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  3. R-Cin 300 Capsule 10's

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R-Cin 300 Capsule 10's, Pack of 10 CAPSULES
R-Cin 300 Capsule 10's, Pack of 10 CAPSULES
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy

R-Cin 300 Capsule is used in combination with other medicines to treat tuberculosis (TB). It contains Rifampicin, which inhibits the growth of bacteria. In some cases, you may experience certain common side effects, such as drowsiness, dizziness, headache, weakness, muscle pain, heartburn, diarrhoea, gas, and numbness or tingling sensations. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

RIFAMPICIN-300MG

Manufacturer/Marketer :

Lupin Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About R-Cin 300 Capsule

R-Cin 300 Capsule is used in combination with other medicines to treat tuberculosis (TB). Tuberculosis is an infectious respiratory disease that affects the lungs but can also spread to other body parts such as the kidneys, brain, spine, and bone marrow. It is also used to treat other bacterial infections. R-Cin 300 Capsule does not work against infections caused by the virus, including cold and flu. The bacteria causing tuberculosis (TB) are highly contagious and spread from one person to another via tiny droplets released into the air (through coughs or sneezes).

R-Cin 300 Capsule consists of a drug called 'rifampicin', which works by inactivating a bacterial protein enzyme (RNA-polymerase) and inhibiting bacterial cell death. R-Cin 300 Capsule acts against the bacteria called Mycobacterium tuberculosis, which causes TB (tuberculosis).

R-Cin 300 Capsule should be taken as recommended by your doctor. It should be taken 30 minutes before food or 2 hours after food on an empty stomach. In some cases, you may experience certain common side effects, such as drowsiness, dizziness, headache, weakness, muscle pain, heartburn, diarrhoea, gas, and numbness or tingling sensations. Most of these side effects are mild and subside over time. However, if any of these effects persist, contact your doctor immediately.

R-Cin 300 Capsule may raise liver enzymes like ALT and can cause jaundice if taken for a long time. Hence, a regular liver function test (LFT) is recommended while taking treatment with R-Cin 300 Capsule . Maintain a gap of one hour between R-Cin 300 Capsule and antacid medicines. R-Cin 300 Capsule is not recommended if you are pregnant or planning for pregnancy. Avoid breastfeeding while taking R-Cin 300 Capsule as it passes into breast milk. R-Cin 300 Capsule may cause dizziness and vision problems; hence, avoid driving vehicles or operating machines that require mental concentration. Avoid alcohol consumption while taking R-Cin 300 Capsule as it could lead to increased drowsiness, dizziness, and liver damage.

Uses of R-Cin 300 Capsule

R-Cin 300 Capsule is used to treat bacterial infections, especially those affecting the lungs and other organs. The detailed uses of R-Cin 300 Capsule are as follows: <br/> • Treatment of tuberculosis (TB): Used as a first-line medicine in combination with other drugs to treat active pulmonary and extrapulmonary tuberculosis.<br/> • Treatment of leprosy: Used with other antimicrobials to treat Hansen’s disease (leprosy) effectively.<br/> • Prophylaxis for meningococcal meningitis: Prevents the transmission of Neisseria meningitidis in close contact with sick patients.<br/> • Treatment of brucellosis: Used in combination with other antibiotics to treat brucellosis, a bacterial infection spread by animals.<br/> • Management of certain staphylococcal infections: Occasionally used with other antibiotics to treat infections caused by Staphylococcus aureus.<br/>

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Directions for Use

  • Take R-Cin 300 Capsule 30 minutes before or 2 hours after food on an empty stomach.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow R-Cin 300 Capsule as a whole with a glass of water.
  • Do not chew, crush or break it.

Medicinal Benefits

R-Cin 300 Capsule contains 'Rifampicin' that treats Tuberculosis (TB) by inactivating a bacterial genetic material that allows TB bacteria to make a copy of their protein for further growth inside the host cell (human). R-Cin 300 Capsule is active against gram-positive cocci bacteria like Mycobacteria and Clostridium difficile and gram-negative bacteria like Neisseria meningitides, N. gonorrhoeae and Hemophilus influenzae. R-Cin 300 Capsule is also used as a second-line treatment in the treatment of cholestatic pruritus. It also treats leprosy and severe gram-positive bacterial infections (like osteomyelitis, endocarditis, brain abscess, meningitis and implant infections) in combination with other antibiotics.

How R-Cin 300 Capsule Works

R-Cin 300 Capsule consists of a drug called 'rifampicin', which works by inactivating a bacterial protein enzyme (RNA-polymerase) and inhibits bacterial cell death. R-Cin 300 Capsule acts against the bacteria called Mycobacterium tuberculosis, which causes TB (tuberculosis).

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of R-Cin 300 Capsule
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Drink plenty of fluids and stay hydrated.
  • Avoid foods containing sugars, salts and processed food.
  • Avoid consumption of alcohol.
  • Take healthy diet containing fiber, carbohydrates and lean proteins.
  • Exercise regularly and maintain a healthy lifestyle.
Managing Medication-Triggered Pancreatitis: A Step-by-Step Guide:
  • If you take medication and get severe stomach pain, feel nauseous, vomit, or have a fever, get emergency medical help right away. This could be a sign of pancreatitis, an inflammation of the pancreas.
  • Your doctor may alter your treatment plan, provide supportive therapy, or prescribe alternative medications to manage the reaction. They will also perform regular tests to monitor your progress and adjust your treatment as needed.
  • Follow your doctor's advice, including dietary recommendations and lifestyle changes, and avoid triggers like alcohol and fatty foods.
  • Monitor your condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.

What if I have taken an overdose of R-Cin 300 Capsule

Do not take more than the prescribed dose of R-Cin 300 Capsule as it may cause an overdose. The symptoms of overdose include stomach pain, itching, headache, nausea, vomiting, loss of consciousness, fast or irregular heartbeat, and yellowing of the skin or eyes. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

R-Cin 300 Capsule should be avoided if you are allergic to any of its contents. Inform your doctor if you have diabetes, epilepsy, gout, mental health problems, HIV infection, malnutrition, peripheral neuropathy, porphyria, bleeding problems, kidney or liver problems on priority before starting treatment with R-Cin 300 Capsule . Avoid foods and drinks containing histamines or tyramine, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer, while treating with R-Cin 300 Capsule as they might cause interaction. Maintain a gap of one hour between R-Cin 300 Capsule and antacid medicines. R-Cin 300 Capsule is not recommended for pregnant women. Hence, inform your doctor if you are pregnant or planning for pregnancy. Avoid breastfeeding while using R-Cin 300 Capsule as it passes into breast milk. R-Cin 300 Capsule should be given to children only if prescribed by the paediatrician. R-Cin 300 Capsule may cause dizziness or drowsiness, so avoid driving vehicles. Avoid alcohol consumption along with R-Cin 300 Capsule as it could lead to increased drowsiness, dizziness and liver damage.

Drug-Drug Interactions

verifiedApollotooltip
RifampicinDarunavir
Critical
RifampicinIndinavir
Critical

Drug-Drug Interactions

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RifampicinDarunavir
Critical
How does the drug interact with R-Cin 300 Capsule:
Taking darunavir with R-Cin 300 Capsule can decrease the blood levels of darunavir, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between darunavir and R-Cin 300 Capsule, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinIndinavir
Critical
How does the drug interact with R-Cin 300 Capsule:
When Indinavir is taken with R-Cin 300 Capsule, it can reduce the blood levels and effects of Indinavir.

How to manage the interaction:
Although there is an interaction between indinavir and R-Cin 300 Capsule, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinSaquinavir
Critical
How does the drug interact with R-Cin 300 Capsule:
Taking saquinavir with R-Cin 300 Capsule can increase the risk or severity of side effects.

How to manage the interaction:
Although there is an interaction between pyrazinamide and R-Cin 300 Capsule, they can be taken together if prescribed by a doctor. However, if you experience fever, stomach pain, less desire to eat, nausea, yellowing of the skin or eyes, or dark urine, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinVoriconazole
Critical
How does the drug interact with R-Cin 300 Capsule:
Taking Voriconazole with R-Cin 300 Capsule can increase blood level of Voriconazole.

How to manage the interaction:
Although there is an interaction between Voriconazole with R-Cin 300 Capsule, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinPirfenidone
Critical
How does the drug interact with R-Cin 300 Capsule:
Taking pirfenidone with R-Cin 300 Capsule can reduce the levels and effects of pirfenidone

How to manage the interaction:
Although there is an interaction between pirfenidone and R-Cin 300 Capsule, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinRanolazine
Critical
How does the drug interact with R-Cin 300 Capsule:
When ranolazine is taken with R-Cin 300 Capsule, it can reduce the blood levels and effects of ranolazine.

How to manage the interaction:
Although there is an interaction between ranolazine and R-Cin 300 Capsule, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinCefotetan
Severe
How does the drug interact with R-Cin 300 Capsule:
Taking R-Cin 300 Capsule together with cefotetan can increase the risk of bleeding

How to manage the interaction:
Taking Cefotetan with R-Cin 300 Capsule together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, contact your doctor if you experience any signs of bleeding, like blood in your urine or stools, vomiting, headache, dizziness, or weakness. Do not stop using any medications without consulting a doctor.
RifampicinTolvaptan
Severe
How does the drug interact with R-Cin 300 Capsule:
Taking R-Cin 300 Capsule and tolvaptan together may possibly reduce the effects of tolvaptan.

How to manage the interaction:
Although taking R-Cin 300 Capsule and tolvaptan together can possibly result in an interaction, it can be taken if your doctor has prescribed it. Do not discontinue any medications without consulting your doctor.
RifampicinDiltiazem
Severe
How does the drug interact with R-Cin 300 Capsule:
Taking diltiazem with R-Cin 300 Capsule can decrease the blood levels of diltiazem, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between diltiazem and R-Cin 300 Capsule, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
RifampicinTenofovir alafenamide
Severe
How does the drug interact with R-Cin 300 Capsule:
Taking tenofovir alafenamide with rifampin may lower the tenofovir alafenamide levels in your blood, possibly decreasing its effectiveness in treating your condition.

How to manage the interaction:
Although taking R-Cin 300 Capsule together with Tenofovir alafenamide can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Try to take foods rich in vitamin C, such as oranges, kiwis, broccoli, and bell peppers, which help in improving the immune system.
  • Avoid consuming processed and fried foods.
  • Warm ginger tea or warm soup can help provide relief from a cough.
  • Avoid foods and drinks containing histamine or tyramine, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine and beer.
  • Smoking and alcohol consumption should be avoided as they cause dizziness.
  • Drinking pineapple juice might help soothe the symptoms of a cough and a cold. It also has anti-inflammatory and mucolytic properties.

Habit Forming

No

Therapeutic Class

ANTI- TUBERCULOSIS

R-Cin 300 Capsule Substitute

Substitutes safety advice
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Alcohol

Caution

R-Cin 300 Capsule intake is not recommended with alcohol. A patient is not advised to take alcohol with R-Cin 300 Capsule as it may increase chances of liver damage.

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Pregnancy

Unsafe

Not recommended during pregnancy. Tell your doctor if you are pregnant or planning to become pregnant. R-Cin 300 Capsule should not be taken during pregnancy as it can affect your unborn baby's growth and may cause complications to the mother and baby after birth.

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Breast Feeding

Unsafe

Not recommended while breastfeeding. A patient should not breast-feed while taking R-Cin 300 Capsule . This is because a small amount of R-Cin 300 Capsule may pass into the mother’s milk. So, if you are breastfeeding or planning to breastfeed, talk to your doctor.

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Driving

Caution

Caution should be maintained by a patient while driving a motor vehicle or doing hazardous work. A patient may experience dizziness, have problems with vision or have other side effects that could affect his ability to drive after taking this medicine. If this happens, do not drive.

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Liver

Caution

Not recommended to be taken in liver patients without a doctor's consultation as R-Cin 300 Capsule has been found to affect liver function with raised ALT enzymes.

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Kidney

Caution

Not recommended for kidney patients without a doctor's consultation. Intake of R-Cin 300 Capsule in these people may result in symptoms like blood in the urine, a change in the amount of urine passed and feeling drowsy or weak.

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Children

Safe if prescribed

R-Cin 300 Capsule is safe to be prescribed in children below 12 years. Dose adjustments by the doctor are done according to age, weight, and severity of infection.

FAQs

R-Cin 300 Capsule belongs to the group of medicines called macrolide antibiotics, primarily used to treat tuberculosis (TB).

Do not stop taking R-Cin 300 Capsule despite symptomatic relief. To treat your condition effectually, continue taking R-Cin 300 Capsule for as long as it has been prescribed by doctor and must be taken strictly at proper times.

R-Cin 300 Capsule is a bactericidal drug, which means it kills bacteria. It acts by blocking the activity of a bacterial enzyme called DNA-dependent RNA polymerase, which is essential for bacterial survival, thereby killing the bacteria.

R-Cin 300 Capsule has no known serious drug interaction with ibuprofen or aspirin. Inform your doctor about all the medications you are currently taking to avoid harmful interactions that may reduce treatment effectiveness.

Yes, in some cases, a headache can be caused as a side effect of R-Cin 300 Capsule . A patient must consult a doctor if it progresses over time.

R-Cin 300 Capsule is safe when used at prescribed doses for the prescribed duration. Constant monitoring of liver function is important while on treatment with R-Cin 300 Capsule . Please consult your doctor if you have any liver problems before taking R-Cin 300 Capsule as it may worsen the situation. However, prolonged use of R-Cin 300 Capsule can cause raised ALT (liver enzyme), and the person taking the treatment can develop jaundice symptoms like yellowing of the eyes, skin, etc. In this case, stop taking R-Cin 300 Capsule and immediately contact a doctor.

R-Cin 300 Capsule may cause temporary discolouration of urine, tears, and other secretions, which may become orange-red in colour. Avoid using contact lenses since they may become discoloured. Contact your doctor for further advice.

No, R-Cin 300 Capsule is not a penicillin, amoxicillin, or sulfa drug. It is an antibiotic in the rifamycin class, combined with other medicines to treat tuberculosis.

R-Cin 300 Capsule is an inducer (increases enzyme activity) of cytochrome P450 enzymes.

R-Cin 300 Capsule may lead to side effects like weight loss, hair loss, and yeast infections, though constipation is less common. Consult your doctor if you experience any of these effects.

R-Cin 300 Capsule causes side effects such as drowsiness, dizziness, headache, muscle pain, weakness, heartburn, diarrhoea, gas, and numbness or tingling sensation. Most of these are temporary and do not require any medical attention, as they will gradually reduce over time. Please contact a doctor if these persist for longer periods.

Country of origin

India

Manufacturer/Marketer address

Lupin Ltd, 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India Country of Origin: India
Other Info - RCI0002

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Santoshini Reddy GDoctor badge

Reviewed By

Santoshini Reddy G

M Pharmacy

Last Updated

Jul 21, 2025 | 1:10 PM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.8789.pdf
  2. https://medlineplus.gov/druginfo/meds/a682403.html
  3. https://www.ncbi.nlm.nih.gov/books/NBK557488/
  4. https://www.mims.com/philippines/drug/info/rifampicin?mtype=generic

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