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compositionComposition:ETHAMBUTOL-800MG+ISONIAZID-300MG+RIFAMPICIN-450MG
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Prescription Medicine
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Rhe Kit Tablet is used to treat tuberculosis (TB) caused by the bacteria mycobacterium tuberculin. It prevents or kills the bacteria and prevents its spread. It may cause common side effects like nausea, vomiting, fever, dark-coloured urine, sweating, and increased saliva. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ETHAMBUTOL-800MG+ISONIAZID-300MG+RIFAMPICIN-450MG

Manufacturer/Marketer :

Macleods Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Rhe Kit Tablet

Rhe Kit Tablet is a combination prescription medicine used to treat active tuberculosis (TB) infections. It works by targeting the specific bacteria responsible for the infection, helping to stop their growth and clear them from your body. Because tuberculosis is a persistent infection, this multi-medicine approach is necessary to ensure all bacteria are successfully eliminated.

To achieve the best results, you must take Rhe Kit Tablet consistently every day exactly as prescribed by your doctor. It is typically taken once daily on an empty stomach, either 1 hour before or 2 hours after a meal, to ensure the medicine is properly absorbed. Alongside your medication, eating a nutrient-rich diet, resting adequately, and completely avoiding alcohol will support your body’s recovery.

While taking Rhe Kit Tablet, you may notice some mild, common side effects, such as a harmless red-orange discolouration of your urine, sweat, or tears. However, you must contact your doctor immediately if you experience serious symptoms like yellowing of your skin or eyes, changes in your vision, or numbness and tingling in your hands and feet.

Before starting this medicine, tell your doctor if you have a history of liver problems, kidney disease, gout, or eye conditions. Do not take this if you have had a severe allergic reaction to any of its active components or if you currently have severe liver damage or optic nerve inflammation.

This medicine can interact with other substances; for example, alcohol increases your risk of liver damage, and antacids can prevent the medication from working properly. If you are pregnant, breastfeeding, or managing health conditions in your elderly years, you should consult your doctor to ensure this treatment is safe for you.

Uses of Rhe Kit Tablet

Rhe Kit Tablet is used to treat active tuberculosis (TB) infections. The detailed uses of Rhe Kit Tablet are as follows:

  • Tuberculosis (TB): Rhe Kit Tablet is prescribed to treat active pulmonary and extra-pulmonary tuberculosis infections. It combines multiple active agents to destroy the bacteria and prevent them from developing resistance to the treatment.
     

Key Benefits

Rhe Kit Tablet brings clinical recovery and peace of mind by targeting the infection at its source. By using multiple active ingredients at once, the medicine stops the bacteria from multiplying, which helps you feel stronger and reduces your symptoms over time.

  • Prevents Drug Resistance: Combining these medicines together makes it much harder for the tuberculosis bacteria to survive and become resistant to treatment.
  • Reduces Transmission Risk: By rapidly reducing the number of active bacteria in your body, Rhe Kit Tablet helps lower the chances of passing the infection to your family and community.
  • Consistent Symptom Relief: As the treatment progresses, it relieves chronic tuberculosis symptoms like persistent coughing, night sweats, fever, and unexplained weight loss.
Side effects of Rhe Kit Tablet
  • To improve liver health and aid in the removal of toxins, drink lots of water.
  • Alcohol consumption should be reduced or stopped because it can raise ALT levels and impair liver function.
  • Consume a well-rounded diet full of whole grains, fruits, and vegetables. Limit items that strain the liver, such as processed, fatty, or fried foods.
  • You can monitor your ALT levels and make treatment modifications with the support of routine blood tests.
  • Consume more fruits, vegetables, and cruciferous foods like cabbage, kale, and broccoli.
  • Reduced alcohol intake can enhance liver enzyme function.
  • Oxidative stress can be managed by eating foods rich in antioxidants, such as vitamins C and E.
  • Liver function tests regularly can help manage increased levels of AST.
  • Yellow discolouration of skin and eyes is a significant liver issue that needs immediate medical attention.
  • Eating a balanced diet can help manage such side effects and must be taken as a dietician suggests.
  • Exercise regularly to maintain a good metabolism in your body.
  • Avoid alcohol consumption as it can affect liver functioning and worsen if there is a yellow discolouration of the skin and eyes.
  • Prevent toxins from chemicals that can be touched and inhaled. Ensure to manage your medications carefully.

Directions for Use

  • Recommended to take Rhe Kit Tablet on an empty stomach, 30 minutes before or 2 hours after meals or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.
  • Swallow the medicine as a whole with glass of water.
  • Do not crush, break, or chew it.

How Rhe Kit Tablet Works

Rhe Kit Tablet works by attacking the tuberculosis bacteria in three distinct ways to ensure they are thoroughly eliminated. Each component plays a specific role in breaking down the bacteria's defence systems. The rifampicin component works by blocking the genetic copying machinery of the bacteria, preventing them from making the essential proteins they need to survive. The isoniazid component targets the bacteria's protective outer cell wall, stopping them from building and maintaining this barrier. Finally, the ethambutol component interferes with the synthesis of other vital cell wall structures, which stops the bacteria from multiplying. Together, these actions disrupt the bacteria at multiple stages of growth, completely clearing the infection from your body.
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Alcohol

Unsafe

Consuming alcohol and Rhe Kit Tablet causes flushing, increased heartbeat, chest pain, nausea, thirst and low blood pressure. So avoid the use of alcohol with Rhe Kit Tablet.

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Pregnancy

Caution

Please consult the doctor. There are no adequate and well-controlled studies on pregnant women. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Safe if prescribed

Consult your doctor, and there is no substantial research yet on the use of Rhe Kit Tablet in breastfeeding/nursing mothers.

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Driving

Caution

Rhe Kit Tablet may affect your ability to drive as it produces drowiness and sleep. So, it should not be taken before driving a motor vehicle.

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Liver

Caution

Limited information was available for the use of Rhe Kit Tablet in patients suffering from liver impairment. Please consult your doctor if you have any concerns regarding using Rhe Kit Tablet in patients with liver impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Limited information was available for the use of Rhe Kit Tablet in patients suffering from kidney impairment. Please consult your doctor if you have any concerns regarding using Rhe Kit Tablet in patients with kidney impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Unsafe

Rhe Kit Tablet is not recommended for use in children as its safety and efficacy have not been established.

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Heart

Caution

Rhe Kit Tablet can be used in heart patients if prescribed by the physician. Please consult your physician if you have any concerns.

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Geriatrics

Consult your doctor

Rhe Kit Tablet should be given to elderly patients only if recommended by a doctor. Please consult your doctor before using Rhe Kit Tablet.

What if I have taken an overdose of Rhe Kit Tablet

If you suspect an overdose, seek emergency medical care immediately. Watch for signs such as severe vomiting, dizziness, extreme sleepiness, or a sudden, intense orange colour on your skin or in your eyes.

Diet & Lifestyle Advise

  • Avoid alcohol entirely: Alcohol strains your liver, and combining it with this medicine greatly increases your risk of serious liver damage.
  • Limit certain foods: Avoid eating large amounts of aged cheese, red wine, soy sauce, and certain fish like tuna. These foods contain substances called tyramine and histamine, which can interact with the medicine and cause flushing, sweating, a fast heartbeat, or high blood pressure.
  • Support your nutrition: Eat a balanced diet high in protein and vitamins to help your body rebuild its strength and recover from the infection.
  • Ask about Vitamin B6: Talk to your doctor about taking a pyridoxine (Vitamin B6) supplement, as this medicine can lower your body's vitamin levels, which may cause nerve tingling in your hands and feet.
health query

Have a query?

How Soon It Starts Working

The time required for Rhe Kit Tablet to start to work: The time required for Rhe Kit Tablet to show its action is unknown. The time for which the effects of Rhe Kit Tablet last: The duration of action for Rhe Kit Tablet is unknown.

What if you forget to take Rhe Kit Tablet

If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed one.

Storage

•Store Rhe Kit Tablet at room temperature, ideally between 15°C and 30°C (59°F to 86°F). •Keep the tablets in their original blister pack or container to protect them from direct light and moisture.

Drug Warnings

  • Expect your urine, sweat, and tears to turn an orange-red colour. Avoid wearing soft contact lenses during treatment, as they may become permanently stained.
  • Schedule regular eye exams. Report any visual changes, blurriness, or difficulty seeing colours to your doctor immediately.
  • Keep all appointments for your routine blood tests, as your doctor will need to monitor your liver function closely throughout your treatment.
  • Do not take antacids containing aluminium or magnesium within 2 hours of taking Rhe Kit Tablet, as they can stop your body from absorbing the medicine.
  • Ensure you complete the entire course of your prescription. Skipping doses or stopping early can make the bacteria resistant to treatment.

Drug-Drug Interactions

verifiedApollotooltip
  • Blood thinners (like warfarin): This medicine may decrease the effectiveness of blood thinners, requiring closer monitoring of your blood clotting times.
  • Hormonal contraceptives: Rhe Kit Tablet can make birth control pills, patches, and implants less effective, so you should use a reliable non-hormonal barrier method (like condoms) during treatment.
  • Anti-seizure medications (like phenytoin): This medicine can increase the levels of anti-seizure drugs in your body, raising the risk of side effects.
  • Antacids: Medications containing aluminium or magnesium can block the absorption of Rhe Kit Tablet if taken at the same time.
     
Ethambutol + Isoniazid + RifampicinIndinavir
Critical
Ethambutol + Isoniazid + RifampicinSaquinavir
Critical

Drug-Drug Interactions

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Ethambutol + Isoniazid + RifampicinIndinavir
Critical
How does the drug interact with Rhe Kit Tablet:
Co-administration of Indinavir with Ethambutol, Isoniazid, and Rifampicin can decrease the blood levels of Voriconazole.

How to manage the interaction:
Although there is an interaction between Indinavir and Ethambutol, Isoniazid, and Rifampicin, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Ethambutol + Isoniazid + RifampicinSaquinavir
Critical
How does the drug interact with Rhe Kit Tablet:
Taking Saquinavir with Ethambutol, Isoniazid and Rifampicin can increase the side effects.

How to manage the interaction:
Although there is an interaction between Saquinavir and Ethambutol, Isoniazid and Rifampicin, they can be taken if prescribed by a doctor. However, if you experience any unusual symptoms like stomach pain, nausea, vomiting, yellowing of eyes or skin, dark colour urine or light colour stools, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Ethambutol + Isoniazid + RifampicinDarunavir
Critical
How does the drug interact with Rhe Kit Tablet:
Co-administration of Darunavir with Ethambutol, Isoniazid, and Rifampicin can decrease the blood levels of Voriconazole.

How to manage the interaction:
Although there is an interaction between Darunavir and Ethambutol, Isoniazid, and Rifampicin, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Ethambutol + Isoniazid + RifampicinPirfenidone
Critical
How does the drug interact with Rhe Kit Tablet:
Co-administration of Pirfenidone with Ethambutol, Isoniazid, and Rifampicin can decrease the blood levels of Voriconazole.

How to manage the interaction:
Although there is an interaction between Pirfenidone and Ethambutol, Isoniazid, and Rifampicin, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Ethambutol + Isoniazid + RifampicinRanolazine
Critical
How does the drug interact with Rhe Kit Tablet:
Co-administration of Ranolazine with Ethambutol, Isoniazid, and Rifampicin can decrease the blood levels of Voriconazole.

How to manage the interaction:
Although there is an interaction between Ranolazine and Ethambutol, Isoniazid, and Rifampicin, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Ethambutol + Isoniazid + RifampicinVoriconazole
Critical
How does the drug interact with Rhe Kit Tablet:
Co-administration of Voriconazole with Ethambutol, Isoniazid, and Rifampicin can decrease the blood levels of Voriconazole.

How to manage the interaction:
Although there is an interaction between Voriconazole and Ethambutol, Isoniazid, and Rifampicin, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Ethambutol + Isoniazid + RifampicinNifedipine
Severe
How does the drug interact with Rhe Kit Tablet:
Co-administration of Nifedipine with Ethambutol, Isoniazid, and Rifampicin can decrease the blood levels of Nifedipine.

How to manage the interaction:
Although there is an interaction between Nifedipine and Ethambutol, Isoniazid, and Rifampicin, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Ethambutol + Isoniazid + RifampicinCitalopram
Severe
How does the drug interact with Rhe Kit Tablet:
Taking Citalopram with Ethambutol, Isoniazid and Rifampicin can increase the blood levels of Citalopram.

How to manage the interaction:
Although there is an interaction between Citalopram and with Ethambutol, Isoniazid and Rifampicin, they can be taken if prescribed by a doctor. However, if you experience any unusual symptoms like dizziness, lightheadedness, fainting, shortness of breath, or rapid heart rate, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Ethambutol + Isoniazid + RifampicinRifabutin
Severe
How does the drug interact with Rhe Kit Tablet:
Taking Rifabutin with Ethambutol, Isoniazid and Rifampicin can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Ethambutol, Isoniazid and Rifampicin with Rifabutin can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, a skin rash or itching, loss of hunger, nausea, vomiting, or yellowing of the skin or the whites of the eyes, consult a doctor. Do not stop using any medications without talking to a doctor.
Ethambutol + Isoniazid + RifampicinMycophenolic acid
Severe
How does the drug interact with Rhe Kit Tablet:
Co-administration of Mycophenolic acid with Ethambutol, Isoniazid, and Rifampicin can decrease the blood levels of Mycophenolic acid.

How to manage the interaction:
Although there is an interaction between Mycophenolic acid and Ethambutol, Isoniazid, and Rifampicin, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • High-fat meals: Eating fatty foods right before taking this medicine can significantly reduce how much of the drug gets absorbed into your body.
  • Tyramine and histamine-rich foods: Consuming aged cheese, red wine, yeast extracts, or certain fish can trigger flushing, high blood pressure, and a rapid heartbeat.
     
ETHAMBUTOL-800MG+ISONIAZID-300MG+RIFAMPICIN-450MGTyramine-containing food, Caffeine containing foods/drinks
Moderate

Drug-Food Interactions

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ETHAMBUTOL-800MG+ISONIAZID-300MG+RIFAMPICIN-450MGTyramine-containing food, Caffeine containing foods/drinks
Moderate
Common Foods to Avoid:
Pepperoni, Miso Soup, Natto, Ricotta, Salami, Shoyu, Shrimp, Stilton Cheese, Swiss Cheese, Tamari, Tempeh, Fish, Farm Cheese, Fava Beans, Fermented Seafood, Fermented Tofu, Gorgonzola Cheese, Chicken Liver, Chocolates, Cottage Cheese, Cream Cheese, Dried Sausage, Dry-Type Summer Sausages, Cheddar Cheese, Cashews, Camembert, Beef Liver, American Cheese, Almonds, Avocado, Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Consuming Tyramine containing food and Caffeine with Rhe Kit Tablet can increase the risk of toxicity. Avoid consuming Tyramine-containing food and Caffeine with Rhe Kit Tablet. Contact a doctor immediately if you experience any symptoms such as headache, diaphoresis, flushing, diarrhea, nausea, vomiting, tachycardia, dyspnea, and hypotension.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTI- TUBERCULOSIS]

FAQs

Rhe Kit Tablet is used to treat tuberculosis (TB) caused by the bacteria Mycobacterium tuberculin. It prevents or kills the bacteria and prevents its spread.
No, Rhe Kit Tablet decreases the action of birth control pills. So, use other contraceptive devices or methods to avoid unwanted pregnancies. Discuss with your doctor before taking this medicine.
It is best to take Rhe Kit Tablet on an empty stomach 1 hour before or 2 hours after meals.
The full form of DOTS is (Directly Observed Therapy Short Term). It is a defined treatment regimen initiated by the Government to cure tuberculosis. The initial treatment phase consists of 8 weeks of the four drugs, namely: Isoniazid (H), Rifampicin (R), Pyrazinamide (Z) and Ethambutol (E). Then, the continuation phase should consist of the three drugs: Isoniazid, Rifampicin and Ethambutol, which should be given for another 16 weeks.
Yes, it may take at least 6-8 months for the treatment of TB. Remember, you should regularly take DOTS therapy as instructed by the doctor or DOTS worker provided by the government agency.
Do not Panic, as Rhe Kit Tablet can cause bright red-orange colour urine, faeces, saliva, sputum, sweat, and tear. It won't occur as soon as you stop the use of drugs.
Taking Rhe Kit Tablet combination tablet is convenient, helps you take your medication correctly, and reduces mistakes in administering.
The duration of taking Rhe Kit Tablet for getting relief from the symptoms can vary depending on the individual's health condition. Generally, noticeable improvements can occur within a few days to a week after starting treatment. Follow your doctor's instructions regarding dose and duration and complete the full course as prescribed.
You will know the treatment is working when you start to feel better, experience a reduction in symptoms like coughing, fever, and fatigue, and if follow-up tests show improvement. Complete the full course of treatment even if you start feeling better.
To ensure you are fully cured of tuberculosis, your doctor will conduct follow-up tests like sputum cultures or chest X-rays. Complete the entire course of treatment and attend all follow-up appointments to ensure the infection is fully cured.
Rhe Kit Tablet can make birth control pills less effective. Use an alternative method of contraception, such as condoms or diaphragms,while taking this medication. Discuss with your doctor for personalized advice.
Store Rhe Kit Tablet at room temperature, away from moisture and heat. Keep out of reach of children and pets.
Rhe Kit Tablet may cause discoloration of the urine in some individuals as it is a common side effect. However, this effect vanishes over time as the medication adapts to the body. If this symptom becomes more uncomfortable and worsens please consult a doctor for relief.
No, don't discontinue taking Rhe Kit Tablet even if you feel well. Complete the full course of treatment as prescribed by your doctor to ensure the infection is fully cleared. If you are having any concerns please discuss them with your doctor.
Rhe Kit Tablet can cause visual impairment, primarily due to Ethambutol in its composition. It can lead to optic neuritis, causing decreased vision, blind spots, and colour vision changes. Have regular eye tests and report any vision changes to your doctor immediately.
The common side effects of Rhe Kit Tablet that may occur in some individuals are nausea, vomiting, fever, dark-coloured urine, sweating, and increased saliva. However, these symptoms vanish as your body adjusts to the medication. If these symptoms worsen, please consult a doctor for relief.
No, you must avoid alcohol completely. Both alcohol and this medicine place significant stress on your liver, and combining them increases your risk of severe liver damage. Talk to your doctor if you need support with avoiding alcohol.
Taking Rhe Kit Tablet on an empty stomach, either 1 hour before or 2 hours after meals, allows your body to absorb the medicine fully. Food, especially high-fat foods, can block absorption and make the treatment less effective. Talk to your doctor if you struggle with this routine.
Tingling, burning, or numbness in your hands and feet can be a sign of nerve irritation. Your doctor can prescribe a vitamin B6 (pyridoxine) supplement to help prevent or ease this symptom. Talk to your doctor as soon as you notice these sensations.
If you are pregnant or planning to become pregnant, you must discuss this with your doctor. Untreated tuberculosis is highly dangerous for both mother and baby, so your doctor will carefully evaluate the risks and benefits to create a safe treatment plan. Talk to your doctor for guidance.

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Country of origin

India

Manufacturer/Marketer address

Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, INDIA.
Other Info - RHE0024
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