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Composition:RANOLAZINE-500MG

Prescription Medicine

ROLAZIN TABLET is used alone or with other medicines to treat angina pectoris. It helps prevent any further attack of angina by making the heart work more efficiently, and it is used as an add-on to existing treatment in patients whose disease is not adequately controlled by other medicines for angina pectoris, such as beta-blockers or calcium antagonists, or in patients who cannot take these medicines. In some cases, it may cause side effects such as constipation, dizziness, headache, or feeling sick. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

Written By Bayyarapu Mahesh Kumar , M Pharmacy

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

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More about the Product

Composition :

RANOLAZINE-500MG

Manufacturer/Marketer :

Macleods Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About ROLAZIN TABLET

ROLAZIN TABLET is a prescription oral medication primarily used to treat chronic chest pain, also known as angina. It is prescribed for long-term management to help reduce the frequency of chest pain episodes. This medication is not intended to treat sudden, acute attacks of angina.

To work effectively, ROLAZIN TABLET must be taken consistently every day, usually twice daily, as directed by your doctor. You can take this medication with or without food, but it is important to be consistent with whichever method you choose. Combining this treatment with heart-healthy lifestyle habits, such as eating a balanced diet and engaging in light, doctor-approved physical activity, can significantly improve your overall outcomes.

While taking this medicine, some patients may experience mild side effects like dizziness, headache, nausea, or constipation. If you experience serious symptoms such as an irregular heartbeat, severe lightheadedness, or shortness of breath, you should contact your doctor immediately.

Do not take this if you have moderate to severe liver damage, as your body will not be able to process the medicine safely. Before starting, tell your healthcare provider if you have kidney problems or a family history of heart rhythm issues.

ROLAZIN TABLET can interact with certain medications, grapefruit juice, and alcohol, which can increase the risk of side effects like dizziness or heart rhythm changes. Pregnant women, breastfeeding mothers, and elderly patients should consult their doctor before starting this medicine to ensure it is safe for their specific circumstances.

Uses of ROLAZIN TABLET

The following are the primary therapeutic uses of ROLAZIN TABLET:

Chronic Angina: ROLAZIN TABLET helps by preventing and reducing the frequency of ongoing chest pain in patients with coronary artery disease, allowing for improved daily functioning.

Key Benefits

When taken as prescribed, ROLAZIN TABLET offers several benefits for people managing chronic angina:

Reduces angina episodes: Helps decrease the frequency of chest pain attacks, improving day-to-day comfort.
Supports physical activity: Enables patients to perform routine activities with less angina-related discomfort.
Does not significantly lower heart rate: Suitable for patients who may not tolerate medications that slow the heart excessively.
Has minimal impact on blood pressure: Can be a useful option for individuals with low blood pressure or those sensitive to blood pressure-lowering effects.
Improves quality of life: Helps patients maintain a more active and independent lifestyle by providing better symptom control.

Side effects of Rolazin Tablet

Constipation

Here are the steps to cope with constipation as a side effect of medication:

Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

Nausea

Overcome Medication-Induced Nausea: A 9-Step Plan

Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
Divide your daily food intake into smaller, more frequent meals to reduce nausea.
Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
Use ginger (tea, ale, or candies) to help relieve nausea.
Get adequate rest and also avoid strenuous activities that can worsen nausea.
Talk to your doctor about taking anti-nausea medication if your nausea is severe.
Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Vomiting

To prevent, manage, and treat Constipation caused by medication usage, follow these steps:

Preventing Vomiting (Before it Happens)
Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
Having a small meal before taking your medication can help reduce nausea and vomiting.
Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
Managing Vomiting (If it Happens)
Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
What to Do if Vomiting Persists
Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Dizziness

Here are the 7 steps to manage Dizziness caused by medication:

Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
When standing up, do so slowly and carefully to avoid sudden dizziness.
Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Headache

Dealing with Medication-Induced Headache:

Hydrate your body: Drink enough water to prevent dehydration and headaches.
Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
Take rest: lie down in a quiet, dark environment.
Cold or warm compresses can help reduce tension.
Stay Upright: Maintain good posture to keep symptoms from getting worse.
To treat headaches naturally, try acupuncture or massage therapy.
Over-the-counter pain relievers include acetaminophen and ibuprofen.
Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
Frequent Headaches: If you get reoccurring headaches, consult your doctor.
Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Weakness

Rest well; get enough sleep.
Eat a balanced diet and drink enough water.
Manage stress with yoga and meditation.
Limit alcohol and caffeine.
Physical activities like walking or jogging might help boost energy and make you feel less tired.

Directions for Use

Swallow the tablet whole with a full glass of water.
Do not crush, chew, or break the tablet, as this can release the medication too quickly and increase the risk of side effects.
Take it at the same times every day to maintain a steady level of the medicine in your body.
You may take this medicine with or without food, but keep your routine consistent.

Always follow your doctor's exact instructions regarding how and when to take this medication.

How ROLAZIN TABLET Works

ROLAZIN TABLET works by targeting the electrical and chemical processes inside the heart muscle cells. During chronic chest pain, heart cells can experience an abnormal buildup of sodium. This excess sodium leads to an overload of calcium, which prevents the heart muscle from fully relaxing between beats. By selectively blocking these late sodium channels, ROLAZIN TABLET prevents calcium buildup. This allows the heart muscle to relax properly, improving blood flow and oxygen delivery to the heart without altering your normal resting heart rate or blood pressure.

Alcohol

Safe if prescribed

ROLAZIN TABLET does not have any reported interaction; hence, if you experience any difficulty, discuss with your doctor.

Pregnancy

Unsafe

ROLAZIN TABLET should not be used when pregnancy unless necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing ROLAZIN TABLET.

Breast Feeding

Consult your doctor

ROLAZIN TABLET should not be used in nursing mothers. Please consult the doctor if you have any concerns regarding this.

Driving

Safe if prescribed

ROLAZIN TABLET does not have any reported interaction; hence, in case you experience any difficulty, discuss with your doctor.

Liver

Caution

ROLAZIN TABLET to be taken with caution, especially if you have a history of liver disease. The dose may have to be adjusted by your doctor.

Kidney

Caution

ROLAZIN TABLET to be taken with caution, especially if you have a history of kidney disease. The dose may have to be adjusted by your doctor.

Children

Unsafe

ROLAZIN TABLET is not recommended for children below the age of 18. The safety and effectiveness of ROLAZIN TABLET have not been established in children due to limited testing of this drug on children by competent authorities worldwide.

Heart

Consult your doctor

Please consult your physician if you have any heart-related problems before taking ROLAZIN TABLET.

Geriatrics

Consult your doctor

Your doctor will recommend ROLAZIN TABLET if needed in the geriatric population. Please consult your doctor.

What if I have taken an overdose of ROLAZIN TABLET

Do not take more than the prescribed dose of ROLAZIN TABLET as it may cause overdose. The symptoms of overdose include nausea, vomiting, confusion, dizziness, double vision, fainting, difficulty speaking, uncontrollable shaking of a part of the body, hallucinations and burning, pain, numbness, or tingling in any part of the body. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

Avoid Grapefruit: Do not drink grapefruit juice or eat grapefruit while taking this medicine, as it can dangerously increase the levels of the drug in your system.
Monitor Salt Intake: Adopt a low-sodium diet to help manage underlying coronary artery disease and reduce strain on your cardiovascular system.
Stay Hydrated: Drink adequate amounts of water to help prevent constipation, which is a common side effect of this medication.
Engage in Gentle Exercise: Participate in moderate, doctor-approved activities like walking to support heart health without overexerting yourself.

Have a query?

How Soon It Starts Working

The time required for ROLAZIN TABLET to start to work: The time required for ROLAZIN TABLET to show its action is not clinically established. The time for which the effects of ROLAZIN TABLET last: The effect of ROLAZIN TABLET lasts for 21 days.

What if you forget to take ROLAZIN TABLET

Take the missed dose as soon as you remember. However, if it is time for the next dose, skip the missed dose and follow your regular dosing schedule. Do not take a double dose to make up for your missed dose.

Storage

• Store ROLAZIN TABLET tablets at room temperature, ideally between 20°C to 25°C (68°F to 77°F). • Keep the medication in its original container to protect it from moisture and direct light.

Drug Warnings

Avoid driving initially: Do not drive or operate machinery until you know how ROLAZIN TABLET affects you, as it commonly causes dizziness.
Check other prescriptions: Always let your doctor know about all other medications, supplements, or herbal products you are taking to prevent dangerous interactions.
Do not stop suddenly: Keep taking this medication even if you feel well; stopping it abruptly can cause your chest pain to return.
Stand up slowly: To reduce the risk of dizziness or fainting, rise slowly from sitting or lying positions.

Drug-Drug Interactions

Drug-Drug Interactions

The following medicines may interact with ROLAZIN TABLET and affect its safety or effectiveness:

Strong CYP3A inhibitors: These medicines can increase the level of ROLAZIN TABLET in your blood, raising the risk of side effects.
Strong CYP3A inducers: These drugs can reduce the effectiveness of ROLAZIN TABLET by lowering its concentration in the body.
Heart rhythm medications: Taking these with ROLAZIN TABLET may increase the risk of abnormal heart rhythms.
Tuberculosis medications: Certain TB treatments can alter how ROLAZIN TABLET is metabolised, affecting its effectiveness.
Anti-seizure medications: These medicines may interfere with the blood levels and action of ROLAZIN TABLET.

Drug-Food Interactions

Certain foods and beverages may affect how ROLAZIN TABLET works in your body:

Grapefruit and grapefruit juice: Avoid these completely, as they can increase the amount of ROLAZIN TABLET in your bloodstream to unsafe levels.
Alcohol: Limiting alcohol intake is advised, as it may worsen dizziness and other side effects.

Drug-Disease Interactions

Some existing medical conditions may affect whether ROLAZIN TABLET is suitable for you:

Severe liver disease (cirrhosis): Do not take ROLAZIN TABLET if you have severe liver impairment, as it may lead to harmful drug accumulation.
Moderate-to-severe kidney disease: Use with caution, as impaired kidney function may affect how the medicine is processed.
Long QT syndrome: If you have a personal or family history of this heart rhythm disorder, ROLAZIN TABLET may increase the risk of serious cardiac complications.

RanolazineThioridazine

Critical

RanolazineRibociclib

Critical

Drug-Drug Interactions

RanolazineThioridazine

Critical

How does the drug interact with Rolazin Tablet:
When Thioridazine is taken with Rolazin Tablet, may significantly increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Rolazin Tablet with Thioridazine together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, contact a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.

RanolazineRibociclib

Critical

How does the drug interact with Rolazin Tablet:
When Ribociclib is taken with Rolazin Tablet, may increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Rolazin Tablet with Rifampicin is not recommended, please consult a doctor before taking it. They can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms such as excessive drowsiness, dizziness, lightheadedness, fainting, confusion, shortness of breath, or heart palpitations. Do not stop taking any medications without consulting a doctor.

RanolazineOxcarbazepine

Critical

How does the drug interact with Rolazin Tablet:
When Rolazin Tablet is taken with Oxcarbazepine, may significantly reduce the blood levels of Rolazin Tablet, which may make the medication ineffective or less effective.

How to manage the interaction:
Taking Oxcarbazepine with Rolazin Tablet is not recommended as it can lead to an interaction, they can be taken together if advised by a doctor. Do not stop taking any medications without consulting a doctor.

RanolazineNafcillin

Critical

How does the drug interact with Rolazin Tablet:
When Nafcillin is taken with Rolazin Tablet, may significantly reduce the blood levels of Rolazin Tablet, which may make the medication ineffective or less effective.

How to manage the interaction:
Taking Nafcillin with Rolazin Tablet can lead to an interaction, please consult a doctor before taking it. They can be taken together if advised by a doctor. Do not stop taking any medications without consulting a doctor.

RanolazineSaquinavir

Critical

How does the drug interact with Rolazin Tablet:
When Rolazin Tablet is taken with Saquinavir, may significantly increase the blood levels and effects of Rolazin Tablet.

How to manage the interaction:
Taking Rolazin Tablet with Saquinavir together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.

RanolazineNevirapine

Critical

How does the drug interact with Rolazin Tablet:
Co-administration of Nevirapine with Rolazin Tablet may significantly reduce the blood levels of Rolazin Tablet. This can lead to low treatment outcomes.

How to manage the interaction:
Taking Nevirapine with Rolazin Tablet is generally avoided as it can lead to an interaction, they can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms. Do not stop taking any medications without consulting a doctor.

RanolazineGriseofulvin

Critical

How does the drug interact with Rolazin Tablet:
When Rolazin Tablet is taken with Griseofulvin, may significantly reduce the blood levels of Rolazin Tablet, which may make the medication ineffective or less effective.

How to manage the interaction:
Taking Griseofulvin with Rolazin Tablet is not recommended, they can be taken together if advised by a doctor. Do not stop taking any medications without consulting a doctor.

RanolazineRitonavir

Critical

How does the drug interact with Rolazin Tablet:
Taking Ritonavir and Rolazin Tablet may significantly increase the blood levels and effects of Rolazin Tablet.

How to manage the interaction:
Co-administration of Rolazin Tablet with Ritonavir can possibly result in an interaction, but it can be taken if a doctor has advised it. In case you experience any symptoms like feeling lightheaded, fainting, or rapid heartbeats, consult a doctor. Do not stop using any medications without a doctor's advice.

RanolazineMifepristone

Critical

How does the drug interact with Rolazin Tablet:
When Mifepristone is taken with Rolazin Tablet, may cause an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Phenylbutazone with Rolazin Tablet can lead to an interaction. They can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms such as dizziness, lightheadedness, fainting, or fast or pounding heartbeats. Do not stop taking any medications without consulting a doctor.

RanolazineDexamethasone

Critical

How does the drug interact with Rolazin Tablet:
When Dexamethasone is taken with Rolazin Tablet, may significantly reduce the blood levels of Rolazin Tablet.

How to manage the interaction:
Co-administration of Rolazin Tablet and Dexamethasone can lead to an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

RANOLAZINE-500MGGrapefruit and Grapefruit Juice

Severe

Drug-Food Interactions

RANOLAZINE-500MGGrapefruit and Grapefruit Juice

Severe

Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Grapefruit juice can increase the levels of Rolazin Tablet, and high blood levels of food can occasionally cause an irregular heart rhythm that may be serious. Grapefruit and grapefruit juice should be avoided while taking Rolazin Tablet if possible.

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Habit Forming

Therapeutic Class

[ANTIANGINALS]

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Author Details

Written By

Bayyarapu Mahesh Kumar
M Pharmacy

Reviewed By

Dr Aneela Siddabathuni
MPharma., PhD

Last Updated

Jun 26, 2026 | 1:18 PM IST

We provide you with authentic, trustworthy and relevant information.

See our editorial policy

Reference

Country of origin

India

Manufacturer/Marketer address

Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, INDIA.

Other Info - ROL0016

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ROLAZIN TABLET

Delivery Information

More about the Product

Composition :

Manufacturer/Marketer :

Consume Type :

Expires on or after :

Return Policy :

About ROLAZIN TABLET

Uses of ROLAZIN TABLET

Key Benefits

Constipation

Nausea

Vomiting

Dizziness

Headache

Weakness

Directions for Use

How ROLAZIN TABLET Works

Alcohol

Pregnancy

Breast Feeding

Driving

Liver

Kidney

Children

Heart

Geriatrics

What if I have taken an overdose of ROLAZIN TABLET

Diet & Lifestyle Advise

How Soon It Starts Working

What if you forget to take ROLAZIN TABLET

Storage

Drug Warnings

Drug-Drug Interactions

Drug-Drug Interactions

Drug-Food Interactions

Drug-Food Interactions

All Substitutes & Brand Comparisons

Ranogard 500 Tablet 10's

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FAQs

What is the use of ROLAZIN TABLET?

How does ROLAZIN TABLET works?

Can ROLAZIN TABLET stop acute attacks of angina?

Can I take alcohol along with ROLAZIN TABLET?

Can smoking decrease the efficacy of ROLAZIN TABLET?

Can ROLAZIN TABLET cause stomach upset?

Does ROLAZIN TABLET cause drowsiness?

What are the serious side effects of ROLAZIN TABLET?

In case I accidentally take an excess of ROLAZIN TABLET, what will happen?

Is it safe to take ROLAZIN TABLET if I am already taking metoprolol?

I am a diabetic and am taking metformin. My doctor has prescribed ROLAZIN TABLET, is it safe to take both together?

I have been taking simvastatin to keep my cholesterol levels in check. Can I take ROLAZIN TABLET with it?

Can I crush or split ROLAZIN TABLET tablets to make them easier to swallow?

What should I do if I experience dizziness while taking ROLAZIN TABLET?

Does ROLAZIN TABLET lower blood pressure or heart rate?

Can I eat grapefruit while taking this medicine?

How long does it take for ROLAZIN TABLET to start working?

Can I take ROLAZIN TABLET if I am pregnant or breastfeeding?

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