Prograf 0.5 mg Capsule 10's

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MRP ₹216.5

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Written By Veda Maddala , M Pharmacy

Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

Prograf 0.5 mg Capsule is used to prevent rejection of a transplanted organ, such as a liver, kidney, or heart. It contains Tacrolimus, which works by suppressing the activity of T and B lymphocytes (cells in the immune system) that usually attack foreign invaders and defend the body against foreign cells and infection. Thus, it prevents organ rejection in transplanted patients and helps the body to accept the new organ.

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About Prograf 0.5 mg Capsule

Prograf 0.5 mg Capsule is used to prevent rejection of a transplanted organ, such as a liver, kidney, or heart. Organ rejection occurs when a patient’s immune system recognises the donor organ as foreign and tries to eliminate it.

Prograf 0.5 mg Capsule contains Tacrolimus, which works by suppressing the activity of T and B lymphocytes (cells in the immune system) that usually attack foreign invaders and defend the body against foreign cells and infection. Thus, it prevents organ rejection in transplanted patients and helps the body to accept the new organ.

Take Prograf 0.5 mg Capsule as prescribed. You are advised to use Prograf 0.5 mg Capsule for as long as your doctor has recommended it for you based on your medical condition. Some people may experience nausea, diarrhoea, headache, kidney problems, infection, fever, constipation or high blood pressure. Most of these side effects of Prograf 0.5 mg Capsule do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Tacrolimus or any other medicines, please tell your doctor. If you are pregnant or a breastfeeding mother, it is advised to consult a doctor before using Prograf 0.5 mg Capsule . Avoid alcohol consumption with Prograf 0.5 mg Capsule . Drive only if you are alert, as Prograf 0.5 mg Capsule may cause some people vision problems or nervous disturbances. If you are about to get vaccinated, inform your doctor before taking Prograf 0.5 mg Capsule . Prograf 0.5 mg Capsule may increase the risk of infections or skin cancer as it lowers the body’s immune defence system.

Uses of Prograf 0.5 mg Capsule

Prograf 0.5 mg Capsule is used to treat various medical conditions. The detailed uses are as follows:

Prevention of Organ Transplant Rejection: Prograf 0.5 mg Capsule is used to stop the body from rejecting a transplanted kidney, liver, heart, or lung. It works by lowering the activity of certain immune cells that could attack the new organ. It is usually given along with other anti-rejection medicines.
Other Off-Label Uses: In some cases, Prograf 0.5 mg Capsule may be used for graft-versus-host disease (after bone marrow or stem cell transplant), autoimmune liver diseases (autoimmune hepatitis, lupus nephritis), autoimmune eye conditions (uveitis, scleritis), and other immune-related disorders such as rheumatoid arthritis, Crohn’s disease, or myasthenia gravis, particularly when standard treatments are not effective.

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Directions for Use

Take Prograf 0.5 mg Capsule at least 1 hour before or 2 to 3 hours after a meal or as advised by your doctor.
Strictly follow your doctor's recommendation regarding the dosage and duration.
Swallow it as a whole with water.
Do not crush, break or chew it.

Key Benefits

Prograf 0.5 mg Capsule belongs to the class of medicines called immunosuppressants, which reduce the activity of the body's immune system, and it contains Tacrolimus as the active ingredient.
It works by lowering the activity of certain white blood cells (T-lymphocytes) that trigger immune reactions, helping to prevent the body from attacking transplanted organs and reducing harmful immune responses.
It is used to prevent rejection of kidney, liver, heart, or lung transplants, usually along with other anti-rejection medicines.
It may also be used for graft-versus-host disease, autoimmune liver conditions, autoimmune eye inflammation, and certain severe autoimmune diseases (such as rheumatoid arthritis, Crohn's disease, or myasthenia gravis) when other treatments are not effective.
It provides several benefits, including protecting transplanted organs from rejection, improving long-term transplant survival, reducing the need for high-dose steroids, managing severe immune reactions in certain diseases, and improving quality of life for transplant patients.

How Prograf 0.5 mg Capsule Works

Prograf 0.5 mg Capsule contains Tacrolimus, which works by suppressing the activity of T and B lymphocytes (cells in the immune system) that usually attack foreign invaders and defend the body against foreign cells and infection. Thus, it prevents organ rejection in transplanted patients and helps the body to accept the new organ.

Storage

Store in a cool and dry place away from sunlight

Side effects of Prograf 0.5 mg Capsule

Swelling In The Feet And Ankles

Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
Gently massage the swollen area with firm but not painful pressure.
Keep the swollen area clean and moisturized to prevent injury and infection.
Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.

Chest Pain

Chest pain may last for a while and needs immediate medical attention as it is a significant health issue to be attended to.
Take rest and refrain from doing physical activity for a while, and restart after a few days.
Try applying an ice pack to the strained area for at least 20 minutes thrice a day. Ice pack thus helps reduce inflammation.
Sit upright and maintain proper posture if there is persistent chest pain. • Use extra pillows to elevate your position and prop your chest up while sleeping.

Loose And Watery Stools

Here are the precise steps to cope with diarrhoea caused by medication usage:

Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Nausea

Overcome Medication-Induced Nausea: A 9-Step Plan

Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
Divide your daily food intake into smaller, more frequent meals to reduce nausea.
Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
Use ginger (tea, ale, or candies) to help relieve nausea.
Get adequate rest and also avoid strenuous activities that can worsen nausea.
Talk to your doctor about taking anti-nausea medication if your nausea is severe.
Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Constipation

Here are the steps to cope with constipation as a side effect of medication:

Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

Vomiting

To prevent, manage, and treat Constipation caused by medication usage, follow these steps:

Preventing Vomiting (Before it Happens)
Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
Having a small meal before taking your medication can help reduce nausea and vomiting.
Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
Managing Vomiting (If it Happens)
Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
What to Do if Vomiting Persists
Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Indigestion

Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:

Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.

What if I have taken an overdose of Prograf 0.5 mg Capsule

Do not take more than the prescribed dose. Using more medication will not improve your symptoms; rather, it may cause poisoning or serious side effects. If you suspect that you may have overdosed of Prograf 0.5 mg Capsule or if you experience any adverse events, please go to the emergency department of the closest hospital.

Drug Warnings

Inform your doctor if you are allergic to Tacrolimus or any other medicines before starting Prograf 0.5 mg Capsule .
If you are pregnant or breastfeeding, consult your doctor before using Prograf 0.5 mg Capsule to ensure it is safe for you and your baby.
Avoid alcohol consumption while taking Prograf 0.5 mg Capsule , as it may increase side effects.
Drive or operate machinery only if you feel alert, since Prograf 0.5 mg Capsule may occasionally cause vision problems, dizziness, or nervous system disturbances.
Inform your doctor before receiving any vaccines, as Prograf 0.5 mg Capsule suppresses the immune system and may reduce the effectiveness of certain vaccines.
Prograf 0.5 mg Capsule can increase the risk of infections and skin cancer due to lowered immune defence; use protective clothing and sunscreen while outdoors.
When preparing the oral suspension, use glass or metal containers only, as the granules can stick to plastic (PVC) and result in an incomplete dose.
Avoid inhaling the granules or letting them, or the prepared suspension, come into contact with your skin or eyes. If accidental contact occurs, wash the area thoroughly with soap and water or rinse eyes with plain water.

Drug-Drug Interactions

TacrolimusSaquinavir

Critical

TacrolimusDronedarone

Critical

Drug-Drug Interactions

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TacrolimusSaquinavir

Critical

How does the drug interact with Prograf 0.5 mg Capsule:
Taking Prograf 0.5 mg Capsule with saquinavir can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Prograf 0.5 mg Capsule with Saquinavir is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.

TacrolimusDronedarone

Critical

How does the drug interact with Prograf 0.5 mg Capsule:
Taking Prograf 0.5 mg Capsule with dronedarone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Prograf 0.5 mg Capsule with Dronedarone is not recommended, but can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.

TacrolimusMifepristone

Critical

How does the drug interact with Prograf 0.5 mg Capsule:
Taking Prograf 0.5 mg Capsule with Mifepristone may significantly increase the blood levels of Prograf 0.5 mg Capsule, which may increase the risk and/or severity of side effects.

How to manage the interaction:
Taking Prograf 0.5 mg Capsule with Mifepristone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience unusual symptoms. Do not discontinue any medications without consulting a doctor.

TacrolimusThioridazine

Critical

How does the drug interact with Prograf 0.5 mg Capsule:
Combining Prograf 0.5 mg Capsule with Thioridazine can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Prograf 0.5 mg Capsule with Thioridazine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.

TacrolimusZiprasidone

Critical

How does the drug interact with Prograf 0.5 mg Capsule:
Taking Prograf 0.5 mg Capsule with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Prograf 0.5 mg Capsule with Ziprasidone together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.

TacrolimusCidofovir

Critical

How does the drug interact with Prograf 0.5 mg Capsule:
Taking cidofovir with Prograf 0.5 mg Capsule can increase the risk of kidney problems.

How to manage the interaction:
Taking Prograf 0.5 mg Capsule with Cidofovir is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor immediately if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without first talking to your doctor.

TacrolimusNeomycin

Severe

How does the drug interact with Prograf 0.5 mg Capsule:
Taking Prograf 0.5 mg Capsule with neomycin may increase risk of kidney problems.

How to manage the interaction:
Although taking Prograf 0.5 mg Capsule and neomycin together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.

TacrolimusHydroxychloroquine

Severe

How does the drug interact with Prograf 0.5 mg Capsule:
Taking Prograf 0.5 mg Capsule and Hydroxychloroquine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Prograf 0.5 mg Capsule and Hydroxychloroquine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.

TacrolimusColchicine

Severe

How does the drug interact with Prograf 0.5 mg Capsule:
Coadministration of colchicine and Prograf 0.5 mg Capsule increases colchicine levels in the blood.

How to manage the interaction:
Although taking Colchicine and Prograf 0.5 mg Capsule together may possibly result in an interaction, they can be taken together if your doctor prescribes it. However, if you experience any symptoms like nausea, vomiting, abdominal pain, numbness or tingling in your hands and legs, muscle pain, or weakness, contact your doctor immediately. Do not discontinue any medication without consulting your doctor.

TacrolimusIbandronic acid

Severe

How does the drug interact with Prograf 0.5 mg Capsule:
Taking Prograf 0.5 mg Capsule and Ibandronic acid together may increase the risk of kidney problems.

How to manage the interaction:
Although taking Prograf 0.5 mg Capsule and Ibandronic acid together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

TACROLIMUS-0.5MGGrapefruit and Grapefruit Juice

Moderate

Drug-Food Interactions

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TACROLIMUS-0.5MGGrapefruit and Grapefruit Juice

Moderate

Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking of grapefruit or grapefruit juice while on Prograf 0.5 mg Capsule treatment may lead to increased Prograf 0.5 mg Capsule levels in blood. Avoid or limit grapefruit or grapefruit juice intake during treatment with Prograf 0.5 mg Capsule.

Diet & Lifestyle Advise

Eat a balanced diet rich in fruits, vegetables, whole grains, lean proteins, and healthy fats to support immune system balance and overall recovery after transplant.
Limit salt intake to help manage blood pressure, which can be affected by Tacrolimus and other transplant medications.
Avoid grapefruit and grapefruit juice, as they can increase Tacrolimus levels in the blood and raise the risk of side effects.
Stay hydrated by drinking enough water daily to support kidney function and prevent dehydration.
Limit alcohol consumption or avoid it entirely, as it can stress the liver and interfere with medication effectiveness.
Avoid undercooked or raw meat, seafood, and unpasteurised dairy products to reduce the risk of infections that can compromise your immune system.
Practice good hand hygiene and food safety to minimise exposure to harmful bacteria or viruses.
Maintain a healthy weight through a balanced diet and light physical activity, as recommended by your doctor.
Avoid herbal supplements or over-the-counter medicines without medical advice, as they can interact with Tacrolimus and other immunosuppressants.
Manage stress and get adequate rest, as this supports immune health and overall well-being during long-term transplant recovery.

Habit Forming

No

Therapeutic Class

[IMMUNOSUPPRESSANTS]

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Alcohol

Safe if prescribed

Avoid alcohol consumption with Prograf 0.5 mg Capsule as it may increase the risk of adverse effects. Please consult a doctor before consuming alcohol with Prograf 0.5 mg Capsule .

Pregnancy

Consult your doctor

Using Tacrolimus during pregnancy may cause kidney dysfunction or neonatal hyperkalemia (high potassium levels in the blood). Therefore, please consult a doctor if you are pregnant before taking Prograf 0.5 mg Capsule and if you are a woman of childbearing age, use effective contraceptive methods while using Prograf 0.5 mg Capsule .

Breast Feeding

Consult your doctor

Prograf 0.5 mg Capsule may be excreted in breast milk. Therefore, please inform your doctor if you are a breastfeeding mother before taking Prograf 0.5 mg Capsule . You should avoid taking Prograf 0.5 mg Capsule during breastfeeding or avoid breastfeeding while on treatment with Prograf 0.5 mg Capsule .

Driving

Safe if prescribed

Prograf 0.5 mg Capsule may cause vision problems or nervous disturbances in a few people. Therefore, avoid driving if you experience any of these symptoms after taking Prograf 0.5 mg Capsule .

Liver

Consult your doctor

Please consult a doctor if you have liver diseases/conditions before taking Prograf 0.5 mg Capsule .

Kidney

Consult your doctor

Please consult a doctor if you have Kidney diseases/conditions before taking Prograf 0.5 mg Capsule .

Children

Safe if prescribed

Prograf 0.5 mg Capsule should be used in children in doses as advised by a doctor only.

Heart

Prograf 0.5 mg Capsule can be used in heart patients, especially post-transplant, but it require close monitoring due to risks like arrhythmias, hypertension, and kidney strain. Always consult your cardiologist before starting, as dose adjustments and regular ECG and blood tests may be necessary.

Geriatrics

Consult your doctor

Prograf 0.5 mg Capsule can be taken by geriatric patients, but they require careful monitoring due to increased sensitivity to side effects like kidney dysfunction and high blood pressure. Dose adjustments and regular blood tests are essential to ensure safety and effectiveness.

FAQs

Country of origin

INDIA

Manufacturer/Marketer address

Astellas Pharma India Pvt Ltd, 301, 3rd Floor, C and B Square, 127 Andheri Kurla Road, Chakala, Andheri East, Mumbai 400 069.

Other Info - PRO0894

Author Details

Written By

Veda Maddala

M Pharmacy

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Oct 14, 2025 | 1:05 PM IST

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