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  3. Rapamune 1mg Tablet

Rapamune 1mg Tablet, Pack of 1 Tablet
Rapamune 1mg Tablet, Pack of 1 Tablet
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Rapamune 1mg Tablet is used to prevent organ rejection after a transplant. It contains Sirolimus which works by weakening the body's defence system (immune system) and assisting the body in accepting the new organ. In some cases, this medicine may cause side effects like abdominal pain, diarrhoea, headache, fever, urinary tract infection, anaemia, nausea, pain, and oedema.
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Composition :

SIROLIMUS-1MG

Manufacturer/Marketer :

Pfizer Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Rapamune 1mg Tablet

Rapamune 1mg Tablet belongs to a class of drugs called 'immunosuppressants' used to prevent organ rejection after a transplant. Organ rejection occurs when a patient's immune system recognizes the donor organ as foreign and tries to eliminate it.

Rapamune 1mg Tablet contains Sirolimus is an immunosuppressant. It weakens your body's defence system (immune system) to help your body accept the new organ as if it were your own. Thereby preventing organ rejection in transplanted patients and assisting the body in accepting the new organ.

Use Rapamune 1mg Tablet as prescribed by your doctor. You are advised to use Rapamune 1mg Tablet for as long as your doctor has prescribed it based on your medical condition. Some people may experience abdominal pain, diarrhoea, headache, fever, urinary tract infection, anaemia, nausea, arthralgia, pain, and oedema. Most of these side effects of Rapamune 1mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

To treat your condition effectually, continue using Rapamune 1mg Tablet for as long as your doctor has prescribed it. Do not use Rapamune 1mg Tablet without a doctor's advice if you are allergic to Rapamune 1mg Tablet or other medicines. Consult your doctor before using Rapamune 1mg Tablet if you are pregnant or breastfeeding. Avoid alcohol consumption with Rapamune 1mg Tablet as it may increase the risk of severe adverse effects. Keep your doctor informed about your health condition and all the medicines you take before taking Rapamune 1mg Tablet to rule out any side effects.

Uses of Rapamune 1mg Tablet

Used to prevent organ rejection

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Rapamune 1mg Tablet contains Sirolimus is an immunosuppressant. It weakens your body's defence system (immune system) to help your body accept the new organ as if it were your own. Thereby preventing organ rejection in transplanted patients and assisting the body in accepting the new organ.

How Rapamune 1mg Tablet Works

Rapamune 1mg Tablet contains Sirolimus is an immunosuppressant. It weakens your body's defence system (immune system) to help your body accept the new organ as if it were your own. Thereby preventing organ rejection in transplanted patients and assisting the body in accepting the new organ.

Storage

Store in a cool and dry place away from sunlight
Side effects of Rapamune 1mg Tablet
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
  • Exercise for at least 30 minutes most days of the week.
  • Limit alcohol consumption.
  • Consider a low carbohydrate diet that limits grains, starchy vegetables and fruit. Include foods rich in protein and fat.
  • Avoid excess sugar, fatty foods and carbohydrates.
  • Aim for weight loss as it helps to improve cardiovascular health and minimize the risk of complications related to obesity.
  • Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
  • Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
  • Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
  • Gently massage the swollen area with firm but not painful pressure.
  • Keep the swollen area clean and moisturized to prevent injury and infection.
  • Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
  • If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
Managing Medication-Triggered UTIs: A Comprehensive Approach:
  • Inform your doctor about the medication you're taking and the UTI symptoms you're experiencing.
  • Your doctor may adjust your medication regimen or consider alternative medications or dosages that may reduce the risk of UTIs.
  • Drink plenty of water (at least 8-10 glasses a day) to help flush out bacteria. Avoid sugary drinks and caffeine, which can exacerbate UTI symptoms.
  • Urinate when you feel the need rather than holding it in. This can help prevent bacterial growth and reduce the risk of UTIs.
  • Consider cranberry supplements: Cranberry supplements may help prevent UTIs by preventing bacterial adhesion.
  • Monitor UTI symptoms and report any changes to your doctor.
  • If antibiotics are prescribed, take them as directed and complete the full course.
Here are the steps to manage Joint Pain caused by medication usage:
  • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
  • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
  • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.

What if I have taken an overdose of Rapamune 1mg Tablet

Take Rapamune 1mg Tablet only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Therapeutic drug monitoring is required for all patients receiving Rapamune 1mg Tablet. To treat your condition effectually, continue using Rapamune 1mg Tablet for as long as your doctor has prescribed it. Do not use Rapamune 1mg Tablet without a doctor's advice if you are allergic to Rapamune 1mg Tablet or other medicines. Consult your doctor before using the Rapamune 1mg Tablet if you are pregnant or breastfeeding. Avoid alcohol consumption with Rapamune 1mg Tablet as it may increase the risk of severe adverse effects. Do not use Rapamune 1mg Tablet in more than prescribed doses or longer duration as it may cause adverse effects. And also, keep your doctor informed about your health condition and all the medicines you take before taking Rapamune 1mg Tablet to rule out any side effects.

Drug-Drug Interactions

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SirolimusMifepristone
Critical
SirolimusBCG vaccine
Critical

Drug-Drug Interactions

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SirolimusMifepristone
Critical
How does the drug interact with Rapamune 1mg Tablet:
Coadministration of Rapamune 1mg Tablet with Mifepristone can increase the levels of Rapamune 1mg Tablet in the blood, which can increase the risk or severity of side effects.

How to manage the interaction:
Taking Rapamune 1mg Tablet with Mifepristone is not recommended, they can be taken together if a doctor advises. However, contact a doctor if you experience any symptoms like back pain · difficulty falling asleep or staying asleep, fever, headache, joint pain, rash, stomach pain, constipation, or diarrhea. Do not stop taking any medications without consulting a doctor.
SirolimusBCG vaccine
Critical
How does the drug interact with Rapamune 1mg Tablet:
Coadministration of Rapamune 1mg Tablet with the BCG vaccine can make the vaccine less effective.

How to manage the interaction:
Taking Rapamune 1mg Tablet with the BCG vaccine is not recommended, they can be taken together if advised by your doctor. However, contact your doctor if you experience any symptoms. Do not stop taking any medications without consulting a doctor.
SirolimusVoriconazole
Critical
How does the drug interact with Rapamune 1mg Tablet:
Coadministration of Rapamune 1mg Tablet and Voriconazole can increase blood levels and side effects of Voriconazole.

How to manage the interaction:
Taking Voriconazole with Rapamune 1mg Tablet is generally avoided as it can result in an interaction, please consult a doctor before taking it. Contact a doctor if you experience nausea, fever, abdominal pain, or yellowing of the skin or eyes. Do not stop using any medication without consulting a doctor.
SirolimusCidofovir
Critical
How does the drug interact with Rapamune 1mg Tablet:
Co-administration of Cidofovir and Rapamune 1mg Tablet can increase the risk or severity of Kidney problems.

How to manage the interaction:
Taking Rapamune 1mg Tablet with Cidofovir is not recommended, but it can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
SirolimusPosaconazole
Critical
How does the drug interact with Rapamune 1mg Tablet:
Coadministration of Rapamune 1mg Tablet with posaconazole can lower the levels of Rapamune 1mg Tablet in the blood.

How to manage the interaction:
Although there is an interaction between posaconazole with Rapamune 1mg Tablet, they can be taken together if a doctor advises. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
SirolimusAmprenavir
Severe
How does the drug interact with Rapamune 1mg Tablet:
Co-administration of Amprenavir and Rapamune 1mg Tablet can increase the side effects of Rapamune 1mg Tablet.

How to manage the interaction:
Although there is a possible interaction between Rapamune 1mg Tablet and Amprenavir, you can take these medicines together if prescribed by your doctor. However, if you experience nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, fluid retention, swelling, difficulty breathing, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, fever, chills, diarrhea, sore throat, breathing difficulty, blood in your coughing fluid, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not discontinue any medications without a doctor's advice.
SirolimusPhenytoin
Severe
How does the drug interact with Rapamune 1mg Tablet:
Co-administration of Rapamune 1mg Tablet and Phenytoin can reduce the blood levels and effectiveness of Rapamune 1mg Tablet.

How to manage the interaction:
Although there is a possible interaction between Phenytoin and Rapamune 1mg Tablet, they can be taken together if a doctor has prescribed it. Do not stop using any medications without talking to a doctor.
Sirolimusvalacyclovir
Severe
How does the drug interact with Rapamune 1mg Tablet:
Coadministration of Rapamune 1mg Tablet with Valacyclovir may increase the risk or severity of kidney problems.

How to manage the interaction:
Although taking Rapamune 1mg Tablet and Valacyclovir together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of appetite, increased urination, weight loss, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without consulting a doctor.
SirolimusOxaprozin
Severe
How does the drug interact with Rapamune 1mg Tablet:
Co-administration of Rapamune 1mg Tablet and Oxaprozin can increase the risk of Kidney problems.

How to manage the interaction:
Co-administration of Rapamune 1mg Tablet with Oxaprozin can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, fluid retention, swelling, difficulty breathing, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
SirolimusSulindac
Severe
How does the drug interact with Rapamune 1mg Tablet:
Coadministration of Sulindac and Rapamune 1mg Tablet can increase the risk or severity of kidney problems.

How to manage the interaction:
Although taking Rapamune 1mg Tablet and Sulindac together can evidently cause an interaction, it can be taken if a doctor has suggested it. However, if you experience nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, fluid retention, swelling, difficulty breathing, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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SIROLIMUS-1MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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SIROLIMUS-1MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking Rapamune 1mg Tablet with Grapefruit and Grapefruit juice may increase the side effects of Rapamune 1mg Tablet. Avoid or limit consumption of Grapefruit and Grapefruit juice while taking Rapamune 1mg Tablet.

Habit Forming

No

Therapeutic Class

IMMUNOSUPPRESSANTS

Rapamune 1mg Tablet Substitute

Substitutes safety advice

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    ₹122.85per tablet

Product Substitutes

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Alcohol

Caution

It is advised to avoid alcohol intake since it may worsen the side effects.

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Pregnancy

Caution

Consult your doctor, and there is no substantial research yet on the use of Rapamune 1mg Tablet in pregnant women.

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Breast Feeding

Caution

Consult your doctor, and there is no substantial research yet on the use of Rapamune 1mg Tablet in breastfeeding/nursing mothers.

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Driving

Caution

Do not drive or operate machinery if you experience dizziness or drowsiness while using Rapamune 1mg Tablet. Rapamune 1mg Tablet can also sometimes cause dizziness/drowsiness; hence avoid driving in such situations. Seek medical attention if the symptoms persist longer.

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Liver

Caution

Please consult your doctor if you have any concerns regarding using Rapamune 1mg Tablet in patients with liver impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Please consult your doctor if you have any concerns regarding using Rapamune 1mg Tablet in patients with kidney impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Caution

There is limited information available on the use of Rapamune 1mg Tablet in children. Please consult your doctor.

Have a query?

FAQs

Rapamune 1mg Tablet is used to prevent organ rejection after a transplant.

Rapamune 1mg Tablet contains Sirolimus is an immunosuppressant. It works by weakening your body's defence system (immune system) to help your body accept the new organ as if it were your own.

No, it is a prescribed drug given by a physician for preventing specific medical conditions. Taking it on your own can cause unwanted side effects.

Rapamune 1mg Tablet is safe if used in the dose and duration recommended by your doctor. Take it exactly as directed, and do not skip any dose. Follow your doctor's guidelines carefully and inform your doctor if any of the side effects disturb you.

Please do not stop using Rapamune 1mg Tablet without consulting your doctor on your own. Continue using Rapamune 1mg Tablet for as long as your doctor has prescribed it to treat your condition effectually. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Rapamune 1mg Tablet.

Take the missed dose as soon as possible. However, skip the missed dose and return to your regular dosing schedule if it is time for the next dose.

Country of origin

India
Other Info - RA87023

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:47 PM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/021083s056,021110s074lbl.pdf
  2. https://www.drugs.com/drug-interactions/sirolimus.
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