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compositionComposition:DULOXETINE-30MG+PREGABALIN-75MG
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Prescription Medicine
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Prixain D 75/30 Tablet is used in the treatment of diabetic neuropathic pain and fibromyalgia. It contains Pregabalin and Duloxetine. Pregabalin belongs to an anticonvulsant class of drugs, whereas Duloxetine is a selective serotonin reuptake (SSRI) inhibitor. This medicine mainly works by increasing the chemical messengers in the brain responsible for regulating pain. Prixain D 75/30 Tablet may cause certain side effects such as nausea, constipation, headache, dry mouth, increased sweating, loss of appetite, dizziness, and burning sensation.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DULOXETINE-30MG+PREGABALIN-75MG

Manufacturer/Marketer :

Ajanta Pharma Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Prixain D 75/30 Tablet

Prixain D 75/30 Tablet is an oral prescription medication designed to help manage persistent nerve discomfort, also known as neuropathic pain, and fibromyalgia. It serves the vital medical purpose of soothing overactive nerves, helping to restore daily physical function and comfort. This medicine is intended for long-term management of nerve pain rather than immediate, on-demand relief.

For best results, you should take Prixain D 75/30 Tablet consistently every day at the same scheduled times. It can be taken with or without food, though taking it with a light meal may help prevent initial stomach upset. Gentle lifestyle adjustments, such as pacing your daily physical activities and keeping a regular pain diary, can significantly support your treatment progress.

While taking Prixain D 75/30 Tablet , you may experience mild, temporary side effects like dry mouth, sleepiness, or mild dizziness. However, you must consult your doctor immediately if you experience serious symptoms, such as sudden changes in your mood, severe skin rashes, or swelling of your face. Your doctor will monitor your progress to ensure the medication is working safely and effectively.

Do not take this if you have severe kidney issues or severe liver damage, or if you have a history of allergic reactions to similar medications. Before starting, tell your doctor if you have a history of glaucoma, heart disease, high blood pressure, or psychiatric conditions. This medication is not suitable for children unless specifically prescribed by a specialist.

This medication can interact with other substances; for instance, drinking alcohol while taking Prixain D 75/30 Tablet can cause extreme drowsiness and increase liver strain. Special populations, including pregnant or breastfeeding women and elderly individuals, must consult their doctor or pharmacist before starting this treatment to evaluate potential risks.

Uses of Prixain D 75/30 Tablet

Prixain D 75/30 Tablet is used to treat persistent neuropathic pain. The detailed uses of Prixain D 75/30 Tablet are as follows:

  • Diabetic Neuropathy: Helps manage burning, tingling, or shooting pain in the feet, legs, or hands caused by nerve damage from diabetes.
  • Fibromyalgia: Reduces widespread musculoskeletal pain, tenderness, and muscle stiffness throughout the body.
  • Post-Herpetic Neuralgia: Relieves persistent, sharp nerve pain that remains after a shingles infection has healed.

Key Benefits

Prixain D 75/30 Tablet helps relieve chronic nerve-related pain by calming overactive pain signals in the nervous system. By reducing persistent discomfort, it supports better movement, sleep, and overall quality of life.

  • Relieves Nerve Pain: By reducing the abnormal pain signals sent by damaged nerves, Prixain D 75/30 Tablet helps ease burning, shooting, tingling, and other chronic nerve pain symptoms.
  • Improves Sleep and Daily Comfort: As pain decreases, Prixain D 75/30 Tablet can help improve sleep quality, reduce nighttime discomfort, and help you feel more rested and energised.
  • Supports Better Quality of Life: With consistent use, Prixain D 75/30 Tablet may help you return to everyday activities such as walking, working, and enjoying hobbies more comfortably, while also reducing the emotional stress that often accompanies chronic pain conditions.

Directions for Use

  • Prixain D 75/30 Tablet can be taken with or without food as advised by the doctor.
  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Prixain D 75/30 Tablet as a whole with a glass of water.
  • Do not chew, crush or break it.

How Prixain D 75/30 Tablet Works

Prixain D 75/30 Tablet contains two distinct active ingredients that target pain pathways from different angles. The first active component, duloxetine, works by increasing the levels of serotonin and norepinephrine, natural chemical messengers in the brain and spinal cord that help block pain signals from travelling to the brain. The second active component, pregabalin, acts directly on damaged, hyperactive nerves. It binds to specific calcium channels in the nerve cells, which reduces the release of excess chemical signals that cause pain and anxiety. Together, these two mechanisms help to calm overexcited nerves and restore balance to your body's pain-sensing system.
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Alcohol

Unsafe

Avoid alcohol consumption during treatment with $nmae as it may increase the risk of serious side effects and worsen your health.

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Pregnancy

Caution

If you are pregnant, especially in the last trimester or planning pregnancy, inform your doctor before taking Prixain D 75/30 Tablet . It may cause foetal abnormalities if taken in the last trimester of pregnancy. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

If you are breastfeeding, inform your doctor before taking Prixain D 75/30 Tablet . Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Unsafe

Prixain D 75/30 Tablet may cause drowsiness. Hence, avoid driving vehicles or operating machines after taking Prixain D 75/30 Tablet .

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Liver

Caution

If you have liver conditions, inform your doctor before taking Prixain D 75/30 Tablet . Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have kidney conditions, inform your doctor before taking Prixain D 75/30 Tablet . Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Prixain D 75/30 Tablet is not recommended for children below 18 years as the safety and efficacy of use for this medicine are not established. Please seek medical advice for more information.

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Heart

Caution

If you have a pre-existing or a history of heart disease, inform your doctor before receiving Prixain D 75/30 Tablet . Your doctor will weigh the benefits and potential risks before prescribing this medicine.

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Geriatrics

Caution

Prixain D 75/30 Tablet should be used with caution in elderly patients. Please consult your doctor before use.

What if I have taken an overdose of Prixain D 75/30 Tablet

In case of an accidental overdose, seek immediate medical attention. Symptoms of an overdose may include extreme drowsiness, confusion, agitation, or a rapid heart rate.

Diet & Lifestyle Advise

  • Keep your blood sugar levels well-managed if you are treating diabetic neuropathy, as stable blood sugar prevents further nerve damage.
  • Engage in low-impact physical exercises, such as swimming, walking, or gentle stretching, to improve blood circulation and keep your joints flexible.
  • Avoid alcohol completely, as it can worsen nerve pain and interact dangerously with your medication, increasing the risk of severe drowsiness, dizziness, impaired coordination, and liver damage.
  • Increase your daily water intake and eat fibre-rich foods like vegetables and whole grains to prevent mild constipation.
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How Soon It Starts Working

The time required for Prixain D 75/30 Tablet to start to work: Prixain D 75/30 Tablet ideally shows its action within 2 hours after administration. The time for which the effects of Prixain D 75/30 Tablet last: The duration of action for Prixain D 75/30 Tablet is clinically unknown.

What if you forget to take Prixain D 75/30 Tablet

If you miss a dose of Prixain D 75/30 Tablet , take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

•Store Prixain D 75/30 Tablet capsules at controlled room temperature, ideally between 15°C and 30°C (59°F to 86°F), unless otherwise stated on the product label or by your pharmacist.

Drug Warnings

  • Do not drive or operate machinery when first starting Prixain D 75/30 Tablet , as it can cause significant dizziness or sleepiness until your body adjusts.
  • Never stop taking this medication suddenly; abrupt withdrawal can cause anxiety, sleep disturbances, sweating, and a rapid return of pain. Your doctor will provide a schedule for safely tapering down the dose.
  • Check your mood and mental well-being daily, and ensure a close family member or caregiver is aware you are taking this medicine so they can help monitor for unusual behavioural changes.
  • If you are scheduled for any surgery or dental procedure, inform your surgeon or dentist that you are taking Prixain D 75/30 Tablet .

verifiedApollotooltip
  • Central nervous system (CNS) depressants (e.g., sleeping pills, opioid pain relievers, or muscle relaxants): Taking these medicines together may increase drowsiness, dizziness, slowed breathing, and impaired alertness.
  • Anticoagulants (blood thinners) (e.g., warfarin): Combined use may increase the risk of bleeding or bruising. Your doctor may recommend closer monitoring, particularly if you notice unusual bleeding.
  • Monoamine oxidase inhibitors (MAOIs): Do not take this medicine with MAOIs or within 14 days of stopping an MAOI, as this combination can cause serious and potentially life-threatening reactions, including dangerously high blood pressure or serotonin syndrome.

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  • Alcohol: Avoid drinking alcohol while taking this medicine. Alcohol can significantly increase drowsiness, dizziness, impaired coordination, and the risk of liver damage, particularly due to the duloxetine component.

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All Substitutes & Brand Comparisons

Habit Forming

Yes

Therapeutic Class

[ANTICONVULSANT]

FAQs

Prixain D 75/30 Tablet is used in the treatment of diabetic neuropathic pain and fibromyalgia. This medicine mainly works by increasing the chemical messengers in the brain responsible for regulating pain.
Do not stop using Prixain D 75/30 Tablet suddenly as it can cause withdrawal symptoms. Your doctor will gradually reduce the dose based on your clinical condition.
Seek medical attention immediately if you notice any depressive thoughts while using Prixain D 75/30 Tablet . Your doctor may change the dose or medicine to treat your condition.
Neuropathic pain/ peripheral neuropathy is pain that occurs when the nervous system is not working properly or is damaged.
Prixain D 75/30 Tablet contains Pregabalin and Duloxetine. Pregabalin is an anticonvulsant drug, whereas Duloxetine is a selective serotonin reuptake (SSRI) inhibitor. Both medicines mainly work by increasing the chemical messengers in the brain responsible for regulating pain.
To manage weight gain associated with the use of Prixain D 75/30 Tablet , maintain a balanced diet and engage in regular exercise. Use the lowest effective dose to help reduce the chances of gaining weight. Keep track of your weight and consult your doctor if you notice significant changes. They can help adjust your treatment or suggest ways to manage your weight more effectively.
Prixain D 75/30 Tablet may cause sleepiness or drowsiness in some individuals as a mild side effect. If you experience these symptoms, it is important to avoid activities that require full alertness, such as driving or operating machinery. If drowsiness persists for a longer period, please consult your doctor.
Prixain D 75/30 Tablet may take several weeks or longer to show its full effects. While some patients may notice improvements within the first week, it is important to continue taking the medication as prescribed to achieve the full benefits. Your doctor will likely reduce your dose gradually to avoid withdrawal symptoms.
If you forget to take Prixain D 75/30 Tablet , take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
No, taking a higher dose of Prixain D 75/30 Tablet than recommended will not necessarily make it more effective and may increase the risk of side effects. Additionally, it can become habit-forming if misused or taken in larger amounts than prescribed for a prolonged period, leading to dependence. If you feel your current dose is not effective, please consult your doctor for proper adjustments, rather than increasing the dose on your own.
It is not recommended to drink alcohol while taking Prixain D 75/30 Tablet , as it may increase the risk of side effects such as drowsiness and dizziness. These effects impair your ability to perform tasks that require focus, so avoid driving or operating machinery while taking Prixain D 75/30 Tablet . Always consult your doctor for personalized advice.
Prixain D 75/30 Tablet should typically be stored in a cool and dry place, away from direct sunlight and moisture. Keep it out of reach of children.
Prixain D 75/30 Tablet may cause common side effects such as nausea, constipation, headache, dry mouth, increased sweating, loss of appetite, dizziness, and burning sensation. These side effects do not require medical attention and gradually resolve over time. However, if any of these side effects persist or worsen, please inform your doctor.
This medication is generally not recommended during pregnancy unless your doctor decides the benefits clearly outweigh the risks to the unborn baby. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor before taking this medicine.
You should consult a healthcare professional before combining this medicine with any over-the-counter pain relievers, as some can interact and increase your risk of side effects like stomach irritation or bleeding. Talk to your doctor or pharmacist for safe recommendations.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. ScienceDirect Topics. S0304395913002856 - Research & Medical Applications Summary. Amsterdam, Netherlands: Elsevier; 2025. [Accessed on 02 Jun. 2026]Check here
  2. National Center for Biotechnology Information (NCBI). Pmc3127557 Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  3. MedlinePlus. A604030 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  4. MedlinePlus. A605045 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  5. Pregabalin Pregabalin. 2009. [Accessed on 23 Jan. 2019]Check here
  6. Duloxetine hydrochloride. 2004. [Accessed on 23 Jan. 2019]Check here
  7. Pregablin Pregablin. 2004. [Accessed on 22 Mar. 2019]Check here

Country of origin

India

Manufacturer/Marketer address

Ajanta House, Charkop, Kandivli West, Mumbai 400 067, India.
Other Info - PRI0617

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