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Primiwal-E2 Tablet is used for hormonal replacement therapy for treating hypoestrogenism (estrogen deficiency), osteoporosis (thinning of bones) and symptoms associated with menopause (itching, dryness in the vagina, hot flashes). In addition to this, it also helps in preventing osteoporosis. It is prescribed when the body is not producing a sufficient amount of natural estrogen. It contains estradiol, which regulates the menstrual cycle and ovulation. It works by replacing the normal hormone estrogen functions in the body and treats symptoms associated with menopause. In some cases, it may cause side effects such as headache, bloating, hair loss, nausea, breast pain, weight gain, and irregular vaginal bleeding.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Composition :

ESTRADIOL-2MG

Manufacturer/Marketer :

Zydus Cadila

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Primiwal-E2 Tablet

Primiwal-E2 Tablet is an oral hormone replacement therapy prescribed primarily to relieve moderate to severe symptoms of menopause, such as hot flashes and night sweats. It is also used to treat estrogen deficiency caused by ovarian conditions or to help prevent osteoporosis in postmenopausal individuals. By supplementing the body's declining hormone levels, this medication helps restore systemic hormonal balance.

You should take Primiwal-E2 Tablet consistently at the same time every day to maintain steady hormone levels in your body. It can be taken with or without food, though taking your daily tablet with a meal may help prevent mild stomach upset. Combining this treatment with a balanced diet rich in calcium and regular weight-bearing exercise can help support your overall results and bone health.

While many people tolerate Primiwal-E2 Tablet well, some may experience mild side effects such as nausea, breast tenderness, or occasional headaches. If you experience severe side effects, such as unusual vaginal bleeding, chest pain, or sudden severe headaches, you must contact your doctor immediately. Regular check-ups are essential to ensure the medication continues to be safe for you.

Before starting Primiwal-E2 Tablet , discuss your medical history with your doctor, especially if you have a history of high blood pressure, diabetes, gallbladder disease, or liver damage. Do not take this medicine if you are pregnant, have undiagnosed vaginal bleeding, or have a history of blood clots, stroke, or estrogen-sensitive cancers, such as breast or uterine cancer.

Certain medicines, such as those used for thyroid conditions or seizures, can change how Primiwal-E2 Tablet works, while smoking significantly increases your risk of serious side effects like blood clots and stroke. Pregnant and breastfeeding women should not use this medication, and elderly individuals should use it with caution under close medical supervision. Always consult your doctor or pharmacist before combining this therapy with other treatments or supplements.

Uses of Primiwal-E2 Tablet

Primiwal-E2 Tablet is used in the treatment of hormone replacement therapy, osteoporosis and hypoestrogenism. The detailed uses of Primiwal-E2 Tablet are as follows:

  • Menopause symptoms: Primiwal-E2 Tablet helps by replacing the natural estrogen that your body stops making, which reduces hot flashes, night sweats, and vaginal dryness.
  • Estrogen deficiency (hypogonadism or ovarian failure): Primiwal-E2 Tablet provides the necessary estrogen that your body is unable to produce naturally due to ovarian conditions or surgical removal of the ovaries.
  • Osteoporosis prevention: Primiwal-E2 Tablet helps preserve bone density and reduce the risk of fractures in postmenopausal individuals who are at high risk of bone loss.

Key Benefits

Primiwal-E2 Tablet offers significant relief from the disruptive symptoms of menopause and provides crucial long-term health protection, helping improve your daily comfort and overall quality of life.

Benefits may include:

  • Effectively reduces the frequency and intensity of sudden hot flashes and night sweats, allowing for more comfortable days and restful nights.
  • It helps control night sweats, which aids in achieving deeper, more restorative sleep, leading to reduced daytime fatigue and increased energy levels.
  • Restores vaginal tissue by relieving dryness, itching, and discomfort, which can make intimacy more comfortable and help maintain urinary health.
  • Helps prevent postmenopausal osteoporosis by preserving bone density, significantly lowering your long-term risk of painful fractures.
  • Helps to even out mood fluctuations and reduce the irritability often associated with the hormonal changes of menopause.
Side effects of Primiwal-E2 Tablet
Managing back pain as a side effect of medication requires a combination of self-care techniques, lifestyle modifications, and medical interventions. Here are the steps:
  • Talk to your doctor about your back pain and potential medication substitutes or dose changes.
  • Try yoga or Pilates and other mild stretching exercises to increase flexibility and strengthen your back muscles.
  • To lessen the tension on your back, sit and stand upright and maintain proper posture.
  • To alleviate discomfort and minimize inflammation, apply heat or cold packs to the afflicted area.
  • Under your doctor's supervision, think about taking over-the-counter painkillers like acetaminophen or ibuprofen.
  • Make ergonomic adjustments to your workspace and daily activities to reduce strain on your back.
  • To handle tension that could make back pain worse, try stress-reduction methods like deep breathing or meditation.
  • Use pillows and a supportive mattress to keep your spine in the right posture as you sleep.
  • Back discomfort can worsen by bending, twisting, and heavy lifting.
  • Speak with a physical therapist to create a customized training regimen to increase back strength and flexibility.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the steps to manage Gastrointestinal Air and Swelling (GAS) caused by medication:
  • Tell your doctor about your GAS symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
  • To manage GAS symptoms, eat a balanced diet of fibre, vegetables, and fruits.
  • Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
  • Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
  • Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
  • Take medication for GAS symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
  • If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.

Directions for Use

  • Swallow the tablet whole with a full glass of water. Do not chew, crush, or break the tablet, as this can affect how the medicine is absorbed.
  • Take your tablet at the same time every day to keep a steady amount of medicine in your body.
  • You can take this medicine with or without food. If you experience mild nausea, taking it with a meal may help.
  • Always follow your doctor's exact instructions regarding how long to take this medication. Never adjust your dose or stop taking it without consulting your healthcare provider first.

How Primiwal-E2 Tablet Works

As individuals approach menopause, or if they have had their ovaries surgically removed, natural estrogen levels drop significantly. This drop triggers symptoms like hot flashes, mood changes, and thinning bones. Primiwal-E2 Tablet works by mimicking the natural estrogen hormones produced by the ovaries.
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Alcohol

Unsafe

You are recommended not to consume alcohol along with Primiwal-E2 Tablet to avoid unpleasant side effects.

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Pregnancy

Unsafe

Primiwal-E2 Tablet is not recommended during pregnancy, as it may harm the foetus and cause serious complications for the baby and mother.

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Breast Feeding

Unsafe

Primiwal-E2 Tablet is not recommended for breastfeeding mothers as it is known to cause harm to the baby.

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Driving

Safe if prescribed

It is not known to cause any side effects which may affect driving.

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Liver

Caution

Primiwal-E2 Tablet should be taken with caution, especially if you have a history of liver disease.

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Kidney

Caution

Primiwal-E2 Tablet should be taken with caution, especially if you have a history of kidney disease.

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Children

Unsafe

Primiwal-E2 Tablet is not recommended for children below 12 years of age.

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Heart

Caution

Please consult your doctor if you have any concerns regarding the use of Primiwal-E2 Tablet in heart patients.

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Geriatrics

Safe if prescribed

Please consult your doctor if you have any concerns regarding the use of Primiwal-E2 Tablet in elderly patients.

What if I have taken an overdose of Primiwal-E2 Tablet

In case of an accidental overdose, seek immediate medical attention or contact a poison control centre right away. Symptoms of an overdose may include severe nausea, vomiting, or unusual vaginal bleeding.

Diet & Lifestyle Advise

  • Boost calcium and vitamin D: Increase your intake of calcium and vitamin D through foods like leafy greens, dairy, or fortified products to support your bone health.
  • Support bone strength: Engage in regular weight-bearing and muscle-strengthening exercises, such as walking or light strength training, to keep your bones strong and reduce the risk of osteoporosis.
  • Avoid smoking: Stop smoking, as tobacco use significantly increases your risk of developing blood clots, stroke, and heart issues while taking oral Primiwal-E2 Tablet .
  • Limit alcohol: Reduce your alcohol intake to protect your liver, as both alcohol and oral hormones are processed by the liver.
  • Manage hot flashes: Stay cool by wearing layered clothing and avoiding triggers like spicy foods, caffeine, and hot beverages, which can worsen hot flashes.
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How Soon It Starts Working

  • The time required for Primiwal-E2 Tablet to start to work: The time required for Primiwal-E2 Tablet to start to work is 3 to 6 hours after administration.
  • The time for which the effects of Primiwal-E2 Tablet last: The effect of Primiwal-E2 Tablet lasts for 4 to 5 days.

What if you forget to take Primiwal-E2 Tablet

If you miss a dose of Primiwal-E2 Tablet , take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed tablet and resume your regular schedule. Do not take a double dose to make up for a missed one. Talk to your doctor or pharmacist if you frequently forget to take your medication.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Schedule routine screenings: Schedule regular physical exams, including pelvic exams and mammograms, as directed by your doctor to monitor your health while on hormone therapy.
  • Perform breast self-exams: Perform monthly breast self-exams and report any new lumps, changes, or unusual discharge to your healthcare provider immediately.
  • Plan for surgeries or bed rest: If you need major surgery or will be on prolonged bed rest, inform your doctor well in advance, as you may need to temporarily stop taking Primiwal-E2 Tablet to reduce blood clot risks.
  • Monitor blood pressure: Check your blood pressure regularly, as oral estrogens can sometimes cause blood pressure levels to rise.
  • Watch for contact lens changes: If you wear contact lenses, notify your doctor if you experience changes in your vision or feel discomfort while wearing them.

Drug-Drug Interactions

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Drug-Drug Interaction:

  • Thyroid medications: Primiwal-E2 Tablet may decrease the effectiveness of thyroid hormone replacements, meaning your doctor may need to adjust your thyroid dose.
  • Anti-seizure medications (such as carbamazepine or phenobarbital): These can speed up how your liver processes Primiwal-E2 Tablet , making it less effective.
  • Certain antibiotics or antifungals (such as rifampin or ketoconazole): These can alter the levels of Primiwal-E2 Tablet in your blood, either reducing its effect or increasing side effects.

Drug-Food Interaction:

  • Grapefruit juice: Grapefruit and grapefruit juice can interfere with how your body processes this medicine, which may increase the risk of side effects.

Drug-Disease Interaction:

  • Liver disease: Do not take Primiwal-E2 Tablet if you have active liver damage, as the liver processes this medication, and damaged tissue cannot metabolise it safely.
  • Blood clotting disorders: Taking Primiwal-E2 Tablet can worsen or trigger blood clotting events in individuals with a history of deep vein thrombosis or pulmonary embolism.
  • Estrogen-sensitive cancers: Primiwal-E2 Tablet must be avoided if you have a history of breast cancer or uterine cancer, as estrogen can stimulate the growth of these cancer cells.

Drug-Drug Interactions

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How does the drug interact with Primiwal-E2 Tablet:
When Etodolac is taken with Bivalirudin, the risk or severity of bleeding and haemorrhage increases.

How to manage the interaction:
Taking Bivalirudin with Primiwal-E2 Tablet can cause an interaction, consult a doctor before taking it. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Primiwal-E2 Tablet:
Co-administration of Primiwal-E2 Tablet and Pomalidomide can increase the risk of serious blood clots.

How to manage the interaction:
There may be a possibility of interaction between Primiwal-E2 Tablet and Pomalidomide, but it can be taken if prescribed by a doctor. However, if you experience symptoms like chest pain, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness, or swelling in an arm or leg, or numbness or weakness on one side of the body, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
EstradiolDantrolene
Severe
How does the drug interact with Primiwal-E2 Tablet:
The usage of Primiwal-E2 Tablet with dantrolene might have significant adverse effects on your liver.

How to manage the interaction:
Taking Primiwal-E2 Tablet with Dantrolene together can result in an interaction, but it can be taken if a doctor has advised it. However, if you have a fever, chills, joint pain or swelling, severe fatigue or weakness, unusual bleeding or bruising, skin rash or itching, lack of appetite, nausea, vomiting, or yellowing of the skin or whites of your eyes, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Primiwal-E2 Tablet:
Primiwal-E2 Tablet may interfere with anastrozole's function and make it less effective in treating your condition.

How to manage the interaction:
Co-administration of Anastrozole with Primiwal-E2 Tablet can result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without a doctor's advice.
How does the drug interact with Primiwal-E2 Tablet:
Taking thalidomide together with Primiwal-E2 Tablet may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking Primiwal-E2 Tablet and thalidomide together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Primiwal-E2 Tablet:
Coadministration of Primiwal-E2 Tablet and Lenalidomide can increase the risk of blood clots.

How to manage the interaction:
Although there is an interaction between lenalidomide and Primiwal-E2 Tablet, it can be taken if your doctor has advised it. However, if you experience chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Primiwal-E2 Tablet:
When taken in combination, clindamycin can lower the amount or action of Primiwal-E2 Tablet.

How to manage the interaction:
Co-administration of Primiwal-E2 Tablet with Clindamycin can result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without a doctor's advice.
How does the drug interact with Primiwal-E2 Tablet:
Letrozole may have a negative effect when used with Primiwal-E2 Tablet, making it less effective in treating your disease.

How to manage the interaction:
Although taking Letrozole and Primiwal-E2 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Primiwal-E2 Tablet:
Co-administration of Primiwal-E2 Tablet with Tranexamic acid can increase the risk of blood clots.

How to manage the interaction:
Taking Primiwal-E2 Tablet with Tranexamic acid can lead to an interaction; however, it can be taken only if a doctor has advised it. If you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, and numbness or weakness on one side of the body contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Primiwal-E2 Tablet:
Carfilzomib can cause serious blood clots and taking it alongside Primiwal-E2 Tablet may enhance the risk.

How to manage the interaction:
Co-administration of Primiwal-E2 Tablet with Carfilzomib can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience symptoms like chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness, or swelling in an arm or leg, or numbness or weakness on one side of the body, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[HORMONES]

FAQs

Primiwal-E2 Tablet is used to treat hypoestrogenism (estrogen deficiency), osteoporosis (thinning of bones) and symptoms associated with menopause (itching, dryness in the vagina, hot flashes). This medicine is prescribed when the body is not producing a sufficient amount of natural estrogen.
Primiwal-E2 Tablet works by replacing the normal hormone estrogen functions in the body and treats symptoms associated with menopause.
Do not use Primiwal-E2 Tablet if you are allergic to peanuts, have unusual vaginal bleeding, have/had any cancer (breast or uterus cancer), or undergoing any other estrogen treatment. Tell your doctor if you had a heart attack, stroke, blood clot, or liver problems, if you are pregnant, breastfeeding, or planning to get pregnant.
No, Primiwal-E2 Tablet should not be taken if you are undergoing surgery. You should inform your doctor, and he might ask you to stop hormone replacement therapy about 4 to 6 weeks before surgery to reduce the risk of blood clots.
Primiwal-E2 Tablet may cause weight gain or loss, a common side effect. Regular exercise and a healthy diet can help prevent weight gain.
Do not discontinue Primiwal-E2 Tablet without consulting your doctor as stopping the medicine can cause your symptoms to come back. Consult the doctor, he/she might reduce the dose gradually.
If you miss a dose of Primiwal-E2 Tablet take it as soon as you remember, However, if it is almost time for the scheduled dose, skip the missed dose and take the next dose at the scheduled time.
You may experience side effects like headaches, bloating, hair loss, nausea, breast pain, weight gain, and irregular vaginal bleeding. Consult the doctor if the side effects persist or worsen.
Foods like flaxseeds, soy, peaches, garlic, sesame seeds, kale, broccoli, Brussels sprouts, peanuts, almonds, cashews, and pistachios can be included in your diet for oestrogen deficiency.
Do not take Primiwal-E2 Tablet if you are allergic to any of its components or if you had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina or have undiagnosed vaginal bleeding, liver disease, or a bleeding disorder.
Primiwal-E2 Tablet should be swallowed as a whole with water; do not crush or chew it. It can be taken with or without food; taking with food or after meals may help prevent stomach upset.
Yes. In fact, individuals who have had a hysterectomy (removal of the uterus) are often prescribed Primiwal-E2 Tablet alone. If you still have your uterus, your doctor will typically prescribe a second hormone (progestin) alongside Primiwal-E2 Tablet to protect the uterine lining. Talk to your doctor for personalised advice.
Many people begin to feel relief from hot flashes and other menopausal symptoms within a few weeks of starting treatment. However, it may take several weeks to experience the full benefits of the medication. Talk to your doctor if your symptoms do not improve.
Yes, you can take Primiwal-E2 Tablet with or without food. If you find that the medicine causes a mild upset stomach or nausea, taking your daily tablet with a meal or a light snack can help reduce this feeling. Talk to your doctor or pharmacist if stomach discomfort persists.
Take the missed tablet as soon as you remember. If your next dose is due within a few hours, skip the missed dose and resume your regular schedule. Do not take two tablets at once to make up for a missed dose. Talk to your doctor or pharmacist if you frequently miss doses.
Yes, smoking significantly increases the risk of serious cardiovascular side effects, including blood clots, stroke, and heart attacks, while taking oral estrogen. It is strongly advised to quit smoking before starting this medication. Talk to your doctor about smoking cessation resources.
No, Primiwal-E2 Tablet is not recommended for individuals who are breastfeeding. Estrogen can pass into breast milk and may also decrease the quantity and quality of breast milk produced. Talk to your doctor about alternative options for symptom relief.
Hormone therapy is generally recommended at the lowest effective dose for the shortest possible duration to manage symptoms. Your doctor will re-evaluate your treatment plan every 3 to 6 months to determine if you should continue. Talk to your doctor about your specific health needs.

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While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

INDIA

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads,Ahmedabad – 380015 Gujarat, India
Other Info - PRI0403
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