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  3. Rulace Plus Syrup

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Rulace Plus Syrup, Pack of 1 Syrup
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Rulace Plus Syrup is used to reduce pain and inflammation. It helps in relieving pain from conditions like headaches, mild migraine, muscle pain, dental pain, rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. It contains Aceclofenac and Paracetamol, which work by blocking the chemical messengers responsible for causing pain, inflammation, and fever. In some cases, it may cause side effects like dizziness, nausea, digestion problems (constipation, flatulence, diarrhoea) and skin reactions (like rashes and hives). Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

ACECLOFENAC-50MG/5ML + PARACETAMOL-125MG/5ML

Consume Type :

ORAL

Return Policy :

Not Returnable

About Rulace Plus Syrup

Rulace Plus Syrup is used to reduce pain and inflammation. The pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage. Inflammation is a localized physical condition in which part of the body becomes reddened, swollen, hot and often painful.

Rulace Plus Syrup is composed of aceclofenac and paracetamol. Aceclofenac and Paracetamol both work by blocking the chemical messengers responsible for causing pain, inflammation, and fever.

Rulace Plus Syrup may cause side effects like dizziness, nausea, constipation, flatulence, diarrhoea, rashes and hives. Most of the side effects of Rulace Plus Syrup do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Avoid taking Rulace Plus Syrup if you are allergic to any of the ingredients present in it. Taking more than the daily prescribed dose of Rulace Plus Syrup may cause liver damage or allergic reactions like swelling of the mouth, face, throat, difficulty in breathing, skin rash, itching, gastrointestinal bleeding and/or ulcer. 

Uses of Rulace Plus Syrup

Rulace Plus Syrup is used in the treatment of Pain, Inflammation, and fever. The detailed uses of Rulace Plus Syrup are as follows:

  • Pain Relief: Rulace Plus Syrup is used to relieve pain, by its analgesic effects, which block pain signals and reduce discomfort.
  • Inflammation: Rulace Plus Syrup helps to reduce inflammation and swelling associated with conditions like arthritis, osteoarthritis, and rheumatoid arthritis.
  • Fever Reduction: Rulace Plus Syrup is used to bring down elevated body temperature, providing relief from discomfort associated with fever.

Directions for Use

  • Rulace Plus Syrup can be taken with or without food, preferably with a meal.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Rulace Plus Syrup as a whole with a glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

  • Rulace Plus Syrup helps to reduce pain and inflammation caused by various complications or conditions.
  • It significantly works on providing relief from pain for extended hours.
  • It contains paracetamol, which is less irritant to the stomach than other painkillers. Hence, it is well tolerated by patients who have an allergy to aspirin or a risk of gastrointestinal bleeding or ulcer formation.
  • Besides this, it does not affect bleeding time and also helps in reducing fever due to pain or swelling.

How Rulace Plus Syrup Works

Rulace Plus Syrup is composed of two medicines: Aceclofenac (pain reducer) and Paracetamol (fever reducer). Rulace Plus Syrup helps in relieving pain from conditions like headaches, mild migraine, muscle pain, dental pain, rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. Aceclofenac and Paracetamol both work by blocking the chemical messengers responsible for causing pain, inflammation, and fever.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Rulace Plus Syrup

Do not take more than the prescribed dose of Rulace Plus Syrup as it may cause adverse effects. If you suspect you have taken an overdose, please consult a doctor immediately.

Drug Warnings

  • Do not take Rulace Plus Syrup if you are allergic to it or its components.
  • Taking more than the daily prescribed dose of Rulace Plus Syrup may cause liver damage or allergic reactions like swelling of the mouth, face, throat, difficulty in breathing, skin rash or itching.
  • Most of the cases of liver injury are associated with the use of paracetamol. 
  • Gastrointestinal bleeding and ulcer formation are commonly observed with the use of Rulace Plus Syrup, so the doctor may prescribe you the lowest dose available.
  • Do not take Rulace Plus Syrup if you have asthma or allergies to painkillers, heart, kidney and liver conditions.
  • Rulace Plus Syrup should not be taken during pregnancy or by breastfeeding mothers as it may affect the baby.
  • The components of Rulace Plus Syrup can cause stomach upset. Thus, it is recommended to consume Rulace Plus Syrup with meals to minimize gastric side effects. If you have a diagnosis of peptic ulcer, Rulace Plus Syrup is best avoided unless prescribed by your doctor.
  • Although Rulace Plus Syrup provides symptomatic relief, it is strongly recommended to remain physically active as much as your condition allows.
  • Adopting a healthy lifestyle, coupled with a healthy diet containing high proteins, is the mainstay of the management of arthritic conditions.

Diet & Lifestyle Advise

  • Include more glucosamine, chondroitin sulphate, Vitamin D, and calcium-enriched supplements. Besides this, turmeric and fish oils can help in reducing inflammation in the tissue.
  • Do not go for heavy exercise as it may increase your joint pain and arthritis. Instead, you can do stretching and low-impact aerobic exercises like walking on a treadmill, bike riding, and swimming. You can also strengthen your muscle strength by lifting light weights.
  • In chronic arthritis or joint pain, try to include fish like salmon, trout, tuna, and sardines. These fishes are enriched with omega-3 fatty acids that have a minimum level of chemicals called cytokines, which ramp up inflammation.
  • Your sitting posture is important, especially when you have pain and inflammation conditions. Try to sit as little as possible and only for a short time (10-15 min). Use back support like a rolled-up towel at the back of your curve to minimize pain. Keep your knees and hips at a right angle. Besides this, you can use a footrest if required.

Habit Forming

No

Therapeutic Class

ANALGESIC AND ANTIPYRETIC AGENT

Rulace Plus Syrup Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

You are recommended not to consume alcohol along with Rulace Plus Syrup as it contains paracetamol which can together damage your liver severely.

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Pregnancy

Consult your doctor

The safety of this medicine for use during pregnancy is not known. Hence, it is not recommended for use in pregnancy unless considered essential by your doctor.

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Breast Feeding

Consult your doctor

Rulace Plus Syrup should not be used without consultation with your doctor if you are breast-feeding. It is not known if this medicine passes into breast milk. It is not recommended for use during breast-feeding unless considered essential by your doctor.

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Driving

Unsafe

Rulace Plus Syrup usually causes dizziness, drowsiness and visual disturbances which may affect their ability to drive or operate machinery. Make sure you are not affected before driving or operating machinery.

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Liver

Caution

Rulace Plus Syrup to be taken with caution, especially if you have a history of liver disease. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Rulace Plus Syrup to be taken with caution, especially if you have a history of kidney disease. The dose may have to be adjusted by your doctor.

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Children

Unsafe

The safety and efficacy of Rulace Plus Syrup in children have not been established. Rulace Plus Syrup is not recommended in children.

Have a query?

FAQs

Rulace Plus Syrup is used to reduce pain and inflammation.

No, Rulace Plus Syrup does not cure Rheumatoid arthritis but instead, it helps in reducing the pain and inflammation caused by it as it a pain killer.

Yes, Rulace Plus Syrup is may cause nausea or vomiting in some people. In order to avoid the same, you should take Rulace Plus Syrup with milk or food. In case you are still experiencing excessive nausea while consuming Rulace Plus Syrup, speak with your doctor right away.

No, do not suddenly stop taking Rulace Plus Syrup. If you want to stop taking this medicine, consult your doctor and he might gradually reduce the dose to avoid an unwanted increase in pain or inflammation.

No, Rulace Plus Syrup should ideally not be taken for stomach pain without consulting a physician. This medication can increase the secretion of stomach acid, which may worsen gastritis or an unknown underlying stomach ulcer.

Patients with mild to moderate renal impairment should be kept under surveillance. The lowest effective dose should be used and renal function monitored regularly. Effects on renal function are usually reversible on withdrawal of Rulace Plus Syrup.

Yes, let your doctor know if you are taking any other medicine for pain, arthritis or fever. If you experience dark stools, blood in vomit, or stomach pain, stop taking Rulace Plus Syrup and consult your doctor immediately, as these could be signs of bleeding in your stomach or intestine. Take Rulace Plus Syrup only for the duration as prescribed by your doctor. Do not take more than the prescribed dose, as it may cause an overdose.

Rulace Plus Syrup already contains Paracetamol and Aceclofenac. So, avoid taking additional paracetamol. If your pain does not subside, consult your doctor so that they may increase the dose or add another medicine depending on your condition.

Yes, Rulace Plus Syrup is a painkiller. It contains Aceclofenac and Paracetamol, which helps to relieve pain.

You are recommended to consult your doctor before taking Rulace Plus Syrup with antibiotics to avoid drug interactions.

Rulace Plus Syrup is safe if used as advised by the doctor. Follow your doctor’s instructions.

Yes, the use of Rulace Plus Syrup can cause dizziness (feeling faint, lightheaded, unsteady, or weak) in some patients. If you feel dizzy or lightheaded, take rest for sometime and resume once you feel better.

Rulace Plus Syrup is contraindicated in patients with known allergy to any of its ingredients or in patients or other painkillers (NSAIDs). Patients with a history of stomach ulcers or active, recurrent stomach ulcer/bleeding should ideally avoid taking Rulace Plus Syrup. Additionally, patients with a history of high blood pressure, heart failure, and kidney or liver disease, should also avoid taking Rulace Plus Syrup.

Yes, Rulace Plus Syrup be taken with vitamin B-complex as it helps to treat vitamin deficiency that may be the cause of underlying pain. However, please consult your doctor before using Rulace Plus Syrup with other medicines or supplements.

No, taking higher dose of Rulace Plus Syrup than recommended may cause serious liver damage or allergic reactions such as swelling of the mouth, face and throat; itching; rash or difficulty in breathing. If the pain is not relieved or if you are experience increased severity of pain by the recommended doses, please consult your doctor.

Store Rulace Plus Syrup at room temperature in a dry place. Protect from sunlight. Keep it out of reach of children.

Rulace Plus Syrup may take about 1.5 to 3 hours after oral administration to show its effect. However, the time may vary with every individual patient to get the desired results.

The dosage of Rulace Plus Syrup will be decided by your doctor. Follow doctor’s instructions. Do not take more than the recommended dose.

No, you are not recommended to take Rulace Plus Syrup along with other painkiller tablets as it may cause unwanted side effects such as stomach ulcers or pain. Therefore, please consult your doctor before taking Rulace Plus Syrup with other medicines.

Rulace Plus Syrup is not recommended for children as the safety and efficacy have not been established.

Rulace Plus Syrup contains Aceclofenac (pain reducer) and Paracetamol (fever reducer) which work by blocking the chemical messengers responsible for causing pain, inflammation, and fever.

Take Rulace Plus Syrup as advised by your doctor. Swallow it as whole with a glass of water. Do not crush, chew or break it.

Rulace Plus Syrup may cause side effects such as nausea, dizziness, diarrhoea, flatulence, or constipation. If these side effects persist or worsen, please consult your doctor.

You are preferably advised to take Rulace Plus Syrup after meals, as food helps to prevent any potential gastric irritation the drug might cause when taken on an empty stomach. Follow doctor’s instructions.

If you forget to take a dose of Rulace Plus Syrup, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the next scheduled dose in the prescribed time. Do not double the dose to make up for the missed one as this may increase the risk of side effects.

You are recommended to consult your doctor before taking other medicines with Rulace Plus Syrup to avoid drug interactions.

Country of origin

India
Other Info - RU65614

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 18, 2025 | 1:05 PM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.4240.pdf
  2. https://www.medicines.org.uk/emc/files/pil.10548.pdf
  3. https://www.ciplamed.com/content/voltanec-pr-tablets
  4. https://www.medicineindia.org/pharmacology-for-generic/177/aceclofenac-paracetamol
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