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Religrast 300mcg Injection is used to treat neutropenia (lack of certain white blood cells) caused by cancer, bone marrow transplant, chemotherapy, bacterial infections or other conditions. It contains Filgrastim, which stimulates the bone marrow (the tissue where new blood cells are made) to produce more white blood cells that help fight infection.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

FILGRASTIM-300MCG

Manufacturer/Marketer :

Reliance Formulation Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Religrast 300mcg Injection

Religrast 300mcg Injection is a prescribed medicine injected to help your body produce more white blood cells, specifically neutrophils. It is primarily used to prevent or treat low white blood cell counts, a condition that often occurs after receiving chemotherapy or bone marrow transplants. By increasing these protective cells, the medicine lowers your risk of serious infections during cancer treatments.

This injection is typically given once daily, and keeping a consistent schedule is highly important for the best results. Since it is given as an injection, it is not affected by food, so you do not need to worry about taking it with meals. To support your body during treatment, it is highly recommended to practise strict hygiene and follow a clean, fully cooked diet to avoid accidental exposure to germs.

Like many medicines, Religrast 300mcg Injection can cause side effects, with bone pain and joint discomfort being the most common as your bone marrow works to make new cells. While these are usually manageable, you should seek medical attention immediately if you experience severe pain in your left upper stomach or shoulder, or if you develop breathing difficulties. Always consult your doctor if you experience any persistent or unusual symptoms during your treatment.

Do not take this if you have had a severe allergic reaction to this medicine or similar proteins. Before starting therapy, tell your doctor if you have sickle cell disease, spleen problems, or kidney issues, as this treatment requires careful monitoring under these conditions.

Certain medicines, especially chemotherapy given within 24 hours of your injection, can interfere with how this treatment works. It is also important to tell your doctor if you are pregnant, planning to become pregnant, breastfeeding, or if you are caring for an elderly patient who may be more sensitive to side effects.

Uses of Religrast 300mcg Injection

Religrast 300mcg Injection is injected to help your body produce more white blood cells, specifically neutrophils. The detailed uses of Religrast 300mcg Injection are as follows:

  • Neutropenia from chemotherapy: This medicine helps prevent infections in people receiving strong cancer chemotherapy that lowers white blood cell levels.
  • Bone marrow transplantation: It shortens the time it takes for your bone marrow to recover and start producing healthy blood cells after a transplant.
  • Severe chronic neutropenia: It helps manage and maintain safe white blood cell counts in individuals with long-term, severe natural deficits in these cells.
  • Stem cell collection: It helps release stem cells from your bone marrow into your bloodstream so they can be collected for future transplant procedures.
     

Key Benefits

Religrast 300mcg Injection helps stimulate the production of white blood cells, strengthening your body's ability to fight infections during treatments that suppress the immune system. By supporting healthy immune function, it helps reduce infection-related complications and allows planned treatment to continue.

  • Helps Reduce the Risk of Serious Infections: By increasing the number of infection-fighting white blood cells, Religrast 300mcg Injection helps lower the risk of severe infections and complications associated with low white blood cell counts.
  • Supports Recovery of White Blood Cell Counts: Religrast 300mcg Injection helps the bone marrow produce white blood cells more quickly, allowing your immune system to recover after chemotherapy or other treatments that reduce blood cell counts.
  • Helps Keep Cancer Treatment on Schedule: By promoting faster recovery of white blood cell levels, Religrast 300mcg Injection helps reduce delays in chemotherapy, allowing you to continue your cancer treatment as planned.

Directions for Use

  • Follow your doctor’s recommendations on the dosage and timing of this medication to achieve optimal results.
  • Religrast 300mcg Injection will be administered by a healthcare professional.
  • Do not self-administer.

How Religrast 300mcg Injection Works

Religrast 300mcg Injection contains filgrastim, which works by acting like a natural protein that your body produces, known as granulocyte colony-stimulating factor. When injected, it binds to specific receptors on the stem cells inside your bone marrow. Once connected, it signals these stem cells to grow, mature, and rapidly multiply into active white blood cells called neutrophils. These newly formed cells are then released directly into your bloodstream, where they can immediately begin defending your body against bacteria and other harmful germs.
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Alcohol

Caution

Avoid alcohol consumption while taking Religrast 300mcg Injection . It could lead to increased dizziness and drowsiness.

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Pregnancy

Caution

It is not known whether this Religrast 300mcg Injection will harm an unborn baby. Inform your doctor if you are pregnant or plan to become pregnant.

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Breast Feeding

Caution

It is unknown whether Religrast 300mcg Injection passes over into the breast milk. Please inform your doctor if you are breastfeeding before taking Religrast 300mcg Injection .

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Driving

Caution

Religrast 300mcg Injection may cause dizziness, drowsiness, and tiredness; do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

If you have liver problems, inform your doctor before receiving Religrast 300mcg Injection . Your doctor may adjust the dose based on your condition or prescribe a suitable alternative.

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Kidney

Caution

Religrast 300mcg Injection should be used with caution in patients with kidney diseases. Dose adjustments may be necessary. In some case, Religrast 300mcg Injection cause kidney injury. Inform your doctor immediately if you experience puffiness in your face or ankles, blood in your urine, or brown-coloured urine, or you notice you urinate less than usual.

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Children

Safe if prescribed

Religrast 300mcg Injection is used to treat children who are receiving chemotherapy or who suffer from severe low white blood cell count (neutropenia). The doctor will decide the dose of Religrast 300mcg Injection based on the age, body weight and condition of your child.

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Heart

Consult your doctor

Limited information is available; please consult your doctor.

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Geriatrics

Consult your doctor

Limited information available for use of Religrast 300mcg Injection in elderly patients. Please consult your doctor.

What if I have taken an overdose of Religrast 300mcg Injection

If you suspect an accidental overdose, seek emergency medical care immediately. An overdose can cause excessively high white blood cell levels, which requires monitoring by medical professionals.

Diet & Lifestyle Advise

To help support your immune system and protect your health while using Religrast 300mcg Injection , consider the following evidence-based tips:

  • Follow a neutropenic-safe diet: Avoid raw or undercooked meats, seafood, and eggs. Thoroughly wash all fresh fruits and vegetables, and avoid unpasteurised dairy and juices to minimise infection risks.
  • Practise meticulous hand hygiene: Wash your hands frequently with warm water and soap for at least 20 seconds, especially before meals, after using the restroom, and after being in public spaces.
  • Avoid crowded places: Stay away from large crowds and individuals who are actively sick, coughing, or showing signs of a cold or flu.
  • Maintain gentle dental care: Use a soft-bristled toothbrush to prevent bleeding gums, which can be an entry point for bacteria.
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How Soon It Starts Working

The time required for Religrast 300mcg Injection to start to work: The time required for Religrast 300mcg Injection to show its action is not clinically established. The time for which the effects of Religrast 300mcg Injection last: The duration of action for Religrast 300mcg Injection is not clinically established.

What if you forget to take Religrast 300mcg Injection

If you miss an injection, take it as soon as you remember. However, if it is almost time for your next scheduled injection, skip the missed dose and return to your regular routine. Do not inject a double dose to make up for a missed one. Talk to your doctor or pharmacist if you are unsure of what to do.

Storage

•Store the medicine in the refrigerator between 2°C and 8°C (36°F to 46°F). •Keep the syringes or vials in their original carton to protect them from light.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Do not shake the medicine: Shaking the syringe or vial vigorously can damage the protein, making it ineffective. Always handle it gently.
  • Check the administration timing: Do not inject this medicine within 24 hours before or 24 hours after receiving your chemotherapy treatment, as this can interfere with how both therapies work.
  • Rotate your injection sites: Keep track of where you inject each day to avoid skin irritation, tissue damage, or scarring.
  • Inspect the solution first: Before injecting, look closely at the liquid. It should be clear and colourless; do not use if you see any floating particles or discolouration.
  • Never reuse needles or syringes: Use a brand-new syringe for every single injection, and discard it immediately after a single use into a designated sharps container.

Drug-Drug Interactions

verifiedApollotooltip
  • Chemotherapy medications: Injecting this medicine too close to chemotherapy doses (within 24 hours before or after) may interfere with the production of new white blood cells.
  • Lithium: Taking lithium alongside this treatment can cause your body to release even more white blood cells. This combination requires close monitoring by your doctor.
     
FilgrastimRomidepsin
Severe

Drug-Drug Interactions

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FilgrastimRomidepsin
Severe
How does the drug interact with Religrast 300mcg Injection 0.5 ml:
Coadministration of Religrast 300mcg Injection 0.5 ml with Romidepsin can reduce the effect of Religrast 300mcg Injection 0.5 ml.

How to manage the interaction:
Although there is an interaction between Religrast 300mcg Injection 0.5 ml and Romidepsin, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Religrast 300mcg Injection 0.5 ml:
Combining Religrast 300mcg Injection 0.5 ml with Bleomycin can increase the risk of developing lung disorders.

How to manage the interaction:
There may be a possibility of interaction between Religrast 300mcg Injection 0.5 ml and Bleomycin, it can be taken if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Religrast 300mcg Injection 0.5 ml:
Coadministration of Religrast 300mcg Injection 0.5 ml with Azacitidine can reduce the effects of Religrast 300mcg Injection 0.5 ml.

How to manage the interaction:
Although there is an interaction between Religrast 300mcg Injection 0.5 ml and azacitidine, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Religrast 300mcg Injection 0.5 ml:
Co-administration of Religrast 300mcg Injection 0.5 ml together with Melphalan can reduce the effect of Religrast 300mcg Injection 0.5 ml.

How to manage the interaction:
Although taking Religrast 300mcg Injection 0.5 ml and Melphalan together can cause an interaction, it can be taken if a doctor has suggested it. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Religrast 300mcg Injection 0.5 ml:
Coadministration of Religrast 300mcg Injection 0.5 ml with Busulfan can reduce the effects of Religrast 300mcg Injection 0.5 ml.

How to manage the interaction:
Although there is a possible interaction between Religrast 300mcg Injection 0.5 ml and Busulfan, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without talking to your doctor.
How does the drug interact with Religrast 300mcg Injection 0.5 ml:
Using Religrast 300mcg Injection 0.5 ml together with lenalidomide can reduce the effect of Religrast 300mcg Injection 0.5 ml.

How to manage the interaction:
Co-administration of Religrast 300mcg Injection 0.5 ml with Lenalidomide can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Religrast 300mcg Injection 0.5 ml:
Taking Religrast 300mcg Injection 0.5 ml together with Imatinib can reduce the effect of Religrast 300mcg Injection 0.5 ml.

How to manage the interaction:
There may be a possibility of interaction between Religrast 300mcg Injection 0.5 ml and Imatinib, but it can be taken if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Religrast 300mcg Injection 0.5 ml:
Co-administration of Religrast 300mcg Injection 0.5 ml together with Mercaptopurine can reduce the effects of Religrast 300mcg Injection 0.5 ml.

How to manage the interaction:
Although taking Religrast 300mcg Injection 0.5 ml and Mercaptopurine together can cause an interaction, it can be taken if a doctor has suggested it. Do not stop using any medications without a doctor's advice.
How does the drug interact with Religrast 300mcg Injection 0.5 ml:
Using Religrast 300mcg Injection 0.5 ml together with mitomycin reduce the effects of Religrast 300mcg Injection 0.5 ml.

How to manage the interaction:
Co-administration of Religrast 300mcg Injection 0.5 ml with Mitomycin can result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
FilgrastimPentostatin
Severe
How does the drug interact with Religrast 300mcg Injection 0.5 ml:
Using Religrast 300mcg Injection 0.5 ml together with pentostatin can reduce the effect of Religrast 300mcg Injection 0.5 ml.

How to manage the interaction:
Although there is a possible interaction between Religrast 300mcg Injection 0.5 ml and Pentostatin, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Religrast 300mcg Injection when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[HEMATOPOIETIC]

FAQs

Religrast 300mcg Injection is used to treat neutropenia (lack of certain white blood cells) caused by cancer, bone marrow transplant, chemotherapy, bacterial infections or other conditions.
Religrast 300mcg Injection contains 'Filgrastim' is a growth factor that stimulates the bone marrow to produce white blood cells. These cells protect the body against infections.
If you have a history of spleen disease or an enlarged spleen, tell your doctor before starting Religrast 300mcg Injection . This medicine may increase the risk of splenic enlargement or, rarely, splenic rupture. Seek immediate medical attention if you develop pain in the upper left side of your abdomen or pain in your left shoulder.
If you are being treated for severe chronic neutropenia for a longer period, Religrast 300mcg Injection may cause blood in your urine (haematuria). Your doctor may regularly test your urine if you experience this side effect or if a protein is found in your urine (proteinuria).
If you have asthma or a history of allergic conditions, inform your doctor before using Religrast 300mcg Injection . Although uncommon, Religrast 300mcg Injection may cause serious allergic reactions, including wheezing, shortness of breath, or difficulty breathing. Seek immediate medical attention if you develop these symptoms.
If you have heart disease, tell your doctor before starting Religrast 300mcg Injection . Your doctor will decide whether this medicine is suitable for you and monitor you if necessary. Rarely, Religrast 300mcg Injection has been associated with inflammation of the aorta (aortitis). Contact your doctor immediately if you develop unexplained fever, abdominal pain, back pain, or persistent tiredness during treatment.
Yes, Religrast 300mcg Injection may interfere with certain lab tests such as bone imaging and blood tests (elevation in lactate dehydrogenase and alkaline phosphate), possibly causing false test results. Make sure your doctor and laboratory staff know you use Religrast 300mcg Injection .
Religrast 300mcg Injection is generally safe when used as prescribed by your doctor. However, like all medications, it can cause side effects, some of which may be serious. Common side effects are usually mild and temporary. Still, following your doctor's instructions and attending regular check-ups to monitor your health is essential. If you experience any unusual or persistent symptoms, contact your doctor promptly. Additionally, inform your doctor about your medical history, allergies, and other medications to minimize the risk of adverse reactions. You can minimize potential risks and ensure safe treatment by using Religrast 300mcg Injection as directed and under medical supervision.
There is no clear evidence that Religrast 300mcg Injection causes cancer. Sharing your medical history and risk factors with your doctor is crucial. They'll explain the benefits and potential risks of taking Religrast 300mcg Injection , including any long-term effects. If you have concerns about cancer or other health issues, consult your doctor or a qualified healthcare professional for personalized advice.
Religrast 300mcg Injection is used to treat children receiving chemotherapy or suffering from severe low white blood cell count (neutropenia). The doctor will decide the dose of Religrast 300mcg Injection based on your child's age, body weight and condition. Follow your doctor's directions to achieve better results.
Religrast 300mcg Injection should be used with caution if you have kidney disease. It may increase the risk of kidney problems, so your doctor will monitor you closely. They may adjust your dose or watch for signs of kidney issues. If you have kidney disease, tell your doctor before taking Religrast 300mcg Injection , and they'll help you use it safely.
Religrast 300mcg Injection may cause dizziness, drowsiness, and tiredness.do not drive or operate heavy machinery if you feel dizzy.
Common side effects of Religrast 300mcg Injection may include thrombocytopenia (low platelets level), anaemia (low red blood cell), headache, diarrhoea, vomiting, nausea, alopecia (unusual hair loss), tiredness, soreness, swelling of the digestive tract, fever. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
Religrast 300mcg Injection should only be used during pregnancy and breastfeeding if clearly needed and under a doctor's guidance. If you're pregnant or breastfeeding, consult your doctor before taking Religrast 300mcg Injection to discuss the benefits and risks and make an informed decision for you and your baby.
Yes, many patients or their caregivers can safely inject this medicine at home. Your healthcare provider will give you thorough training on how to prepare and inject the medicine properly before you do it yourself. Talk to your doctor if you feel uncomfortable or need a refresher on the technique.
Bone pain is a common side effect because the medicine stimulates the bone marrow (the soft tissue inside your bones) to rapidly produce new white blood cells. This increased cell production can create temporary pressure and aching. Talk to your doctor about safe over-the-counter pain relievers you can take.
Yes, you can travel with this medicine, but you must keep it cool. Carry it in an insulated travel bag with a cold pack, ensuring it does not touch the ice directly to prevent freezing. Talk to your doctor or pharmacist for more specific travel tips regarding your medication.
If the medicine is left at room temperature, it is generally safe to use for up to 24 hours, provided it is kept away from direct light and heat. If it remains at room temperature for longer than 24 hours, do not use it and discard it safely. Talk to your doctor or pharmacist if you are unsure whether a syringe is still safe to use.
Chemotherapy drugs target and destroy rapidly dividing cells, which includes the new white blood cells that this medicine helps produce. Injecting them too close together can make the medicine less effective or cause severe side effects. Talk to your doctor about your specific treatment schedule.
Your doctor will schedule regular blood tests, called a complete blood count (CBC), to measure your white blood cell levels and verify that the treatment is working. You will not feel the medicine working directly, but your lab results will show the change. Talk to your doctor to review your lab numbers.

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Country of origin

INDIA

Manufacturer/Marketer address

Dhirubhai Ambani Life Sciences Centre, R-282, TTC Area of MIDC, Thane-Belapur Road, Rabale, Navi Mumbai 400 701
Other Info - REL0078
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