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compositionComposition:ABEMACICLIB-100MG
prescription
Prescription Medicine
info
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Ramiven 100 mg Tablet is an anti-cancer medicine used in the treatment of certain types of breast cancer. This medicine contains abemaciclib which works by blocking cyclin-dependent kinase 4 and 6 proteins, which are necessary for the growth and division of the cells, thus reducing the growth of cancer cells. Common side effects include nausea, diarrhoea, abdominal pain, and fatigue.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ABEMACICLIB-100MG

Manufacturer/Marketer :

Eli Lilly and Company (India) Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Ramiven 100 mg Tablet

Ramiven 100 mg Tablet is a prescription medicine used to treat hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) breast cancer. It is prescribed for cancer that has spread to other parts of the body or early-stage breast cancer that has a high risk of returning. By targeting specific proteins in the body, this medicine helps slow down the progression and spread of cancer cells.

To achieve the best results, you must take Ramiven 100 mg Tablet consistently every day. You can take this tablet with or without food, but you should try to take it at the same time each day to maintain steady levels of the medicine in your body. Along with taking your medicine, staying well-hydrated and eating a balanced diet can help support your body during treatment.

While taking Ramiven 100 mg Tablet, you may experience common side effects such as diarrhoea, nausea, or low white blood cell counts. It is vital to monitor how you feel and talk to your doctor right away if you experience severe diarrhoea, signs of an infection like a fever, or unusual bruising.

Do not take this if you have had a severe allergic reaction to abemaciclib or any other ingredients in Ramiven 100 mg Tablet. Before starting this treatment, discuss your medical history with your doctor, especially if you have a history of liver damage, kidney problems, or active infections.

This medicine can interact with certain other therapies, changing how well it works or increasing side effects. If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider immediately, as this medicine can harm an unborn baby.

Uses of Ramiven 100 mg Tablet

Your doctor may prescribe Ramiven 100 mg Tablet to help manage the following conditions:

  • Advanced or Metastatic Breast Cancer: Ramiven 100 mg Tablet is used to treat HR-positive, HER2-negative breast cancer that has progressed or spread to other parts of the body, often combined with hormone therapies.
  • Early Breast Cancer with High Risk of Recurrence: Ramiven 100 mg Tablet is taken after surgery alongside standard hormone therapy to lower the chances of the breast cancer returning in patients with high-risk features.

Key Benefits

When taken as prescribed, Ramiven 100 mg Tablet may provide the following benefits:

  • Helps Slow Cancer Progression: Helps slow the growth and spread of hormone receptor-positive (HR+), HER2-negative breast cancer by targeting proteins involved in cancer cell division.
  • Helps Reduce the Risk of Cancer Returning: When used after treatment for early-stage breast cancer in eligible patients, Ramiven 100 mg Tablet may help lower the risk of the cancer coming back.
  • Supports Longer Disease Control: When used alone or with hormone therapy, Ramiven 100 mg Tablet may help keep the cancer under control for longer before it worsens.
  • Provides a Convenient Oral Treatment Option: As an oral medicine, Ramiven 100 mg Tablet can be taken at home as prescribed, reducing the need for frequent hospital visits for treatment.
Side effects of Ramiven 100 mg Tablet
  • Increased creatinine levels must be corrected immediately with the help of a doctor.
  • Reduce strenuous activities that can lead to muscle breakdown and production of creatinine.
  • Sleep for 7-8 hours per night to assist your body in repairing and rebuilding tissue.
  • Manage your blood pressure by implementing changes in lifestyle like losing weight, reducing stress and exercising regularly.
  • Avoid smoking and drinking alcohol.
  • Avoid taking raw fruits, nuts and vegetables.
  • Do not share your personal things with others like toothbrushes.
  • Clean the wounds and cuts using soap and water.
  • Wash your hands thoroughly and frequently and maintain hygiene.
  • Get a good quality of sleep.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Your doctor will perform a physical examination and review your medical history to identify possible causes of lymphocytosis, ranging from infections to autoimmune disorders or even blood cancers.
  • Monitor your lymphocytes with regular blood tests.
  • Regular exercise, such as walking or yoga, helps strengthen the immune system.
  • Try to get enough sleep that will be enhancing the immune system for your body's recovery.
  • Give up smoking and drink within limit to keep your immune system and health in good condition.
  • Consult a hematologist or doctor to identify the cause of thrombocytopenia (decreased platelet count) and plan treatment.
  • Foods rich in vitamins B12, C, folate, and iron may help boost platelet count.
  • Avoid heavy lifting, bending, or straining to reduce bleeding risk.
  • Stay hydrated by drinking plenty of water to help prevent bleeding.
  • Avoid alcohol and tobacco to prevent lowering platelet count and reduce bleeding risk.
  • Regular blood tests help monitor platelet count and detect any changes.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.

Directions for Use

  • Take Ramiven 100 mg Tablet with or without food as advised by the doctor.
  • Usually, it is to be taken twice daily, or as directed by your doctor.
  • Swallow Ramiven 100 mg Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Ramiven 100 mg Tablet Works

Ramiven 100 mg Tablet contains the active ingredient abemaciclib, which belongs to a group of medicines called cyclin-dependent kinase (CDK) 4 and 6 inhibitors. CDK4 and CDK6 are proteins that help control how cells grow and divide. In some hormone receptor-positive, HER2-negative breast cancers, these proteins become overactive, allowing cancer cells to multiply uncontrollably. By blocking the activity of CDK4 and CDK6, Ramiven 100 mg Tablet slows or stops the division of cancer cells. This helps slow tumour growth, delay disease progression, and reduce the risk of cancer returning when used as part of treatment for eligible patients with early-stage breast cancer.
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Alcohol

Unsafe

It is not recommended to consume alcohol with Ramiven 100 mg Tablet. Please consult your doctor if you have any concerns.

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Pregnancy

Unsafe

Ramiven 100 mg Tablet is not recommended during pregnancy. Please consult your doctor in case of any concerns.

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Breast Feeding

Caution

Ramiven 100 mg Tablet is not recommended during breastfeeding. Please consult your doctor in case of any concerns.

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Driving

Caution

Ramiven 100 mg Tablet may cause dizziness and tiredness, which may affect your ability to drive. Do not drive if you experience any side effects after using Ramiven 100 mg Tablet.

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Liver

Unsafe

Ramiven 100 mg Tablet should be avoided in case of established liver disease. Please consult your doctor to address any concerns.

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Kidney

Caution

Exercise caution before using Ramiven 100 mg Tablet in case of established kidney disease. Please consult your doctor to address any concerns.

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Children

Unsafe

Ramiven 100 mg Tablet is not recommended for use in children as the safety and effectiveness have not been established. Please consult your doctor in case of any concerns.

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Heart

Caution

Ramiven 100 mg Tablet should be taken with caution in patients with heart problems. Therefore, please talk to your doctor before using Ramiven 100 mg Tablet.

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Geriatrics

Caution

Ramiven 100 mg Tablet should be given with caution in elderly patients due to an increased risk of side effects. Talk to your doctor if you have any concerns.

What if I have taken an overdose of Ramiven 100 mg Tablet

If you suspect an overdose or have taken too many tablets, seek immediate medical attention.

Diet & Lifestyle Advise

  • Manage Diarrhoea Early: Keep an anti-diarrhoeal medicine (like loperamide) at home as recommended by your doctor, and start taking it at the first sign of a loose stool.
  • Stay Hydrated: Drink plenty of clear fluids, such as water, clear broths, or electrolyte drinks, to prevent dehydration, especially if you experience diarrhoea or nausea.
  • Avoid Grapefruit: Do not eat grapefruit or drink grapefruit juice while taking this medicine, as it can cause unsafe levels of the drug to build up in your body.
  • Prevent Infections: Wash your hands frequently, avoid crowded places, and stay away from people who are currently sick to protect your immune system.
health query

Have a query?

How Soon It Starts Working

The time required for Ramiven 100 mg Tablet to start to work: Ramiven 100 mg Tablet ideally shows its action within 1 to 2 hours of administration. The time for which the effects of Ramiven 100 mg Tablet last: Ramiven 100 mg Tablet effect lasts for 24 hours.

What if you forget to take Ramiven 100 mg Tablet

If you miss a dose or if you vomit after taking your tablet, skip that dose entirely. Take your next scheduled dose at your regular time. Do not take two doses at once to make up for a missed or vomited dose. Talk to your doctor or pharmacist if you are unsure what to do.

Storage

•Store Ramiven 100 mg Tablet tablets at room temperature, specifically between 20°C and 25°C (68°F to 77°F). •Keep the tablets in their original packaging to protect them from light and moisture.

Drug Warnings

  • Act on diarrhoea quickly: Diarrhoea can cause rapid dehydration. Start taking anti-diarrhoeal medicine and increase your fluid intake at the very first loose stool, and notify your doctor immediately.
  • Keep up with blood tests: You will need regular blood tests before and during your treatment so your doctor can check your liver function and monitor your blood cell counts.
  • Inspect your pills: Do not take any tablet that is broken, chipped, or has an unusual colour.
  • Use reliable birth control: You must use highly effective birth control during your treatment and for at least 3 weeks after your final dose to prevent pregnancy.
  • Watch your breathing: Inform your doctor immediately if you develop any new or worsening cough, chest pain, or shortness of breath.

Drug-Drug Interactions

verifiedApollotooltip
  • Strong CYP3A inhibitors (e.g., ketoconazole, clarithromycin): May significantly increase the levels of abemaciclib in your blood, which increases your risk of severe side effects.
  • Strong CYP3A inducers (e.g., rifampin, phenytoin): May decrease the levels of the medicine in your body, making the treatment much less effective against the cancer.
AbemaciclibFingolimod
Severe
AbemaciclibCladribine
Severe

Drug-Drug Interactions

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AbemaciclibFingolimod
Severe
How does the drug interact with Ramiven 100 mg Tablet:
Taking Ramiven 100 mg Tablet with Fingolimod can lead to or increase the risk or severity of developing serious infections.

How to manage the interaction:
Taking Ramiven 100 mg Tablet with Fingolimod together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms of fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in sputum, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AbemaciclibCladribine
Severe
How does the drug interact with Ramiven 100 mg Tablet:
Taking Ramiven 100 mg Tablet with Cladribine can lead to or increase the risk or severity of infections.

How to manage the interaction:
Taking Ramiven 100 mg Tablet with Cladribine together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms of fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in sputum, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AbemaciclibKetoconazole
Severe
How does the drug interact with Ramiven 100 mg Tablet:
Using Ramiven 100 mg Tablet together with ketoconazole can significantly increase the blood levels of Ramiven 100 mg Tablet.

How to manage the interaction:
Taking Ketoconazole and Ramiven 100 mg Tablet together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, diarrhea, abdominal pain, decreased appetite, mouth sores, blood clots, hair loss, liver problems, and impaired bone marrow function resulting in low numbers of different types of blood cells, consult a doctor. Do not discontinue any medication without consulting a doctor.
AbemaciclibClozapine
Severe
How does the drug interact with Ramiven 100 mg Tablet:
Taking Ramiven 100 mg Tablet with Clozapine can lead to or increase the risk or severity of developing serious infections.

How to manage the interaction:
Taking Ramiven 100 mg Tablet with Clozapine together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms of fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in sputum, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AbemaciclibVoriconazole
Severe
How does the drug interact with Ramiven 100 mg Tablet:
Taking Ramiven 100 mg Tablet with Voriconazole can lead to or increase the risk or severity of developing serious infections.

How to manage the interaction:
Taking Ramiven 100 mg Tablet with Voriconazole together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience fever, shortness of breath, abdominal pain, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AbemaciclibBoceprevir
Severe
How does the drug interact with Ramiven 100 mg Tablet:
Taking Ramiven 100 mg Tablet with Boceprevir can increase the levels of Ramiven 100 mg Tablet in the body. This increases the risk or severity of liver problems or impaired bone marrow which can increase the risk of developing serious infections.

How to manage the interaction:
Taking Ramiven 100 mg Tablet with Boceprevir together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in the phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
AbemaciclibDelavirdine
Severe
How does the drug interact with Ramiven 100 mg Tablet:
Taking Ramiven 100 mg Tablet with Delavirdine can lead to or increase the risk or severity of developing liver damage or serious infections.

How to manage the interaction:
Taking Ramiven 100 mg Tablet with Delavirdine together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms of fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in sputum, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AbemaciclibLeflunomide
Severe
How does the drug interact with Ramiven 100 mg Tablet:
Taking Ramiven 100 mg Tablet with Leflunomide can lead to or increase the risk or severity of developing liver problems or serious infections.

How to manage the interaction:
Taking Ramiven 100 mg Tablet with Leflunomide together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms of fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in sputum, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AbemaciclibConivaptan
Severe
How does the drug interact with Ramiven 100 mg Tablet:
Taking Ramiven 100 mg Tablet with Conivaptan can lead to or increase the risk or severity of developing serious infections or liver damage.

How to manage the interaction:
Taking Ramiven 100 mg Tablet with Conivaptan together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms of fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in sputum, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AbemaciclibNefazodone
Severe
How does the drug interact with Ramiven 100 mg Tablet:
Taking Ramiven 100 mg Tablet with Nefazodone can lead to or increase the risk or severity of developing liver damage or serious infections.

How to manage the interaction:
Taking Ramiven 100 mg Tablet with Nefazodone together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms of fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in sputum, abdominal pain, decreased appetite, weight loss, red or inflamed skin, paleness, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit and grapefruit juice: Can block the enzymes that break down the medicine, leading to dangerously high levels of Ramiven 100 mg Tablet in your body and severe side effects.
ABEMACICLIB-100MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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ABEMACICLIB-100MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consuming Grapefruit or Grapefruit juice with Ramiven 100 mg Tablet dose can increase the blood levels of Ramiven 100 mg Tablet. You should avoid or limit the consumption of grapefruit and grapefruit juice during treatment with Ramiven 100 mg Tablet. Contact a doctor immediately if you experience symptoms of nausea, vomiting, diarrhea, abdominal pain, decreased appetite, or mouth sores.

Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

Ramiven 100 mg Tablet belongs to the group of anti-cancer drugs called kinase inhibitors used alone or in combination with other anti-cancer drugs to treat certain types of breast cancer.
Ramiven 100 mg Tablet works by inhibiting CDK 4 and 6, which are proteins that cause uncontrolled growth of cancer cells.
Ramiven 100 mg Tablet might cause fertility problems in males and may affect your ability to father a child. Talk to your doctor if you have any concerns regarding this.
No. Do not stop taking Ramiven 100 mg Tablet unless your doctor tells you to. Continue treatment for as long as your doctor prescribes, depending on how well your body tolerates the medicine and whether your cancer is stable or responding to treatment. If you have any concerns or experience troublesome side effects, speak with your doctor before making any changes.
Yes. Diarrhoea is a common side effect of Ramiven 100 mg Tablet and can sometimes be severe. At the first sign of loose stools, drink plenty of fluids and your doctor may recommend an anti-diarrhoeal medicine such as loperamide. Contact your doctor promptly if diarrhoea is severe or persistent. Your doctor may temporarily stop treatment or reduce your dose if needed.
Ramiven 100 mg Tablet might cause neutropenia (low blood cell count). Regular monitoring of white blood cell count before and during treatment with Ramiven 100 mg Tablet is advised.
Avoid taking ketoconazole (anti-fungal medication) while on treatment with Ramiven 100 mg Tablet. Also, avoid grapefruit, and its juice while on treatment with Ramiven 100 mg Tablet as it might increase the amount of Ramiven 100 mg Tablet in blood.
Yes, you can take Ramiven 100 mg Tablet with or without food. However, you must avoid consuming grapefruit or grapefruit juice during your treatment. Talk to your doctor or pharmacist if you have specific dietary concerns.
Diarrhoea is a very common side effect. You should start taking an anti-diarrhoeal medicine like loperamide at the first loose stool, drink plenty of fluids, and contact your doctor right away for guidance.
While there is no direct chemical interaction, drinking alcohol can worsen side effects like nausea, tiredness, and dehydration from diarrhoea. Talk to your doctor or pharmacist for personalised advice.
Yes, some people experience hair thinning or mild hair loss while taking Ramiven 100 mg Tablet. If this concerns you, talk to your doctor or pharmacist about gentle hair care routines during your treatment.
If you miss a dose or vomit after taking your tablet, skip the missed dose and take your next dose at your regular time. Do not take a double dose to make up for it. Talk to your doctor or pharmacist if you miss multiple doses.
You should avoid certain vaccines, especially live vaccines, while taking Ramiven 100 mg Tablet because your immune system may be weakened. Always talk to your doctor before receiving any vaccination.
Yes, Ramiven 100 mg Tablet can cause liver damage or changes in your liver enzyme levels. Your doctor will perform regular blood tests to monitor your liver health during your treatment. If you notice yellowing of your skin or dark urine, talk to your doctor immediately.

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Country of origin

UNITED STATES

Manufacturer/Marketer address

Plot# 92, Sector 32, Institutional Area, Gurgaon-122001, Haryana, India
Other Info - RAM0278
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