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compositionComposition:UROKINASE-500000IU
prescription
Prescription Medicine
info
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Renokinase 500000IU Injection belongs to a class of drugs called antithrombotic agents. It is used in the treatment of blood clots mainly in conditions like peripheral vascular thromboembolism (blood clot in a large vein), cerebral thrombosis, cerebral infarction (stroke), and myocardial infarction (heart attack). This medicine works by converting plasminogen to the plasmin enzyme, which dissolves the blood clots, thus restoring the blood flow to the affected area.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

UROKINASE-500000IU

Manufacturer/Marketer :

Biosena Life Sciences

Consume Type :

Parenteral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Renokinase 500000IU Injection

Renokinase 500000IU Injection is an injectable medicine used to dissolve dangerous blood clots that form in the blood vessels. It is primarily prescribed to treat blood clots in the lungs and to clear blockages in medical tubes, such as central venous catheters. This medicine acts quickly to break down clots and restore normal blood flow in life-threatening situations.

Because this medicine is used for emergency situations or specific medical procedures, it is injected as a short-term treatment in a hospital setting rather than taken on a regular daily schedule. There are no specific food restrictions when receiving this injection, but following a heart-healthy diet can support your recovery. Regular medical monitoring by your healthcare team is required throughout the duration of this treatment.

Common side effects of this treatment include bruising, minor bleeding at the injection site, and a mild fever. However, you must seek immediate medical attention if you experience serious side effects like severe, unstoppable bleeding or sudden extreme weakness. Your healthcare team will closely watch for these signs during and after the injection.

Before you receive this medicine, tell your doctor if you have a history of high blood pressure, liver damage, kidney problems, recent injuries, or a previous stroke. Do not receive Renokinase 500000IU Injection if you have active internal bleeding, have recently had brain or spinal surgery, have a history of haemorrhagic stroke (bleeding in the brain), or have severe, uncontrolled high blood pressure. Your medical team will carefully evaluate your health history before starting the procedure.

This medicine can interact with blood thinners, aspirin, and certain pain relievers, which may significantly increase your risk of bleeding. It is also important to consult your doctor if you are pregnant, breastfeeding, or are an elderly individual, as these groups require extra caution and monitoring during treatment.

Uses of Renokinase 500000IU Injection

Renokinase 500000IU Injection is used in specific medical situations where rapid clot breakdown is needed to restore blood flow and prevent serious complications. It may help manage the following conditions:

  • Pulmonary embolism: Renokinase 500000IU Injection helps by rapidly dissolving life-threatening blood clots that have travelled to the lungs, restoring proper oxygen levels and reducing strain on the heart.
  • Blocked medical catheters: Renokinase 500000IU Injection helps by breaking down clots that clog central venous access lines, allowing fluids, nutrition, or other medicines to flow freely again without needing surgery to replace the tube.
  • Deep vein thrombosis: In specific clinical situations, Renokinase 500000IU Injection helps dissolve severe blood clots in the deep veins of the legs to prevent them from breaking free and travelling to the lungs.

Key Benefits

Using Renokinase 500000IU Injection may provide the following benefits:

  • Rapid clot breakdown: Renokinase 500000IU Injection helps quickly dissolve dangerous blood clots that block blood flow, helping restore circulation in affected areas.
  • Supports organ function: By clearing blood vessel blockages, this medicine helps improve oxygen delivery to vital organs and may reduce symptoms such as severe shortness of breath and chest discomfort during clot-related emergencies.
  • Helps manage blocked catheters: Renokinase 500000IU Injection can dissolve clots inside medical tubes, helping restore proper flow of fluids, nutrition, or medicines without the need for catheter replacement procedures.
  • Reduces treatment-related complications: By helping clear blockages without surgical intervention, Renokinase 500000IU Injection may reduce the discomfort, risks, and delays associated with replacing blocked medical devices.
Side effects of Renokinase 500000IU Injection

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Renokinase 500000IU Injection should be administered by a nurse or doctor.
  • Do not self-administer.

How Renokinase 500000IU Injection Works

Renokinase 500000IU Injection contains urokinase, a clot-dissolving enzyme that works by activating the body's natural system for breaking down blood clots. When injected, Renokinase 500000IU Injection converts an inactive protein in your blood called plasminogen into its active form, plasmin. Plasmin breaks down the tough fibrin mesh (the sticky protein structure that holds a clot together), causing the clot to dissolve and allowing blood to flow naturally through the affected blood vessel or catheter. This process helps restore circulation, prevent tissue damage, and reduce pressure on the cardiovascular system. Renokinase 500000IU Injection is one of several clot-dissolving medicines available. Other thrombolytic medicines, such as alteplase and tenecteplase, may be preferred in certain clinical situations. Your doctor will choose the most suitable medicine based on your condition, clot location, availability, and individual risk factors.
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Alcohol

Unsafe

Avoid the consumption of alcohol with Renokinase 500000IU Injection as it may increase the risk of bleeding.

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Pregnancy

Unsafe

Renokinase 500000IU Injection is not recommended during pregnancy or immediately after the delivery unless advised by the doctor. Please consult a doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Breastfeeding is not recommended during treatment with Renokinase 500000IU Injection. Please consult a doctor if you have any concerns.

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Driving

Caution

It is unclear whether Renokinase 500000IU Injection impacts your ability to drive or operate machinery. However, drive or operate machinery only if you are alert.

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Liver

Caution

Let your doctor know if you have a history of liver diseases/conditions. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Let your doctor know if you have a history of kidney diseases/conditions. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Unsafe

Renokinase 500000IU Injection is not recommended for children as safety and effectiveness have not been established.

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Heart

Caution

Renokinase 500000IU Injection should be used with caution in patients with heart conditions, as it may increase the risk of side effects. Please inform your doctor if you have any heart problems before receiving Renokinase 500000IU Injection.

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Geriatrics

Caution

Renokinase 500000IU Injection should be administered with caution in elderly patients due to an increased risk of side effects. Seek medical advice if you have any concerns.

What if I have taken an overdose of Renokinase 500000IU Injection

An overdose is rare because the injection is prepared and given by trained medical staff. If an overdose occurs, it can cause severe bleeding. The medical team is trained to recognise these signs immediately, stop the infusion, and provide appropriate supportive care.

Diet & Lifestyle Advise

  • Follow a heart-healthy diet: Eat a heart-healthy diet rich in fruits, vegetables, and whole grains and low in sodium to support your overall cardiovascular system during recovery.
  • Avoid injury-prone activities: Avoid contact sports or any physical activities that carry a high risk of injury, falls, or bruising for at least 24–48 hours after your treatment, or as directed by your doctor.
  • Use compression stockings if advised: Wear supportive compression stockings if recommended by your doctor to help improve blood flow in your legs and prevent future clots.
  • Stay physically active as advised: Avoid sitting or lying still for long periods once your doctor clears you to move; simple leg stretches and light walking can help keep blood circulating.
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How Soon It Starts Working

The time required for Renokinase 500000IU Injection to start to work: Renokinase 500000IU Injection ideally shows its action within 1 to 2 hours after administration. The time for which the effects of Renokinase 500000IU Injection last: The effect of Renokinase 500000IU Injection lasts for 12 to 24 hours.

What if you forget to take Renokinase 500000IU Injection

Since this medicine is given by a medical professional in a controlled hospital setting, it is highly unlikely that you will miss a dose. Your healthcare team will ensure that your treatment schedule is followed precisely.

Storage

• Unopened vials of Renokinase 500000IU Injection must be stored in a refrigerator at a temperature between 2°C and 8°C (36°F to 46°F).

Drug Warnings

  • Inspect the solution before use: Always make sure the medical team inspects the solution before injection; it should be clear, colourless, and free of any visible floating particles.
  • Prevent injuries and bleeding: Avoid using sharp objects or performing activities that could cause cuts, and use a soft-bristled toothbrush to prevent gum bleeding after receiving this medicine.
  • Avoid certain pain relievers: Do not take aspirin, ibuprofen, or other pain relievers after your treatment unless specifically instructed by your doctor, as they can increase your risk of bleeding.
  • Inform healthcare providers: Tell all healthcare providers you visit, including dentists, that you have recently received this medicine.

Drug-Drug Interactions

verifiedApollotooltip
  • Blood thinners (such as warfarin or heparin): May significantly increase the risk of severe, uncontrolled bleeding when used alongside Renokinase 500000IU Injection.
  • Antiplatelet medicines (such as aspirin or clopidogrel): can enhance the clot-dissolving effects and increase the chance of bleeding.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs like ibuprofen or naproxen): May increase bleeding risk and irritate the stomach lining.
     
UrokinaseDeferasirox
Severe
UrokinaseEnoxaparin
Severe

Drug-Drug Interactions

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UrokinaseDeferasirox
Severe
How does the drug interact with Renokinase 500000IU Injection:
Using deferasirox together with Renokinase 500000IU Injection may increase the risk of gastrointestinal ulcers.

How to manage the interaction:
Co-administration of Renokinase 500000IU Injection with Deferasirox can possibly result in an interaction, but it can be taken if your doctor has advised it. This risk is higher in older people with certain blood disorders or low platelet counts.If you have symptoms like stomach pain, bloating, dizziness, or black stools, it's important to consult a doctor. Do not stop using any medications without a doctor's advice.
UrokinaseEnoxaparin
Severe
How does the drug interact with Renokinase 500000IU Injection:
Taking Renokinase 500000IU Injection with Enoxaparin can increase the risk or severity of bleeding.

How to manage the interaction:
Although there is a possible interaction between Enoxaparin and Renokinase 500000IU Injection, you can take these medicines together if prescribed by your doctor. If you notice any symptoms like bleeding, bruising, dizziness, black or tarry stools, weakness, vomiting, or headaches, it is important to contact a doctor right away. Do not stop using any medications without talking to a doctor.
UrokinaseFondaparinux
Severe
How does the drug interact with Renokinase 500000IU Injection:
Taking Renokinase 500000IU Injection with fondaparinux can increase the risk of bleeding.

How to manage the interaction:
Although there is an interaction between Fondaparinux and Renokinase 500000IU Injection, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience bleeding, severe back pain, dizziness, black or red stools, severe headache, weakness, and vomiting. Do not discontinue any medications without consulting a doctor.
UrokinaseDasatinib
Severe
How does the drug interact with Renokinase 500000IU Injection:
Combining Dasatinib with Renokinase 500000IU Injection can increase the risk and severity of bleeding and hemorrhage.

How to manage the interaction:
Co-administration of Renokinase 500000IU Injection with Dasatinib can result in an interaction, but it can be taken if a doctor has advised it. If you notice any of these signs, it's important to contact a doctor right away: bleeding, problems, bruising, feeling dizzy or lightheaded, stools that are red or black and sticky, intense headache, weakness, bleeding, or vomiting. Do not discontinue any medications without consulting a doctor.
UrokinaseApixaban
Severe
How does the drug interact with Renokinase 500000IU Injection:
Coadministration of Renokinase 500000IU Injection and Apixaban co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Renokinase 500000IU Injection and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
UrokinaseRivaroxaban
Severe
How does the drug interact with Renokinase 500000IU Injection:
Co-administration of Renokinase 500000IU Injection and Rivaroxaban can increase the risk of bleeding problems.

How to manage the interaction:
Co-administration of Renokinase 500000IU Injection and Rivaroxaban can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
UrokinasePrasugrel
Severe
How does the drug interact with Renokinase 500000IU Injection:
Co-administration of Prasugrel with Renokinase 500000IU Injection can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Although taking Prasugrel and Renokinase 500000IU Injection together can evidently cause an interaction, it can be taken if a doctor has suggested it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
UrokinaseWarfarin
Severe
How does the drug interact with Renokinase 500000IU Injection:
Coadministration of warfarin with Renokinase 500000IU Injection can increase the risk of bleeding.

How to manage the interaction:
Although taking Renokinase 500000IU Injection and warfarin together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
UrokinaseCangrelor
Severe
How does the drug interact with Renokinase 500000IU Injection:
Co-administration of Renokinase 500000IU Injection with Cangrelo can enhance the blood-thinning effects of Cangrelor.

How to manage the interaction:
Although taking Renokinase 500000IU Injection and Cangrelor together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you notice any of these signs, it's important to contact a doctor right away: bleeding, problems, bruising, feeling dizzy or lightheaded, stools that are red or black and sticky, intense headache, weakness, bleeding, or vomiting. Do not stop using any medications without a doctor's advice.
UrokinaseIbrutinib
Severe
How does the drug interact with Renokinase 500000IU Injection:
Co-administration of Ibrutinib with Renokinase 500000IU Injection can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Ibrutinib with Renokinase 500000IU Injection together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Renokinase 500000IU Injection when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTICOAGULANT/ANTITHROMBOTIC]

FAQs

Renokinase 500000IU Injection belongs to a class of drugs called antithrombotic agents used to dissolve harmful blood clots in blood vessels. It is used in conditions such as peripheral vascular thromboembolism (blood clot in a large vein), cerebral thrombosis (blood clot in venous sinuses of the brain), cerebral infarction (stroke), myocardial infarction and pulmonary embolism (blood clots in the lungs).
Renokinase 500000IU Injection works by dissolving the harmful blood clots in the blood vessels. This restores the blood flow to the affected blood vessels, preventing various illnesses caused by blood clots.
Yes, Renokinase 500000IU Injection raises the possibility of bleeding. Always exercise caution when engaging in activities that could result in an injury or bleeding. Notify your doctor right away if you notice any unusual bruises or bleeding.
To determine blood clotting time, tests such as platelet count, factor V assay, fibrinogen level test, prothrombin time test (PT or PT-INR), and the INR (international normalised ratio) are utilised.
If you are scheduled for surgery, please consult your doctor. The doctor may advise you to stop taking Renokinase 500000IU Injection a few days before surgery because it increases the chance of bleeding during surgery.
Renokinase 500000IU Injection is not recommended for use in people with severe uncontrolled high blood pressure.
Renokinase 500000IU Injection may interact with certain medications such as anticoagulant medications (warfarin) and medications with platelet antiaggregant effects (aspirin, ticlopidine hydrochloride, dipyridamole). So, avoid taking these medications together. However, it is better to consult a doctor before taking any medication while on treatment with Renokinase 500000IU Injection to ensure safety.
The common side effects of Renokinase 500000IU Injection that may occur in some individuals such as unusual bleeding, nausea, vomiting, and loss of appetite. Most of these side effects do not necessitate medical treatment and fade away with time. Please visit your doctor if the side effects persist or worsen.
It is injected or infused directly into a vein or directly into a blocked catheter by a trained healthcare professional in a hospital setting. Talk to your doctor if you have questions about the procedure.
It is designed to dissolve newly formed clots made of fibrin, typically in the lungs or within medical tubes. Talk to your doctor to see if this treatment is appropriate for your specific condition.
These pain relievers can increase your risk of bleeding and should generally be avoided immediately after treatment. Talk to your doctor or pharmacist to find a safe pain relief alternative.
Signs include sudden, severe headache, bleeding that will not stop, blood in your urine, or signs of an allergic reaction like swelling and breathing difficulty. Seek emergency medical attention immediately or call emergency services (dial 112 in India) if you notice these symptoms.
Yes, it is frequently used in very small doses to dissolve clots blocking central venous catheters so they can function properly again. Talk to your doctor or nurse if you suspect a blockage.
It is generally reserved for life-threatening situations during pregnancy where the benefits outweigh the risks to the baby. Talk to your doctor to understand the risks and benefits.

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Country of origin

India
Other Info - RE14887
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