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Synonym

BENDAMUSTINE HYDROCHLORIDE

Manufacturer/Marketer

Janssen Pharmaceuticals Pvt Ltd

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Jan-25

for this medicine

About Ribomustin Injection

Ribomustin Injection belongs to a class of anti-cancer medicines used in the treatment of Leukemia. Leukemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. This medicine is used in the treatment of Chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin’s leukemia (NHL) that has progressed during six months of treatment with rituximab or rituximab-containing treatment.

Ribomustin Injection contains Bendamustine, which belongs to the alkylating agents class. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis.

Ribomustin Injection may cause certain side effects, such as nausea, vomiting, diarrhea, stomach pain, anorexia, decreased weight, constipation, fever, decreased platelet count, fatigue, cough, headache, rash, injection site reactions and pain at the site of injection. If the side effects bother you, inform your doctor. A trained healthcare professional will administer Ribomustin Injection. Hence, do not self-administer.

Ribomustin Injection should be avoided if you are allergic to it or any other components present in it. Before receiving this injection, inform your doctor if you have any pre-existing or a history of liver/kidney disease, cardiac disorders, cancer, active infections, skin problems, or any allergic conditions. Ribomustin Injection is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand.

Uses of Ribomustin Injection

Treatment of Non-Hodgkin's disease and Chronic Lymphocytic Leukaemia

Medicinal Benefits

Ribomustin Injection contains Bendamustine, which belongs to the class of alkylating agents. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This causes shrinkage of tumor cells and thereby prevents the growth and further spread of cancerous or non-cancerous cells. This medicine is used in the treatment of chronic lymphocytic leukemia and non-Hodgkin’s leukemia.

Side Effects of Ribomustin Injection

  • Diarrhoea
  • Back pain
  • Vomiting
  • Stomach pain
  • Cough
  • Bruising or bleeding gums
  • Pain at the site of injection
  • Fever
  • Anorexia
  • Constipation
  • Decreased platelet count
  • Rashes
  • Decreased weight
  • Injection site reactions

Directions for Use

A trained healthcare professional will administer Ribomustin Injection. Hence, do not self-administer. 

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Ribomustin Injection should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before receiving this injection, inform your doctor if you have any history of liver/kidney disease, cardiac disorders, cancer, active infections, skin problems, or any allergic conditions. Ribomustin Injection may cause myelosuppression, active infections, severe skin reactions, tumor lysis syndrome (tumor cells release their contents into the bloodstream), other malignancies, and hypersensitivity reactions in some patients. Hence, careful monitoring should be done during the entire treatment. Ribomustin Injection may cause embryo-fetal toxicity. Hence, if you are pregnant or planning to become pregnant, inform your doctor beforehand. Before nursing, a breastfeeding mother should ask her oncologist whether this medicine is safe for use or not. Ribomustin Injection is not recommended for use in children as the safety and efficacy are not established.

Therapeutic Class

ANTINEOPLASTIC

Drug Interactions

Drug-Drug Interactions: Ribomustin Injection may interact with vaccines, CYP1A2 inhibitors (ketoconazole, clopidogrel, ritonavir, imipramine, clozapine), CYP1A2 inducers (Cimetidine, rifampicin, verapamil, phenytoin), monoclonal antibodies ((etanercept, baricitinib, certolizumab, golimumab, infliximab), vaccines and other medicines.

Drug-Food Interactions: Avoid alcohol consumption and smoking.

Drug-Disease Interactions: Inform your doctor if you have kidney or liver disease, skin diseases, and infections before receiving Ribomustin Injection.

Drug-Drug Interactions Checker List

  • KETOCONAZOLE
  • CLOPIDOGREL
  • RITONAVIR
  • CLOZAPINE
  • CIMETIDINE
  • RIFAMPICIN
  • PHENYTOIN
  • ETANERCEPT
  • GOLIMUMAB
  • INFLIXIMAB
  • BARICITINIB

Diet & Lifestyle Advise

  • After your treatment begins, dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals to take during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans, and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast and fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

What if I have taken an overdose of Ribomustin Injection

As Ribomustin Injection is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away. Overdose of Ribomustin Injection may cause rapid, irregular, or pounding heartbeat.

Special Advise

  • A blood test should be performed, such as a liver function test, or renal function test, to check for liver/kidney function.
  • Weekly blood tests should be done during the treatment to check for CBC (Complete blood count).

Disease/Condition Glossary

Indolent B-cell Non-Hodgkin’s Leukemia: Non-Hodgkin’s disease or Non-Hodgkin’s lymphoma is a blood cancer that affects your lymph system. It causes the uncontrollable growth of cancer cells in the lymph nodes. The lymph system is a part of the immune system which protects your body from disease and infections. In indolent B cell Non-Hodgkin’s lymphoma, the cancer cells grow slowly in the B lymphocytes. Symptoms include lymph node swelling, abdominal pain, chest pain, cough, fever, and night sweats.

Chronic Lymphocytic Leukaemia: It is a type of cancer that occurs in the bone marrow and blood. It increases the number of lymphocytes (a type of white blood cell). The symptoms include fever, enlarged liver, bone or joint pain, shortness of breath, weakness, and bleeding from gums or bruises.

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Alcohol

Caution

Limit or avoid consumption of alcohol as it may worsen your condition.

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Pregnancy

Unsafe

Ribomustin Injection is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Ribomustin Injection. Use reliable methods of birth control while on treatment with Ribomustin Injection.

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Breast Feeding

Caution

If you are a nursing mother, inform your doctor before receiving Ribomustin Injection. You should not breastfeed while on treatment with Ribomustin Injection.

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Driving

Not applicable

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Ribomustin Injection. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition. Ribomustin Injection is not recommended for use in patients with severe liver disease.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Ribomustin Injection. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition. This medicine should be avoided for patients with CrCl <40 ml/min.

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Children

Unsafe

Ribomustin Injection is not recommended for use in children as the safety and efficacy is not established.

Country of origin

India

Manufacturer/Marketer address

Johnson & Johnson Private Limited., 501 Arena Space, Behind Majas Bus Depot, Off Jogeshwari Vikhroli Link Road, Jogeshwari (E), Mumbai 400 060
Other Info - RIB0102

FAQs

Ribomustin Injection is used to treat Non-Hodgkin’s disease and Chronic Lymphocytic Leukaemia.
Ribomustin Injection contains Bendamustine, which inhibits the DNA and RNA transcription essential for cancer cell growth.
Ribomustin Injection may cause reactivation of serious infections, myelosuppression, tumour lysis syndrome, and anaphylactic reactions in some patients. Hence, inform your oncologist about your complete medical history, including current medication, to rule out any side effects/interactions.
Ribomustin Injection is safe when used as per the dose and duration advised by a doctor.
Ribomustin Injection has the vesicant (irritant) properties.
Yes, the use of Ribomustin Injection can cause hair loss and constipation as a side effect. This will gradually reduce over time and does not require any medical attention. However, please contact a doctor if this condition persists for longer or worsens.
Ribomustin Injection can cross the blood-brain barrier and can be utilized for treating cancers that have spread to the brain.
Ribomustin Injection may cause side effects such as diarrhoea, back pain, vomiting, stomach pain, cough, pain at the site of injection, fever, constipation, decreased blood pressure, rashes, and decreased weight. Please, contact a doctor if these side effects persist for longer durations.

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Keep Refrigerated. Do not freeze.