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compositionComposition:CEFPROZIL-500MG
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Prescription Medicine
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Refzil O 500 Tablet is used to treat bacterial infections. It contains Cefprozil which works by inhibiting the growth of bacteria. In some cases, this medicine may cause side effects such as stomach pain, dizziness, diarrhoea, nausea, and vomiting. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

CEFPROZIL-500MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Refzil O 500 Tablet

Refzil O 500 Tablet is an antibiotic used to treat various bacterial infections, including middle ear infections, skin infections, and throat infections like tonsillitis. It functions by stopping the growth of bacteria, helping your body's immune system clear the illness. This medicine is designed strictly for bacterial conditions and will not work against viral infections such as the flu or common cold.

To ensure maximum effectiveness, it is vital to take Refzil O 500 Tablet consistently at evenly spaced times throughout the day exactly as your doctor instructs. You can take this medicine with or without food, though taking it with meals can help prevent stomach irritation. Incorporating plenty of rest, staying hydrated, and eating a balanced diet will further support your body's recovery during treatment.

While most patients tolerate this medicine well, some may experience mild side effects like nausea, mild diarrhoea, or a temporary skin rash. However, you must contact your doctor immediately if you develop serious symptoms such as severe, watery, or bloody diarrhoea, stomach cramping, or signs of a severe allergic reaction.

Before starting your treatment, talk to your doctor if you have kidney problems or a history of digestive issues like colitis. Do not take this medicine if you have ever had a severe allergic reaction to cephalosporin antibiotics or penicillins.

Certain medications, such as strong diuretics or gout treatments, can interact with Refzil O 500 Tablet by slowing down how your kidneys process the drug. It is also important to consult your healthcare provider if you are pregnant, breastfeeding, or are an older adult, as your dosage may need special consideration.

Uses of Refzil O 500 Tablet

Refzil O 500 Tablet is used to treat certain bacterial infections affecting the ears, throat, respiratory tract, sinuses, skin, and soft tissues. Its main uses include:

  • Middle ear infections (Otitis media): Refzil O 500 Tablet helps clear painful bacterial infections in the middle ear, particularly in children.
  • Throat and tonsil infections (Pharyngitis and Tonsillitis): It eliminates the bacteria responsible for severe sore throats and swollen tonsils.
  • Bronchitis and lung infections: It treats bacterial flare-ups in the airways, reducing coughing and chest congestion.
  • Skin and soft tissue infections: It targets bacteria causing localised skin redness, swelling, and mild infections.
  • Sinus infections (Sinusitis): It helps clear bacterial blockages and inflammation in the nasal passages.

Key Benefits

Refzil O 500 Tablet is an antibiotic used to treat certain susceptible bacterial infections. By controlling the bacteria responsible for the infection, it helps relieve symptoms and supports recovery.

  • Treats Bacterial Infections: Helps eliminate susceptible bacteria responsible for certain respiratory tract, ear, throat, sinus, and skin infections.
  • Relieves Infection-Related Symptoms: As the infection comes under control, symptoms such as fever, throat pain, congestion, swelling, or discomfort may gradually improve.
  • Supports Recovery: Effective treatment helps the body's immune system clear the infection, allowing you to gradually return to normal daily activities.
  • Helps Prevent Infection Progression: Timely and appropriate treatment may reduce the risk of a susceptible bacterial infection worsening or spreading to other parts of the body.
  • Offers Convenient Oral Treatment: As an oral antibiotic, Refzil O 500 Tablet can usually be taken at home as prescribed, without the need for injectable or intravenous administration.
Side effects of Refzil O 500 Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Directions for Use

  • Refzil O 500 Tablet can be taken with or without food as advised by a doctor.
  • It is advised to take Refzil O 500 Tablet twice daily exactly as prescribed by your doctor, following the recommended dosage and duration for your specific medical condition to achieve optimal results
  • Swallow Refzil O 500 Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Refzil O 500 Tablet Works

Refzil O 500 Tablet contains cefprozil, which belongs to a class of medications called cephalosporin antibiotics. It works by interfering with the construction of the bacterial cell wall. Bacteria need a strong, stable outer wall to survive and multiply in your body. Refzil O 500 Tablet binds to specific proteins in the bacterial cell wall, preventing the bacteria from locking their protective wall together. Without this shield, the bacterial cells rupture and die, allowing your body's natural immune system to easily clear the remaining infection.
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Alcohol

Caution

Avoid consuming alcohol along with Refzil O 500 Tablet to avoid unpleasant side effects.

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Pregnancy

Caution

Please consult your doctor if you are pregnant before taking Refzil O 500 Tablet. Your doctor will weigh the benefits and any potential risks before prescribing this medicine.

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Breast Feeding

Safe if prescribed

Refzil O 500 Tablet is probably safe when used in breastfeeding. Please consult your doctor. Your doctor will weigh the benefits and any potential risks before prescribing.

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Driving

Caution

Refzil O 500 Tablet may cause dizziness, so do not drive or operate heavy machinery if you feel dizzy after taking this medicine.

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Liver

Safe if prescribed

Refzil O 500 Tablet is probably safe when used in patients with liver diseases. However, please consult your doctor before taking this medicine.

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Kidney

Caution

Refzil O 500 Tablet should be used with caution if you have kidney problems. Your doctor may adjust the dose based on your condition.

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Children

Caution

Use Refzil O 500 Tablet in children in prescribed doses. The dose will be determined by your doctor based on your child's condition, age and body weight.

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Heart

Safe if prescribed

Refzil O 500 Tablet is safe for use in heart patients if prescribed by the physician. Please consult your physician if you have any concerns.

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Geriatrics

Caution

Refzil O 500 Tablet can be given in elderly patients with extreme caution, if prescribed by the physician. Dosage adjustment may be needed.

What if I have taken an overdose of Refzil O 500 Tablet

Taking too much of this medication can lead to serious health complications, such as severe stomach upset or seizures. If you suspect an overdose, seek immediate medical attention or contact your local poison control centre right away.

Diet & Lifestyle Advise

  • Support your gut health: Taking a high-quality probiotic or eating fermented foods like yoghurt with active cultures can help restore the balance of friendly gut bacteria that antibiotics can disrupt. Take your probiotic at least two hours before or after your antibiotic dose so they do not interfere with each other.
  • Stay well-hydrated: Drink plenty of water throughout the day to help your kidneys efficiently process and clear the medication from your body.
  • Rest to recover: Allow your body ample rest. Sleep is crucial for your immune system to work alongside the antibiotic to eliminate the bacterial infection.
health query

Have a query?

How Soon It Starts Working

The time required for Refzil O 500 Tablet to start to work: The time required for Refzil O 500 Tablet to show its action is not clinically established. The time for which the effects of Refzil O 500 Tablet last: The duration of action for Refzil O 500 Tablet is not clinically established.

What if you forget to take Refzil O 500 Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular routine. Do not take a double dose to make up for a missed one, as this can increase your risk of unwanted side effects.

Storage

•For the liquid suspension form, store the mixed liquid in the refrigerator. •Keep the bottle tightly closed, do not freeze it, and safely discard any unused portion after 14 days.

Drug Warnings

  • Shake the liquid well: If you are using the liquid suspension, shake the bottle thoroughly before measuring each dose to ensure the medicine is evenly distributed.
  • Watch for skin rashes: Stop taking the medicine and contact your doctor immediately at the first sign of a skin rash or blistering, as this could be an early warning sign of a severe allergic reaction.
  • Do not share your medicine: Even if someone has similar symptoms, never share Refzil O 500 Tablet, as it must only be taken under a doctor's supervision.
  • Monitor for thrush: Prolonged use of antibiotics can sometimes lead to yeast overgrowth. Watch for white patches in the mouth (oral thrush) or vaginal itching, and report these to your doctor.

Drug-Drug Interactions

verifiedApollotooltip

The following medicines may interact with Refzil O 500 Tablet and require caution, closer monitoring, or treatment adjustments:

  • Gout Medications (like probenecid): Taking these alongside Refzil O 500 Tablet can slow down how your kidneys clear the antibiotic, raising its levels in your blood and increasing the risk of side effects.
  • Loop Diuretics: Medicines such as furosemide may require additional caution when used with Refzil O 500 Tablet, particularly in people with existing kidney problems or other risk factors for kidney impairment.
  • Hormonal Contraceptives: No clinically significant reduction in the effectiveness of hormonal contraceptives has been established with Refzil O 500 Tablet or cephalosporin antibiotics in general. However, severe vomiting or diarrhoea can reduce the absorption of oral contraceptive pills; follow the missed-pill or illness instructions for your contraceptive product and ask your doctor or pharmacist if you are unsure.
     
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Refzil O 500 Tablet when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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FAQs

No, you should never stop taking Refzil O 500 Tablet early, even if you feel completely better. Stopping early can leave stronger bacteria alive, which can cause the infection to return and become resistant to antibiotics. Talk to your doctor if you feel unable to finish your prescription.
It depends on how severe your penicillin allergy is. Since Refzil O 500 Tablet belongs to a similar family of antibiotics, there is a small risk of cross-reaction. If you have had a severe reaction like hives or trouble breathing with penicillin, you should generally avoid this medicine. Talk to your doctor or pharmacist to find a safer alternative.
Yes, mild diarrhoea is a common side effect of Refzil O 500 Tablet because it can disrupt the natural balance of bacteria in your digestive tract. However, if you experience severe, watery, or bloody diarrhoea with stomach cramps, stop taking the medication and call your doctor immediately. Talk to your doctor before taking any anti-diarrhoea medicines.
Yes, if you have been prescribed the liquid suspension form of Refzil O 500 Tablet, it must be stored in the refrigerator. Do not freeze it, and make sure to throw away any unused liquid after 14 days. Talk to your pharmacist if you have questions about storing your medication.
While alcohol does not directly stop Refzil O 500 Tablet from working, it is highly recommended to avoid alcohol during your recovery. Alcohol can worsen side effects like dizziness and stomach upset, and it can dehydrate your body, slowing down your recovery. Talk to your doctor or pharmacist for more personalised advice.
Refzil O 500 Tablet should only be used during pregnancy if it is clearly needed and prescribed by your doctor. Small amounts of the medicine can pass into breast milk, which may affect a nursing infant. Talk to your doctor or pharmacist to weigh the benefits and risks.
Yes. Refzil O 500 Tablet can generally be taken with food, including milk, yoghurt, and other dairy products. Calcium in ordinary foods is not known to meaningfully reduce Refzil O 500 Tablet absorption. If the medicine causes stomach upset, taking it with food may help.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 050664S024,050665S024Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Cefprozil Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. Cefprozil Cefprozil. 2024. [Accessed on 09 Jan. 2026]Check here
  4. Cefprozil. A review of its antibacterial activity, pharmacokinetic properties, and therapeutic potential. NCBI. National Center for Biotechnology information. National library of Medicine. February 1993. [Accessed on 14th August 2024]Check here
  5. Cefprozil. National Library of Medicine. MedlinePlus. [Revised in January 2022]. [Accessed on 14th August 2024]Check here
  6. Central Drugs Standard Control Organisation (CDSCO). [Accessed on 28 Mar. 2019]Check here
  7. Sandoz Canada Inc. Cefprozil Tablets (cefprozil as cefprozil monohydrate). Tablets, 250 mg and 500 mg. [Revised in October 2020]. [Accessed on 14th August 2024] pm/00058690.PDFCheck here

Country of origin

India

Manufacturer/Marketer address

SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - REF0012
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