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PV-10 Tablet 10's is used to treat Neuropathic pain. It contains Mecobalamin, Pregabalin, and Nortriptyline. Mecobalamin is a vitamin that aids in producing myelin, which protects nerve fibres and regenerates damaged nerve cells. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Together, it helps to treat neuropathic pain.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

MECOBALAMIN-1500MCG+NORTRIPTYLINE-10MG+PREGABALIN-75MG

Manufacturer/Marketer :

Jv Health Care

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About PV-10 Tablet 10's

PV-10 Tablet 10's is a prescription medication specifically designed to target and relieve persistent nerve pain, also known as neuropathic pain. This medicine is commonly prescribed to manage long-term discomfort caused by conditions such as diabetic neuropathy, shingles, or spinal injuries.

For the best results, you should take this medication consistently every day at the same time, exactly as directed by your healthcare provider. It can be taken with or without food. Combining this treatment with daily lifestyle changes, such as keeping a balanced diet and doing gentle stretching, can greatly improve how well you manage your symptoms.

While taking you may experience some common side effects like mild sleepiness, dry mouth, or dizziness. However, if you develop serious symptoms such as severe mood swings, sudden swelling in your face or limbs, or rapid weight gain, please consult your doctor immediately.

Before starting this medication, talk to your doctor if you have a history of kidney disease, heart problems, or depression. Do not take this if you have recently had a heart attack or are currently taking certain medications for depression, such as monoamine oxidase inhibitors (MAOIs).

This medicine can interact with alcohol, which may severely increase drowsiness and dizziness. If you are pregnant, breastfeeding, or are an older adult, consult your doctor or pharmacist to discuss whether this medication is safe for your specific situation. Older adults may be more likely to experience drowsiness, dizziness, confusion, or falls. Your doctor may start treatment with a lower dose and monitor you closely. 
 

Uses of PV-10 Tablet 10's

Your doctor may recommend this medicine to help manage the following conditions:

  • Neuropathic pain: Helps calm burning, throbbing, or shooting nerve pain caused by diabetes or spinal cord injury.
  • Postherpetic neuralgia: Relieves the sharp, ongoing nerve pain that persists after an outbreak of shingles.
     

Key Benefits

When taken consistently as directed, this medicine may provide the following health benefits:

  • Relieves nerve pain: This medicine helps reduce burning, tingling, stabbing, or shooting nerve pain, making everyday activities more comfortable.
  • Improves sleep and comfort: By calming overactive nerves, it may reduce discomfort that disrupts sleep, helping you rest better at night.
  • Supports daily mobility: With better pain control, this medicine may help you move more comfortably, perform daily tasks with greater ease, and improve your overall quality of life.
     

Directions for Use

  • PV-10 Tablet 10's can be taken with or without food as directed by your doctor.
  • It is advised to take PV-10 Tablet 10's once or twice daily; however, follow your doctor's advice regarding the dosage and duration.
  • Swallow the whole medicine with a glass of water.
  • Do not break, crush or chew PV-10 Tablet 10's.

How PV-10 Tablet 10's Works

PV-10 Tablet 10's is a combination medication that uses three active ingredients: Mecobalamin, Pregabalin and Nortriptyline to relieve nerve pain from multiple angles: Mecobalamin is the active form of Vitamin B12; this ingredient helps produce myelin, the protective covering that surrounds nerve fibres. By restoring this protective shield, it promotes the healing and repair of damaged nerves. Pregabalin reduces the release of specific chemical messengers in the brain and spinal cord that transmit pain signals. By calming overactive nerves, it helps decrease the intensity of the pain you feel. Nortriptyline is the active ingredient and belongs to a group of medicines called tricyclic antidepressants (TCAs). It works by blocking the reabsorption (reuptake) of norepinephrine and, to a lesser extent, serotonin in the brain and spinal cord. This helps strengthen the body's natural pain-control pathways, reducing the transmission of pain signals to the brain and helping relieve nerve pain.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking PV-10 Tablet 10's as it may increase drowsiness and sleepiness.

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Pregnancy

Caution

If you're pregnant, don't take PV-10 Tablet 10's unless your doctor tells you to. Please consult your doctor if you have any concerns about this; your doctor will only prescribe if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor as there is no substantial research yet on the use of PV-10 Tablet 10's in breastfeeding/nursing mothers.

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Driving

Caution

PV-10 Tablet 10's causes drowsiness, sleepiness and blurred vision. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Inform your doctor before receiving the PV-10 Tablet 10's if you have a history of liver diseases/conditions. Your doctor may adjust your dose depending on your current liver conditions.

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Kidney

Caution

Inform your doctor before receiving the PV-10 Tablet 10's if you have a history of kidney diseases/conditions. Your doctor may adjust your dose depending on your current liver conditions.

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Children

Unsafe

PV-10 Tablet 10's should not be given to children as the safety and efficacy have not been established.

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Heart

Consult your doctor

Please consult your doctor before receiving PV-10 Tablet 10's if you have pre-existing heart problems. Your doctor will prescribe PV-10 Tablet 10's if the benefits outweigh the risks.

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Geriatrics

Safe if prescribed

PV-10 Tablet 10's is generally considered safe when used under medical supervision in geriatric patients; however, significant precautions should be taken due to age-related sensitivities.

What if I have taken an overdose of PV-10 Tablet 10's

If you suspect an overdose, or if someone has accidentally taken too much and is experiencing severe drowsiness, confusion, or rapid heartbeat, seek immediate medical attention.

Diet & Lifestyle Advise

  • Eat a balanced diet: Include foods rich in B vitamins, such as whole grains, eggs, and lean meats, to help support healthy nerve function.
  • Manage blood sugar: If you have diabetes, keep your blood sugar levels under control to help prevent further nerve damage.
  • Stay active: Engage in low-impact activities, such as walking or gentle stretching, to improve circulation and support nerve health.
  • Stay hydrated: Drink plenty of water throughout the day. If you experience dry mouth, try sugar-free candies or ice chips for relief.
     
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How Soon It Starts Working

The time required for PV-10 Tablet 10's to start to work: The time required for PV-10 Tablet 10's to show its action is not clinically established. The time for which the effects of PV-10 Tablet 10's last: The duration of action for PV-10 Tablet 10's is not clinically established.

What if you forget to take PV-10 Tablet 10's

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular schedule. Do not take two doses at the same time to make up for a missed one.

Storage

• Store it at room temperature, ideally between 15°C and 30°C (59°F to 86°F).

Drug Warnings

  • Avoid activities requiring alertness: Do not drive, operate machinery, or perform tasks requiring full attention until you know how this medicine affects you, as it may cause drowsiness or dizziness.
  • Contraindications: Do not take this medicine if you are allergic to any of its ingredients or have recently had a heart attack. Tell your doctor if you have urinary retention, liver disease, or are taking MAO inhibitors before starting treatment.
  • Do not stop suddenly: Stopping this medicine abruptly may cause withdrawal symptoms. Your doctor will advise you on how to reduce the dose gradually.
  • Watch for mood changes: Contact your doctor immediately if you notice worsening depression, unusual mood changes, or thoughts of self-harm.
  • Avoid alcohol: Drinking alcohol while taking this medicine may increase drowsiness, dizziness, and other serious side effects.

verifiedApollotooltip
  • Medicines that cause drowsiness: Taking this medicine with sleeping pills, anti-anxiety medicines, muscle relaxants, opioid pain medicines, or other medicines that cause drowsiness may increase the risk of excessive sleepiness, dizziness, falls, slowed breathing, or other serious side effects.
  • Medicines that affect serotonin: Taking this medicine with SSRIs, SNRIs, MAO inhibitors, tramadol, linezolid, or St. John's wort may increase the risk of serotonin syndrome. Seek immediate medical attention if you develop agitation, confusion, fever, muscle stiffness, or a fast heartbeat.
  • Blood pressure medicines and antidepressants: Taking this medicine with certain blood pressure medicines or antidepressants (such as MAO inhibitors) may increase the risk of significant changes in blood pressure. Tell your doctor about all the medicines you are taking before starting treatment.
     

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  • Alcohol: Avoid consuming alcohol, as it can significantly increase drowsiness and dizziness when combined with this medication.

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[NEUTRACEUTICAL, MISCELLANEOUS ANALGESICS]

FAQs

PV-10 Tablet 10's is used to treat Neuropathic pain.
PV-10 Tablet 10's contains Mecobalamin, Pregabalin, and Nortriptyline. Mecobalamin aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Nortriptyline alters the way nerves receive pain signals, thereby decreasing pain. Together, PV-10 Tablet 10's helps to treat neuropathic pain.
Dry mouth could be a side-effect of PV-10 Tablet 10's. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.
Do not stop taking PV-10 Tablet 10's without consulting your doctor, as this could result in withdrawal symptoms. Continue taking PV-10 Tablet 10's for as long as prescribed to treat your condition effectively. If you experience any difficulty while taking PV-10 Tablet 10's, do not be afraid to speak with your doctor.
PV-10 Tablet 10's is used to treat diabetic neuropathy. Diabetic neuropathy is a condition that causes nerve damage due to high blood glucose levels. It primarily affects the nerves in the legs and feet.
PV-10 Tablet 10's may cause peripheral oedema. The swelling of the hands and lower legs are known as peripheral oedema. If you experience oedema, avoid sitting or standing for extended periods. Raise your legs by laying down and placing a pillow under them.
Taking PV-10 Tablet 10's can affect your sexual life. You might experience lower sex drive, erectile dysfunction, or problems with ejaculation or orgasm. If you notice any of these changes, it's important to tell your doctor. They can help you find solutions or adjust your medication to minimize these effects.
The common side effects of PV-10 Tablet 10's may include dizziness, sleepiness, nausea, blurred vision, peripheral oedema (swelling of the lower legs and hands), weight gain, and dry mouth. These side effects do not necessitate medical attention and will subside gradually over time. However, you should consult your doctor if you are experiencing these side effects regularly.
The time it takes for PV-10 Tablet 10's to take effect can vary from person to person. Some people may start feeling better within a couple of weeks, while others may need 4 to 6 weeks to experience the full benefits. The exact treatment duration will depend on your medical condition, and your doctor will provide personalized guidance on the recommended treatment course.
Focus on nutrient-dense foods, be mindful of your portion sizes, and avoid high-calorie snacks like crisps, cakes, biscuits, and sweets. Instead, opt for fresh fruits and vegetables, low-calorie foods, whole grains, and lean protein sources. Regular exercise will also help stabilize your weight and support overall health and well-being.
If you forget to take PV-10 Tablet 10's, take it as soon as you remember if it's within a few hours. If it's almost time for your next dose, skip the missed one and continue as usual. Don't take a double dose to make up for it. If you're unsure or frequently forget doses, consult your doctor or pharmacist for guidance. Taking medication at the same time every day can help make it a habit and reduce the likelihood of forgetting.
Do not take more PV-10 Tablet 10's than prescribed. Be aware of serious side effects like abnormal heartbeat, seizures, allergic reactions, and suicidal thoughts. If you experience any of these, tell your doctor right away and get medical help immediately to avoid serious problems.
Taking more than the recommended dose of PV-10 Tablet 10's won't improve its effectiveness and can be harmful. Stick to the recommended dosage to minimize risks and maximize benefits. If you have concerns, consult your doctor for personalized guidance.
While taking PV-10 Tablet 10's, be aware of potential interactions and risks. Avoid excessive alcohol consumption, driving, and operating heavy machinery until you know how the medication affects you. Also, consult your doctor before taking other medications, or supplements, or changing your diet and exercise routine. Limit grapefruit intake and exercise caution with opioid medications, as they may interact with PV-10 Tablet 10's. By following your doctor's guidance, you can minimize risks and ensure the medication works effectively for you.
Regular doctor's visits are important when receiving medical treatment. How often you visit will depend on your situation, but expect more frequent visits during the initial treatment phase to adjust plans and monitor side effects. Even during maintenance, regular check-ins will help track progress and address concerns. This helps ensure you receive the best care and stay on track with your treatment.
PV-10 Tablet 10's should be stored in a cool and dry place away from sunlight and keep it out of reach of children. When disposing, check the expiration date, remove the label, and throw it away in a plastic bag in the household trash. Do not flush it down the toilet or sink. Follow these steps to keep the medication safe and effective.
Yes, weight gain is a known common side effect for some people taking this medication. Managing your diet, staying physically active, and discussing any rapid weight changes with your doctor can help manage this effect.
No, it is not safe. Alcohol can increase the side effects of medicine, such as extreme drowsiness, dizziness, and difficulty concentrating. It is best to avoid alcohol entirely during your treatment.
Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed one and continue with your regular schedule. Do not take two doses at once to make up for a missed one. If you are unsure, talk to your doctor or pharmacist.
It is generally not recommended during pregnancy or breastfeeding unless your doctor decides the benefits clearly outweigh the risks. If you are planning a pregnancy or are currently breastfeeding, talk to your doctor before starting this medicine.
Yes, drowsiness and dizziness are very common side effects of this medication, especially when you first start taking it. Avoid driving, riding a bicycle, or operating tools and machinery until you are sure how this medicine affects you.
If you have kidney problems, you must inform your doctor before starting it. Your kidneys help clear this medicine from your body, and a lower dose or a modified schedule may be necessary to ensure your safety. Talk to your doctor.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. National Health Service (NHS). Nortriptyline - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  2. National Health Service (NHS). Pregabalin - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  3. National Center for Biotechnology Information (NCBI). Pmc3888748 Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  4. National Center for Biotechnology Information (NCBI). Pmc6003018 Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  5. Drugs.com Clinical Review Team. Pregabalin Drug Interactions Reference. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  6. Drugs.com Clinical Review Team. Nortriptyline Drug Interactions Reference. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  7. Electronic Medicines Compendium (EMC). Pil.5044 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here

Country of origin

India

Manufacturer/Marketer address

SCF 516,1st Floor Near Petrol Pump Motor Market, Manimajra Chnadigarh
Other Info - PV10001

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