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  3. Regonat 40 mg Tablet 28's

Regonat 40 mg Tablet 28's, Pack of 1 TABLET
Regonat 40 mg Tablet 28's, Pack of 1 TABLET
Regonat 40 mg Tablet 28's, Pack of 1 TABLET
Regonat 40 mg Tablet 28's, Pack of 1 TABLET
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Regonat 40 mg Tablet is used to treat colorectal carcinoma. It contains Regorafenib as an active ingredient, which belongs to the class of medicines known as kinase inhibitors. It works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells. This medicine is not recommended for use in pregnant and breastfeeding mothers due to embryo-fetal toxicity.

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Composition :

REGORAFENIB-40MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Regonat 40 mg Tablet

Regonat 40 mg Tablet is an anti-cancer medicine used in the treatment of colorectal carcinoma. Colorectal cancer is a disease in which the cancer or the malignant cells grow out of control in the colon or rectum.

Regonat 40 mg Tablet contains Regorafenib as an active ingredient, which belongs to the class of medicines known as kinase inhibitors. It works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells.

Regonat 40 mg Tablet may cause certain side effects such as diarrhea, rash, tiredness, decreased appetite, nausea, weight loss, fatigue, stomach pain, loss of appetite, hoarseness, and dizziness. These side effects do not require medical attention and gradually resolve over time. Regonat 40 mg Tablet should be taken as advised by your doctor.

Avoid taking Regonat 40 mg Tablet if you are allergic to it or any other components of it. Before taking this medicine, inform your doctor if you have/had liver or kidney disease, gastrointestinal disorders, hypertension, heart problems, blood disorders, plan of any surgery, or any skin disorders. This medicine is not recommended for use in pregnant and breastfeeding mothers due to embryo-fetal toxicity.

Uses of Regonat 40 mg Tablet

Treatment of Colorectal Cancer

Directions for Use

Take Regonat 40 mg Tablet as prescribed by the doctor. It should be taken with a low-fat breakfast. Swallow it as a whole with a glass of water. Do not crush, break, or chew the medicine. This medicine should be taken once daily for 21 days and then stopped for 7 days. This is called 1 cycle of therapy. Repeat the same until your doctors tells you. Avoid taking more than the prescribed dose of medicine.

Medicinal Benefits

Regonat 40 mg Tablet contains, Regorafenib which used in the treatment of colorectal cancer (CRC) in patients who have previously been treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an antiVEGF therapy, and, if KRAS wild type, an anti-EGFR therapy. It works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body. In this way, Regonat 40 mg Tablet stops the body's production, spread and growth of cancerous cells.

How Regonat 40 mg Tablet Works

Regonat 40 mg Tablet contains Regorafenib as an active ingredient, which belongs to the class of medicines known as kinase inhibitors. It works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells.

Storage

Store in a cool and dry place away from sunlight
Side effects of Regonat 40 mg Tablet
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • If you experience symptoms such as mouth ulcers, redness, difficulty in swallowing or talking, abdominal pain, and painful bowel movements as a drug side effect, consult your doctor as they may adjust the dose if necessary or prescribe alternative medication.
  • Practice good hygiene, such as washing your hands regularly, to prevent infection.
  • Drink plenty of water to keep your mucous membranes hydrated and promote healing.
  • Avoid spicy or acidic foods, which can irritate the mucous membranes and exacerbate inflammation.
  • Increase your intake of omega-3 fatty acids, found in fatty fish, nuts, and seeds, to reduce inflammation.
  • Follow a soft food diet to reduce discomfort and promote healing.
  • Weight loss without physical activity needs immediate medical attention.
  • Get a physical examination and blood tests done to identify factors causing weight loss that could be related to metabolism and thyroid function.
  • Avoid smoking and alcohol intake as it can alter your liver condition and increase your weight loss.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes of weight loss.
  • Talk to your dietician and consume food which can maintain ideal weight.
  • Wash your hands regularly with soap and water or use a hand sanitizer to prevent the spread of infections.
  • Wear masks, gloves and other protective clothing.
  • Cover sneezes and coughs with a medical mask or tissue or your elbow.
  • Take vaccinations to enhance your immunity to specific diseases.
  • Clean your utensils, linen and surfaces regularly.

What if I have taken an overdose of Regonat 40 mg Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Regonat 40 mg Tablet may include gastrointestinal bleeding, hypertension, acute renal failure, respiratory depression, and coma. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

To treat your condition effectually, continue taking Regonat 40 mg Tablet for the period that your doctor has prescribed. Avoid taking Regonat 40 mg Tablet if you are allergic to it or any other components present in it. Breastfeeding should be discontinued in nursing mothers during the treatment as it passes into breast milk and may cause a possible risk to the infant. This medicine is not recommended for use in children below 18 years of age as the safety and efficacy are not established. Regonat 40 mg Tablet may cause hypertension, heart attack, hand-foot skin reaction, gastrointestinal perforation, haemorrhage, hepatotoxicity, and Reversible Posterior Leukoencephalopathy Syndrome (RPLS) in some patients. Hence, inform your doctor about your complete medication and medical history before taking Regonat 40 mg Tablet . Inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment, as this medicine is known to cause embryo-fetal toxicity. Avoid driving and operating machines, as this medicine may cause dizziness.

Drug-Drug Interactions

verifiedApollotooltip
RegorafenibDexamethasone
Critical
RegorafenibBosentan
Critical

Drug-Drug Interactions

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RegorafenibDexamethasone
Critical
How does the drug interact with Regonat 40 mg Tablet:
When Regonat 40 mg Tablet is taken with Dexamethasone, may significantly reduce the blood levels of Regonat 40 mg Tablet.

How to manage the interaction:
Co-administration of Regonat 40 mg Tablet and Dexamethasone can lead to an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor's advice.
RegorafenibBosentan
Critical
How does the drug interact with Regonat 40 mg Tablet:
Taking Regonat 40 mg Tablet with bosentan it can increases the risk of side effects.

How to manage the interaction:
Taking Regonat 40 mg Tablet with Bosentan is not recommended, please consult your doctor before taking it. They can be taken together if advised by your doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
RegorafenibEnzalutamide
Critical
How does the drug interact with Regonat 40 mg Tablet:
Taking Enzalutamide with Regonat 40 mg Tablet may decrease the blood levels of Regonat 40 mg Tablet, which may make Regonat 40 mg Tablet less effective in treating your condition.

How to manage the interaction:
Taking Enzalutamide with Regonat 40 mg Tablet is not recommended, as it may lead to an interaction, it can be taken if prescribed by the doctor. Do not discontinue any medications without a doctor's advice.
RegorafenibImatinib
Critical
How does the drug interact with Regonat 40 mg Tablet:
When Regonat 40 mg Tablet is taken with Imatinib, it may increase the level of imatinib which may lead to side effects.

How to manage the interaction:
Taking Regonat 40 mg Tablet with Imatinib is not recommended, it can be taken if prescribed by your doctor. However, if you experience any unusual symptoms, consult the doctor.
RegorafenibCarbamazepine
Critical
How does the drug interact with Regonat 40 mg Tablet:
When Regonat 40 mg Tablet is taken with Carbamazepine, it may decrease the blood levels of Regonat 40 mg Tablet, which may make Regonat 40 mg Tablet less effective in treating your condition.

How to manage the interaction:
Taking Regonat 40 mg Tablet with Carbamazepine is generally not advised, but it can be taken if prescribed by the doctor. Without consulting a doctor, never stop taking any drugs.
RegorafenibClarithromycin
Critical
How does the drug interact with Regonat 40 mg Tablet:
When Regonat 40 mg Tablet is taken with Clarithromycin, may alter the blood levels and effects of Regonat 40 mg Tablet.

How to manage the interaction:
Co-administration of Clarithromycin and Regonat 40 mg Tablet can lead to an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor's advice.
RegorafenibKetoconazole
Critical
How does the drug interact with Regonat 40 mg Tablet:
When Regonat 40 mg Tablet is taken with Ketoconazole, it can increase the levels of Regonat 40 mg Tablet, which may lead to side effects.

How to manage the interaction:
Taking Regonat 40 mg Tablet with Ketoconazole is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. Do not stop using any medications without talking to a doctor.
RegorafenibIsoniazid
Critical
How does the drug interact with Regonat 40 mg Tablet:
When Isoniazid is taken with Regonat 40 mg Tablet, it can increase the levels of Regonat 40 mg Tablet leading to side effects.

How to manage the interaction:
Taking Regonat 40 mg Tablet with Isoniazid is not recommended, it taken can be taken if prescribed by the doctor.
RegorafenibPrasugrel
Severe
How does the drug interact with Regonat 40 mg Tablet:
Combining Prasugrel with Regonat 40 mg Tablet can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
There may be a possibility of interaction between Prasugrel and Regonat 40 mg Tablet, but it can be taken if prescribed by a doctor. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
RegorafenibDabigatran etexilate
Severe
How does the drug interact with Regonat 40 mg Tablet:
Taking Dabigatran etexilate with Regonat 40 mg Tablet can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Dabigatran etexilate with Regonat 40 mg Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles, reduces fatigue, helps in weight loss, and gives strength. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Getting adequate sleep as resting helps improve your health and mental ability and improves attention.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Eat food rich in antioxidants such as berries, spinach, etc.
  • Foods containing fibre help in better digestion. These include beans, peas, lentils, whole grains, nuts, and seeds.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Regonat 40 mg Tablet Substitute

Substitutes safety advice

  • Adgorif 40 Tablet 28's

    by Others

    ₹353.57per tablet

  • NUBLEXA 40MG TABLET 28'S

    by Others

    ₹1161.76per tablet

  • Regdual Tablet 28's

    by Others

    ₹142.86per tablet

Product Substitutes

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Alcohol

Unsafe

Avoid alcohol consumption while taking Regonat 40 mg Tablet .

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Pregnancy

Unsafe

Regonat 40 mg Tablet is not recommended for use in pregnancy as it may cause embryo-fetal toxicity and harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking Regonat 40 mg Tablet . You should not become pregnant while you are taking Regonat 40 mg Tablet and for at least two weeks after your treatment. Using effective birth control methods while on treatment with Regonat 40 mg Tablet is suggested.

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Breast Feeding

Unsafe

Regonat 40 mg Tablet should not be taken if you are breastfeeding as it passes into breast milk and may harm your infant.

bannner image

Driving

Unsafe

Regonat 40 mg Tablet may cause dizziness in some patients. Hence, do not drive, operate machinery, or engage in any activity that needs concentration until you are confident that you can do so safely while you are on treatment with Regonat 40 mg Tablet .

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Liver

Caution

If you have a pre-existing or a history of liver problems, tell your doctor before taking this medicine. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney diseases, inform your doctor before taking Regonat 40 mg Tablet . Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

bannner image

Children

Unsafe

Regonat 40 mg Tablet is not recommended for use in children below 18 years of age as the safety and efficacy is not established.

Have a query?

FAQs

Regonat 40 mg Tablet is used to treat Colorectal Cancer.

Regonat 40 mg Tablet contains Regorafenib, which works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells.

Regonat 40 mg Tablet is safe to be taken by a diabetic person. However, take Regonat 40 mg Tablet only after consulting with a doctor, as they may adjust the dosing according to your condition.

You should know that this medicine may reduce fertility in both men and women. Discuss the risks of taking an irinotecan injection with your doctor.

Yes, Regonat 40 mg Tablet is a chemotherapy agent used in the treatment of colon and rectal cancer.

Regonat 40 mg Tablet should be taken with a low-fat breakfast. Swallow it as a whole with a glass of water. Do not crush, break, or chew the medicine.

Yes, Regonat 40 mg Tablet works by shrinking the tumours or stopping their growth. Thereby, it helps treat colorectal cancer.

Regonat 40 mg Tablet may cause side effects such as diarrhoea, rash, tiredness, decreased appetite, nausea, weight loss, fatigue, stomach pain, loss of appetite, hoarseness, and dizziness. Consult the doctor if any of these side effects persist or worsen.

Country of origin

INDIA

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - REG0179

Disclaimer

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 9:32 AM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/203085lbl.pdf
  2. https://www.drugs.com/drug-interactions/regorafenib.html
  3. https://go.drugbank.com/drugs/DB08896
  4. https://www.stivarga-us.com/
  5. https://reference.medscape.com/drug/stivarga-regorafenib-999774
  6. https://www.cancerresearchuk.org/about-cancer/treatment/drugs/regorafenib
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