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compositionComposition:CARBOPROST-250MCG
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Prescription Medicine
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PROSTODIN 0.25MG AMPULE 1ML is used for the initiation or improvement of uterine contraction and producing uterine contraction during the third stage of labour. Besides this, it also controls postpartum bleeding or haemorrhage after childbirth. PROSTODIN 0.25MG AMPULE 1ML is also used for the medical termination of the pregnancy between the 13th to 20th week of pregnancy (second trimester of the pregnancy).

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CARBOPROST-250MCG

Manufacturer/Marketer :

Astra Zeneca Pharma India Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About PROSTODIN 0.25MG AMPULE 1ML

PROSTODIN 0.25MG AMPULE 1ML is a specialised prescription injection used to treat severe, life-threatening bleeding after childbirth, a condition known as postpartum haemorrhage, when other standard treatments have not worked. It is also used to end a pregnancy during the second trimester, typically between the 13th and 20th weeks. This medication works by causing strong contractions in the uterus, which helps compress bleeding blood vessels or safely empty the uterine cavity.

Because this medication is used for emergencies or specific medical procedures, it is not given on a regular daily schedule. A trained healthcare professional will inject it into a muscle in a hospital or clinic setting, sometimes repeating the dose at specific intervals depending on your body's response. There are no routine lifestyle or diet changes required to make this medicine work, though resting and staying hydrated after your procedure is highly recommended.

Common side effects of this injection include diarrhoea, nausea, vomiting, fever, chills, and a temporary warm, flushed feeling. While these mild reactions are very common due to how the medicine acts on smooth muscles, you must alert your healthcare team immediately if you experience severe shortness of breath, sudden chest tightness, or signs of a severe allergic reaction.

Before receiving this medicine, tell your doctor if you have a history of asthma, high blood pressure, diabetes, or heart problems. Do not take this if you have active pelvic inflammatory disease or severe untreated diseases of the lungs, heart, kidneys, or liver, as this medication can worsen these conditions.

This injection can interact with other medicines that cause uterine contractions, which may increase the risk of uterine damage. Since it is intended for specific reproductive health situations, its use in breastfeeding or elderly individuals is limited and requires careful discussion with a healthcare provider to ensure safety.

Uses of PROSTODIN 0.25MG AMPULE 1ML

PROSTODIN 0.25MG AMPULE 1ML is used to treat severe, life-threatening bleeding after childbirth, a condition known as postpartum haemorrhage, when other standard treatments have not worked. The detailed uses of PROSTODIN 0.25MG AMPULE 1ML are as follows:

  • Postpartum Haemorrhage: It is used to control severe, ongoing bleeding after giving birth when other methods have failed. It does this by making the uterine muscles contract, which squeezes the bleeding blood vessels shut.
  • Pregnancy Termination: It is used to end a pregnancy during the second trimester (weeks 13 to 20). It stimulates uterine contractions to help empty the uterus safely under medical supervision.

Key Benefits

This medication offers critical, life-saving benefits during obstetrical emergencies and specific medical procedures:

  • Rapid control of severe bleeding: For mothers experiencing severe bleeding after delivery, this injection acts within minutes to contract the uterus, stopping blood loss quickly and preventing dangerous complications like shock.
  • Reliable uterine emptying: In medical procedures where a pregnancy must be ended or in cases of incomplete miscarriage, it provides a highly effective, predictable way to clear the uterus without always needing immediate major surgery.
Side effects of Prostodin 0.25mg Ampule 1ml
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
Managing Medication-Triggered Flushing (Reddening of the skin): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
  • Always wear loose-fitting clothes suitable for your activity during hot flashes.
  • Include a diet containing fruits like watermelon, grapes, bananas and green leafy vegetables.
  • Drink plenty of water and stay hydrated.
  • Stay calm and lower your anxiety by practising yoga or meditation.
  • Rest well; get enough sleep.
  • Wear comfortable layers of clothes and get to a warm place.
  • Drink warm fluids like coffee, tea or hot chocolate.
  • Warm up using a blanket or heating pad.

Directions for Use

  • Follow your doctor’s recommendations on the dosage and timing of this medication to achieve optimal results.
  • PROSTODIN 0.25MG AMPULE 1ML will be administered by a healthcare professional.
  • Do not self-administer.

How PROSTODIN 0.25MG AMPULE 1ML Works

PROSTODIN 0.25MG AMPULE 1ML contains carboprost, which is a synthetic form of a naturally occurring substance in the body called a prostaglandin. It targets the smooth muscles of the uterus, causing them to contract strongly. These contractions mimic natural labour or the natural postpartum process. By forcing the uterus to contract and tighten, it directly compresses the open blood vessels that feed the placenta, stopping heavy bleeding quickly. Additionally, it can stimulate the muscles of the digestive tract, which explains why some patients experience temporary stomach upset during treatment.
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Alcohol

Unsafe

Avoid or limit consumption of alcohol after taking PROSTODIN 0.25MG AMPULE 1ML as it may cause serious side effects.

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Pregnancy

Safe if prescribed

PROSTODIN 0.25MG AMPULE 1ML is used to induce contractions in the uterus. Hence, it is considered safe to be used during pregnancy. PROSTODIN 0.25MG AMPULE 1ML is also used for medical termination of pregnancy.

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Breast Feeding

Caution

It is unknown whether PROSTODIN 0.25MG AMPULE 1ML passes into breast milk or if it could harm a nursing baby. If you are breastfeeding, inform your doctor before taking PROSTODIN 0.25MG AMPULE 1ML.

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Driving

Unsafe

Patients should refrain from driving until they know that PROSTODIN 0.25MG AMPULE 1ML does not affect their ability to drive or use machines.

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Liver

Caution

If you have a history or a pre-existing liver disease, inform your doctor before receiving this injection. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition. PROSTODIN 0.25MG AMPULE 1ML is contraindicated in patients with severe active hepatic disease.

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Kidney

Caution

PROSTODIN 0.25MG AMPULE 1ML to be taken with caution, especially if you have a history of kidney diseases. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Unsafe

PROSTODIN 0.25MG AMPULE 1ML is not recommended for children under the age of 18. The safety and effectiveness of PROSTODIN 0.25MG AMPULE 1ML have not been established in children due to limited testing of this drug on children by competent authorities worldwide.

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Heart

Unsafe

This medicine is not recommended in cardiac patients due to its adverse effects. However, if prescribed extreme caution should be exercised.

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Geriatrics

Consult your doctor

The safety and efficacy of PROSTODIN 0.25MG AMPULE 1ML in elderly patients is not established.

What if I have taken an overdose of PROSTODIN 0.25MG AMPULE 1ML

Because this injection is administered by trained professionals, an overdose is rare. However, if too much is given, it can cause severe uterine spasms, high blood pressure, or intense breathing difficulties. Your clinical team will monitor you closely and treat any symptoms immediately. If you suspect an issue, alert your doctor or nurse right away.

Diet & Lifestyle Advise

  • Stay hydrated: Drink plenty of water and clear fluids to replace fluids lost from sweating, vomiting, or diarrhoea, which are common side effects of this medicine.
  • Rest: Rest quietly in bed after receiving the injection to allow your uterus to recover and to avoid dizziness from sudden blood pressure changes.
  • Gentle nutrition: Stick to bland, simple foods (like crackers, toast, or rice) once your doctor says you can eat, as this helps soothe your stomach after experiencing nausea or diarrhoea.
  • Avoid strenuous activity: Avoid lifting heavy objects or engaging in intense physical exercise until your doctor confirms your body has fully recovered from childbirth or the medical procedure.
health query

Have a query?

How Soon It Starts Working

The time required for PROSTODIN 0.25MG AMPULE 1ML to start to work: The time required for PROSTODIN 0.25MG AMPULE 1ML to start to work is immediately after administration. The time for which the effects of PROSTODIN 0.25MG AMPULE 1ML last: The duration of action for PROSTODIN 0.25MG AMPULE 1ML is unknown.

What if you forget to take PROSTODIN 0.25MG AMPULE 1ML

Since this medicine is given by a healthcare provider in a controlled clinical environment as needed, a missed dose is highly unlikely. Your clinical team will manage the schedule closely.

Storage

•PROSTODIN 0.25MG AMPULE 1ML must be kept in a refrigerator at a temperature between 2°C and 8°C (36°F to 46°F). •Keep the medicine in its original carton to protect it from light.
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Keep Refrigerated. Do not freeze.

Drug Warnings

  • Check the solution: Before use, your healthcare provider will inspect the vial. The liquid should be clear and colourless to pale yellow. Do not use if there are particles or discolouration.
  • Asthma warning: Alert your medical team immediately if you have asthma. This medication can tighten the airways, making it dangerous for people with active asthma.
  • Blood pressure checks: Expect frequent blood pressure monitoring during and after the injection, as this drug can cause a sudden, temporary rise in blood pressure.
  • Uterine monitoring: Your healthcare provider will physically check your abdomen to ensure the uterus is contracting properly and tightening up.

Drug-Drug Interactions

verifiedApollotooltip
  • Other oxytocic medicines (e.g., oxytocin): Combining PROSTODIN 0.25MG AMPULE 1ML with other medicines that stimulate uterine contractions is generally not recommended, as it may cause excessively strong or prolonged contractions, increasing the risk of uterine rupture or other serious complications. This combination should only be used under specialist medical supervision when clinically indicated.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with PROSTODIN 0.25MG AMPULE 1ML when used as directed. 

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[OXYTOCIC, UTEROTONIC, ECBOLIC]

FAQs

PROSTODIN 0.25MG AMPULE 1ML is used for the initiation or improvement of uterine contraction (antepartum) and producing uterine contraction during the third stage of labour. Besides this, it also controls postpartum bleeding or haemorrhage after childbirth. It is also used for the medical termination of the pregnancy between the 13th to 20th week of pregnancy (second trimester of the pregnancy).
PROSTODIN 0.25MG AMPULE 1ML contains carboprost that stimulates contraction of the uterine muscles, helping to control post-delivery bleeding.
If you have a previous premature delivery or a c-section, or cervical surgery, please inform your doctor before starting PROSTODIN 0.25MG AMPULE 1ML. Also, mention a detailed medical history to your doctor to avoid complications.
No, PROSTODIN 0.25MG AMPULE 1ML is not known to affect any future chances of fertility. PROSTODIN 0.25MG AMPULE 1ML is used for medical abortion of pregnancy.
You should not receive PROSTODIN 0.25MG AMPULE 1ML, if you have a pelvic inflammatory disease, breathing disorder, heart fitted with an artificial valve, heart diseases like high blood pressure or high blood cholesterol levels (increased fat in your blood), have asthma, have blood clot problems, have a bleeding disorder, have liver or kidney disease, have anaemia (low haemoglobin) or otherwise malnourished. Taking PROSTODIN 0.25MG AMPULE 1ML in these conditions can cause life-threatening conditions in an individual. Please inform your doctor, your doctor will decide whether to give PROSTODIN 0.25MG AMPULE 1ML.
After taking PROSTODIN 0.25MG AMPULE 1ML, you may or may not experience vaginal bleeding, which is not an indication of complete abortion. Your doctor will examine by ultrasonography to confirm if the abortion is complete.
The most common side effects of PROSTODIN 0.25MG AMPULE 1ML include nausea, vomiting, headache, diarrhoea, and increased or decreased blood pressure. You might also feel increased uterine contractions for some time, but these are manageable under medical supervision.
The dose of PROSTODIN 0.25MG AMPULE 1ML can vary depending on the individual medical condition. Your doctor will decide the dose based on your medical condition.
It is given as an injection directly into a muscle, usually in the thigh or buttock, by a trained healthcare professional in a hospital or clinic. It is never self-administered at home. Talk to your doctor if you have questions about the injection process.
Depending on how your body responds and whether the bleeding stops, your doctor may decide to give you additional doses spaced at least 15 to 90 minutes apart. Talk to your doctor to understand your specific treatment plan.
It is not fully known how much of this medicine passes into breast milk. If you are breastfeeding, discuss this with your healthcare provider before the procedure so they can advise you on the safest timing for feeding your baby. Talk to your doctor or pharmacist for personalised guidance.
Although rare, a severe allergic reaction can occur. Look out for sudden hives, swelling of your face, lips, tongue, or throat, and severe dizziness or trouble breathing. If you experience any of these, alert your healthcare provider immediately.
This medication stimulates smooth muscle tissue. While its main target is the uterus, it also stimulates the smooth muscles of your digestive tract, which can lead to temporary diarrhoea and nausea. Talk to your doctor or pharmacist if these symptoms become severe.
No, this injection is only used to end a pregnancy under specific medical conditions or to treat severe bleeding after childbirth. It should never be used during a normal pregnancy that you intend to carry to term. Talk to your doctor for more information.
No, this medication can cause your airways to tighten (bronchospasm), which can be highly dangerous if you have asthma. Be sure to tell your healthcare provider if you have any history of breathing problems. Talk to your doctor about safer alternatives.

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Country of origin

India

Manufacturer/Marketer address

Corporate & Registered Office, Block N1, 12th Floor, Manyata Embassy Business Park, Rachenahalli, Outer Ring Road, 560045, Bangalore
Other Info - PRO0068
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