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compositionComposition:PRUCALOPRIDE-2MG
prescription
Prescription Medicine
info
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Prulizest-2 Tablet 10's is used to treat chronic idiopathic constipation(long-term constipation with no known cause). It contains prucalopride, which works on the muscles of the gut to increase movement and help restore normal bowel function. In some cases, this medicine may cause side effects, such as headache, diarrhoea, nausea, and abdominal pain. Before using Prulizest-2 Tablet 10's, tell your doctor if you are pregnant, breastfeeding, taking other medications, or have any existing health conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PRUCALOPRIDE-2MG

Manufacturer/Marketer :

CAPRION PHARMA PVT LTD

Consume Type :

Oral

Expires on or after :

Jan-29

Return Policy :

Not Returnable

About Prulizest-2 Tablet 10's

Prulizest-2 Tablet 10's is a prescription medication used to treat chronic idiopathic constipation in adults who have not found sufficient relief from other laxatives. It helps restore the natural movement of your bowels, making it easier to pass stool regularly. This medication acts on the gut to help you establish a more consistent and comfortable bathroom routine.

This medication is typically taken once daily, and it is important to take it consistently at the same time each day to maintain its beneficial effects. You can take Prulizest-2 Tablet 10's with or without food, as your daily meals do not change how the medicine is absorbed in your body. Along with taking this medicine, drinking plenty of water and eating a fibre-rich diet can help improve your overall results.

Some people may experience mild, temporary side effects when starting this medication, such as headaches, nausea, or mild stomach pain. These symptoms usually improve after a few days as your body adjusts to the treatment. However, if you develop severe diarrhoea, intense abdominal cramping, or sudden mood changes, you should consult your doctor immediately.

Before taking Prulizest-2 Tablet 10's, talk to your doctor if you have a history of kidney disease, liver damage, or heart problems. Do not take this if you have a blockage in your bowel, a tear in your intestinal wall, or severe inflammatory bowel diseases like Crohn's disease or ulcerative colitis. Your doctor will help determine if this treatment is safe and appropriate for your medical history.

Some medicines can interfere with how this drug works, and drinking alcohol may worsen stomach upset or dizziness during treatment. If you are pregnant, planning to become pregnant, breastfeeding, or are over the age of 65, talk to your doctor or pharmacist to ensure this treatment is safe for your specific situation.

Uses of Prulizest-2 Tablet 10's

Your doctor may prescribe Prulizest-2 Tablet 10's for the following condition:

  • Chronic idiopathic constipation: Prulizest-2 Tablet 10's helps by stimulating the natural muscle contractions in your colon, allowing for more frequent and comfortable bowel movements when standard laxatives have not worked.

Key Benefits

Taking Prulizest-2 Tablet 10's can significantly improve your daily comfort and quality of life by addressing the root cause of chronic constipation. Here are the key benefits of this treatment:

  • Restores natural bowel rhythm: Instead of simply softening stool, it helps your intestines move naturally, encouraging a more predictable and regular bowel schedule.
  • Reduces abdominal discomfort: By promoting regular bowel movements, it helps relieve the painful bloating, straining, and fullness associated with chronic constipation.
  • Provides long-term relief: Unlike some temporary over-the-counter laxatives, this medication is designed to support ongoing bowel function for individuals dealing with long-term, unexplained constipation.

Directions for Use

  • Prulizest-2 Tablet 10's can be taken with or without food.
  • It is recommended to take Prulizest-2 Tablet 10's once daily or as advised by your doctor.
  • Swallow Prulizest-2 Tablet 10's as a whole with a glass of water.
  • Do not break, chew, or crush it.

How Prulizest-2 Tablet 10's Works

Prulizest-2 Tablet 10's contains prucalopride, which works by targeting specific receptors in the walls of your intestines, known as 5-HT4 receptors. These receptors are responsible for sending signals to the muscles in your digestive tract to contract and move waste through your system. When you take Prulizest-2 Tablet 10's, it activates these receptors, which stimulate the natural squeezing motion of your colon (known as peristalsis). This increased movement helps push stool through your bowels more efficiently, making your bowel movements more regular and decreasing the need to strain.
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Alcohol

Consult your doctor

It is not known if alcohol interacts with Prulizest-2 Tablet 10's. Please consult your doctor if you have any concerns regarding this.

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Pregnancy

Unsafe

Prulizest-2 Tablet 10's is not recommended during pregnancy. Use a reliable method of contraception while taking Prulizest-2 Tablet 10's. Inform your doctor if you are pregnant, think you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Prulizest-2 Tablet 10's might pass into breastmilk. Avoid breastfeeding while taking Prulizest-2 Tablet 10's.

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Driving

Caution

Prulizest-2 Tablet 10's is unlikely to affect your ability to drive. However, sometimes Prulizest-2 Tablet 10's might cause dizziness and tiredness, so drive only if you are alert.

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Liver

Consult your doctor

Please consult your doctor if you have liver impairment/liver disease.

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Kidney

Consult your doctor

Please consult your doctor if you have kidney impairment/kidney disease.

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Children

Unsafe

Prulizest-2 Tablet 10's is not recommended for children below 18 years as safety and effectiveness have not been established.

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Heart

Caution

Prulizest-2 Tablet 10's should be used with caution in patients with heart problems. Inform your doctor about any heart-related conditions before taking Prulizest-2 Tablet 10's.

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Geriatrics

Caution

Prulizest-2 Tablet 10's should be given with caution in elderly patients due to an increased risk of side effects. Dose adjustment may be required based on their health condition.

What if I have taken an overdose of Prulizest-2 Tablet 10's

If you suspect an overdose, seek immediate medical attention or contact a poison control centre. Symptoms of an overdose may include severe diarrhoea, headache, and nausea.

Diet & Lifestyle Advise

  • Increase your fibre intake gradually: Incorporate more whole grains, fruits, vegetables, and beans into your meals to help bulk up your stool and make it easier to pass.
  • Stay well-hydrated: Drink plenty of water throughout the day. Hydration is essential for keeping stool soft and helping Prulizest-2 Tablet 10's work effectively.
  • Engage in regular physical activity: Light exercise, such as walking for 20 to 30 minutes a day, stimulates the natural muscles in your digestive tract and promotes movement.
  • Establish a regular toilet routine: Try to visit the bathroom at the same times each day, especially after meals when your bowel is naturally more active, and do not ignore the urge to go.
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How Soon It Starts Working

  • The time required for Prulizest-2 Tablet 10's to start to work: Prulizest-2 Tablet 10's ideally shows its action within 2 to 3 hours of administration.
  • The time for which the effects of Prulizest-2 Tablet 10's last: Prulizest-2 Tablet 10's effect lasts for 24 hours.

What if you forget to take Prulizest-2 Tablet 10's

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at the same time to make up for a missed one.

Storage

• Store Prulizest-2 Tablet 10's tablets in their original packaging at room temperature, ideally between 68°F and 77°F (20°C to 25°C).

Drug Warnings

  • Monitor for dehydration: If you develop severe diarrhoea, you may lose essential fluids and salts. Drink electrolyte solutions and contact your doctor if the diarrhoea does not stop within a few days.
  • Watch your mood: Pay close attention to any sudden changes in your mood, thoughts, or behaviour. Report any signs of depression or unusual thoughts to your doctor immediately.
  • Check the packaging: Always inspect the tablet blister pack before use. Do not take the medication if the foil is broken or if the tablets appear damaged.
  • Inform all healthcare providers: Make sure your doctors, dentists, and pharmacists know you are taking Prulizest-2 Tablet 10's before you start any new medications or undergo medical procedures.

verifiedApollotooltip

Prulizest-2 Tablet 10's may interact with certain medicines, affecting its effectiveness or increasing the risk of side effects.

  • Anticholinergic medications: Taking these medicines alongside Prulizest-2 Tablet 10's may reduce its effectiveness, as they have opposing effects on gut movement.
  • Other laxatives: Using strong laxatives at the same time may increase the risk of severe diarrhoea and dehydration. Talk to your doctor before combining treatments.

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verifiedApollotooltip
  • There are no major established food interactions with Prulizest-2 Tablet 10's. It can be safely taken with or without food.

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[GASTROPROKINETIC AGENTS]

FAQs

Prulizest-2 Tablet 10's is used to treat chronic idiopathic constipation.
Prulizest-2 Tablet 10's acts on the muscle walls of the gut and increases bowel motility. Thereby, helps restore the normal functioning of the bowel and treats constipation.
Diarrhoea might occur if Prulizest-2 Tablet 10's is taken in larger doses. Drink lots of fluids and eat non-spicy food if you experience diarrhoea. Contraceptive pills might become ineffective in case of severe diarrhoea. In such conditions, use an extra method of contraception.
Do not take Prulizest-2 Tablet 10's for longer durations unless advised by the doctor, as it might lead to dependency on Prulizest-2 Tablet 10's for a bowel movement. Consult your doctor if your bowel movement is irregular even after taking Prulizest-2 Tablet 10's for four weeks.
Drink plenty of fluids and consume fibre-rich food, whole-grain bread, unprocessed bran, fruits and vegetables. Try to exercise regularly.
If you miss a dose, try to take it as soon as you remember. However, if it is almost time for the scheduled dose, skip the missed dose and take the scheduled dose instead. Avoid taking the double dose as it might cause unpleasant side effects or overdose.
Prulizest-2 Tablet 10's may cause side effects such as vomiting, nausea, diarrhoea, headache, tiredness and stomach cramps/pain. If these side effects persist or worsen, please consult your doctor.
Prulizest-2 Tablet 10's has been shown to act quickly but the effect varies from person to person. This is because each patient reacts differently to particular medication. Generally, Prulizest-2 Tablet 10's causes a bowel movement within 2-3 hours. However, it may take about 4-5 days to show full effect and rapid bowel movements.
Prulizest-2 Tablet 10's is not recommended during pregnancy. Use a reliable method of contraception while taking Prulizest-2 Tablet 10's. Inform your doctor if you are pregnant, think you are pregnant or are planning a pregnancy.
Take Prulizest-2 Tablet 10's as advised by your doctor. It can be taken at any time of the day. It is typically administered once daily orally, with or without food.
Prulizest-2 Tablet 10's has been proven to be beneficial in cases of gastroparesis and constipation. Gastroparesis is a disorder that stops or slows the food movement from stomach to small intestine, even though there is no blockage in the intestines or stomach.
You should avoid taking Prulizest-2 Tablet 10's if you are allergic to it, if you have a tear in your intestinal or stomach wall, a bowel blockage or inflammatory conditions of the intestinal wall like ulcerative colitis or Crohn’s disease. Always consult your doctor before starting Prulizest-2 Tablet 10's.
While it treats constipation, Prulizest-2 Tablet 10's is not a traditional laxative. It is a prokinetic medication, meaning it works by stimulating the natural muscle movements of your intestines to help move waste through. Talk to your doctor.
Alcohol does not directly stop this medication from working, but it can worsen common side effects like headaches, dizziness, or stomach upset. To minimise these risks, limit your alcohol consumption and talk to your doctor.
If you experience severe or persistent diarrhoea, stop taking the medication and drink plenty of fluids to prevent dehydration. You should contact your healthcare provider right away to discuss your symptoms. Talk to your doctor.
Some medications can affect how this medicine works or increase the risk of side effects. Always provide your doctor or pharmacist with a complete list of all prescription and over-the-counter medicines you are taking. Talk to your doctor.
Weight changes are not a common side effect of this medication. However, relieving chronic constipation and bloating may make you feel lighter or less full. If you experience unexpected weight changes, talk to your doctor.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.584 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 210166S000Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Prucalopride Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. MedlinePlus. A619011 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  5. Prucalopride succinate [EMC SmPC]. 2022. [Accessed on 28 Jan. 2019]Check here
  6. Prucalopride [EMC SmPC]. 2022. [Accessed on 28 Mar. 2019]Check here
  7. Information H, Diseases D. Constipation - NIDDK [Internet]. National Institute of Diabetes and Digestive and Kidney Diseases. 2021 [Accessed on 7 March 2022]Check here

Country of origin

India

Manufacturer/Marketer address

Plotno d6/137, Basement, Chitrakoot, Vaishali Nagar, Jaipur-302022
Other Info - PRU0172
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