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compositionComposition:AMINOPHYLLINE-25MG
prescription
Prescription Medicine
info
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Renophylline 25 mg Injection is used to treat Asthma and Chronic obstructive pulmonary disease (COPD). It contains Aminophylline, which relaxes and opens air passages in the lungs, making breathing easier. Besides this, it relieves various symptoms such as cough, wheezing, shortness of breath, and trouble breathing by increasing airflow through the bronchial tubes. Common side effects of Renophylline 25 mg Injection are upset stomach, stomach pain, diarrhoea, headache, restlessness, injection site reactions and irritability.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

AMINOPHYLLINE-25MG

Manufacturer/Marketer :

Rathi Laboratories (Hindustan) Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Renophylline 25 mg Injection

Renophylline 25 mg Injection is a prescription injection used to treat severe breathing difficulties associated with asthma, chronic bronchitis, and emphysema. It works by opening up the airways in your lungs, allowing you to breathe more easily during sudden flare-ups. This medicine is typically reserved for situations where standard inhalers or other first-line treatments have not provided enough relief.

Because this medicine is injected directly into a vein, it is typically given in a hospital or clinic setting. The frequency of your doses will depend on your specific medical condition and how well you respond to the treatment. While food does not affect how this medicine is absorbed since it bypasses your stomach, maintaining a consistent diet and avoiding tobacco smoke are crucial to help your lungs recover and ensure the medicine works safely.

While receiving this medicine, you may experience some common side effects such as mild headaches, nausea, or a feeling of restlessness. Most of these symptoms are temporary, but you should consult your doctor immediately if you experience severe symptoms like a very fast or irregular heartbeat, confusion, or muscle twitching.

Before you receive this injection, it is vital to discuss your medical history with your healthcare provider, especially if you have heart disease, thyroid issues, a history of stomach ulcers, or liver damage. You should not receive this medicine if you have had a severe allergic reaction to similar lung medications in the past.

This medicine can interact with several common substances; for example, smoking or drinking alcohol can speed up or slow down how your body processes it, which can either reduce its effectiveness or increase your risk of side effects. If you are pregnant, breastfeeding, or an older adult, you must consult your doctor before starting treatment, as your dose may need to be carefully monitored.

It may be used in newborns to manage apnoea of prematurity (temporary pauses in breathing in premature babies) under specialist medical supervision. It can be given to children, but the dosage must be extremely carefully calculated and monitored by a paediatrician based on the child's age, weight, and blood levels.

Uses of Renophylline 25 mg Injection

Your doctor may recommend this medication to help manage the following conditions:

  • Severe asthma attacks: It helps open up tightly constricted airways when standard rescue inhalers are not working well enough.
  • Chronic Obstructive Pulmonary Disease (COPD) flare-ups: It relaxes the muscles in the lungs to relieve sudden, severe chest tightness and shortness of breath.
  • Acute bronchospasm: It quickly reverses the sudden narrowing of the airways caused by chronic lung diseases or sudden irritations.

Key Benefits

When taken consistently as directed, this medication may provide the following physiological benefits:

  • Provides rapid relief: This medicine provides rapid relief from severe chest tightness and wheezing by going directly into your bloodstream. This quick delivery helps you regain control of your breathing much faster during a medical emergency.
  • Improves breathing: By widening your air passages, it improves the overall flow of oxygen into your lungs. This reduces the exhausting physical effort required to breathe, helping you feel more comfortable and relaxed as your lungs recover.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • Renophylline 25 mg Injection will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How Renophylline 25 mg Injection Works

Renophylline 25 mg Injection belongs to a group of medicines known as bronchodilators. It works by directly relaxing the smooth muscles that wrap around your airways. When these muscles relax, the airways widen, making it much easier for air to flow in and out of your lungs. In addition to opening your airways, this medicine helps reduce the swelling and inflammation in your lungs that cause breathing distress. It also strengthens the contractions of your diaphragm, which is the main muscle you use to breathe, helping your lungs work more efficiently.
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Alcohol

Caution

Alcohol may increase the levels of aminophylline in the blood, leading to serious side effects. Discuss with your doctor if you have concerns.

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Pregnancy

Caution

If you are pregnant or planning pregnancy, inform your doctor before receiving Renophylline 25 mg Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

Small amounts of aminophylline are excreted in human milk. Hence, if you are breastfeeding, inform your doctor before receiving Renophylline 25 mg Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Not applicable

Renophylline 25 mg Injection has no or negligible influence on the ability to drive.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Renophylline 25 mg Injection. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Renophylline 25 mg Injection. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition. Kidney disease in an infant less than three months of age may affect the functioning of Renophylline 25 mg Injection.

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Children

Caution

Caution should be maintained while using Renophylline 25 mg Injection in infants less than three months and with kidney disease. Please consult your doctor. Your doctor may prescribe this medicine for your child if the benefits outweigh the risks.

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Heart

Caution

Renophylline 25 mg Injection should be used with caution in patients with heart disease. Please consult the doctor if you have heart problems.

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Geriatrics

Caution

Renophylline 25 mg Injection should be used with caution in elderly patients. Please consult your doctor before use.

What if I have taken an overdose of Renophylline 25 mg Injection

Because your medical team will monitor you closely during treatment, an overdose is very rare. If you experience symptoms like severe nausea, constant vomiting, a rapid heartbeat, or confusion during your injection, tell your healthcare provider immediately. If you suspect an overdose after leaving the clinic, seek emergency medical attention right away.

Diet & Lifestyle Advise

  • Avoid smoking: Cigarette smoke can speed up how your body processes this medicine, which makes it less effective. If you start or stop smoking, you must notify your doctor right away so they can adjust your treatment.
  • Limit caffeine intake: Avoid excessive coffee, tea, colas, energy drinks, and chocolate. Caffeine can increase the risk of side effects like jitters, anxiety, and a rapid heart rate.
  • Stay consistently hydrated: Drinking plenty of water helps thin the mucus in your lungs, making it easier for you to breathe and clear your airways.
  • Maintain a stable diet: Sudden changes to high-protein or high-carbohydrate diets can alter how your body processes this medicine. Keep your eating habits steady and consult your doctor before starting any strict diet.
health query

Have a query?

How Soon It Starts Working

The time required for Renophylline 25 mg Injection to start to work: The time required for Renophylline 25 mg Injection to show its action is unknown. The time for which the effects of Renophylline 25 mg Injection last: The duration of action for Renophylline 25 mg Injection is unknown.

What if you forget to take Renophylline 25 mg Injection

Since this medicine is injected by a healthcare professional in a clinical setting, it is highly unlikely that you will miss a dose. However, if you miss a scheduled clinic appointment for your treatment, contact your doctor or healthcare provider immediately to reschedule.

Storage

• It should be kept at room temperature, ideally between 20 and 25 °C (68°F and 77°F).

Drug Warnings

  • Check before injection: Always inspect the liquid vial before it is injected; the solution must be clear and colourless. Do not allow it to be injected if you see any particles, cloudiness, or discolouration.
  • Regular monitoring: Be prepared for regular blood tests, as your doctor will need to monitor the level of the medicine in your body to ensure it remains in a safe and effective range.
  • Monitor injection site: Keep a close eye on the injection site for any signs of irritation, redness, pain, or swelling, and report these to your nurse or doctor immediately.
  • Inform your healthcare provider: Inform your healthcare provider about all other medicines, supplements, or herbal products you are currently taking before receiving this injection.

Drug-Drug Interactions

verifiedApollotooltip
  • Certain antibiotics (such as erythromycin or ciprofloxacin) and ulcer medications (such as cimetidine): These can slow down how your body removes medication, which can increase the risk of side effects.
  • Seizure medicines (such as phenytoin or carbamazepine): These can speed up how your body clears this medicine, potentially making it less effective.
  • Beta-blockers (used for blood pressure or heart issues): These medications can cause your airways to narrow, directly blocking the beneficial breathing effects of this medication.
AminophyllineRiociguat
Critical
AminophyllineMetrizamide
Severe

Drug-Drug Interactions

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AminophyllineRiociguat
Critical
How does the drug interact with Renophylline 25 mg Injection 10 ml:
Coadministration of Renophylline 25 mg Injection 10 ml with Riociguat may significantly lower your blood pressure.

How to manage the interaction:
Taking Renophylline 25 mg Injection 10 ml with Riociguat can cause an interaction, however, it can be taken only if a doctor has advised it. If you experience dizziness, lightheadedness, shortness of breath, fainting, flushing, headache, and nasal congestion, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AminophyllineMetrizamide
Severe
How does the drug interact with Renophylline 25 mg Injection 10 ml:
Coadministration of Metrizamide with Renophylline 25 mg Injection 10 ml can increase the risk of seizure (a sudden, violent, uncontrollable contraction of a group of muscles).

How to manage the interaction:
Co-administration of Renophylline 25 mg Injection 10 ml with Metrizamide can result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
AminophyllineMetoprolol
Severe
How does the drug interact with Renophylline 25 mg Injection 10 ml:
Coadministration of Renophylline 25 mg Injection 10 ml with Metoprolol together can make metoprolol less effective and increase the effects of Renophylline 25 mg Injection 10 ml.

How to manage the interaction:
Taking Renophylline 25 mg Injection 10 ml with Metoprolol may lead to an interaction, it can be taken only if a doctor has advised it. If you experience nausea, vomiting, sleeplessness, restlessness, irregular heartbeats, or difficulty in breathing, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AminophyllineTramadol
Severe
How does the drug interact with Renophylline 25 mg Injection 10 ml:
Coadministration of Tramadol with Renophylline 25 mg Injection 10 ml can increase the risk of cause seizure (a sudden, violent, uncontrollable contraction of a group of muscles).

How to manage the interaction:
Taking Renophylline 25 mg Injection 10 ml and tramadol together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience any symptoms such as seizures, dizziness, drowsiness, or difficulty concentrating, contact a doctor immediately. Do not discontinue the medication without a doctor's advice.
AminophyllineMetoprolol Succinate
Severe
How does the drug interact with Renophylline 25 mg Injection 10 ml:
Co-administration of Renophylline 25 mg Injection 10 ml with Metoprolol could reduce the effects of Metoprolol and increase the affects of Renophylline 25 mg Injection 10 ml.

How to manage the interaction:
Taking Renophylline 25 mg Injection 10 ml with Metoprolol can cause an interaction; however, it can be taken only if a doctor has advised it. If you experience nausea, vomiting, sleeplessness, restlessness, irregular heartbeats, or difficulty in breathing, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AminophyllineFluvoxamine
Severe
How does the drug interact with Renophylline 25 mg Injection 10 ml:
Coadministration of Renophylline 25 mg Injection 10 ml with Fluvoxamine may significantly increases the blood levels of Renophylline 25 mg Injection 10 ml, which may lead to serious side effects.

How to manage the interaction:
Taking Renophylline 25 mg Injection 10 ml with Fluvoxamine can result in an interaction, it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, sleeplessness, restlessness, irregular heartbeats, difficulty breathing, or loss of appetite (less desire to eat) contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AminophyllineLabetalol
Severe
How does the drug interact with Renophylline 25 mg Injection 10 ml:
Combination of Renophylline 25 mg Injection 10 ml with Labetalol can make labetalol less effective and increase the side effects of Renophylline 25 mg Injection 10 ml which can be serious.

How to manage the interaction:
Although taking Labetalol and Renophylline 25 mg Injection 10 ml together can result in an interaction, it can be taken only if a doctor has advised it. However, if you experience irregular heartbeats, or difficulty in breathing, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AminophyllineNadolol
Severe
How does the drug interact with Renophylline 25 mg Injection 10 ml:
Coadministration of Renophylline 25 mg Injection 10 ml with Nadolol together make nadolol less effective and increase the effects of Renophylline 25 mg Injection 10 ml.

How to manage the interaction:
Taking Renophylline 25 mg Injection 10 ml with Nadolol can cause an interaction, however, it can be taken only if a doctor has advised it. If you experience nausea, vomiting, sleeplessness, restlessness, irregular heartbeats, or difficulty in breathing, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AminophyllinePropranolol
Severe
How does the drug interact with Renophylline 25 mg Injection 10 ml:
Coadministration of Renophylline 25 mg Injection 10 ml with Propranolol together can make propranolol less effective and increase the effects of Renophylline 25 mg Injection 10 ml.

How to manage the interaction:
Taking Renophylline 25 mg Injection 10 ml with Propranolol can cause an interaction. However, it can be taken only if a doctor has advised it. If you experience nausea, vomiting, sleeplessness, restlessness, irregular heartbeats, or difficulty in breathing, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AminophyllineHalothane
Severe
How does the drug interact with Renophylline 25 mg Injection 10 ml:
Using halothane together with Renophylline 25 mg Injection 10 ml may increase the risk of cardiac side effects such as irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Renophylline 25 mg Injection 10 ml and Halothane, you can take these medicines together if prescribed by your doctor. If you experience irregular heart rhythm or any complications, it is important to contact a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • Caffeine: Eating or drinking large amounts of chocolate, coffee, tea, or energy drinks can worsen side effects like anxiety, shaky hands, and a rapid heartbeat.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[BRONCHODILATOR]

FAQs

Renophylline 25 mg Injection is used to treat Asthma and Chronic obstructive pulmonary disease (COPD).
Renophylline 25 mg Injection contains Aminophylline, a bronchodilator that relaxes and widens the muscles of the airways, thereby making it easier for asthma and COPD patients to breathe.
Avoid aerated drinks, fried foods, excess salts (sodium chloride or table salt), dairy products, cruciferous veggies, cold cuts, and cured meats. Also, avoid consuming high amounts of caffeine-containing tea, coffee, chocolate, and cola, as these foods already contain aminophylline, an active constituent of Renophylline 25 mg Injection. Sulfites in alcoholic beverages can trigger symptoms of asthma and COPD, so avoid consuming alcoholic beverages.
No, you are not recommended to smoke while receiving Renophylline 25 mg Injection as it may reduce the effectiveness of Renophylline 25 mg Injection and damage your lung's airways (alveoli). Long-term smoking may cause breathing problems like asthma, bronchitis and COPD. Quitting smoking is the best way to keep your lungs healthy.
Renophylline 25 mg Injection should be used with caution in patients suffering from fits as it may worsen the condition. Therefore, inform your doctor if you have a history of fits before taking Renophylline 25 mg Injection so that the dose may be adjusted or an alternate medicine may be prescribed.
No, Renophylline 25 mg Injection does not relieve sudden asthma symptoms. Therefore, it is advised to carry a rescue inhaler always to treat sudden asthma symptoms.
You are not recommended to take Renophylline 25 mg Injection with antibiotics such as erythromycin, tetracycline, amoxicillin, amikacin and gentamicin at the same time as it may reduce the effectiveness of antibiotics. However, if you are supposed to take these medicines together, maintain a time gap of a minimum of 2 hours between taking Renophylline 25 mg Injection and antibiotics. However, please consult a doctor before using Renophylline 25 mg Injection with antibiotics or other medicines.
You should only receive this medicine during pregnancy if your doctor determines that the benefits clearly outweigh the risks. Talk to your doctor to understand how this treatment might affect you and your baby.
Blood tests are necessary because this medicine has a narrow safe range; too little will not help your breathing, while too much can cause serious side effects. Regular testing helps your doctor find the perfect, safest dose for you.
It is highly recommended to limit or avoid coffee and other caffeinated beverages during treatment, as caffeine can significantly increase side effects like tremors, anxiety, and a rapid heartbeat. Talk to your doctor or pharmacist about your daily caffeine habits.
Tell your nurse or doctor immediately if you feel dizzy, lightheaded, or nauseous during your injection, as they may need to adjust the speed of the drip or check your blood pressure.
Yes, it can be given to children, but the dosage must be extremely carefully calculated and monitored by a paediatrician based on the child's age, weight, and blood levels. Talk to your doctor for specific pediatric guidance.
Unlike a rescue inhaler that you carry with you and breathe in, this medicine is injected directly into a vein under medical supervision, usually when inhalers are not providing enough relief during a severe breathing crisis.

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Reference

  1. DailyMed Database. Druginfo.Cfm Clinical Monograph. Bethesda, MD: National Library of Medicine; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Mayo Clinic Staff. Drg 20073584 Inhalation and Dosage Monograph. Rochester, MN: Mayo Foundation for Medical Education; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Aminophylline Injection Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Aminophylline Aminophylline. 1990. [Accessed on 01 Apr. 2019]Check here
  5. Central Drugs Standard Control Organisation (CDSCO). [Accessed on 01 Apr. 2019]Check here
  6. Showlabeling.Aspx. [Accessed on 02 Jun. 2026]Check here
  7. New Zealand Medicines and Medical Devices Safety Authority (Medsafe). Aminophyllineinj Consumer Medicine Information (CMI). Wellington, NZ: Medsafe; 2024. [Accessed on 02 Jun. 2026]Check here

Country of origin

India

Manufacturer/Marketer address

Industrial Area Patna 800013
Other Info - REN0065
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