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compositionComposition:DOSULEPIN-50MG+METHYLCOBALAMIN-1500MCG
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Prescription Medicine
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Prothiaden M 50 Tablet is used in the treatment of depression. It contains Dosulepine and Methylcobalamin, which increase neurotransmitter (serotonin and noradrenaline) activity in the brain that regulates mood, memory, and the ability to concentrate. It may cause common side effects, such as dry mouth, blurred vision, headache, increased or decreased appetite, nausea or vomiting, diarrhoea, changes in heartbeat, constipation, difficulty urinating, and sweating. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

DOSULEPIN-50MG+METHYLCOBALAMIN-1500MCG

Manufacturer/Marketer :

Abbott India Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Prothiaden M 50 Tablet

Prothiaden M 50 Tablet is a prescription oral medicine used to manage chronic nerve pain, also known as neuropathic pain. It is commonly prescribed for conditions like diabetic neuropathy, shingles, or back pain where nerves are irritated or damaged. This medication helps relieve persistent discomfort and improves daily physical functioning.

To get the best results, you must take Prothiaden M 50 Tablet regularly at the same time every day, exactly as directed by your healthcare provider. It is typically taken once daily, often at bedtime because it can make you feel sleepy. You can take this medicine with or without food. Making healthy lifestyle choices, such as eating a nutrient-rich diet and doing gentle stretching exercises, can further support your nerve recovery.

Some people taking this medicine may experience mild side effects like drowsiness, a dry mouth, or mild constipation. These effects often improve as your body gets used to the medication. However, if you experience serious symptoms such as a rapid or irregular heart rate, severe dizziness, difficulty passing urine, or sudden mood changes, you must contact your doctor immediately.

Talk to your doctor before starting Prothiaden M 50 Tablet if you have a history of heart problems, glaucoma, liver damage, or urinary difficulties. Do not take this medicine if you have recently had a heart attack or if you are currently taking certain medicines for depression known as MAO inhibitors.

This medication can interact with alcohol, which can cause extreme drowsiness and increase the risk of side effects. Avoid smoking, as it may decrease how well the medication works in your body. If you are pregnant, planning a pregnancy, breastfeeding, or are an older adult, consult your healthcare provider to ensure this treatment is safe for you.
 

Uses of Prothiaden M 50 Tablet

Prothiaden M 50 Tablet is used to manage chronic nerve pain. The detailed uses of Prothiaden M 50 Tablet are as follows:

  • Neuropathic Pain: Prothiaden M 50 Tablet helps soothe irritated nerves, reducing the burning, tingling, or stabbing sensations associated with conditions like diabetic nerve damage or shingles.
  • Chronic Pain Syndromes: In some cases, this medicine may be used off-label to manage certain long-term pain conditions, such as fibromyalgia, only under specialist medical guidance when your healthcare provider considers it appropriate.
  • Nerve Regeneration: It supports the repair of the protective covering around nerves, helping to restore normal nerve function and reduce numbness.

 

Key Benefits

Prothiaden M 50 Tablet helps support nerve health by relieving symptoms of nerve damage and promoting healthy nerve function. By addressing nutritional deficiencies and supporting nerve repair, it helps improve comfort and overall quality of life.

  • Helps Relieve Nerve Pain and Discomfort: By supporting healthy nerve function, Prothiaden M 50 Tablet helps reduce symptoms such as tingling, numbness, burning sensations, and nerve pain, allowing you to carry out daily activities more comfortably.
  • Supports Nerve Repair and Recovery: Prothiaden M 50 Tablet helps nourish damaged nerves and supports their natural repair process, promoting healthier nerve function over time.
  • Promotes Better Sleep and Daily Wellbeing: By reducing nerve discomfort, particularly at night, Prothiaden M 50 Tablet helps improve sleep quality, allowing you to wake up feeling more rested and better able to manage your daily routine.
     
Side effects of Prothiaden M 50 Tablet
  • Get enough sleep. Maintain a regular sleep cycle.
  • Eat a healthy diet and exercise regularly.
  • Manage stress with yoga or meditation.
  • Limit alcohol and caffeine.
  • Avoid driving or operating machinery unless you are alert.
  • Change positions or take a break from activity to relieve symptoms.
  • Avoid postures that put a lot of pressure on just one area of the body.
  • If you have vitamin deficiency, take supplements or change your diet.
  • Exercise regularly like cycling, walking or swimming.
  • Avoid sitting with your legs crossed.
  • Clench and unclench your fists and wiggle your toes.
  • Massage the affected area.
  • Maintain consistent habits, sleep patterns and food times to help maintain stability and reduce confusion.
  • Mindfulness techniques such as deep breathing or meditation help you stay focused and in the now.
  • Participate in cognitive therapy to enhance your ability to remember, focus and solve problems.
  • As directed by your physician, take your medications to help control underlying disorders like depression, anxiety or cognitive impairment.
  • Always wear loose-fitting clothes which are suitable for your activity.
  • Include the diet containing fruits like watermelon, grapes, bananas and green leafy vegetables.
  • Drink plenty of water stay hydrated.
  • Avoid moving more and staying in hot sun.
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.

Directions for Use

  • Take Prothiaden M 50 Tablet with or without food or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure its safety.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Prothiaden M 50 Tablet Works

Prothiaden M 50 Tablet is a combination medicine that works in two distinct ways to relieve nerve pain and restore nerve health. The first active ingredient, dosulepin, is a tricyclic antidepressant that helps relieve neuropathic pain through multiple mechanisms. It inhibits the reuptake of the neurotransmitters serotonin and noradrenaline, increasing their availability in the brain and spinal cord to strengthen the body's natural pain-control pathways. It also has sodium channel-modulating effects, which may help reduce abnormal pain signalling from damaged nerves, contributing to relief of chronic nerve pain. The second active ingredient, methylcobalamin, is a highly active form of vitamin B12. It helps produce a vital substance called myelin, which forms a protective sheath around your nerves. By rebuilding this protective layer, it aids in repairing damaged nerve cells and restores proper nerve signalling.
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Alcohol

Unsafe

Alcohol increases the risk of side effects.

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Pregnancy

Unsafe

Prothiaden M 50 Tablet is a category C drug. So, it is not recommended for use in pregnant women.

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Breast Feeding

Consult your doctor

Prothiaden M 50 Tablet should be used with caution in breastfeeding mothers.

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Driving

Unsafe

Prothiaden M 50 Tablet may cause drowsiness. So, do not drive or operate heavy machinery while taking this medicine.

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Liver

Caution

Prothiaden M 50 Tablet should be used with caution in patients with liver diseases. Dose adjustments may be necessary.

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Kidney

Caution

Prothiaden M 50 Tablet should be used with caution in patients with kidney diseases. Dose adjustments may be necessary.

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Children

Consult your doctor

Prothiaden M 50 Tablet should not be used in children below 12 years of age without a doctor's advice.

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Heart

Unsafe

Prothiaden M 50 Tablet is not recommended for use in heart patients due to its adverse effects.

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Geriatrics

Caution

Prothiaden M 50 Tablet should be given with caution in elderly patients due to an increased risk of side effects. Seek medical advice before using Prothiaden M 50 Tablet .

What if I have taken an overdose of Prothiaden M 50 Tablet

If you suspect an overdose, seek emergency medical care immediately. Symptoms of an overdose may include extreme drowsiness, rapid heart rate, severe confusion, or seizures.

Diet & Lifestyle Advise

  • Eat a diet rich in B-vitamins, including leafy greens, eggs, and fortified foods, to support natural nerve health and recovery.
  • Stay well-hydrated and increase your fibre intake to prevent constipation, which is a common side effect of this medicine.
  • Engage in gentle, low-impact exercises like walking or swimming to promote blood circulation to your nerves, unless advised otherwise by your physician.
  • Avoid alcohol completely while taking this medication, as it can dangerously increase drowsiness and dizziness.
     

Health Queries

I am taking Prothiaden M 50, Provanol Plus 5, and Naxdom 250 for dizziness, but my symptoms are not improving. Can these medications cause constipation as a side effect and worsen my piles, and what alternative treatment options do I have?

G.santoshini Reddy

G.santoshini Reddy

M Pharmacy (Pharmaceutics)

Yes, your medications specifically the tricyclic antidepressant (dosulepin) and calcium channel blocker (flunarizine) components commonly cause constipation. This straining can certainly worsen your piles. Since your dizziness is not improving, please consult your doctor before making changes. They can safely adjust your doses or switch you to alternative treatments with fewer digestive side effects, such as alternative migraine preventatives or vestibular physical therapy. For immediate relief from constipation, increase your water and fiber intake, and ask your doctor about a safe stool softener. Do not stop your current medications abruptly.
health query

Have a query?

How Soon It Starts Working

The time required for Prothiaden M 50 Tablet to start to work: The time required for Prothiaden M 50 Tablet to show its action is unknown. The time for which the effects of Prothiaden M 50 Tablet last: The duration of action for Prothiaden M 50 Tablet is unknown.

What if you forget to take Prothiaden M 50 Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store Prothiaden M 50 Tablet at room temperature, ideally between 15°C and 30°C (59°F to 86°F).

Drug Warnings

  • Check your medication packaging before each use to ensure the tablets are intact and have not changed colour.
  • Avoid driving, operating heavy machinery, or performing tasks that require alertness until you know how this medicine affects you, as it can cause significant drowsiness.
  • Stand up slowly from a sitting or lying position to reduce the risk of dizziness and prevent falls.
  • Do not stop taking this medication suddenly, as doing so can lead to withdrawal symptoms like headache, nausea, or irritability; your doctor will guide you on gradually reducing your dose safely.
  • Always inform any healthcare provider, including dentists or surgeons, that you are taking this medicine before undergoing any procedures.
     

Drug-Drug Interactions

verifiedApollotooltip
  • MAO Inhibitors (MAOIs): Do not take this medicine with or within 14 days of taking MAOIs, as this can lead to dangerously high blood pressure or serious brain reactions.
  • Sedatives and Sleeping Pills: Combining this medicine with other sedatives can cause severe drowsiness and slow breathing.
    Antihistamines: May increase the risk of dry mouth, constipation, and blurred vision.
  • Blood Pressure Medications: May affect how certain blood pressure drugs work, potentially causing sudden drops in blood pressure when standing.

 

Dosulepin + MecobalaminParoxetine
Severe
Dosulepin + MecobalaminAmitriptyline
Severe

Drug-Drug Interactions

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Dosulepin + MecobalaminParoxetine
Severe
How does the drug interact with Prothiaden M 50 Tablet:
Coadministration of Prothiaden M 50 Tablet together with paroxetine might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Although taking Prothiaden M 50 Tablet together with paroxetine can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience confusion, increased heart rate, fever, excessive sweating, blurred vision, muscle spasms, nausea, vomiting, and diarrhea contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Dosulepin + MecobalaminAmitriptyline
Severe
How does the drug interact with Prothiaden M 50 Tablet:
Co-administration of Prothiaden M 50 Tablet with Amitriptyline may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Prothiaden M 50 Tablet with Amitriptyline may result in an interaction, it can be used when a doctor recommends it. If you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, contact a doctor immediately. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Consuming alcohol with this medicine increases the risk of extreme drowsiness, coordination issues, and liver strain.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIDEPRESSANT]

FAQs

Prothiaden M 50 Tablet is used in the treatment of depression.
Prothiaden M 50 Tablet contains Dosulepin and Methylcobalamin. It treats depression by enhancing mood, improving memory, and also reduces problems associated with sleeping and eating. It also treats vitamin B12 deficiency, which is a risk factor for depression.
Prothiaden M 50 Tablet should not be used in patients with heart problems as it may worsen the condition. Discuss the potential benefits and risks with your doctor before using Prothiaden M 50 Tablet .
The common side effects of Prothiaden M 50 Tablet are dry mouth, blurred vision, headache, increased or decreased appetite, nausea or vomiting, diarrhoea, changes in heartbeat, constipation, difficulty urinating, and sweating. If the symptoms persist or worsen, consult a doctor immediately.
Prothiaden M 50 Tablet should not be used in patients with thyroid problems as it may exacerbate the condition by causing iatrogenic effects (drug-inducing side effects). So, discuss the risks and benefits of this medication with your doctor before using Prothiaden M 50 Tablet .
Prothiaden M 50 Tablet increases suicidal thoughts and worsens depression in young adults. Your doctor may prescribe this medicine with adjustments to the dose. So, do not use Prothiaden M 50 Tablet without consulting your doctor.
No, Prothiaden M 50 Tablet isn’t a muscle relaxant. It belongs to a class of medicines called antidepressants used in the treatment of depression.
Prothiaden M 50 Tablet and doxepin are different medications but belong to a similar chemical class. In low doses, doxepin can help patients with insomnia to sleep better. It is also available in a topical form for treating various neurodermatitis syndromes, particularly for relieving itching.
You are recommended to stop Prothiaden M 50 Tablet after consulting a doctor. So that you can gradually reduce the dose of Prothiaden M 50 Tablet as discontinuing suddenly may cause blurred vision, anxiety, aggression, constipation, and concentration impairment.
Prothiaden M 50 Tablet is generally not fatal when taken as prescribed. However, taking too much or using it incorrectly can lead to life-threatening or serious side effects such as irregular heartbeat, fast heart rate, hyperthermia (elevated body temperature), or orthostatic hypotension. If you experience any of these symptoms, seek medical treatment immediately.
You are recommended to avoid taking Prothiaden M 50 Tablet with diazepam as it can increase the chances of side effects like sleepiness or drowsiness. However, consult your doctor before taking Prothiaden M 50 Tablet with other medicines to avoid possible interactions.
No, Prothiaden M 50 Tablet is not recommended for treating trigeminal neuralgia. Trigeminal neuralgia is a chronic pain condition that affects the trigeminal nerve (the 5th cranial nerve), one of the most widely distributed nerves in the head.
No, Prothiaden M 50 Tablet is not used for treating burning mouth syndrome. This condition causes burning, scalding, tingling, or numb sensation in the mouth, which can occur daily for months or even longer. Consult a doctor immediately if the condition persists for longer.
No, Prothiaden M 50 Tablet is not recommended for treating Irritable Bowel Syndrome (IBS). IBS is a functional gastrointestinal disorder marked by chronic or recurring stomach pain or discomfort, along with changes in bowel habits.
Yes, Prothiaden M 50 Tablet may help to treat sleep problems (insomnia) with depression. Its calming effects make it useful for improving sleep in those with depression. Therefore, please consult your doctor before taking Prothiaden M 50 Tablet . Do not self-medicate.
Prothiaden M 50 Tablet may not be approved for treating fibromyalgia. Fibromyalgia is a chronic pain condition that causes widespread tenderness but doesn’t involve actual damage to muscles, ligaments, or joints. Consult your doctor before using Prothiaden M 50 Tablet .
Yes, Prothiaden M 50 Tablet may be used for nerve pain. Consult with and follow the instructions provided by the physician for Prothiaden M 50 Tablet , as advised, to minimise potential side effects. Do not self-medicate.
This medicine frequently causes drowsiness and blurred vision, especially when you first start taking it. You should avoid driving or operating machinery until you know how it affects your alertness. Talk to your doctor if you have concerns.
No, you should avoid alcohol while taking this medicine. Alcohol can significantly increase the central nervous system (CNS) depressant effects of the medication, leading to excessive drowsiness, dizziness, impaired coordination, slower reaction times, and an increased risk of falls or accidents. Talk to your doctor or pharmacist if you have questions about alcohol use during treatment.
This medicine is generally not recommended during pregnancy unless your doctor decides the benefits outweigh the risks. If you are pregnant or planning to become pregnant, talk to your doctor before starting this treatment.
Dry mouth is a common side effect of this medicine. You can manage it by taking frequent sips of water, chewing sugarless gum, or using a saliva substitute. Talk to your doctor or pharmacist if the problem persists.
No, do not stop taking this medicine abruptly even if you feel better. Stopping suddenly can cause withdrawal symptoms or cause your pain to return. Your doctor will help you by gradually decreasing the dose over time. Talk to your doctor before making any changes.
Some people may experience an increased appetite or weight changes while taking this medication. Maintaining a balanced diet and regular physical activity can help manage this. Talk to your doctor if you notice significant changes in your weight.
It is usually recommended to take this medicine once daily at bedtime because it can make you feel sleepy. However, always follow the specific timing and schedule advised by your doctor.

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While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

16th Floor, Godrej BKC, Plot – C, “G” Block, Bandra-Kurla Complex, Bandra (East), Mumbai – 400 051, India
Other Info - PRO1514

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