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  3. Ributin Capsule 6's

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Ributin Capsule 6's, Pack of 6 CAPSULES
Ributin Capsule 6's, Pack of 6 CAPSULES
Ributin Capsule 6's, Pack of 6 CAPSULES
Ributin Capsule 6's, Pack of 6 CAPSULES
Ributin Capsule 6's, Pack of 6 CAPSULES
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Ributin Capsule is used to prevent or treat tuberculosis in patients with HIV infection. It contains Rifabutin which works by killing infection-causing bacteria. In some cases, this medicine may cause side effects such as heartburn, diarrhoea, gas, nausea, and abdominal pain. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

RIFABUTIN-150MG

Manufacturer/Marketer :

Lupin Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Ributin Capsule

Ributin Capsule belongs to the group of medicines called anti-tuberculosis drugs primarily used to treat and prevent tuberculosis in individuals dealing with human immunodeficiency virus (HIV) infection. Tuberculosis (TB) is an infectious disease that mainly affects the lungs, but it can also spread to other body parts such as the kidneys, brain, spine, and bone marrow. HIV is a virus that weakens the immune system and increases the risk of TB infection. 

Ributin Capsule consists of a drug called 'Rifabutin' that comes into 'antimycobacterial'. It works by inactivating a bacterial RNA-polymerase, an enzyme that allows TB bacteria to make and replicate essential proteins. It destroys the bacteria named Mycobacterium tuberculosis, which causes TB (tuberculosis), thus treating TB infection.

Take Ributin Capsule as prescribed by your doctor. You are suggested to take $ame as long as your doctor has prescribed it after checking your medical condition. In some cases, you may experience certain common side effects such as drowsiness, dizziness, headache, weakness, muscle pain, heartburn, diarrhea, gas, and numbness or tingling sensation. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Before starting Ributin Capsule, please inform your doctor if you have diabetes, epilepsy, gout, mental health problems, HIV infection, malnutrition, peripheral neuropathy, porphyria, bleeding problems, or kidney or liver problems. Consult your doctor before taking Ributin Capsule if you are pregnant or planning for pregnancy. Avoid breastfeeding while taking Ributin Capsule as it passes into breast milk. Ributin Capsule is not recommended for use in children. Ributin Capsule may cause dizziness, and vision problems, so drive with caution. Avoid alcohol consumption while taking Ributin Capsule as it could lead to increased drowsiness, dizziness, and liver damage.

Uses of Ributin Capsule

Treatment of Tuberculosis in patients infected HIV

Directions for Use

• Take Ributin Capsule with or without food as advised by your doctor.• Adhere to your doctor's guidance regarding the dosage and timing of this medication for optimal effectiveness.• Swallow Ributin Capsule as a whole with a glass of water.• Do not crush, chew, or break it.

Medicinal Benefits

Ributin Capsule is indicated in patients dealing with TB caused by HIV infection to prevent or slow down the spread of TB infection. Persons who are living with HIV infection are at risk of developing TB. This disease can quickly progress in persons whose immune system is already weakened by the HIV infection, so Ributin Capsule helps to stop the growth and spread of bacteria responsible for causing and spreading infection. It does so by stopping the synthesis of a protein required by bacteria to grow and spread rapidly. 

How Ributin Capsule Works

Ributin Capsule consists Rifabutin that comes into antimycobacterial. It works by inactivating a bacterial RNA-polymerase, an enzyme that allows TB bacteria to make and replicate essential proteins. It destroys the bacteria named Mycobacterium tuberculosis, which causes TB (tuberculosis), thus treating TB infection.

Storage

Keep Ributin Capsule out of reach and sight of children.
Side effects of Ributin Capsule
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Eating and drinking slowly can help swallow less air, which reduces burps.
  • Avoid consuming foods like gum and hard candy and drinking carbonated drinks as they release carbon dioxide gas in your body.
  • Prevent smoking as it can impact your whole body.
  • Seek medical help to treat gastric problems and heart burn that may lead to frequent burps.
  • Check your dentures because if they are loosely fit, excess air can be swallowed that causes burbs more frequently.

What if I have taken an overdose of Ributin Capsule

Avoid exceeding the recommended dose as it might cause an overdose. Seek immediate medical attention if you experience any unusual symptoms.

Drug Warnings

A Ributin Capsule may raise your liver enzymes like ALT and cause jaundice if taken for a longer duration. So, a regular liver function test (LFT) is recommended while taking treatment with Ributin Capsule. Maintain a gap of one hour between Ributin Capsule and antacid medicines. Do not take Ributin Capsule if you are allergic to any of its contents if you have jaundice or take HIV medicines (saquinavir or ritonavir). Avoid foods and drinks containing histamine or tyramine such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer while taking Ributin Capsule as they might cause interaction. Ributin Capsule may affect the action of some bacterial vaccines like typhoid vaccine, so it is suggested to don't go for any vaccination unless your doctor has suggested you do so.

Drug-Drug Interactions

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RifabutinVoriconazole
Critical
RifabutinClarithromycin
Critical

Drug-Drug Interactions

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RifabutinVoriconazole
Critical
How does the drug interact with Ributin Capsule:
When Voriconazole is taken with Ributin Capsule, the amount of Voriconazole in the blood may decrease.

How to manage the interaction:
Taking Ributin Capsule with Voriconazole is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, consult a doctor immediately If you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
RifabutinClarithromycin
Critical
How does the drug interact with Ributin Capsule:
Taking Ributin Capsule and Clarithromycin together may increase the blood levels of Ributin Capsule.

How to manage the interaction:
Taking Ributin Capsule with Clarithromycin is not recommended as it can possibly result in an interaction, it can be taken if a doctor has advised it. However, consult a doctor immediately If you experience unusual symptoms. Do not discontinue any medications without consulting a doctor.
RifabutinRanolazine
Critical
How does the drug interact with Ributin Capsule:
Taking Ributin Capsule and Ranolazine may significantly reduce the blood levels of Ranolazine.

How to manage the interaction:
There may be a possibility of interaction between Ributin Capsule and Ranolazine, but it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RifabutinLurasidone
Critical
How does the drug interact with Ributin Capsule:
Lurasidone administration with Ributin Capsule may result in significantly lower blood levels of lurasidone.

How to manage the interaction:
There is an interaction between Lurasidone and Ributin Capsule, so it is not recommended that you take it unless a doctor has prescribed it. Consult a doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
RifabutinPanobinostat
Critical
How does the drug interact with Ributin Capsule:
Taking Ributin Capsule and Panobinostat may significantly reduce the blood levels of Panobinostat.

How to manage the interaction:
Taking Ributin Capsule with Panobinostat is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately, iff you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
RifabutinIvabradine
Severe
How does the drug interact with Ributin Capsule:
Coadministration of ivabradine with Ributin Capsule can significantly reduces the blood levels of ivabradine. This increases the risk or severity of side effects.

How to manage the interaction:
Taking Ivabradine with Ributin Capsule together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms consult the doctor immediately. Do not discontinue any medications without first consulting your doctor.
RifabutinLemborexant
Severe
How does the drug interact with Ributin Capsule:
Taking lemborexant and Ributin Capsule may reduce the blood levels of lemborexant, which may make the medication less effective in treating your condition.

How to manage the interaction:
Co-administration of Lemborexant with Ributin Capsule can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RifabutinIbrutinib
Severe
How does the drug interact with Ributin Capsule:
Taking Ributin Capsule and Ibrutinib significantly reduce the blood levels of ibrutinib, which may decrease its effectiveness.

How to manage the interaction:
Co-administration of Ibrutinib with Ributin Capsule can result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
RifabutinNifedipine
Severe
How does the drug interact with Ributin Capsule:
Coadministration of Nifedipine with Ributin Capsule may significantly reduces the blood levels of nifedipine which may make the medication less effective.

How to manage the interaction:
Taking Nifedipine with Ributin Capsule together is usually avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RifabutinNorethisterone
Severe
How does the drug interact with Ributin Capsule:
Coadministration of Norethisterone with Ributin Capsule can reduce the blood levels and effects of norethindrone.This increases the risk of severe bleeding and unintended pregnancy.

How to manage the interaction:
Taking Norethisterone with Ributin Capsule together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of abnormal bleeding, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Pineapple juice might help soothe the symptoms of cough and cold. It also has anti-inflammatory and mucolytic properties.
  • Foods rich in vitamin C, such as kiwi, broccoli, and bell pepper, help improve the immune system. 
  • Avoid processed and fried foods.
  • Warm ginger tea or warm soup can help in providing relief from cough.
  • Avoid foods and drinks containing histamine or tyramine, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer.
  • Quit smoking and avoid alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTI- TUBERCULOSIS
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Alcohol

Unsafe

Avoid alcohol consumption while taking Ributin Capsule as it could lead to increased drowsiness, dizziness, and liver damage.

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Pregnancy

Caution

Please consult your doctor if you are pregnant. Your doctor will prescribe Ributin Capsule only if the benefits outweigh the risks.

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Breast Feeding

Unsafe

Ributin Capsule passes into breast milk. Do not breastfeed while taking Ributin Capsule. Consult your doctor for further advice.

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Driving

Caution

Ributin Capsule may cause dizziness, drowsiness, numbness, and tingling sensation in hands and feet. Do not drive or operate machinery if you experience these symptoms.

bannner image

Liver

Caution

Dose adjustment may be needed. Please consult your doctor before taking Ributin Capsule if you have liver impairment/liver disease.

bannner image

Kidney

Caution

Dose adjustment may be needed. Please consult your doctor if you have any concerns regarding this or kidney impairment/kidney disease before taking Ributin Capsule.

bannner image

Children

Unsafe

Ributin Capsule is not recommended for use in children unless prescribed by a child specialist.

Have a query?

FAQs

Ributin Capsule is used to treat tuberculosis in individuals with HIV infection.

Ributin Capsule consists of a drug called "Rifabutin" that comes into "antimycobacterial". It works by inactivating a bacterial RNA-polymerase, an enzyme that allows TB bacteria to make and replicate essential proteins. It destroys the bacteria named Mycobacterium tuberculosis, which causes TB (tuberculosis), thus treating TB infection.

Do not stop taking Ributin Capsule despite symptomatic relief. To treat your condition effectually, continue taking Ributin Capsule for as long as it has been prescribed for you.

Do not take Ributin Capsule along with antacids as it might decrease the effectiveness of Ributin Capsule. Maintain a minimum gap of 1hour between both.

Consult your doctor before taking Ributin Capsule with other medicines. Medicines used to treat TB such as PAS (P-amino salicylic acid) and cycloserine should be taken 8hours apart from Ributin Capsule.

Ributin Capsule contains isoniazid which might interact with foods and drinks containing histamine or tyramine such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer. Avoid these foods while taking Ributin Capsule.

Ributin Capsule might decrease the effectiveness of oral contraceptives (birth control pills). This could lead to an unplanned pregnancy. Instead, use a reliable barrier method of contraception such as condoms or the coil while taking Ributin Capsule. Consult your doctor if you have any concerns regarding this. Your doctor may suggest an alternate contraception method.

Ributin Capsule may affect the action of some bacterial vaccines like typhoid vaccine, so it is suggested to don't go for any vaccination unless your doctor has suggested you do so.

Country of origin

India

Manufacturer/Marketer address

Lupin Ltd, 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India.
Other Info - RIB0018

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:46 AM IST

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Reference

  1. https://www.cdc.gov/tb/topic/basics/tbhivcoinfection.htm
  2. https://www.nhs.uk/conditions/tuberculosis-tb/causes/
  3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050689s016lbl.pdf

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