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Rhogam 300 mcg Injection is used to prevent rhesus disease. It contains Anti-D (Rh) immunoglobulin which works by neutralising the RhD-positive antigens that may have entered an RhD-negative person's blood. In some cases, this medicine may cause side effects such as pain and tenderness at the injection site. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Manufacturer/Marketer :

Johnson & Johnson Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Rhogam 300 mcg Injection

Rhogam 300 mcg Injection is an injection used to prevent Rh immunisation (sensitisation) in individuals with Rh-negative blood who have been exposed to Rh-positive blood. It is primarily used during pregnancy, after delivery, or following certain medical procedures to protect future pregnancies from haemolytic disease. It is also used to treat immune thrombocytopenic purpura (ITP), a condition that causes dangerously low platelet counts.

Because Rhogam 300 mcg Injection is a specialised injection, it is not used on a daily schedule but is given at specific clinical milestones, such as around the 28th week of pregnancy, within 72 hours of giving birth, or after an event that could cause blood mixing. There are no specific dietary restrictions required for this medication, but maintaining a balanced diet and staying well-hydrated support overall maternal and immune health.

Most people tolerate this injection well, but you may experience mild soreness, redness, or swelling at the injection site, along with a mild fever. If you experience serious side effects like difficulty breathing, a sudden high fever, dark urine, or yellowing of your skin or eyes, contact your doctor immediately.

Do not take this if you have had a severe allergic reaction to human immunoglobulins in the past or if you have a condition called IgA deficiency. It is important to talk to your doctor before receiving this injection if you have a history of blood clotting disorders, anaemia, or kidney problems.

Rhogam 300 mcg Injection can interfere with how your body responds to live virus vaccines (such as measles, mumps, and rubella), so you should tell your healthcare provider if you plan to get any vaccinations soon. This medicine is safe and intended for use during pregnancy and breastfeeding to protect the baby, but its use in elderly patients is typically limited to blood disorders like ITP. Talk to your doctor or pharmacist to understand if this treatment is right for you.

Uses of Rhogam 300 mcg Injection

Rhogam 300 mcg Injection is used to prevent Rh immunisation (sensitisation) in individuals with Rh-negative blood who have been exposed to Rh-positive blood. The detailed uses of Rhogam 300 mcg Injection are as follows:

  • Prevention of Rh sensitisation during pregnancy: Rhogam 300 mcg Injection prevents an Rh-negative mother's immune system from producing antibodies against her Rh-positive baby's blood cells, which helps protect future pregnancies.
  • Management of mismatched blood transfusions: Rhogam 300 mcg Injection is used if an Rh-negative person accidentally receives Rh-positive blood, preventing the body from forming harmful antibodies that destroy red blood cells.
  • Immune thrombocytopenic purpura (ITP): In Rh-positive individuals with this condition, Rhogam 300 mcg Injection helps increase platelet counts to prevent abnormal bleeding and bruising.

Key Benefits

Rhogam 300 mcg Injection provides important immune protection in specific medical conditions by preventing harmful antibody formation or modifying the body's immune response. It helps protect unborn babies in Rh incompatibility and supports the management of certain blood disorders such as immune thrombocytopenic purpura (ITP).

  • Helps Prevent Rh Disease in Future Pregnancies: By preventing the formation of Rh antibodies in Rh-negative mothers, Rhogam 300 mcg Injection helps protect current and future pregnancies from Rh disease, supporting healthy foetal development.
  • Supports the Management of Immune Thrombocytopenic Purpura (ITP): In patients with ITP, Rhogam 300 mcg Injection helps increase platelet counts, reducing the risk of bleeding and improving overall safety during daily activities.
  • Provides Targeted Immune Protection: By modifying the immune response when used for approved indications, Rhogam 300 mcg Injection helps prevent serious complications and supports better treatment outcomes under medical supervision.

Directions for Use

  • Follow your doctor's recommendations on the dosage and timing of this medication to achieve optimal results.
  • Rhogam 300 mcg Injection will be administered by a healthcare professional.
  • Do not self-administer.

How Rhogam 300 mcg Injection Works

Rhogam 300 mcg Injection contains passive antibodies that target and bind to Rh-positive red blood cells that may have entered an Rh-negative person's bloodstream. By binding to these foreign cells, the medication clears them from circulation before the person's own immune system can detect them and start making its own long-lasting antibodies. In cases of ITP, Rhogam 300 mcg Injection works by binding to Rh-positive red blood cells, which temporarily distracts the spleen. Because the spleen is busy destroying these coated red blood cells, it spares the patient's platelets from being destroyed, successfully raising the overall platelet count.
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Alcohol

Safe if prescribed

Rhogam 300 mcg Injection may not interact with alcohol. However, You are recommended not to consume alcohol along with Rhogam 300 mcg Injection to avoid unpleasant side-effects.

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Pregnancy

Safe if prescribed

Rhogam 300 mcg Injection is probably safe as it is intended for use in pregnancy or early after delivery. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Breast Feeding

Safe if prescribed

Rhogam 300 mcg Injection is probably safe when used in breastfeeding mothers. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Driving

Safe if prescribed

Rhogam 300 mcg Injection may not affect your ability to drive.

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Liver

Safe if prescribed

Rhogam 300 mcg Injection is probably safe when used in patients with liver diseases. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Kidney

Safe if prescribed

Rhogam 300 mcg Injection is probably safe when used in patients with kidney diseases. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Children

Safe if prescribed

Rhogam 300 mcg Injection can be given to children if clinically needed.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using Rhogam 300 mcg Injection. Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Rhogam 300 mcg Injection can be used in geriatric patients if prescribed by the physician.

What if I have taken an overdose of Rhogam 300 mcg Injection

Because Rhogam 300 mcg Injection is prepared and given by medical professionals in a controlled clinical environment, an overdose is highly unlikely. However, if you suspect you have received too much or experience severe unusual symptoms, seek immediate medical attention.

Diet & Lifestyle Advise

  • Stay hydrated: Drink plenty of fluids, especially water, after your injection to help your body process the medication and reduce the risk of mild headaches.
  • Eat iron-rich foods: If you are pregnant or have ITP, focus on a diet rich in iron (like spinach, beans, and lean meats) to support healthy red blood cell production.
  • Avoid contact sports: If you are receiving this medication for low platelets, avoid high-impact activities or contact sports that could cause bruising or bleeding.
  • Track your injection dates: Keep a precise paper or digital record of when you received Rhogam 300 mcg Injection during your pregnancy, as this information is crucial for your delivery team.
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How Soon It Starts Working

The time required for Rhogam 300 mcg Injection to start to work: Rhogam 300 mcg Injection ideally shows its action within 5-10 days of intramuscular administration and that of 2 hours with intravenous administration. The time for which the effects of Rhogam 300 mcg Injection last: The duration of action for Rhogam 300 mcg Injection is unknown.

What if you forget to take Rhogam 300 mcg Injection

Since Rhogam 300 mcg Injection is given by a healthcare professional at specific clinical intervals, missing an injection can reduce its effectiveness. If you miss an appointment for your injection, contact your doctor or clinic immediately to reschedule.

Storage

• In a clinical setting, it is kept in a refrigerator between 2°C and 8°C (36°F to 46°F).
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Inspect the solution: Before your injection, ensure the healthcare provider checks that the liquid is clear to slightly pale yellow and free of particles.
  • Report bleeding right away: If you are taking this for ITP, report any new bruising, nosebleeds, or blood in your urine immediately.
  • Wait to get vaccines: Avoid receiving live vaccines (like measles, mumps, rubella, or varicella) for at least 3 months after your last dose of Rhogam 300 mcg Injection, as it can make the vaccine less effective.
  • Know your blood type: Always carry a card or medical record of your Rh-negative blood status and your history of Rhogam 300 mcg Injection injections in case of an emergency.
  • Monitor for 20 minutes: Remain at the clinic for at least 20 to 30 minutes after your injection so healthcare providers can monitor you for any immediate allergic reactions.

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  • Live virus vaccines (such as MMR and chickenpox vaccines): Rhogam 300 mcg Injection may temporarily reduce the effectiveness of these vaccines if given within 3 months of each other.

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  • No clinically significant food interactions are known with Rhogam 300 mcg Injection when used as directed.

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Habit Forming

No

Therapeutic Class

[IMMUNIZING AGENTS]

FAQs

If you have Rh-negative blood and your baby may have Rh-positive blood, your immune system can produce antibodies against your baby's red blood cells. These antibodies can affect the current pregnancy or future pregnancies. Rhogam 300 mcg Injection (Anti-D immunoglobulin) prevents your immune system from forming these antibodies, helping protect your current baby and reducing the risk of complications in future pregnancies. It may also be given after certain pregnancy-related events or blood transfusions where Rh-positive blood exposure is possible.
Rhogam 300 mcg Injection is administered by a qualified healthcare professional as an intramuscular (IM) injection or, in some situations, an intravenous (IV) injection, depending on the specific product and your clinical condition. It should only be given in a clinic or hospital under medical supervision.
Yes. Rhogam 300 mcg Injection can reduce the effectiveness of live vaccines, including MMR (measles, mumps, and rubella) and varicella (chickenpox) vaccines. These vaccines should generally be delayed for at least 3 months after receiving Rhogam 300 mcg Injection. Tell your healthcare provider if you have recently received or are planning to receive any vaccinations so they can advise you on the appropriate timing.
Yes. If you are Rh-negative and have not already become sensitized, you will usually need Anti-D immunoglobulin during each pregnancy in which there is a risk of Rh incompatibility. The protection from each injection is temporary and does not carry over to future pregnancies.
The most common side effects are mild and temporary and include pain, tenderness, redness, or swelling at the injection site, headache, and occasionally a mild fever. These usually improve within a few days. Contact your doctor if the pain becomes severe, persists, or if you develop signs of an allergic reaction.
Yes, Rhogam 300 mcg Injection is safe to receive if you are breastfeeding. It does not pass into breast milk in amounts that would harm the nursing infant. Talk to your doctor or pharmacist if you have any concerns about medications during breastfeeding.
In rare cases, immune globulin products can cause kidney issues. If you have pre-existing kidney disease, your doctor will monitor you closely while you receive Rhogam 300 mcg Injection. Talk to your doctor to evaluate the risks and benefits.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.6791 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Anti Rho-D Immunoglobulin Injection (Monoclonal) [Package Insert]. 2013. [Accessed on 19 Oct. 2023]Check here
  3. Ministry of Health and Family Welfare. National Formulary of India (NFI) 2021. 6th ed. New Delhi, India: IPC; 2021. Clinical Drug Monographs: Antid 300Mcg Ml Injection

Country of origin

India

Manufacturer/Marketer address

Corporate Communications, Johnson & Johnson Private Limited., 501 Arena Space, Behind Majas Bus Depot, Off Jogeshwari Vikhroli Link Road, Jogeshwari (E), Mumbai 400 060.
Other Info - RHO0003
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