Preneurolin Plus Tablet at room temperature, ideally between 15°C and 30°C (59°F to 86°F). •Keep the medicine in its original container to protect it from moisture and direct light.

Drug Warnings

  • Do not drive immediately: Since this medicine can cause dizziness and drowsiness, avoid driving, riding a bicycle, or operating heavy machinery until you know how it affects you.
  • Do not stop taking this medicine suddenly: Stopping abruptly can cause withdrawal symptoms like nausea, headache, anxiety, or trouble sleeping. Your doctor will help you by gradually decreasing the dose.
  • Monitor your mental health: Pay close attention to any sudden changes in your mood or behaviour, and let a family member or doctor know immediately if you feel depressed.
  • Be cautious with alcohol: Drinking alcohol while taking this medicine can make you extremely drowsy and increase your risk of accidents.
     

Drug-Drug Interactions

verifiedApollotooltip
  • Central Nervous System Depressants: Taking Preneurolin Plus Tablet with medicines like opioid pain relievers, sleeping pills, or anxiety medications can lead to extreme drowsiness and dangerous breathing difficulties.
  • ACE Inhibitors: Combining this medicine with certain blood pressure medications (like lisinopril) may increase your risk of severe swelling (angioedema).
  • Antidiabetic Medications: Taking it alongside medicines like pioglitazone may increase the risk of weight gain and fluid retention.
     
Mecobalamin + PregabalinPentazocine
Severe
Mecobalamin + PregabalinTapentadol
Severe

Drug-Drug Interactions

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Mecobalamin + PregabalinPentazocine
Severe
How does the drug interact with Preneurolin Plus Tablet:
Using Pregabalin together with Pentazocine causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate and loss of consciousness).

How to manage the interaction:
Although taking Pentazocine and Pregabalin together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
Mecobalamin + PregabalinTapentadol
Severe
How does the drug interact with Preneurolin Plus Tablet:
Using Tapentadol together with Pregabalin may cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Taking Pregabalin with Tapentadol can result in an interaction, it can be taken if a doctor has advised it. Contact a doctor immediately if you experience signs such as drowsiness, lightheadedness, palpitations, confusion, severe weakness, or difficulty breathing. Do not discontinue any medications without consulting a doctor.
Mecobalamin + PregabalinButorphanol
Severe
How does the drug interact with Preneurolin Plus Tablet:
Using Pregabalin together with Butorphanol causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Butorphanol and pregabalin together can result in an interaction, it can be taken if a doctor has prescribed it. If you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
Mecobalamin + PregabalinRemifentanil
Severe
How does the drug interact with Preneurolin Plus Tablet:
Using Pregabalin together with Remifentanil causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate and loss of consciousness).

How to manage the interaction:
Although taking Remifentanil and Pregabalin together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
Mecobalamin + PregabalinPethidine
Severe
How does the drug interact with Preneurolin Plus Tablet:
Using Pregabalin together with Pethidine causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate and loss of consciousness).

How to manage the interaction:
Although taking Pethidine and Pregabalin together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
Mecobalamin + PregabalinNalbuphine
Severe
How does the drug interact with Preneurolin Plus Tablet:
Using Pregabalin together with Nalbuphine causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate and loss of consciousness).

How to manage the interaction:
Although taking Nalbuphine and Pregabalin together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
Mecobalamin + PregabalinBuprenorphine
Severe
How does the drug interact with Preneurolin Plus Tablet:
Using Pregabalin together with Buprenorphine causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Buprenorphine and Pregabalin together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience dizziness, drowsiness, difficulty concentrating, and impairment in judgment, reaction speed, and motor coordination, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
Mecobalamin + PregabalinCodeine
Severe
How does the drug interact with Preneurolin Plus Tablet:
Using Pregabalin together with Codeine may cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Codeine and Pregabalin together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
Mecobalamin + PregabalinOxycodone
Severe
How does the drug interact with Preneurolin Plus Tablet:
Using Pregabalin together with Oxycodone causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate and loss of consciousness).

How to manage the interaction:
Although taking oxycodone and pregabalin together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
Mecobalamin + PregabalinHydrocodone
Severe
How does the drug interact with Preneurolin Plus Tablet:
Using Pregabalin together with Hydrocodone causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Hydrocodone and pregabalin together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Avoid alcohol while taking this medicine, as it can severely worsen side effects like dizziness and coordination issues.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

Yes

Therapeutic Class

[ANTICONVULSANT]

FAQs

Preneurolin Plus Tablet is used in the treatment of neuropathic pain, a chronic (long-term) progressive nerve disease that causes nerve pain due to nerve damage or the nervous system's malfunctioning.
Preneurolin Plus Tablet is a combination of two medicines: Pregabalin and Methylcobalamin. Preneurolin Plus Tablet block the brain's pain signals and protect nerve cells from further damage, thereby improving nerve signal conduction to the whole body parts. These effects help to reduce pain in patients with neuropathic pain.
Preneurolin Plus Tablet should not be given to children and adolescents under the age of 18 years as it may increase suicidal thoughts.
Preneurolin Plus Tablet should not be stopped abruptly as it may cause withdrawal reactions such as trouble sleeping, headache, nausea, feeling anxious, diarrhea, flu-like symptoms, convulsions, nervousness, depression, pain, sweating, and dizziness. Preneurolin Plus Tablet should be stopped gradually over a minimum of 1 week.
Preneurolin Plus Tablet can be used in patients with diabetes if they have neuropathic pain. However, inform your doctor if you notice any weight gain while using Preneurolin Plus Tablet . Your doctor may change your diabetic medicines to stop weight gain. Also, take some measures to control weight such as eating a balanced diet and exercising regularly.
Preneurolin Plus Tablet may cause drowsiness. So, it is advised to refrain from activities such as driving or operating heavy machinery if you feel sleepy after taking Preneurolin Plus Tablet .
You may notice pain improvement within 2-3 days after taking Preneurolin Plus Tablet . However, it may take 2-3 months for your symptoms to improve depending on your health condition.
Preneurolin Plus Tablet may increase your appetite, which might make you eat more, and thus increases the risk of weight gain. However, it’s easier to prevent weight gain than losing the weight. Try to eat a healthy balanced diet. Avoid consuming high-calorie foods, such as soft drinks, chips, oily food, biscuits, cakes, and sweets. If you feel hungry between meals, do not eat junk food, instead eat vegetables, fruits, and low-calorie foods. Regular exercise helps to prevent weight gain. If you still have any concerns, discuss with your doctor.
Preneurolin Plus Tablet may rarely cause serious side effects such as allergic reaction, suicidal thoughts or swelling of limbs (legs, hands, or feet). If you experience any signs of these side effects, discontinue Preneurolin Plus Tablet and consult your doctor. Signs of an allergic reaction include swelling of your face, lips, mouth, tongue, gums, and neck. Allergic reactions can also lead to skin rash, difficulty breathing, hives (raised bumps) or blisters. Watch out for any changes, especially sudden changes in behaviors, mood, thoughts or feelings, or if you have suicidal thoughts.
Preneurolin Plus Tablet may show an initial benefit after 2 weeks of taking it. However, for full benefits, it may take around 2 to 3 months or more (in some patients).
If you forget to take a dose of Preneurolin Plus Tablet , take it as soon as you remember. But, if it is time for your next dose, skip the missed dose and take your regular dose. Do not take a double dose to make up for a forgotten dose.
No, taking a higher than the recommended dose may not be more effective, rather it may increase the risk of toxicity and serious side effects. If your symptoms are not relieved or there is an increased severity of your symptoms after using the recommended doses, please consult your doctor.
If you have started taking Preneurolin Plus Tablet , you may need to see your doctor regularly. However, if the recommended doses does not improve your symptoms or if the side effects persist or worsen which affect your routine activities, consult your doctor.
Store Preneurolin Plus Tablet at room temperature in a cool place. Protect from light and moisture. Keep it out of reach of children.
The side effects of Preneurolin Plus Tablet include nausea, vomiting, headache, dizziness, drowsiness, increased appetite, weight gain and vision problems. If these side effects persist or worsen, please consult your doctor.
You are recommended to take Preneurolin Plus Tablet only if it is advised by your doctor. Therefore, if you are pregnant or planning pregnancy, take your doctor’s advice.
You are recommended to avoid driving or using any tools or machines until you know how Preneurolin Plus Tablet affects you as it may cause dizziness or drowsiness in some people.
It is highly recommended to avoid alcohol while taking this medicine. Alcohol can increase the risk of severe drowsiness, dizziness, and poor coordination. Talk to your doctor if you find it difficult to avoid alcohol.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.7011 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. MedlinePlus. A605045 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  3. Pregabalin [Prescribing Information]. 2009. [Accessed on 22 Apr. 2019]Check here
  4. Pregabalin [Prescribing Information]. 2004. [Accessed on 22 Apr. 2019]Check here
  5. Yasmin U Dongre and Onkar C Swami. Sustained release pregabalin with Methylcobalamin in neuropathic pain: an Indian real-life experience. NCBI; PMC US National Library of Medicine, National Institute of Health. May 2013. [Accessed on 21st October 2022]Check here
  6. Cipla Ltd. Nova M Capsules (Pregabalin + Methylcobalamin). Ciplamed.com. [Revised in May 2016]. [Accessed on 21st October 2022]Check here

Country of origin

India

Manufacturer/Marketer address

Theon Pharmaceuticals Ltd., Punit Bansal(other), 400, Industrial Area -1, Panchkula - 134113, Haryana, India
Other Info - PRE0340

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