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compositionComposition:PROPOFOL-100MCG
prescription
Prescription Medicine
info
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Profol Spiva Injection is used in giving anesthesia for major surgical procedures. It is given as induction therapy before surgery to sedate the patient. It contains Propofol, which causes loss of consciousness, that is reversible. It may cause side effects such as dizziness, low blood pressure, nausea, headache, vomiting, local site pain, changes in your breathing pattern and slow heartbeat.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PROPOFOL-100MCG

Manufacturer/Marketer :

Claris Lifesciences Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Profol Spiva Injection

Profol Spiva Injection is an intravenous medicine used by healthcare providers to start and maintain anaesthesia or sedation during surgeries and medical procedures. It helps patients remain asleep, relaxed, and free of pain while undergoing these clinical treatments.

This medicine is not for regular daily use and is only injected directly into a vein by a trained professional in a hospital. To prepare for receiving this injection, your doctor will ask you to fast, meaning you must not eat or drink for several hours before your procedure. Strictly following these pre-procedure fasting rules is essential for your safety.

Some people may experience mild side effects, such as a slight sting at the injection site or temporary dizziness upon waking. If you notice any serious issues, such as extreme breathing difficulties, alert your medical team immediately.

Talk to your doctor before receiving this if you have a history of heart issues, lung disease, kidney disease, or liver damage. Do not take this if you are allergic to this medicine or have known severe allergies to eggs or soy, as these are common components in its liquid mixture.

This medicine can interact with alcohol, sleeping pills, or strong pain medicines, which can severely slow down your breathing and brain activity. If you are pregnant, breastfeeding, or elderly, discuss this with your medical team, as they may need to modify the way they inject the medicine. Talk to your doctor or pharmacist to learn more.

Uses of Profol Spiva Injection

Profol Spiva Injection is used to start and maintain anaesthesia or sedation during surgeries and medical procedures. The detailed uses of Profol Spiva Injection are as follows:

  • General anaesthesia: This medicine helps by putting you into a deep sleep before major surgeries, ensuring you do not feel pain or remember the procedure.
  • Sedation for medical procedures: It helps you relax and stay calm during shorter diagnostic tests, scans, or minor surgical interventions.
  • Intensive care sedation: It helps calm and relax patients who require mechanical breathing assistance (ventilators) in intensive care units.

Key Benefits

Profol Spiva Injection offers significant clinical benefits that help make medical procedures much more comfortable and less stressful for patients.

  • Rapid onset of sleep: It works incredibly fast, typically causing you to drift into a relaxed sleep within seconds after being injected.
  • Clear and quick awakening: Once the infusion is stopped, the medicine wears off rapidly, allowing you to wake up feeling clear-headed with minimal grogginess.
  • Smooth procedure experience: By preventing pain and anxiety during surgery, it ensures a stress-free and smooth treatment process.
Side effects of Profol Spiva Injection 20 ml
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.
  • Include omega-3 rich foods in your diet to reduce inflammation.
  • Eat antioxidant-rich foods like fruits, vegetables, and nuts to promote overall skin health.
  • Stay hydrated by drinking plenty of water.
  • Maintain a healthy skin care routine, using gentle, fragrance-free products.
  • Wear loose, breathable clothing to minimize irritation.
  • Keep fingernails short and clean to prevent further skin damage.
  • Use a humidifier to add moisture to the air, reducing dryness and itchiness.
  • Practice stress-reducing techniques like meditation or deep breathing to manage stress levels.
  • Change positions or take a break from activity to relieve symptoms.
  • Avoid postures that put a lot of pressure on just one area of the body.
  • If you have vitamin deficiency, take supplements or change your diet.
  • Exercise regularly like cycling, walking or swimming.
  • Avoid sitting with your legs crossed.
  • Clench and unclench your fists and wiggle your toes.
  • Massage the affected area.
Steps to Manage Low Oxygen Levels Caused by Medication:
  • If you experience symptoms of low oxygen levels, such as shortness of breath, confusion, or chest pain, seek immediate medical attention.
  • Inform your doctor about the medication you're taking and the symptoms you're experiencing. They will assess the situation and provide guidance.
  • Your doctor may recommend monitoring your oxygen levels using a pulse oximeter.
  • Your doctor may adjust your medication or recommend alternative treatments to alleviate low oxygen levels.
  • In severe cases, your doctor may prescribe supplemental oxygen therapy to increase oxygen levels in the blood.
  • Managing underlying conditions, such as respiratory or cardiovascular diseases, can help alleviate low oxygen levels.
  • Engage in relaxation techniques, stay hydrated, avoid strenuous activities, get plenty of rest, and eat a balanced diet to help manage symptoms and improve overall well-being.
Here's a comprehensive approach to managing medication-triggered high blood pressure (hypertension):
  • Inform your doctor if you experience high blood pressure symptoms after starting a new medication or changing your medication regimen.
  • To reduce high blood pressure symptoms, your doctor may change your medication regimen or dose.
  • Monitor your blood pressure regularly to track changes and potential side effects.
  • Make lifestyle changes, such as following a healthy diet, exercising regularly, and reducing sodium intake.
  • Consider incorporating stress-reducing activities, like meditation or deep breathing exercises, into your daily routine.
  • Create a personalized plan with your doctor to manage high blood pressure, which may include additional medications, therapies, or lifestyle modifications.
  • Follow up with your doctor on a frequent basis to assess progress, change treatment plans, and address any concerns or issues.
  • Exercising regularly helps lower the risk of heart problems.
  • Maintain a healthy diet, including vegetables and fruits.
  • Rest well; get enough sleep.
  • Manage stress with yoga and meditation.
  • Limit alcohol and smoking.

Directions for Use

  • Follow your doctor’s recommendations on the dosage and timing of this medication to achieve optimal results.
  • Profol Spiva Injection will be administered by a healthcare professional.
  • Do not self-administer.

How Profol Spiva Injection Works

Profol Spiva Injection contains propofol, which works by acting directly on your central nervous system, which includes your brain and nerves. It boosts the action of a natural calming chemical in your brain called gamma-aminobutyric acid (GABA). By enhancing this chemical, the medicine slows down brain activity, which quickly leads to deep relaxation, sedation, or a temporary state of sleep. Since it is injected directly into your bloodstream, it bypasses the digestive system and goes straight to the brain, providing almost instant relief from anxiety and pain during your medical procedure.
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Alcohol

Unsafe

Profol Spiva Injection can affect alertness if taken along with alcohol. So, the consumption of alcohol should be avoided as it might further reduce alertness.

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Pregnancy

Unsafe

Profol Spiva Injection is not recommended in the last trimester of the pregnancy as it may affect the baby's brain's growth.

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Breast Feeding

Unsafe

Profol Spiva Injection is known to pass through the breastmilk. So, it is not advised to take Profol Spiva Injection during breastfeeding. Consult your doctor for further advice.

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Driving

Unsafe

Profol Spiva Injection can affect alertness and coordination as it is known to cause drowsiness. So, operating machinery which requires concentration should be avoided.

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Liver

Caution

Profol Spiva Injection to be taken with caution, especially if you have had a history of liver disease. Your doctor will have to change the dosage depending on your medical condition and your reaction to treatment.

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Kidney

Caution

Profol Spiva Injection to be taken with caution, especially if you have had a history of kidney disease. Your doctor will have to change the dosage depending on your medical condition and your reaction to treatment.

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Children

Caution

Profol Spiva Injection is not recommended for children below the age of 3 years. For children aged above three, take in dose and duration advised by a doctor.

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Heart

Consult your doctor

Limited information is available; please consult your doctor.

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Geriatrics

Caution

Profol Spiva Injection can be administered in elderly patients with extreme caution, if prescribed by the physician. Dosage adjustment may be needed.

What if I have taken an overdose of Profol Spiva Injection

An overdose is highly unlikely because a trained medical professional will carefully calculate and monitor the amount of medicine you receive. However, if an overdose does occur, the clinical team is fully prepared to provide immediate life support, such as oxygen therapy, breathing assistance, and medications to maintain healthy blood pressure and heart function.

Diet & Lifestyle Advise

  • Follow fasting rules strictly: Avoid eating any solid food or drinking liquids for the exact number of hours specified by your doctor before your procedure.
  • Arrange a safe ride home: Do not drive yourself home after receiving this medicine. Have a responsible family member or friend drive you and stay with you for at least 24 hours.
  • Avoid critical activities: Do not operate heavy machinery, perform dangerous tasks, or sign important legal documents for 24 hours post-procedure, as your coordination and decision-making may be temporarily slowed.
  • Reintroduce food slowly: Start with clear liquids or light, bland foods (like toast or crackers) once your doctor says you can eat to avoid upsetting your stomach after sedation.
health query

Have a query?

How Soon It Starts Working

The time required for Profol Spiva Injection to start to work: The time required for Profol Spiva Injection to start to work is 35 to 40 seconds after administration. The time for which the effects of Profol Spiva Injection last: The effect of Profol Spiva Injection lasts for 3 to 15 minutes.

What if you forget to take Profol Spiva Injection

Since this medicine is given only by a healthcare professional in a hospital setting for a specific procedure, it is not possible for you to miss a dose at home. If your scheduled procedure is delayed, your medical team will adjust the timing of your injection accordingly.

Storage

• This medicine must be kept at a controlled room temperature, typically between 20°C and 25°C (68°F and 77°F). • It must never be frozen, as freezing can break down the liquid mixture, making it unsafe to use.

Drug Warnings

  • Check the liquid appearance: Ensure the healthcare provider inspects the vial before use; the liquid should be a completely uniform, milky-white mixture with no separation or visible droplets.
  • Disclose egg or soy allergies: Always tell your healthcare team if you are allergic to soy, soybeans, eggs, or egg products, as this medicine contains these ingredients.
  • Continuous monitoring is required: Expect to have your breathing, blood pressure, and oxygen levels continuously watched by medical staff while you are under sedation.
  • Report pain immediately: Tell the healthcare professional right away if you feel severe burning or stinging in your vein as they begin to inject the medicine.
  • Avoid alcohol: Do not drink alcohol for at least 24 hours after receiving this medicine, as it can dangerously intensify residual drowsiness.

Drug-Drug Interactions

verifiedApollotooltip
  • Strong pain medicines (opioids): Combining these with Profol Spiva Injection can severely slow down your breathing and lower your blood pressure.
  • Other sedatives or sleeping pills: May cause extreme drowsiness and dangerously deep sleep if used close to your procedure.
  • Blood pressure medicines: Can increase the risk of your blood pressure dropping too low when you receive this injection.
PropofolSelegiline
Critical
PropofolTranylcypromine
Critical

Drug-Drug Interactions

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PropofolSelegiline
Critical
How does the drug interact with Profol Spiva Injection 20 ml:
Co-administration of Selegiline with Profol Spiva Injection 20 ml may significantly affect the blood pressure.

How to manage the interaction:
Taking Selegiline with Profol Spiva Injection 20 ml together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as severe headache, blurred vision, confusion, fits, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and/or fainting Do not discontinue any medications without consulting a doctor.
PropofolTranylcypromine
Critical
How does the drug interact with Profol Spiva Injection 20 ml:
Taking Tranylcypromine with Profol Spiva Injection 20 ml may significantly affect your blood pressure.

How to manage the interaction:
Taking Profol Spiva Injection 20 ml with Tranylcypromine is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting your doctor.
PropofolPhenylephrine
Critical
How does the drug interact with Profol Spiva Injection 20 ml:
Taking Phenylephrine with Profol Spiva Injection 20 ml may lead to increased levels of phenylephrine leading to side effects like high blood pressure.

How to manage the interaction:
Taking Phenylephrine with Profol Spiva Injection 20 ml is not recommended, but it can be taken if prescribed by the doctor. Do not discontinue the medications without consulting a doctor.
PropofolTirzepatide
Severe
How does the drug interact with Profol Spiva Injection 20 ml:
This raises the possibility of regurgitation while under anesthesia, leading to the inhalation of stomach contents into the lungs, which can result in lung inflammation or damage.

How to manage the interaction:
Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interfere with the safety of your anesthesia. It is essential to inform your doctor about all other medications you are taking, including vitamins and herbal supplements. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Drinking alcohol shortly before or after receiving this medicine can cause severe drowsiness and breathing complications.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[GENERAL ANESTHETICS]

FAQs

Profol Spiva Injection is used in giving anesthesia for major surgical procedures. It is given as induction therapy before surgery to sedate the patient.
Profol Spiva Injection belongs to a class of drugs known as 'general anesthetic,'Â containing Propofol, primarily used in giving anesthesia for major surgical procedures. It generally slows down the brain and central nervous system, which is the conscious center.
The most common side effects of Profol Spiva Injection include hypotension (low blood pressure), nausea, headache, vomiting, dizziness, local site pain, changes in your breathing pattern, slow heartbeat. Most of these side effects of Profol Spiva Injection do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.
It is advised that you should not take Profol Spiva Injection if you are allergic to eggs as it may cause an allergic reaction which can be serious. It is best to inform your doctor and do as advised for the best results.
The doctor will constantly monitor your breathing pattern, blood pressure, oxygen levels, kidney function and other vital signs while taking Profol Spiva Injection.
No, Profol Spiva Injection is not a narcotic, it is a general anesthetic used to sedate before major surgery. It has some addictive effect, which is still being studied.
Yes, Profol Spiva Injection is known to cause hypotension (low blood pressure). So, constant monitoring of blood pressure is required while you undergo surgery to avoid any sudden drop in blood pressure, which can be fatal.
No, when used for general anaesthesia, this medicine keeps you in a deep sleep so you will not feel pain or have any memory of the surgery. Talk to your doctor about how pain management is handled during your procedure.
No, you must not drive, operate machinery, or ride a bicycle for at least 24 hours after receiving this medicine. It can temporarily slow your reflexes and impair your judgment, even if you feel completely awake. Talk to your doctor about planning a safe ride home.
Fasting is crucial because sedation relaxes the muscles in your throat, which can cause food or liquid from your stomach to enter your lungs. Following fasting instructions ensures your procedure is as safe as possible. Talk to your doctor if you accidentally eat or drink before your surgery.
You should tell them about all your medical conditions, especially any history of heart, lung, kidney, or liver damage. You must also mention any allergies, especially to eggs or soy, and provide a list of all medications you take. Talk to your doctor to ensure all your health details are reviewed.
This medicine is generally reserved for situations where the benefit outweighs the risk during pregnancy. If you are breastfeeding, you may need to temporarily pause breastfeeding for a certain period after receiving this medicine. Talk to your doctor for specific advice.
The sleep-inducing effects of a single injection usually wear off quickly, within 5 to 10 minutes after the infusion is stopped. However, you may still feel mildly drowsy or relaxed for several hours afterward. Talk to your doctor if you feel unusually sleepy long after your procedure.
While nausea is a common side effect of many anaesthetics, this specific medicine is actually known to cause less nausea and vomiting during recovery compared to other options. However, some mild stomach upset can still occur. Talk to your doctor if you feel sick after your procedure.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.1365 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 019627S066Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. Propofol Propofol. 1986. [Accessed on 23 Jan. 2019]Check here
  4. Propofol Propofol. 2014. [Accessed on 05 Apr. 2019]Check here
  5. Thomas B. Folino; Erind Muco; Anthony O. Safadi; Lance J. Parks. Propofol. StatPearls. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed central. July 2022. [Accessed on 3rd January 2023]Check here
  6. Aspen Pharma Trading Limited. Propofol 10mg/ml (1%) emulsion for injection or infusion propofol. Electronic Medicines Compendium (EMC). [Revised in April 2022] [Accessed on 3rd January 2023]Check here
  7. Baxter Healthcare Limited. Propofol 20 mg/ml Emulsion for injection/infusion. Electronic Medicines Compendium (EMC). [Revised in June 2022] [Accessed on 3rd January 2023]Check here

Country of origin

INDIA

Manufacturer/Marketer address

Claris Corporate Headquarters, Nr. Parimal Crossing, Ellisbridge, Ahmedabad - 380 006, India.
Other Info - PRO0898
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