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compositionComposition:ISONIAZID-300MG+RIFAMPICIN-450MG
prescription
Prescription Medicine
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RF Compound 450 mg Tablet 10's is used to treat and prevent tuberculosis. It contains Rifampicin, and Isoniazid, which works by killing the bacteria causing TB (tuberculosis). In some cases, you may experience certain common side effects, such as drowsiness, dizziness, headache, weakness, muscle pain, heartburn, diarrhoea, gas, and numbness or tingling sensation. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

ISONIAZID-300MG+RIFAMPICIN-450MG

Manufacturer/Marketer :

Sunij Pharma Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About RF Compound 450 mg Tablet 10's

RF Compound 450 mg Tablet 10's is a prescription oral medicine used to treat active and latent tuberculosis infections. It combines two active antibiotics that work together to eliminate the bacteria causing the infection. Taking this medicine helps cure the infection and prevents it from spreading to others.

To work effectively, you must take RF Compound 450 mg Tablet 10's consistently every day exactly as prescribed, even if you start feeling better. It should be taken on an empty stomach, either one hour before or two hours after a meal, with a full glass of water. Maintaining a balanced diet and getting plenty of rest are helpful lifestyle changes during your recovery.

While taking this medicine, you may notice mild side effects like your urine, sweat, or saliva turning an orange-red colour. However, if you experience more serious symptoms such as severe abdominal pain, persistent nausea, or yellowing of your skin and eyes, you must contact your doctor immediately.

Do not take this if you have severe liver damage, acute liver disease, or have previously had a severe allergic reaction to either of its active components. Talk to your doctor before starting RF Compound 450 mg Tablet 10's if you have a history of liver problems, kidney disease, diabetes, or nerve pain.

This medicine can interact with alcohol, significantly raising the risk of serious liver damage, and can reduce the effectiveness of hormonal birth control. If you are pregnant, breastfeeding, or planning a pregnancy, talk to your doctor or pharmacist to discuss the risks and benefits before starting treatment.

Uses of RF Compound 450 mg Tablet 10's

RF Compound 450 mg Tablet 10's is used to treat active and latent tuberculosis infections. The detailed uses of RF Compound 450 mg Tablet 10's are as follows:

  • Tuberculosis Treatment: RF Compound 450 mg Tablet 10's is prescribed to treat active tuberculosis infections in the lungs and other parts of the body by killing the disease-causing bacteria.
  • Tuberculosis Prevention: It is used to prevent active tuberculosis from developing in individuals who have a latent (inactive) tuberculosis infection.
     

Key Benefits

RF Compound 450 mg Tablet 10's helps treat tuberculosis by preventing the growth and spread of the bacteria responsible for the infection. By targeting the underlying cause of the disease, it supports recovery and helps improve symptoms over the course of treatment.

  • Helps Relieve Tuberculosis Symptoms: As the infection comes under control, symptoms such as persistent cough, chest discomfort, fever, night sweats, and fatigue gradually improve, helping you regain strength and overall well-being.
  • Supports Effective Tuberculosis Treatment: The combination of two anti-tuberculosis medicines works together to fight the infection more effectively, helping reduce the bacterial load and support successful treatment outcomes.
  • Simplifies Long-Term Treatment: By combining two medicines into a single oral treatment, RF Compound 450 mg Tablet 10's reduces the number of tablets you need to take each day. This convenience can help improve treatment adherence and support completion of the full course of therapy.
     

Directions for Use

  • Take RF Compound 450 mg Tablet 10's exactly as prescribed by your doctor. Do not change your dose or stop taking it without consulting them.
  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break it.
  • Take this medicine on an empty stomach, either 1 hour before or 2 hours after meals, to ensure the medicine is properly absorbed by your body.
  • Keep taking this medication for the full length of time prescribed by your doctor, even if your symptoms disappear after a few weeks.
     

How RF Compound 450 mg Tablet 10's Works

RF Compound 450 mg Tablet 10's is a combination medicine containing two active ingredients, rifampicin and isoniazid, which target the target bacteria in different ways to ensure the infection is thoroughly cleared. The first active ingredient, rifampicin, works by blocking a specific enzyme known as RNA polymerase, which the bacteria need to make proteins and reproduce. This effectively stops the bacteria from multiplying. The second active ingredient, isoniazid, targets the protective outer cell wall of the bacteria. It prevents the bacteria from building mycolic acid, a crucial component of their cell wall, causing the cell wall to break down and killing the bacteria.
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Alcohol

Unsafe

Avoid alcohol consumption while taking RF Compound 450 mg Tablet 10's as it could lead to increased drowsiness, dizziness and liver damage.

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Pregnancy

Caution

Please consult your doctor if you are pregnant, your doctor will prescribe RF Compound 450 mg Tablet 10's only if the benefits outweigh the risks.

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Breast Feeding

Unsafe

RF Compound 450 mg Tablet 10's passes into breast milk. Do not breastfeed while taking RF Compound 450 mg Tablet 10's.

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Driving

Caution

RF Compound 450 mg Tablet 10's may cause dizziness, drowsiness, numbness and tingling sensation in hands and feet. Do not drive or operate machinery if you experience these symptoms.

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Liver

Caution

Dose adjustment may be needed. Please consult your doctor before taking RF Compound 450 mg Tablet 10's if you have liver impairment/liver disease.

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Kidney

Caution

Dose adjustment may be needed. Please consult your doctor if you have any concerns regarding this or if you have kidney impairment/kidney disease before taking RF Compound 450 mg Tablet 10's.

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Children

Consult your doctor

Please consult your doctor. Your doctor may suggest suitable dose and dosage form based on your child's age, body weight and medical condition. Kid tablets could be used in children if prescribed by the doctor.

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Heart

Caution

RF Compound 450 mg Tablet 10's can be used in heart patients if prescribed by the physician. Please consult your physician if you have any concerns.

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Geriatrics

Unsafe

RF Compound 450 mg Tablet 10's is not recommended for use in elderly patients as it can lead to side effects.

What if I have taken an overdose of RF Compound 450 mg Tablet 10's

Do not take more than the prescribed dose of RF Compound 450 mg Tablet 10's as it may cause overdose. The symptoms of overdose include stomach pain, nausea, vomiting, headache, itching, tiredness, dizziness, lightheadedness, drowsiness, fainting, blurred vision, or hallucinations. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Avoid alcohol completely: Drinking alcohol while taking this medicine significantly increases the risk of serious liver damage.
  • Avoid certain foods: Do not eat foods high in tyramine and histamine, such as aged cheeses, red wine, soy sauce, yeast extracts, and certain fish like tuna or mackerel. Combining these foods with this medicine can trigger flushing, sweating, a rapid heartbeat, or headaches.
  • Take Vitamin B6 (pyridoxine) if recommended: Your doctor may advise taking a vitamin B6 supplement daily to help prevent nerve tingling or numbness caused by isoniazid.
  • Stay hydrated: Drink plenty of water throughout the day to help your kidneys filter the medication safely.
     
health query

Have a query?

How Soon It Starts Working

The time required for RF Compound 450 mg Tablet 10's to start to work: The time required for RF Compound 450 mg Tablet 10's to show its action is unknown. The time for which the effects of RF Compound 450 mg Tablet 10's last: The duration of action for RF Compound 450 mg Tablet 10's is unknown.

What if you forget to take RF Compound 450 mg Tablet 10's

Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and follow your regular dosing schedule. Do not take a double dose to make up for your missed dose.

Storage

• Store RF Compound 450 mg Tablet 10's at room temperature, ideally between 15°C and 30°C (59°F to 86°F), in a dry place. •Keep the medicine in its original container to protect it from direct light and moisture. Do not store it in the bathroom.

Drug Warnings

  • Expect your body fluids (urine, tears, sweat, saliva) to turn red-orange; this is a harmless side effect of the medicine.
  • Avoid wearing soft contact lenses during treatment, as they may become permanently stained by your tears.
  • Do not stop taking this medicine early, even if you feel completely better, to prevent the bacteria from becoming resistant to antibiotics.
  • Use a non-hormonal method of birth control (such as condoms), as RF Compound 450 mg Tablet 10's can make hormonal contraceptives like birth control pills, patches, or implants less effective.
  • Attend all scheduled appointments for blood tests so your doctor can regularly monitor your liver function throughout your treatment.
     

verifiedApollotooltip

Before using RF Compound 450 mg Tablet 10's, it is important to understand how it may interact with other medicines, foods, or existing health conditions.

Drug-Drug Interactions

  • Hormonal contraceptives: RF Compound 450 mg Tablet 10's may reduce the effectiveness of certain hormonal contraceptives. Discuss appropriate contraceptive options with your doctor, who may recommend additional or alternative methods of birth control during treatment.
  • Blood thinners (e.g., warfarin): This medicine may reduce the effectiveness of anticoagulants, potentially affecting blood clotting control. Your doctor may need to monitor your clotting parameters and adjust treatment if necessary.
  • Anti-seizure medicines (e.g., phenytoin): Taking RF Compound 450 mg Tablet 10's with certain anticonvulsants may alter the levels or effects of either medicine, potentially increasing the risk of side effects or affecting seizure control. Close monitoring may be required.
  • Antifungal medicines (e.g., ketoconazole): RF Compound 450 mg Tablet 10's may reduce the absorption and effectiveness of certain antifungal medications, which could make fungal infections more difficult to treat.

Drug-Food Interactions

  • Foods high in tyramine or histamine (e.g., aged cheese, red wine, tuna): Consuming large amounts of these foods may increase the risk of symptoms such as flushing, itching, headache, palpitations, or a rapid heart rate in susceptible individuals.

Drug-Disease Interactions

  • Liver disease: Use RF Compound 450 mg Tablet 10's with caution if you have liver impairment. The medicine may worsen underlying liver conditions or increase the risk of liver-related side effects. Your doctor may recommend regular liver function monitoring during treatment.
  • Diabetes: RF Compound 450 mg Tablet 10's may affect blood glucose control, making blood sugar levels more difficult to manage. Patients with diabetes should monitor their blood sugar regularly and consult their doctor if significant changes occur.
  • Gout: This medicine may increase uric acid levels in the blood, which can trigger or worsen gout attacks in susceptible individuals. Patients with a history of gout should discuss appropriate monitoring and management with their healthcare provider.
     

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Habit Forming

No

Therapeutic Class

[ANTI- TUBERCULOSIS]

FAQs

RF Compound 450 mg Tablet 10's is a combination of two anti-tuberculosis medicines, Rifampicin and Isoniazid, used to treat and prevent tuberculosis (TB). These medicines work together to kill Mycobacterium tuberculosis, the bacteria that causes TB.
RF Compound 450 mg Tablet 10's is a combination of two anti-tuberculosis drugs, namely: Rifampicin, and Isoniazid. Rifampicin inhibits DNA-dependent RNA polymerase activity in the bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Together, RF Compound 450 mg Tablet 10's kills Mycobacterium tuberculosis which causes TB (tuberculosis).
No. Do not stop taking RF Compound 450 mg Tablet 10's even if your symptoms, such as cough, improve. Stopping treatment early may allow the bacteria to survive, causing the infection to return and increasing the risk of drug-resistant tuberculosis. Complete the full course prescribed by your doctor.
Do not take RF Compound 450 mg Tablet 10's along with antacids as it might decrease the effectiveness of RF Compound 450 mg Tablet 10's. Maintain a minimum gap of 1hour between both.
Consult your doctor before taking RF Compound 450 mg Tablet 10's with other medicines. Medicines used to treat TB such as PAS (P-amino salicylic acid) and cycloserine should be taken 8hours apart from RF Compound 450 mg Tablet 10's.
RF Compound 450 mg Tablet 10's contains isoniazid which might interact with foods and drinks containing histamine or tyramine such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer. Avoid these foods while taking RF Compound 450 mg Tablet 10's.
Yes. RF Compound 450 mg Tablet 10's may reduce the effectiveness of hormonal contraceptives, including birth control pills, patches, rings, and implants. Use a reliable non-hormonal method of contraception, such as condoms, while taking this medicine. Consult your doctor for advice on suitable contraceptive options.
RF Compound 450 mg Tablet 10's may cause discolouration of teeth, sweat, urine, sputum (phlegm), saliva, or tears. The colour in tears may last for some time even after you stop taking RF Compound 450 mg Tablet 10's. Do not worry as it is a common side-effect of RF Compound 450 mg Tablet 10's.
Yes, RF Compound 450 mg Tablet 10's might permanently stain soft contact lenses. Use spectacles and avoid wearing contact lens while taking RF Compound 450 mg Tablet 10's.
RF Compound 450 mg Tablet 10's may affect test results of some blood tests such as tests for folate, vitamin B12, and liver function. Inform the person doing the tests that you are taking RF Compound 450 mg Tablet 10's.
Yes, RF Compound 450 mg Tablet 10's may cause liver problems, particularly in adults over 35 years of age. Watch for symptoms such as yellowing of the skin or eyes, dark urine, pale stools, loss of appetite, severe nausea or vomiting, weakness, or persistent pain in the upper right side of the abdomen. Seek medical attention immediately if these symptoms occur. Your doctor may recommend regular liver function tests during treatment.
Before using RF Compound 450 mg Tablet 10's, you should learn about its use, side effects, and limitations.
If you forget a dose of RF Compound 450 mg Tablet 10's, take it immediately when you remember. However, if your next dose is near, skip the missed dose and continue with your regular schedule. Never double dose to make up for a missed dose, as this may increase side effects.
Take RF Compound 450 mg Tablet 10's on an empty stomach, preferably 1 hour before food or 2 hours after food, to ensure optimal absorption and effectiveness.
Store RF Compound 450 mg Tablet 10's in a cool, dry place out of sunlight and children's reach. Check the expiration date regularly. To dispose of it, place it in a plastic bag and throw it away in household trash. Never flush it down the toilet or sink.
You should avoid alcohol while taking RF Compound 450 mg Tablet 10's strictly to ensure safety and efficacy, as it can increase the risk of liver damage when combined with medications like Isoniazid and Rifampicin.
Common side effects of RF Compound 450 mg Tablet 10's may include drowsiness, dizziness, headache, weakness, muscle pain, heartburn, diarrhea, gas, and numbness. However, these symptoms vanish as your body adjusts to the medication. If these symptoms become worse, please consult a doctor for relief.
Before using this medication, you should inform your doctor about your medical history, including any ongoing medicines, to avoid potential interactions and minimize side effects.
Taking more than the recommended dosage does not provide additional relief and can increase the risk of adverse effects.
RF Compound 450 mg Tablet 10's is generally considered safe when used as prescribed by a doctor. However, like all medications, it can have side effects and potential interactions with other drugs. It's important to follow your doctor's instructions and inform them of any pre-existing and existing medical conditions or medication history to avoid negative complications.
Tingling or numbness in your hands or feet can be a sign of nerve irritation. Your doctor may prescribe a vitamin B6 (pyridoxine) supplement to help prevent or treat this issue. Talk to your doctor right away if you notice these symptoms.
If you are pregnant or planning to become pregnant, you must discuss the benefits and potential risks of this medication with your healthcare provider. Treating tuberculosis is very important during pregnancy, but it requires careful medical supervision. Talk to your doctor for personalised advice.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.6124 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Isoniazid And Rifampin Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. Isoniazid/rifampicin. 1999. [Accessed on 10 Apr. 2019]Check here
  4. Isoniazid Isoniazid. 2015. [Accessed on 10 Apr. 2019]Check here
  5. Lee N, Nguyen H. Ethambutol. StatPearls [Internet]. NIH National Library of Medicine. National Center for Biotechnology Information. [Revised in October 2022] [Accessed on 04th March 2023]Check here
  6. Tuberculosis. National Health Service. [Accessed on 04th March 2023]Check here
  7. Isoniazid and Rifampicin combination for latent tuberculosis. [Accessed on 02 Jun. 2026]Check here

Country of origin

India

Manufacturer/Marketer address

T-1/B National Park, Gulbai Tekra, Ahmedabad 380 015, (India)
Other Info - RFC0001
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