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Composition :

DABRAFENIB-75MG

Manufacturer/Marketer :

Novartis India Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Rafinlar 75 mg Capsule

Rafinlar 75 mg Capsule is an anti-cancer medicine used in the treatment of various types of cancers. Cancer is a disease caused by the abnormal growth of cells that divide uncontrollably. This medicine is used as a single agent in treating patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutation. It is also used along with trametinib in treating anaplastic thyroid cancer, non-small cell lung cancer with BRAF V600E mutation, and unresectable or metastatic solid tumours with BRAF V600E mutation.

Rafinlar 75 mg Capsule contains Dabrafenib, which belongs to the class of medicines known as kinase inhibitors. It works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells.

Rafinlar 75 mg Capsule may cause certain side effects such as diarrhoea, decreased appetite, nausea, vomiting, tiredness, itching, rash, headache, fever, acne, increased blood pressure, cough, and abdominal pain. Inform your doctor if any of these side effects bother you. Rafinlar 75 mg Capsule should be taken as prescribed by your doctor. Do not take more than the recommended dose of medicine.

If you are allergic to Rafinlar 75 mg Capsule or its components, inform your doctor. Before taking Rafinlar 75 mg Capsule , inform your doctor if you have/had liver or kidney disease, calcium deficiency, heart problems, increased blood pressure, seizures, bleeding disorders, vision problems, and a history of blood clots. This medicine is known to cause embryo-fetal toxicity. It is not recommended for use in pregnancy and breastfeeding.

Uses of Rafinlar 75 mg Capsule

Rafinlar 75 mg Capsule is used in the treatment of Metastatic melanoma, Anaplastic thyroid cancer, Non-small cell lung cancer and Metastatic solid tumors. The detailed uses of Rafinlar 75 mg Capsule are as follows:<br/>• Melanoma: Rafinlar 75 mg Capsule is used to treat unresectable or metastatic melanoma (a serious form of skin cancer) that has a BRAF V600E mutation. It may be used alone or in combination with trametinib, another targeted therapy, to improve treatment outcomes and delay disease progression.<br/>• Non-Small Cell Lung Cancer (NSCLC): In patients with metastatic NSCLC carrying the BRAF V600E mutation, Rafinlar 75 mg Capsule is used with trametinib to help shrink tumors and manage symptoms when surgery is not an option.<br/>• Anaplastic Thyroid Cancer: For patients with BRAF V600E-positive anaplastic thyroid cancer, which is aggressive and often inoperable, Rafinlar 75 mg Capsule (with trametinib) helps slow the spread of cancer and may improve survival.<br/>• Low-Grade Glioma (LGG): In children aged 1 year and older, Rafinlar 75 mg Capsule is used with trametinib to treat LGG that has the BRAF V600E mutation, especially when the tumor is difficult to remove surgically or has recurred.<br/>• Advanced Solid Tumors: Rafinlar 75 mg Capsule may also be used for BRAF V600E mutation-positive solid tumors (regardless of origin) that are advanced, have no satisfactory alternative treatments, or have progressed after prior therapies.<br/>

Directions for Use

• Rafinlar 75 mg Capsule should be taken 1 hour before a meal or 2 hours after a meal.• It is advised to take Rafinlar 75 mg Capsule two times a day; however, follow your doctor's advice regarding the dosage and duration.• Swallow the capsule as a whole with a glass of water.• Do not break, chew or crush Rafinlar 75 mg Capsule .

Medicinal Benefits

Rafinlar 75 mg Capsule contains Dabrafenib, which is used in treating different types of cancer. It works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body. It also decreases the blood supply to cancer tumors to slow down the growth of the tumor.  In this way, Rafinlar 75 mg Capsule stops the body's production, spread and growth of cancerous cells.

How Rafinlar 75 mg Capsule Works

Rafinlar 75 mg Capsule contains Dabrafenib, which belongs to the class of medicines known as kinase inhibitors. It works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Rafinlar 75 mg Capsule

Do not take more than the prescribed dose. Using more medication will not improve your symptoms; instead, they may cause poisoning or serious side effects. If you suspect that you may have overdosed of Rafinlar 75 mg Capsule or observe any side effects, please go to the emergency department of the closest hospital or nursing home. No specific side effects have been reported under these circumstances.

Drug Warnings

To treat your condition effectually, continue taking Rafinlar 75 mg Capsule for the period that your doctor has prescribed. Avoid taking Rafinlar 75 mg Capsule if you are allergic to it or any other components present in it. Caution should be exercised if you have/had liver or kidney disease, heart disease, blood or bleeding disorders, diabetes, eye problems, or gastrointestinal disorders. Inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment, as this medicine is known to cause embryo-fetal toxicity. Breastfeeding should be discontinued in nursing mothers during the treatment as it passes into breast milk and may cause a possible risk to the infant. Avoid driving and operating machines, as this medicine may cause visual disturbances. This medicine is not recommended for use in children below six years of age as the safety and efficacy are not established. Rafinlar 75 mg Capsule may cause hypertension, thrombotic events, hemorrhagic events, cardiomyopathy, severe skin reactions, Glucose-6-phosphate Dehydrogenase Deficiency (G6PD), uveitis, tumor promotion in BRAF wild-type tumors, the occurrence of new malignancies, and hyperglycemia in some patients. Hence, inform your doctor about your complete medication and medical history before taking Rafinlar 75 mg Capsule .

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Rafinlar 75 mg Capsule:
When Axitinib is taken with Rafinlar 75 mg Capsule, the amount of Axitinib in the blood may decrease which may make Axitinib less effective in treating the condition.

How to manage the interaction:
Although there is a possible interaction between Rafinlar 75 mg Capsule and Axitinib, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Rafinlar 75 mg Capsule:
Coadministration of Rafinlar 75 mg Capsule and fentanyl may reduce the blood levels of fentanyl, which may make the medication less effective in treating your pain.

How to manage the interaction:
Although there is an interaction between Rafinlar 75 mg Capsule and fentanyl, they can be taken together if prescribed by your doctor. However, consult your doctor immediately if you experience watery eyes, excessive sweating, fever, body aches, abdominal cramping, vomiting, diarrhoea, and weight loss. Do not stop taking any medications without consulting your doctor.
How does the drug interact with Rafinlar 75 mg Capsule:
Rafinlar 75 mg Capsule may lower the blood levels and effects of levonorgestrel, making it less effective as a type of birth control.

How to manage the interaction:
Although taking levonorgestrel and Rafinlar 75 mg Capsule together may result in an interaction but can be taken if advised by a doctor. If you are receiving hormone replacement treatment for menopause, you should consult the doctor if you observe an increase in the frequency or severity of your symptoms, such as hot flashes, vaginal dryness, or irregular bleeding. Do not stop using any medications without talking to a doctor.
How does the drug interact with Rafinlar 75 mg Capsule:
When Rafinlar 75 mg Capsule is taken with Ranolazine, it can make the body process Ranolazine faster.

How to manage the interaction:
Taking Rafinlar 75 mg Capsule with Ranolazine together can possibly result in an interaction, but it can be taken if your doctor has advised it. Your doctor can recommend other options that won't cause any problems when taken together. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Rafinlar 75 mg Capsule:
Coadministration of Norethisterone with Rafinlar 75 mg Capsule can reduce the metabolism and decrease the levels of Norethisterone in the body.

How to manage the interaction:
Taking Norethisterone with Rafinlar 75 mg Capsule together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of hot flashes, vaginal dryness, or abnormal bleeding, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Rafinlar 75 mg Capsule:
Taking Rafinlar 75 mg Capsule with cariprazine may reduce the blood levels of cariprazine.

How to manage the interaction:
Although taking Cariprazine and Rafinlar 75 mg Capsule together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor if you experience any unusual symptoms or if your condition worsens, Do not stop using any medications without talking to a doctor.
How does the drug interact with Rafinlar 75 mg Capsule:
Co- administration of Rafinlar 75 mg Capsule with Deflazacort may significantly reduce the blood levels of deflazacort, which may make the medication less effective in treating the condition.

How to manage the interaction:
Although using Rafinlar 75 mg Capsule and Deflazacort together can possibly result in an interaction, they can be taken together if advised by your doctor. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Rafinlar 75 mg Capsule:
When coupled with Rafinlar 75 mg Capsule, the blood level of Ethinylestradiol can be reduced.

How to manage the interaction:
There may be a possibility of interaction between Rafinlar 75 mg Capsule and Ethinylestradiol, but it can be taken if prescribed by a doctor. If you are taking hormone replacement therapy for menopause, you should notify your doctor if you notice an increase in the frequency or severity of your symptoms, such as hot flashes, vaginal dryness, or irregular bleeding. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Rafinlar 75 mg Capsule:
When Rafinlar 75 mg Capsule is taken with Medroxyprogesterone acetate, the amount of Medroxyprogesterone acetate in the blood may decrease.

How to manage the interaction:
Co-administration of Rafinlar 75 mg Capsule with Medroxyprogesterone can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience hot flashes(feeling of heat in the body), dryness, or unusual bleeding, don't hesitate to reach out to your doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat food rich in antioxidants such as berries, spinach, etc.
  • Foods containing fibre help in better digestion. These include beans, peas, lentils, whole grains, nuts, and seeds.
  • Physical activity helps strengthen muscles, reduces fatigue, helps in weight loss, and gives strength. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Getting adequate sleep as resting helps improve your health and mental ability and improves attention.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC
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Alcohol

Consult your doctor

It is unknown whether Rafinlar 75 mg Capsule interacts with alcohol. Consult your doctor.

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Pregnancy

Unsafe

Rafinlar 75 mg Capsule is not recommended for use in pregnancy as it may cause embryo-fetal toxicity and harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking Rafinlar 75 mg Capsule . You should not become pregnant while you are taking Rafinlar 75 mg Capsule for at least two weeks from the last dose of Rafinlar 75 mg Capsule . Using effective birth control methods while on treatment with Rafinlar 75 mg Capsule is suggested.

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Breast Feeding

Unsafe

Inform your doctor if you are intending to breastfeed. Breastfeeding should be avoided while getting Rafinlar 75 mg Capsule and for at least two weeks from the final dosage of administration.

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Driving

Unsafe

Rafinlar 75 mg Capsule may cause visual disturbances such as loss of vision or blurred vision in some patients. Hence, avoid driving and operating machines until you are completely alert.

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Liver

Caution

If you have a pre-existing or a history of liver problems, tell your doctor before taking this medicine.

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Kidney

Caution

If you have a pre-existing or a history of kidney problems, tell your doctor before taking this medicine.

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Children

Caution

Rafinlar 75 mg Capsule is not recommended for use in children below six years of age, as the safety and efficacy have not been established. In children above six years, it is used in the treatment of unresectable or metastatic solid tumours with BRAF V600E mutation when prescribed by your doctor.

Have a query?

FAQs

Rafinlar 75 mg Capsule is used to treat Metastatic melanoma, Anaplastic thyroid cancer, Non-small cell lung cancer and Metastatic solid tumors.

Rafinlar 75 mg Capsule contains Dabrafenib, which works by inhibiting the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells.

It is advised not to miss any dose of medicine. If you miss it, take the medicine as soon as you remember. However, if it is time for your next dose, avoid taking the missed dose and do not double the dose.

Country of origin

India

Manufacturer/Marketer address

Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India
Other Info - RAF0046

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