Rasbelon Injection 1's

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MRP ₹12300

(Inclusive of all Taxes)

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Written By Lakshmithulasi Yarragunta ,

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Rasbelon Injection is used to treat high levels of uric acid (a natural substance that builds up in the blood as tumors break down) in people with certain types of cancer who are being treated with chemotherapy medications. It works by breaking down uric acid so that the body can eliminate it. Rasbelon Injection may cause nausea, vomiting, constipation, diarrhoea, abdominal pain, mouth sores, throat pain, headache, anxiety, joint pain and fever.

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About Rasbelon Injection

Rasbelon Injection is a recombinant version of the enzyme urate oxidase used to reduce uric acid levels in patients with leukaemia, lymphoma, and solid tumor malignancies receiving anti-cancer therapy. Leukaemia, or blood cancer, is a cancer of blood cells or blood-forming tissues. Lymphoma is a cancer of the lymphatic system.

Rasbelon Injection contains Rasburicase, which belongs to the class of recombinant urate-oxidase enzymes. It works by metabolising the recombinant urate oxidase enzyme and thus helps clear the uric acid levels.

Rasbelon Injection may cause certain side effects such as vomiting, nausea, fever, constipation, diarrhoea, oedema, headache, abdominal pain, anxiety, and injection site reactions. Most of these side effects of Rasbelon Injection do not require medical attention and gradually resolve over time. A trained healthcare professional will administer Rasbelon Injection. Hence, do not self-administer.

If you are allergic to Rasbelon Injection, inform your doctor and avoid taking it. Inform your doctor about your complete medical and medication history before starting treatment with Rasbelon Injection. Rasbelon Injection is contraindicated for pregnant women and breastfeeding women due to serious fetal harm. Hence, inform your doctor if you are pregnant or planning to become pregnant. Inform your doctor if you have/had kidney or liver disease.

Uses of Rasbelon Injection

Rasbelon Injection helps remove excess uric acid levels in patients with leukaemia, lymphoma, and solid tumor malignancies. The detailed uses of Rasbelon Injection are as follows:

Management of Tumor Lysis Syndrome (TLS): Rasbelon Injection is used to treat elevated uric acid levels resulting from rapid tumor breakdown during chemotherapy in patients with leukemia, lymphoma, or other malignancies.
Prevention of Kidney Damage in Cancer Patients: Rasbelon Injection helps lower uric acid concentrations in the blood, reducing the risk of acute kidney injury caused by uric acid crystallization in the renal tubules.
Enzymatic Conversion of Uric Acid: Rasbelon Injection works by converting uric acid into allantoin, a more soluble and easily excreted compound, thereby facilitating rapid clearance from the body.

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Directions for Use

Follow your doctor’s instructions on the dosage and timing of this medication.
Rasbelon Injection will be administered by an oncology doctor.
Do not self-administer it

Medicinal Benefits

Rasbelon Injection contains Rasburicase, which belongs to the recombinant urate-oxidase class of drugs. It works directly by metabolising the recombinant urate oxidase enzyme. This converts into allantoin, which is more soluble in urine. It makes it easier for the kidneys to excrete uric acid from the body.

How Rasbelon Injection Works

Rasbelon Injection contains Rasburicase, which belongs to the class of recombinant urate-oxidase enzymes. It works by metabolising the recombinant urate oxidase enzyme and thus helps clear the uric acid levels.

Storage

• Store in a cool and dry place away from sunlight.• Keep Rasbelon Injection out of the sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Side effects of Rasbelon Injection

High Body Temperature

Here's a comprehensive approach to managing medication-triggered fever:

Inform your doctor immediately if you experience a fever after starting a new medication.
Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
Monitor your body temperature to monitor fever progression.
Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.

Vomiting

To prevent, manage, and treat Constipation caused by medication usage, follow these steps:

Preventing Vomiting (Before it Happens)
Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
Having a small meal before taking your medication can help reduce nausea and vomiting.
Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
Managing Vomiting (If it Happens)
Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
What to Do if Vomiting Persists
Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Nausea

Overcome Medication-Induced Nausea: A 9-Step Plan

Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
Divide your daily food intake into smaller, more frequent meals to reduce nausea.
Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
Use ginger (tea, ale, or candies) to help relieve nausea.
Get adequate rest and also avoid strenuous activities that can worsen nausea.
Talk to your doctor about taking anti-nausea medication if your nausea is severe.
Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Rash

Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
Protect your skin from extreme heat and try to apply wet compresses.
Soak in the cool bath, which gives a soothing impact to the affected area.

Hives Or Skin Rash

Avoid trigger foods that can cause allergic reactions, such as nuts, shellfish, or dairy products.
Keep a food diary to track potential food allergens.
Include omega-3 rich foods like salmon and walnuts to reduce inflammation.
Wear loose, comfortable clothing made from soft fabrics like cotton.
Apply cool compresses or take cool baths to reduce itching.
Use gentle soaps and avoid harsh skin products.
Reduce stress through relaxation techniques like meditation or deep breathing.

What if I have taken an overdose of Rasbelon Injection

As Rasbelon Injection is a parenteral formulation, the chance of overdose may be less. If you think there has been an overdose or experiencing any adverse events, get medical care right away.

Drug Warnings

Inform your doctor if you develop any allergic reactions after receiving Rasbelon Injection. Inform your doctor about your complete medical and medication history before starting treatment with Rasbelon Injection. Rasbelon Injection is contraindicated for pregnant women and breastfeeding women due to serious fetal harm. Hence, inform your doctor if you are pregnant or planning to become pregnant. Rasbelon Injection may cause severe hypersensitivity reactions, anaphylactic reactions, methemoglobinemia, and hemolysis in some patients. Hence, inform your doctor if you have/had any pre-existing liver or kidney disease. Avoid alcohol consumption with Rasbelon Injection as it may cause serious side effects. Avoid breastfeeding while receiving Rasbelon Injection as it can cause harm to the baby. This medicine is contraindicated in patients with G6PD deficiency.

Drug-Drug Interactions

RasburicaseEtidocaine

Severe

RasburicaseTetracaine

Severe

Drug-Drug Interactions

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RasburicaseEtidocaine

Severe

How does the drug interact with Rasbelon Injection:
Taking Rasbelon Injection with Etidocaine may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Although there is a possible interaction between Rasbelon Injection and Etidocaine, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, weakess, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without first talking to your doctor.

RasburicaseTetracaine

Severe

How does the drug interact with Rasbelon Injection:
Taking Rasbelon Injection with Tetracaine can increase the risk of methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Taking Rasbelon Injection with Tetracaine together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, tiredness, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without consulting doctor.

RasburicaseLidocaine

Severe

How does the drug interact with Rasbelon Injection:
Taking Rasbelon Injection with Lidocaine can increase the risk of methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Co-administration of Rasbelon Injection with Lidocaine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, weakness, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without consulting doctor.

RasburicasePrilocaine

Severe

How does the drug interact with Rasbelon Injection:
Combining Rasbelon Injection with Prilocaine may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Although taking Rasbelon Injection and Prilocaine together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, tiredness, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without consulting doctor.

RasburicaseRopivacaine

Severe

How does the drug interact with Rasbelon Injection:
Taking Rasbelon Injection with ropivacaine can increase the risk of methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
There may be a possibility of interaction between Rasbelon Injection and Ropivacaine, but it can be taken if prescribed by a doctor. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, tiredness, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without consulting doctor.

RasburicaseProcaine

Severe

How does the drug interact with Rasbelon Injection:
Combining Rasbelon Injection with Procaine can increase the risk of methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
There may be a possibility of interaction between Rasbelon Injection and Procaine, but it can be taken if prescribed by a doctor. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, tiredness, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without consulting doctor.

RasburicaseLevobupivacaine

Severe

How does the drug interact with Rasbelon Injection:
Taking Rasbelon Injection with Levobupivacaine may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Co-administration of Rasbelon Injection with Levobupivacaine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, tiredness, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without consulting doctor.

RasburicaseSodium nitrite

Severe

How does the drug interact with Rasbelon Injection:
Taking Rasbelon Injection with chloroprocaine may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Co-administration of Rasbelon Injection with Sodium nitrite can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, tiredness, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not discontinue any medications without consulting a doctor.

RasburicaseBupivacaine

Severe

How does the drug interact with Rasbelon Injection:
Taking Bupivacaine with Rasbelon Injection can increase the risk of methemoglobinemia(blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Taking Bupivacaine with Rasbelon Injection together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.

RasburicaseChloroprocaine

Severe

How does the drug interact with Rasbelon Injection:
Taking Rasbelon Injection with Chloroprocaine may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Although there is a possible interaction between Rasbelon Injection and Chloroprocaine, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, weakness, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without consulting doctor.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Maintain a balanced diet including fruits and vegetables rich in nutrients and low-fat proteins like lean meats, fish and poultry.
Drink plenty of water daily while taking Rasbelon Injection as some cancer therapies may cause dehydration.
Exercise regularly and maintain a healthy body weight.
Quit smoking.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

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Alcohol

Consult your doctor

It is unknown whether Rasbelon Injection interacts with alcohol. Please consult your doctor.

Pregnancy

Unsafe

It is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Rasbelon Injection. You should not become pregnant while on treatment with Rasbelon Injection.

Breast Feeding

Unsafe

It is not recommended for use in breastfeeding as it may pass into breast milk and harm your infant. If you are breastfeeding, inform your doctor before receiving Rasbelon Injection. Your doctor may suggest you stop feeding while on treatment with this medicine.

Driving

Caution

Rasbelon Injection is administered as a single dose in a hospital setting. however Rasbelon Injection may cause dizziness; therefore, avoid driving vehicles or operating machinery until you return to normal.

Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Rasbelon Injection. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Rasbelon Injection as it may lead to kidney failure. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

Children

Safe if prescribed

Please consult your doctor. Rasbelon Injection can be used in children if prescribed.

Heart

Rasbelon Injection should be used with caution in individuals with heart problems due to potential risks like hypersensitivity reactions, hemolysis, and methemoglobinemia. It’s essential to consult a healthcare provider for cardiac evaluation and close monitoring before administration.

Geriatrics

Caution

Rasbelon Injection may be used in geriatric patients, as studies have not shown age-specific limitations to its effectiveness. However, older adults should receive it under strict medical supervision due to risks like hypersensitivity, hemolysis, and methemoglobinemia.

FAQs

What is the use of Rasbelon Injection?

Rasbelon Injection is used to help remove excess uric acid levels in patients with leukaemia, lymphoma, and solid tumour malignancies.

How does Rasbelon Injection work?

Rasbelon Injection contains Rasburicase, which works by metabolizing the recombinant urate oxidase enzyme and thus helps clear the uric acid levels.

What are the points to be known before receiving Rasbelon Injection:

Rasbelon Injection is known to cause severe hypersensitivity reactions, hemolysis, and methemoglobinemia in some patients. Hence, inform your doctor about your complete medical and medication history before starting the treatment.

Country of origin

India

Manufacturer/Marketer address

Plot No 264, Patrika Nagar Madhapur, Hitech City Hyderabad, Telangana India - 500081

Other Info - RAS0105

Keep Refrigerated. Do not freeze.Prepaid payment required.

Author Details

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Sep 18, 2025 | 11:50 AM IST

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