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compositionComposition:ROFLUMILAST-500MCG
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Prescription Medicine
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ROFUM 500MG TABLET is used to treat chronic obstructive pulmonary disease (COPD). It contains Roflumilast which works by relaxing the airways and making it easier to breathe. In some cases, this medicine may cause side effects such as diarrhoea, nausea, stomach ache, weight loss and headache. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

ROFLUMILAST-500MCG

Manufacturer/Marketer :

Msn Laboratories Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About ROFUM 500MG TABLET

ROFUM 500MG TABLET is prescription medication used to reduce the frequency of flare-ups or worsening symptoms in adults with severe chronic obstructive pulmonary disease (COPD). It is specifically prescribed for individuals who have long-term chest congestion and inflammation, known as chronic bronchitis, and a history of frequent flare-ups. This medicine is a long-term maintenance treatment and is not meant to relieve sudden breathing problems.

You should take ROFUM 500MG TABLET once daily at the same time every day to maintain a consistent level of the medicine in your body. It can be taken with or without food, making it easy to fit into your daily routine. Making healthy choices, such as staying well-hydrated and avoiding smoke exposure, can further support your lung health while using this medication.

Some people taking this medicine may experience common side effects like diarrhoea, nausea, or a decrease in appetite. While these are often mild, you must contact your doctor immediately if you experience severe diarrhoea, significant unexplained weight loss, or changes in your mood.

Before starting ROFUM 500MG TABLET, tell your doctor if you have a history of depression, suicidal thoughts, or liver problems. Do not take this medicine if you have moderate to severe liver damage, as your body may not be able to process the medication safely.

This medicine can interact with certain prescription drugs, including some treatments for seizures or tuberculosis, which can make it less effective. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, talk to your doctor or pharmacist to ensure this treatment is safe for your specific situation.

 

Uses of ROFUM 500MG TABLET

Here is the main condition where ROFUM 500MG TABLET is used to improve long-term lung health and reduce COPD flare-ups:

  • Severe Chronic Obstructive Pulmonary Disease (COPD): ROFUM 500MG TABLET is used as a daily maintenance treatment to lower the risk of sudden breathing flare-ups in adults who have severe, ongoing COPD associated with chronic bronchitis.
     

Key Benefits

ROFUM 500MG TABLET offers real-world relief for individuals living with severe lung conditions by targeting the root cause of swelling in the airways. By taking this medication regularly, patients can experience several clinical benefits that improve their daily lives.

  • Fewer sudden flare-ups: The primary benefit of this medicine is a noticeable reduction in the frequency of sudden, severe worsening of COPD symptoms, which often lead to emergency hospital visits.
  • Better long-term symptom control: Regular use helps keep your airways clearer over time, making it easier to manage your daily activities without frequent interruptions from severe coughing or chest congestion.
  • Consistent respiratory support: Because it works continuously in the body, it provides steady, round-the-clock defence against airway inflammation when taken as directed.

 

Side effects of Rofum 500 Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Weight loss without physical activity needs immediate medical attention.
  • Get a physical examination and blood tests done to identify factors causing weight loss that could be related to metabolism and thyroid function.
  • Avoid smoking and alcohol intake as it can alter your liver condition and increase your weight loss.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes of weight loss.
  • Talk to your dietician and consume food which can maintain ideal weight.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Managing back pain as a side effect of medication requires a combination of self-care techniques, lifestyle modifications, and medical interventions. Here are the steps:
  • Talk to your doctor about your back pain and potential medication substitutes or dose changes.
  • Try yoga or Pilates and other mild stretching exercises to increase flexibility and strengthen your back muscles.
  • To lessen the tension on your back, sit and stand upright and maintain proper posture.
  • To alleviate discomfort and minimize inflammation, apply heat or cold packs to the afflicted area.
  • Under your doctor's supervision, think about taking over-the-counter painkillers like acetaminophen or ibuprofen.
  • Make ergonomic adjustments to your workspace and daily activities to reduce strain on your back.
  • To handle tension that could make back pain worse, try stress-reduction methods like deep breathing or meditation.
  • Use pillows and a supportive mattress to keep your spine in the right posture as you sleep.
  • Back discomfort can worsen by bending, twisting, and heavy lifting.
  • Speak with a physical therapist to create a customized training regimen to increase back strength and flexibility.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
  • Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
  • Prefer foods high in fiber to help feel full for a long time.
  • If you have decreased appetite, eat only when you are hungry.
  • Eat several small meals or snacks all day.
  • Try to take only small sips of fluids while eating.

Directions for Use

  • Take ROFUM 500MG TABLET with or without food or as advised by a doctor.
  • Adhere to your doctor’s guidance regarding the dosage and timing of this medication for optimal effectiveness.
  • Swallow it as a whole with a glass of water.
  • Do not crush, chew, or break it.

How ROFUM 500MG TABLET Works

ROFUM 500MG TABLET contains roflumilast, a phosphodiesterase-4 (PDE4) inhibitor that helps reduce inflammation in the lungs and airways. ROFUM 500MG TABLET works by blocking the action of an enzyme called phosphodiesterase-4 (PDE4), which plays a key role in causing inflammation in the airways. By inhibiting this enzyme, it helps reduce swelling, irritation, and excess mucus production in the lungs, making it easier to breathe. Unlike quick-relief inhalers, ROFUM 500MG TABLET does not provide immediate relief from sudden breathing problems. Instead, it works gradually over time to help prevent flare-ups and keep the airways less inflamed, which is why it should be taken regularly as prescribed. Together, these actions help improve lung function, reduce the frequency of COPD exacerbations, and make breathing easier over the long term.
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Alcohol

Caution

The interaction of ROFUM 500MG TABLET with alcohol is unknown. Please consult a doctor before consuming alcohol with ROFUM 500MG TABLET.

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Pregnancy

Caution

The safety of ROFUM 500MG TABLET in pregnant women is unknown and is given to pregnant women only if the doctor thinks benefits outweigh risks.

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Breast Feeding

Caution

It is unknown whether ROFUM 500MG TABLET is excreted in human milk. It is given to breastfeeding mothers only if the doctor thinks benefits are greater than risks.

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Driving

Unsafe

ROFUM 500MG TABLET may cause blurred vision or dizziness in some people. Therefore, avoid driving if you notice any changes in vision or feel dizzy after taking ROFUM 500MG TABLET.

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Liver

Caution

Do not take ROFUM 500MG TABLET if you have moderate or severe liver problems. ROFUM 500MG TABLET should be used with caution in patients with liver disease. Dose adjustment of ROFUM 500MG TABLET may be needed. Please consult your doctor.

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Kidney

Safe if prescribed

If you have any concerns regarding the use of ROFUM 500MG TABLET in patients with kidney problems, please consult a doctor.

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Children

Unsafe

ROFUM 500MG TABLET should not be used in children and adolescents under 18 years of age.

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Heart

Consult your doctor

It is unknown whether ROFUM 500MG TABLET is safe for use in cardiac patients. Please consult your physician.

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Geriatrics

Safe if prescribed

ROFUM 500MG TABLET is safe for use in elderly patients if prescribed by the physician.

What if I have taken an overdose of ROFUM 500MG TABLET

If you take more than your prescribed dose, seek immediate medical attention or contact your local poison control centre. Overdosing can lead to increased side effects such as severe headache, dizziness, or stomach upset.

Diet & Lifestyle Advise

  • Monitor your weight regularly: Because this medicine can cause unexpected weight loss, weigh yourself once a week and keep a log to share with your healthcare provider.
  • Avoid smoking and secondhand smoke: Tobacco smoke directly damages lung tissue and makes severe lung conditions worse, reducing the positive effects of your medication.
  • Stay well-hydrated: Drinking plenty of water throughout the day helps thin the mucus in your airways, making it easier to clear your lungs.
  • Eat smaller, nutrient-dense meals: If you experience a loss of appetite or nausea, eating smaller, frequent, high-protein meals can help you maintain your strength and prevent unhealthy weight loss.

 

health query

Have a query?

How Soon It Starts Working

The time required for ROFUM 500MG TABLET to start to work: The time required for ROFUM 500MG TABLET to start to work is 1 hour after administration. The time for which the effects of ROFUM 500MG TABLET last: The effect of ROFUM 500MG TABLET lasts for 24 hours.

What if you forget to take ROFUM 500MG TABLET

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular daily schedule. Do not take two doses at the same time to make up for a missed one. Talk to your doctor or pharmacist if you are unsure of what to do.

Storage

• Store ROFUM 500MG TABLET tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Do not use for sudden attacks: Remember that ROFUM 500MG TABLET is not a rescue medication and will not stop a sudden breathing emergency. Always keep your quick-relief inhaler with you.
  • Track your mental health: Pay close attention to any sudden changes in your mood, sleep patterns, or thoughts. Share any concerns immediately with your family and doctor.
  • Do not crush the tablets: Always swallow the tablets whole to prevent the medication from releasing too quickly in your body.
  • Check your liver health: Ensure you complete any blood tests requested by your doctor to monitor your liver function while taking this medicine.
     

Drug-Drug Interactions

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Here are the medicines that may interact with ROFUM 500MG TABLET and affect its safety or effectiveness:

  • Strong liver enzyme activators: Medicines such as rifampin (used for tuberculosis) or certain seizure medications (like carbamazepine, phenobarbital, and phenytoin) can reduce the level of ROFUM 500MG TABLET in your body, making it much less effective.
  • Certain enzyme blockers: Medicines like erythromycin, ketoconazole, or fluvoxamine can increase the level of ROFUM 500MG TABLET in your blood, which may raise your risk of experiencing side effects.
RoflumilastCladribine
Severe

Drug-Drug Interactions

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RoflumilastCladribine
Severe
How does the drug interact with Rofum 500 Tablet:
Taking cladribine together with Rofum 500 Tablet may increase the risk of infections.

How to manage the interaction:
Although there is a interaction between Cladribine and Rofum 500 Tablet, but it can be taken together if prescribed by your doctor. However. if you experience fever, chills, loose stools, sore throat, muscle aches, difficulty breathing, and pain or burning while passing urine, contact a doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with ROFUM 500MG TABLET when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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FAQs

ROFUM 500MG TABLET is used to treat chronic obstructive pulmonary disease (COPD).
No, it is a prescribed drug, given by a physician for preventing specific medical conditions. Taking it on your own can cause unwanted side-effects.
Please take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and go back to your regular dosing schedule.
It is essential to let your doctor know if you have any history of liver disease, cancer, heart disease, current/past infections, mental/mood disorders (depression, thoughts of suicide), unexplained/extreme weight loss, immune system disorders.
No, you are not recommended to stop taking ROFUM 500MG TABLET without consulting your doctor as it may worsen the condition or cause recurring symptoms. Therefore, take ROFUM 500MG TABLET for as long as your doctor has prescribed it, and if you experience any difficulty while taking ROFUM 500MG TABLET, please consult your doctor.
No, ROFUM 500MG TABLET does not relieve sudden symptoms such as shortness of breath. Therefore, it is advised to carry a rescue inhaler always to treat sudden symptoms.
ROFUM 500MG TABLET works by relaxing the airways in your lungs, making breathing easier. It also helps prevent flare-ups and worsening symptoms associated with chronic obstructive pulmonary disease (COPD).
The common side effects of ROFUM 500MG TABLET include diarrhoea, nausea, stomach ache, weight decrease, and headache in some cases. Most of these side effects of ROFUM 500MG TABLET do not require medical attention and gradually resolve over time. However, if the side effects persist, please get in touch with your doctor.
No, ROFUM 500MG TABLET is not a methylxanthine. It is a phosphodiesterase inhibitor medication used to treat chronic obstructive pulmonary disease (COPD) and works by reducing inflammation in the lungs. On the other hand, methylxanthines are a separate group of medications that work by relaxing the smooth muscles of the airways, helping to widen the air passages and ease breathing.
No, ROFUM 500MG TABLET is neither a steroid nor a narcotic. It is a type of medication called a phosphodiesterase inhibitor. Unlike steroids, which are often used to reduce inflammation, ROFUM 500MG TABLET has a different structure and works differently. It works by targeting certain enzymes to help open the airways. Additionally, ROFUM 500MG TABLET is not a narcotic, so it does not cause feelings of euphoria or lead to addiction, as narcotics do.
ROFUM 500MG TABLET may take several weeks to show its full effects. It usually takes 4 weeks or more before you start noticing improvements in your symptoms. However, results can vary from person to person. Be sure to continue taking the medication for the duration prescribed by your doctor to achieve the best outcome.
No, ROFUM 500MG TABLET is not a rescue medicine and will not stop a sudden breathing emergency. It is designed to be taken daily to prevent flare-ups over time. If you experience sudden shortness of breath, use your quick-relief rescue inhaler and seek medical help if your breathing does not improve. Talk to your doctor.
Weight loss is a common side effect of this medicine. You should monitor your weight regularly. If you notice a significant or unexplained drop in weight, contact your doctor to discuss whether you need to adjust your diet or stop the medication. Talk to your doctor.
There is no direct, major interaction between alcohol and this medicine. However, because both alcohol and ROFUM 500MG TABLET can affect your liver, it is best to limit your alcohol intake. Talk to your doctor or pharmacist.
Do not take this medicine if you have moderate to severe liver damage, as your liver cannot process the drug safely, which could increase your risk of side effects. If you have mild liver issues, your doctor will decide if this medicine is safe for you. Talk to your doctor.
Yes, this medicine has been linked to psychiatric side effects, including depression, anxiety, and suicidal thoughts. If you or your family notice any unusual changes in your mood or behaviour, contact your doctor immediately. Talk to your doctor.
No, you must swallow the tablet whole with water. Crushing, chewing, or breaking the tablet can change how the medicine is absorbed, which might reduce its effectiveness or increase side effects. If you have difficulty swallowing pills, talk to your doctor or pharmacist.
The safety of this medicine during pregnancy or breastfeeding is not fully established. It should only be used if the potential benefit justifies the potential risk to the baby. Talk to your doctor.

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Country of origin

India

Manufacturer/Marketer address

MSN Laboratories Pvt.Ltd., MSN House, Plot No: C-24, Industrial Estate, Sanathnagar, Hyderabad - 18 Telangana, INDIA
Other Info - ROF0020
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