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  3. Ristryl Tablet 10's

Ristryl Tablet 10's, Pack of 10 TabletS
Ristryl Tablet 10's, Pack of 10 TabletS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

Ristryl Tablet is used to treat moderate to severe depression associated with moderate to severe anxiety. It contains Amitriptyline and Chlordiazepoxide, which works by affecting certain chemical messengers in the brain that communicate between brain cells, thereby regulating mood and treating depression. Also, it helps suppress the excessive and abnormal activity of the nerve cells in the brain. In some cases, you may experience common side effects such as dizziness, drowsiness, dry mouth, constipation, blurred vision and bloating. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

AMITRIPTYLINE-12.5MG + CHLORDIAZEPOXIDE-5MG

Manufacturer/Marketer :

Dycine Pharmaceuticals

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Ristryl Tablet

Ristryl Tablet is used to treat moderate to severe depression associated with moderate to severe anxiety. Depression is a mood disorder characterised by sadness, unhappiness, anger, hopelessness or loss. Anxiety is a mental health disorder characterised by feelings of anxiety, worry or fear that are strong enough to interfere with one’s daily activities. Anxiety and depression can occur at the same time.

Ristryl Tablet is a combination of two drugs: Amitriptyline (tricyclic anti-depressant) and Chlordiazepoxide (benzodiazepine anxiolytic). Amitriptyline works by affecting certain chemical messengers in the brain that communicate between brain cells, thereby regulating mood and treating depression. Chlordiazepoxide works by increasing the action of a chemical messenger called GABA. This helps suppress the excessive and abnormal activity of the nerve cells in the brain. 

You are advised to take Ristryl Tablet only for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects such as dizziness, drowsiness, dry mouth, constipation, blurred vision and bloating. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Consult your doctor immediately if you have suicidal thoughts, such as killing or harming yourself. Do not take Ristryl Tablet if you are pregnant, as it may cause birth defects. Consult your doctor before taking Ristryl Tablet if you are breastfeeding. Avoid driving or operating machinery as Ristryl Tablet causes sleepiness and dizziness and might impair thinking and motor skills. Avoid consuming alcohol along with Ristryl Tablet as it could lead to increased drowsiness and dizziness. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Ristryl Tablet

Ristryl Tablet is used in the treatment of depression associated with anxiety. The detailed uses of Ristryl Tablet are as follows:
• Managing Anxiety Disorders: Ristryl Tablet is often prescribed to alleviate symptoms of anxiety, offering relief from excessive worry and nervousness.
• Treating Depression: Ristryl Tablet plays a role in treatment plans for depression, helping to improve mood and emotional well-being.
• Sleep Aid: With its sedative properties, Ristryl Tablet may assist in managing insomnia and other sleep-related concerns.
• Neuropathic Pain Relief: Ristryl Tablet is effective in alleviating chronic pain caused by nerve damage, improving the quality of life for affected individuals.
• ADHD Management: As part of a comprehensive treatment approach, Ristryl Tablet can help enhance focus and concentration in patients with attention deficit hyperactivity disorder.

Directions for Use

Take Ristryl Tablet with or without food. Swallow Ristryl Tablet as a whole with a glass of water; do not chew or crush it.

Medicinal Benefits

Ristryl Tablet is a combination of two drugs: Amitriptyline and Chlordiazepoxide. Ristryl Tablet is used to treat moderate to severe depression and anxiety. Amitriptyline is a tricyclic anti-depressant that affects certain chemical messengers (serotonin and/or norepinephrine) in the brain, which communicate between brain cells, thereby regulating mood and treating depression. Chlordiazepoxide is a benzodiazepine anxiolytic that works by increasing the action of a chemical messenger called GABA. This helps suppress the excessive and abnormal activity of the nerve cells in the brain. Ristryl Tablet has a calming effect on various functions of the brain. Thereby, Ristryl Tablet helps in treating anxiety and depression.

How Ristryl Tablet Works

Ristryl Tablet is a combination of two drugs: Amitriptyline (tricyclic anti-depressant) and Chlordiazepoxide (benzodiazepine anxiolytic). Amitriptyline works by affecting certain chemical messengers in the brain that communicate between brain cells, thereby regulating mood and treating depression. Chlordiazepoxide works by increasing the action of a chemical messenger called GABA. This helps suppress the excessive and abnormal activity of the nerve cells in the brain.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Ristryl Tablet

Do not take more than the prescribed dose of Ristryl Tablet as it may cause overdose. The symptoms of overdose include difficulty sleeping, disorientation, dizziness, blurred vision, confusion, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, headache, loss of consciousness, fast/slow/irregular heartbeat, hallucinations, mood or other mental changes, seeing/hearing/feeling things that are not there, nightmares, seizures (fits), sweating, trouble breathing, unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness, or unusual excitement, nervousness, restlessness, or irritability. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Ristryl Tablet if you are allergic to any of its contents, if you recently had a heart attack or heart problems, are taking monoamine oxidase inhibitors (MAOI). Do not take opioids with Ristryl Tablet as it may result in increased sedation, depression, coma and death. Ristryl Tablet should not be taken for longer durations as it may cause physical dependence. Inform your doctor before taking Ristryl Tablet if you have bipolar disorder, eye problems, urination problems, seizures, thyroid problems, kidney or liver problems or if you are due to have any surgery. Consult your doctor immediately if you have suicidal thoughts, such as killing or harming yourself. Talk to your doctor before taking Ristryl Tablet if you have a history of drug abuse, addiction or alcohol abuse as Ristryl Tablet may cause dependence. Do not take Ristryl Tablet if you are pregnant, as it may cause birth defects. Consult your doctor before taking Ristryl Tablet if you are breastfeeding. Avoid driving or operating machinery as Ristryl Tablet causes sleepiness, dizziness and might impair thinking and motor skills. Avoid consuming alcohol along with Ristryl Tablet as it could lead to increased drowsiness and dizziness. Ristryl Tablet should not be given to children as safety and effectiveness have not been established.

Drug-Drug Interactions

verifiedApollotooltip
ChlordiazepoxideSodium oxybate
Critical
AmitriptylineHalofantrine
Critical

Drug-Drug Interactions

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ChlordiazepoxideSodium oxybate
Critical
How does the drug interact with Ristryl Tablet:
Taking Ristryl Tablet with Sodium oxybate increases the risk of breathing difficulty or low blood pressure.

How to manage the interaction:
Taking Ristryl Tablet with Sodium oxybate is generally avoided as it can lead to an interaction, it can be taken if prescribed by a doctor. However, if you experience dizziness, shortness of breath, excessive sweating, or blurred vision, contact your doctor. Do not discontinue any medications without consulting a doctor.
AmitriptylineHalofantrine
Critical
How does the drug interact with Ristryl Tablet:
Combining Ristryl Tablet and Halofantrine may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Ristryl Tablet with Halofantrine may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
AmitriptylineGrepafloxacin
Critical
How does the drug interact with Ristryl Tablet:
Combining Ristryl Tablet and Grepafloxacin may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Ristryl Tablet with Grepafloxacin may result in an interaction, it can be used if a doctor recommends it. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor. Note: Grepafloxacin is no longer available in the market. Grepafloxacin should not be combined with any other medications.
AmitriptylineSelegiline
Critical
How does the drug interact with Ristryl Tablet:
Co-administration of Ristryl Tablet together with Selegiline can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is a mood stabilizer).

How to manage the interaction:
Although using Selegiline and Ristryl Tablet together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken Ristryl Tablet. Do not discontinue any medications without consulting a doctor.
AmitriptylinePhenelzine
Critical
How does the drug interact with Ristryl Tablet:
Using Ristryl Tablet together with Phenelzine can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Although using Phenelzine and Ristryl Tablet together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken Ristryl Tablet. Do not discontinue any medications without consulting a doctor.
AmitriptylineSparfloxacin
Critical
How does the drug interact with Ristryl Tablet:
Combining Ristryl Tablet and Sparfloxacin may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Ristryl Tablet with Sparfloxacin may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor. Note: Sparfloxacin is no longer available in the market. Grepafloxacin should not be combined with any other medications.
AmitriptylineRasagiline
Critical
How does the drug interact with Ristryl Tablet:
Using Ristryl Tablet together with Rasagiline can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Although using Rasagiline and Ristryl Tablet together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Inform a doctor if you have recently taken Ristryl Tablet. Do not discontinue any medications without consulting a doctor.
AmitriptylineMesoridazine
Critical
How does the drug interact with Ristryl Tablet:
Coadministration of Ristryl Tablet and Mesoridazine may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Ristryl Tablet with Mesoridazine may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
AmitriptylineSafinamide
Critical
How does the drug interact with Ristryl Tablet:
Using Ristryl Tablet together with Safinamide can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Although using Safinamide and Ristryl Tablet together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken Ristryl Tablet. Do not discontinue any medications without consulting a doctor.
AmitriptylineThioridazine
Critical
How does the drug interact with Ristryl Tablet:
Ristryl Tablet and Thioridazine can enhance each other's effects when used together.

How to manage the interaction:
Although using Ristryl Tablet and Thioridazine together can cause an interaction, they can be used if prescribed by a doctor. If you have extreme sleepiness, confusion, anxiety, vomiting, vision problems, feeling hot or cold, sweating, muscle stiffness, fainting, fits, or coma, seek medical help. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a healthy diet and exercise regularly as it helps in improving overall health and boosts self-esteem.

  • Regularly attend therapy sessions.

  • Perform meditation and yoga. This helps in relieving stress and provides relaxation.

  • Follow a regular sleep pattern to improve the amount and quality of sleep you get.

  • Include foods rich in omega-fatty acids such as fish, nuts, fresh fruits, vegetables and olive oils.

  • Neurotransmitters are made up of amino acids. Amino acid-rich foods such as meat, dairy products and certain fruits and vegetables help in the proper maintenance of neurotransmitters.

  • Complex carbohydrates help in stimulating serotonin (a feel-good neurotransmitter). These include whole grains, legumes, spinach, broccoli, oranges and pears.

  • Exercising helps in the production of the body’s natural anti-depressants. It also helps in relieving stress, improving mood, boosting self-esteem and providing restful sleep.

  • Avoid smoking and alcohol consumption.

  • Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

Habit Forming

Yes

Therapeutic Class

PSYCHOTHERAPEUTICS

Product Substitutes

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Ristryl Tablet as it may cause increased sleepiness and dizziness.

bannner image

Pregnancy

Unsafe

Avoid taking Ristryl Tablet if you are pregnant unless prescribed by a doctor as it may cause birth defects.

bannner image

Breast Feeding

Caution

Consult your doctor before taking Ristryl Tablet ; your doctor will decide whether Ristryl Tablet can be taken by breastfeeding mothers or not.

bannner image

Driving

Unsafe

Ristryl Tablet may cause sleepiness, dizziness and might impair thinking and motor skills. Do not drive or operate machinery if you experience these symptoms.

bannner image

Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

bannner image

Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

bannner image

Children

Unsafe

Ristryl Tablet should not be given to children as safety and effectiveness have not been established.

Have a query?

FAQs

Ristryl Tablet is used to treat moderate to severe depression associated with moderate to severe anxiety.

Ristryl Tablet contains Amitriptyline and Chlordiazepoxide. Amitriptyline works by affecting certain chemical messengers (serotonin and/or norepinephrine) in the brain, which communicate between brain cells, thereby regulating mood and treating depression. Chlordiazepoxide works by increasing the action of a chemical messenger called GABA. This helps suppress the excessive and abnormal activity of the nerve cells in the brain.

Ristryl Tablet may cause weight gain due to increased appetite. Eat a healthy diet and exercise regularly to maintain a healthy weight.

Do not discontinue Ristryl Tablet without consulting your doctor, as it could cause withdrawal symptoms. To treat your condition effectually, continue taking Ristryl Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Ristryl Tablet .

Dry mouth could be a side-effect of Ristryl Tablet . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.

Constipation might occur as a side-effect of Ristryl Tablet . Drink plenty of fluids and eat fibre-rich food if you experience constipation. Consult your doctor if you experience severe constipation.

Ristryl Tablet may cause side effects like dizziness and tiredness in some people. Consult the doctor if the condition persists or if you experience severe dizziness or tiredness.

Painkillers should be taken with Ristryl Tablet only if advised by the doctor. However, opioid-based analgesics should not be taken with Ristryl Tablet as it may cause drowsiness and breathing problems. Always check with the doctor before taking painkillers or other medicines along with Ristryl Tablet .

Ristryl Tablet may cause suicidal thoughts/behaviour; therefore, monitor the person taking Ristryl Tablet for any changes in mood/behaviour and report to the doctor if you notice any unusual behaviour.

Eat a healthy diet and exercise regularly to manage weight gain associated with the use of Ristryl Tablet . Talk to the doctor if the increase in weight bothers you.

Store Ristryl Tablet at room temperature, protected from light and moisture. Keep it out of sight and reach of children.

Yes, Ristryl Tablet may cause sleepiness. Do not drive or operate machinery unless you know how the medicine affects you.

Ristryl Tablet may cause sexual problems like decreased sexual desire, inability to reach an orgasm and erectile dysfunction in men. Discuss with the doctor if you experience sexual problems during treatment with Ristryl Tablet .

No, do not drink alcohol while taking Ristryl Tablet . Consuming alcohol along with Ristryl Tablet could lead to increased drowsiness & dizziness and very serious side effects.

Ristryl Tablet may change the colour of urine to green or blue. It is generally harmless and resolves once the medicine is stopped. However, consult the doctor if you have any concerns regarding this.

Ristryl Tablet may start working within a week. However, it might take around 4 weeks to notice the full benefits of Ristryl Tablet . Continue taking Ristryl Tablet for the prescribed duration to treat your condition effectively.

The active ingredients of Ristryl Tablet are Amitriptyline (tricyclic anti-depressant) and Chlordiazepoxide (benzodiazepine anxiolytic). It is used to treat moderate to severe depression associated with moderate to severe anxiety.

Ristryl Tablet can be taken with or without food as advised by the doctor. Swallow Ristryl Tablet as a whole with a glass of water; do not chew or crush it.

Yes, Ristryl Tablet is safe if taken in the dose and duration prescribed by the doctor. It should not be taken for longer durations as it may cause physical dependence.

Though Ristryl Tablet may help you sleep better by improving your mood, it should not be used for sleep-related issues. Talk to the doctor if you have sleep-related problems.

Ristryl Tablet may not be beneficial for heart health as it may cause QT prolongation (a condition that affects heart rhythm) in some people. Before starting treatment with Ristryl Tablet discuss you’re your doctor if you have heart rhythm problems.

Side effects of Ristryl Tablet include dizziness, drowsiness, dry mouth, constipation, blurred vision and bloating. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Country of origin

India

Manufacturer/Marketer address

381 Bolck III, Ganga Shopping Complex, Sector 29, NOIDA-201 301
Other Info - RIS0156

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Apr 25, 2025 | 9:09 AM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/016949s040lbl.pdf
  2. https://www.drugs.com/mtm/amitriptyline-and-chlordiazepoxide.html
  3. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=66a756f2-ac77-451c-a19a-08896d73b15c
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