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compositionComposition:SIROLIMUS-1MG
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Prescription Medicine
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Raparen 1 Tablet is used to prevent organ rejection after a transplant. It contains Sirolimus which works by weakening the body's defence system (immune system) and assisting the body in accepting the new organ. In some cases, this medicine may cause side effects like abdominal pain, diarrhoea, headache, fever, urinary tract infection, anaemia, nausea, pain, and oedema.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

SIROLIMUS-1MG

Manufacturer/Marketer :

La Renon Healthcare Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Raparen 1 Tablet

Raparen 1 Tablet is a prescription medicine used to prevent the body from rejecting a kidney transplant. It is also prescribed to treat a rare lung disease called lymphangioleiomyomatosis (LAM). This medicine belongs to a class of drugs known as immunosuppressants, which help control and calm your body's immune system response.

You will typically take Raparen 1 Tablet once daily, and it is highly important to take it at the same time every day. You must choose to take it either consistently with food or consistently without food, as food changes how your body absorbs the medicine. Making healthy lifestyle choices, such as eating a balanced diet low in cholesterol and staying hydrated, can support your body's recovery.

While taking this medicine, you may experience common side effects like swelling in your legs, high blood pressure, or slow wound healing. It is vital to contact your doctor immediately if you experience signs of an infection, such as a fever or sore throat, or if you develop a sudden cough or breathing difficulties.

Talk to your doctor before starting this medicine if you have a history of high cholesterol, liver damage, skin cancer, or lung problems. Do not take this if you have had a severe allergic reaction to Raparen 1 Tablet or any of its inactive ingredients.

This medicine interacts with several medications, including certain antibiotics, heart medicines, and anti-seizure drugs, as well as grapefruit juice. If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider, as this medicine can harm an unborn baby.

Uses of Raparen 1 Tablet

Your doctor may prescribe Raparen 1 Tablet to help manage the following conditions:

  • Kidney transplant rejection: Raparen 1 Tablet helps prevent your immune system from attacking and rejecting your newly transplanted kidney, ensuring the new organ can function properly.
  • Lymphangioleiomyomatosis (LAM): Raparen 1 Tablet helps stabilise lung function and slows down the progression of this rare lung disease by controlling the abnormal growth of smooth muscle cells in the lungs.

Key Benefits

When taken as prescribed, Raparen 1 Tablet may provide the following benefits:

  • Supports Long-term Kidney Transplant Function: Helps protect your transplanted kidney by reducing the immune response, supporting its long-term function and helping you return to your daily activities.
  • Helps Preserve Lung Function: In people with lymphangioleiomyomatosis (LAM), this medicine helps slow the decline in lung function, making it easier to manage symptoms such as shortness of breath and stay active.
  • May Reduce the Need for Higher Doses of Other Immunosuppressants: In some cases, your doctor may reduce the dose of other immunosuppressive medicines, such as corticosteroids, which may help lower the risk of certain long-term side effects.
Side effects of Raparen 1 Tablet
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
  • Exercise for at least 30 minutes most days of the week.
  • Limit alcohol consumption.
  • Consider a low carbohydrate diet that limits grains, starchy vegetables and fruit. Include foods rich in protein and fat.
  • Avoid excess sugar, fatty foods and carbohydrates.
  • Aim for weight loss as it helps to improve cardiovascular health and minimize the risk of complications related to obesity.
  • Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
  • Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
  • Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
  • Gently massage the swollen area with firm but not painful pressure.
  • Keep the swollen area clean and moisturized to prevent injury and infection.
  • Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
  • If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
Managing Medication-Triggered UTIs: A Comprehensive Approach:
  • Inform your doctor about the medication you're taking and the UTI symptoms you're experiencing.
  • Your doctor may adjust your medication regimen or consider alternative medications or dosages that may reduce the risk of UTIs.
  • Drink plenty of water (at least 8-10 glasses a day) to help flush out bacteria. Avoid sugary drinks and caffeine, which can exacerbate UTI symptoms.
  • Urinate when you feel the need rather than holding it in. This can help prevent bacterial growth and reduce the risk of UTIs.
  • Consider cranberry supplements: Cranberry supplements may help prevent UTIs by preventing bacterial adhesion.
  • Monitor UTI symptoms and report any changes to your doctor.
  • If antibiotics are prescribed, take them as directed and complete the full course.
Here are the steps to manage Joint Pain caused by medication usage:
  • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
  • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
  • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.

Directions for Use

  • Raparen 1 Tablet can be taken with or without food.
  • It is recommended to take Raparen 1 Tablet once daily at the same time each day or as advised by your doctor.
  • Swallow Raparen 1 Tablet as a whole with a glass of water.
  • Do not break, chew, or crush it.

How Raparen 1 Tablet Works

Raparen 1 Tablet contains sirolimus, an immunosuppressant that works by blocking a protein called mTOR (mammalian target of rapamycin). This protein helps control the growth and activity of certain cells, including immune cells. After a kidney transplant, blocking mTOR reduces the activity of the immune system, helping prevent it from attacking the transplanted kidney. In people with lymphangioleiomyomatosis (LAM), blocking mTOR slows the abnormal growth of smooth muscle cells in the lungs. This helps preserve lung function and slow the progression of the disease.
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Alcohol

Caution

It is advised to avoid alcohol intake since it may worsen the side effects.

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Pregnancy

Caution

Consult your doctor, and there is no substantial research yet on the use of Raparen 1 Tablet in pregnant women.

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Breast Feeding

Caution

Consult your doctor, and there is no substantial research yet on the use of Raparen 1 Tablet in breastfeeding/nursing mothers.

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Driving

Caution

Do not drive or operate machinery if you experience dizziness or drowsiness while using Raparen 1 Tablet . Raparen 1 Tablet can also sometimes cause dizziness/drowsiness; hence avoid driving in such situations. Seek medical attention if the symptoms persist longer.

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Liver

Caution

Please consult your doctor if you have any concerns regarding using Raparen 1 Tablet in patients with liver impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Please consult your doctor if you have any concerns regarding using Raparen 1 Tablet in patients with kidney impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Caution

There is limited information available on the use of Raparen 1 Tablet in children. Please consult your doctor.

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Heart

Consult your doctor

Inform your doctor if you have any existing heart disease. Your doctor will prescribe this medicine only if the potential benefits outweigh the risks.

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Geriatrics

Caution

Raparen 1 Tablet should be given with caution in elderly patients due to an increased risk of side effects. It is important to inform your doctor before using it.

What if I have taken an overdose of Raparen 1 Tablet

If you take too much Raparen 1 Tablet , seek emergency medical attention. Keep the medicine container with you so the medical staff knows exactly what you have taken.

Diet & Lifestyle Advise

  • Avoid grapefruit and grapefruit juice: Grapefruit contains compounds that can dangerously increase the levels of Raparen 1 Tablet in your blood, raising your risk of serious side effects.
  • Protect yourself from the sun: This medicine can increase your risk of skin cancer. Wear protective clothing, a wide-brimmed hat, and apply a broad-spectrum sunscreen with a high SPF when outdoors.
  • Avoid live vaccines: Because your immune system is suppressed, live vaccines (such as the measles, mumps, and rubella vaccine) could cause a severe infection. Talk to your doctor before getting any vaccinations.
  • Practice good hand hygiene: Wash your hands frequently with soap and water, and avoid close contact with people who have active infections like colds or the flu.
  • Maintain consistent food habits: Decide whether you will take your medicine with food or on an empty stomach, and stick to that choice every single day to keep the medicine levels in your body steady.
health query

Have a query?

How Soon It Starts Working

The time required for Raparen 1 Tablet to start to work: The exact onset time of Raparen 1 Tablet has not been clinically established. The time for which the effects of Raparen 1 Tablet last: Raparen 1 Tablet effect lasts for 24 hours.

What if you forget to take Raparen 1 Tablet

If you miss a dose of Raparen 1 Tablet , take it as soon as you remember. However, if it is within 4 hours of your next scheduled dose, skip the missed dose and return to your regular schedule. Do not take a double dose to make up for a missed one. Talk to your doctor if you are unsure of what to do.

Storage

•Store Raparen 1 Tablet according to the instructions on the product label or patient information leaflet.

Drug Warnings

  • Do not switch brands or formulations: Different brands or forms (tablets vs. solution) of Raparen 1 Tablet may absorb differently in your body. Always check with your pharmacist to ensure you receive the exact formulation prescribed by your doctor.
  • Monitor your wounds: Because this medicine slows down the body's natural healing process, pay close attention to any cuts, surgical wounds, or scrapes. Contact your doctor if you notice redness, swelling, or draining fluid.
  • Get regular blood tests: Your doctor will need to perform regular blood tests to monitor the amount of Raparen 1 Tablet in your system, as well as your kidney function, cholesterol, and blood cell counts.
  • Avoid skin contact with the solution: If you are using the oral solution and it spills on your skin, wash the area thoroughly with soap and water immediately. If it gets in your eyes, rinse them with plain water.

Drug-Drug Interactions

verifiedApollotooltip
  • Certain Antibiotics and Antifungal Medicines: Medicines such as clarithromycin, erythromycin, and ketoconazole can increase the amount of Raparen 1 Tablet in your body, which may increase the risk of side effects.
  • Some Medicines for Seizures or Tuberculosis: Medicines such as carbamazepine, phenytoin, phenobarbital, and rifampicin can reduce the amount of Raparen 1 Tablet in your body, making it less effective.
  • Other Medicines That Affect the Immune System: Medicines such as ciclosporin may interact with Raparen 1 Tablet . Your doctor may adjust your treatment and monitor you closely if these medicines are used together.
SirolimusPosaconazole
Critical
SirolimusCidofovir
Critical

Drug-Drug Interactions

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SirolimusPosaconazole
Critical
How does the drug interact with Raparen 1 Tablet:
Coadministration of Raparen 1 Tablet with posaconazole can lower the levels of Raparen 1 Tablet in the blood.

How to manage the interaction:
Although there is an interaction between posaconazole with Raparen 1 Tablet, they can be taken together if a doctor advises. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
SirolimusCidofovir
Critical
How does the drug interact with Raparen 1 Tablet:
Co-administration of Cidofovir and Raparen 1 Tablet can increase the risk or severity of Kidney problems.

How to manage the interaction:
Taking Raparen 1 Tablet with Cidofovir is not recommended, but it can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
SirolimusVoriconazole
Critical
How does the drug interact with Raparen 1 Tablet:
Coadministration of Raparen 1 Tablet and Voriconazole can increase blood levels and side effects of Voriconazole.

How to manage the interaction:
Taking Voriconazole with Raparen 1 Tablet is generally avoided as it can result in an interaction, please consult a doctor before taking it. Contact a doctor if you experience nausea, fever, abdominal pain, or yellowing of the skin or eyes. Do not stop using any medication without consulting a doctor.
SirolimusBCG vaccine
Critical
How does the drug interact with Raparen 1 Tablet:
Coadministration of Raparen 1 Tablet with the BCG vaccine can make the vaccine less effective.

How to manage the interaction:
Taking Raparen 1 Tablet with the BCG vaccine is not recommended, they can be taken together if advised by your doctor. However, contact your doctor if you experience any symptoms. Do not stop taking any medications without consulting a doctor.
SirolimusMifepristone
Critical
How does the drug interact with Raparen 1 Tablet:
Coadministration of Raparen 1 Tablet with Mifepristone can increase the levels of Raparen 1 Tablet in the blood, which can increase the risk or severity of side effects.

How to manage the interaction:
Taking Raparen 1 Tablet with Mifepristone is not recommended, they can be taken together if a doctor advises. However, contact a doctor if you experience any symptoms like back pain · difficulty falling asleep or staying asleep, fever, headache, joint pain, rash, stomach pain, constipation, or diarrhea. Do not stop taking any medications without consulting a doctor.
SirolimusNeomycin
Severe
How does the drug interact with Raparen 1 Tablet:
Co-administration of Raparen 1 Tablet and Neomycin can increase the risk or severity of kidney problems.

How to manage the interaction:
There may be a possibility of interaction between Raparen 1 Tablet and Neomycin, but it can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, fluid retention, swelling, difficulty breathing, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
SirolimusIbandronic acid
Severe
How does the drug interact with Raparen 1 Tablet:
Co-administration of Raparen 1 Tablet and Ibandronic acid may cause an increase in the risk or severity of kidney damage.

How to manage the interaction:
Although taking Ibandronic acid and Raparen 1 Tablet together may lead to an interaction, it can be taken if a doctor has suggested it. However, if you experience symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, pain in the muscles, weakness, tiredness, dizziness, confusion, and irregular heart rhythm, consult a doctor. Do not stop using any medication without consulting a doctor.
SirolimusIndometacin
Severe
How does the drug interact with Raparen 1 Tablet:
Co-administration of Indomethacin with Raparen 1 Tablet can increase the risk or severity of kidney damage.

How to manage the interaction:
Although taking Indometacin and Raparen 1 Tablet together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor immediately, if you experience nausea, vomiting, decreased hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, breathing difficulty, muscle cramps, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medication without consulting a doctor.
SirolimusPhenytoin
Severe
How does the drug interact with Raparen 1 Tablet:
Co-administration of Raparen 1 Tablet and Phenytoin can reduce the blood levels and effectiveness of Raparen 1 Tablet.

How to manage the interaction:
Although there is a possible interaction between Phenytoin and Raparen 1 Tablet, they can be taken together if a doctor has prescribed it. Do not stop using any medications without talking to a doctor.
SirolimusBoceprevir
Severe
How does the drug interact with Raparen 1 Tablet:
Co-administration of Boceprevir and Raparen 1 Tablet together can increase the risk or severity of side effects.

How to manage the interaction:
Although there is a possible interaction between Raparen 1 Tablet and Boceprevir, you can take these medicines together if prescribed by a doctor. However, if you experience nausea, vomiting, a decrease in hunger, increased or decreased urine, discomfort or burning sensation when you urinate, weight gain or loss that occurs suddenly, fluid retention, swelling, difficulty breathing, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, fever, chills, diarrhea, sore throat, breathing difficulty, blood in your coughing fluid, red or irritated skin, body sores, consult a doctor. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit and Grapefruit Juice: Avoid grapefruit and grapefruit juice while taking Raparen 1 Tablet , as they can increase the amount of medicine in your body and raise the risk of side effects.
  • Food: Take Raparen 1 Tablet either always with food or always without food. Changing between taking it with food and without food can affect how your body absorbs the medicine.
SIROLIMUS-1MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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SIROLIMUS-1MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking Raparen 1 Tablet with Grapefruit and Grapefruit juice may increase the side effects of Raparen 1 Tablet. Avoid or limit consumption of Grapefruit and Grapefruit juice while taking Raparen 1 Tablet.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[IMMUNOSUPPRESSANTS]

FAQs

Raparen 1 Tablet is used to prevent organ rejection after a transplant.
Raparen 1 Tablet contains Sirolimus is an immunosuppressant. It works by weakening your body's defence system (immune system) to help your body accept the new organ as if it were your own.
No, it is a prescribed drug given by a physician for preventing specific medical conditions. Taking it on your own can cause unwanted side effects.
Raparen 1 Tablet is safe if used in the dose and duration recommended by your doctor. Take it exactly as directed, and do not skip any dose. Follow your doctor's guidelines carefully and inform your doctor if any of the side effects disturb you.
No, you must never stop taking Raparen 1 Tablet without your doctor's explicit instructions. If you are taking it to prevent transplant rejection, stopping it suddenly can cause your body to reject the new organ. Talk to your doctor before making any changes.
Your doctor needs to measure the amount of the medicine in your blood to make sure you are getting the correct dose. If the level is too low, the medicine may not work; if it is too high, it can cause harmful side effects. Talk to your doctor about your scheduled blood tests.
No, you should never take Raparen 1 Tablet with grapefruit juice. Grapefruit interferes with the enzymes that break down this medicine in your body, which can lead to dangerously high levels of the drug in your bloodstream. Talk to your doctor or pharmacist if you have questions about your diet.
Yes, because Raparen 1 Tablet lowers your immune system's ability to fight off illnesses, you are more likely to catch infections. Avoid close contact with sick individuals and wash your hands frequently. If you develop a fever, chills, or sore throat, talk to your doctor immediately.
You should measure the oral solution using the provided syringe, mix it with water or orange juice in a glass, stir well, and drink it immediately. Never mix it with grapefruit juice or other liquids. Talk to your pharmacist if you need a demonstration on how to use the oral syringe.
If you miss a dose, take it as soon as you remember. However, if your next scheduled dose is less than 4 hours away, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up. Talk to your doctor if you miss multiple doses.
You should avoid receiving live vaccines, such as those for chickenpox, shingles, or MMR, while taking Raparen 1 Tablet because your suppressed immune system may not be able to handle them. Non-live vaccines are generally safe but may be less effective. Talk to your doctor before getting any vaccines.
Yes, Raparen 1 Tablet can increase the levels of cholesterol and triglycerides in your blood. Your doctor will monitor your lipid levels regularly and may prescribe cholesterol-lowering medication or recommend dietary changes if needed. Talk to your doctor if you are concerned about your cholesterol.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 021083S056,021110S074Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Sirolimus. Drug Interactions Reference. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. Sirolimus Sirolimus. 2001. [Accessed on 23 Jan. 2019]Check here
  4. Augustine JJ, Bodziak KA, Hricik DE. Use of sirolimus in solid organ transplantation. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. 2007. [Accessed on 20th June 2022].Check here
  5. Pfizer Ireland Pharmaceuticals. Electronic Medicines Compendium (EMC). [Revised in July 2021] [Accessed on 20th June 2022].Check here
  6. Wyeth Pharmaceuticals Inc. U.S. Food & Drug Administration. [Revised in July 2011] [Accessed on 20th June 2022]. docs/label/2017/021083s059,021110s076lbl.pdCheck here

Country of origin

India

Manufacturer/Marketer address

Behind Rajpath Club, Kensville Road, Opp. Infostretch Building, Off S.G. Highway, Ahmedabad- 380059, Gujarat- India
Other Info - RAP0162
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