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compositionComposition:RUCAPARIB-300MG
prescription
Prescription Medicine
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Ruparib 300 Tablet is indicated in the treatment of ovarian, fallopian tube, and primary peritoneal cancer. It contains Rucaparib, which works by blocking an enzyme that repairs damaged DNA in cancer cells, resulting in their death. Thus, it kills cancer cells and helps treat cancer. In some cases, it may cause side effects such as fatigue, nausea, vomiting, diarrhoea, and decreased or loss of appetite.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

RUCAPARIB-300MG

Manufacturer/Marketer :

Emcure Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Ruparib 300 Tablet

Ruparib 300 Tablet is a prescription medication used to treat advanced cancers of the ovaries, fallopian tubes, and primary peritoneum, as well as certain types of advanced prostate cancer. This medicine is typically prescribed after other treatments have been tried or to help keep the cancer from returning after successful chemotherapy. It belongs to a class of drugs that target specific proteins in cancer cells to stop them from growing.

To get the best results, you must take this medicine exactly as prescribed, keeping a consistent daily schedule. You can take Ruparib 300 Tablet with or without food, making it easy to fit into your daily routine. Staying well-hydrated and eating small, frequent meals can also help your body adjust to the medication.

While taking Ruparib 300 Tablet , you may experience common side effects like nausea, tiredness, or changes in how food tastes. However, you must contact your doctor immediately if you experience severe symptoms such as extreme fatigue, easy bruising, unusual bleeding, or signs of an infection, as these can point to serious underlying issues.

Do not take this if you are pregnant or planning to become pregnant, as this medication can harm an unborn baby. It is also important to tell your doctor before starting this medicine if you have a history of liver damage or kidney disease.

Some medications, as well as alcohol and smoking, can change how this medicine works or increase your risk of liver damage. Women who are breastfeeding and elderly individuals should talk to their doctor to discuss the risks and benefits before starting this treatment.
 

Uses of Ruparib 300 Tablet

Ruparib 300 Tablet may be prescribed for certain advanced cancers based on the type, stage, and specific characteristics of the cancer:

  • Advanced Ovarian, Fallopian Tube, or Primary Peritoneal Cancer: Ruparib 300 Tablet helps by keeping these cancers from returning or growing larger after they have responded to platinum-based chemotherapy.
  • BRCA-mutated Advanced Ovarian Cancer: This medicine is used to treat ovarian cancers with specific gene changes (BRCA mutations) that have already been treated with two or more chemotherapies.
  • Metastatic Castration-Resistant Prostate Cancer: For patients with specific gene mutations, Ruparib 300 Tablet helps stop the spread of advanced prostate cancer that no longer responds to medical or surgical treatments that lower testosterone.
     

Key Benefits

Ruparib 300 Tablet is a PARP inhibitor used to treat certain cancers, including ovarian, fallopian tube, and primary peritoneal cancers, in patients who meet specific treatment criteria. It works by interfering with cancer cells' ability to repair damaged DNA, which can slow or stop their growth.

  • Helps Control Cancer Growth: Blocks PARP enzymes involved in DNA repair, making it harder for certain cancer cells to repair themselves and survive.
  • May Delay Disease Progression: Helps slow the growth or progression of eligible cancers, which may extend the period before the disease worsens.
  • Supports Maintenance Treatment: May be used as maintenance therapy after a response to platinum-based chemotherapy in certain patients, helping maintain control of the cancer.
  • Provides Oral Treatment: Available as an oral tablet, allowing treatment to be taken at home without requiring an intravenous infusion for each dose.
  • Offers Targeted Treatment: Its effectiveness is particularly relevant to cancers with certain DNA-repair deficiencies, including some cancers associated with BRCA mutations.
     
Side effects of Ruparib 300 Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Regularly brush and floss your teeth.
  • Rinse your mouth with water and baking soda a solution to neutralize acid in the mouth. This makes your food taste as it should.
  • Drink plenty of water or non-caffeinated drinks to prevent dry mouth which may lead to altered taste.
  • Try ginger, peppermint, fruit or green teas, lemonade, ginger ale or fruit juice to help mask unpleasant tastes.
  • Try sucking on sugar-free ice pops or ice cubes to prevent dry mouth.
  • High levels of liver enzymes need immediate medical attention.
  • Watch your diet and consume low-fat foods, like green leafy vegetables, fish, whole grains, nuts, etc.
  • Regularly do strengthening exercises to control your cholesterol levels.
  • Avoid drinking alcohol as it can affect your liver.
  • Focus on losing weight as it can help control cholesterol and maintain liver enzymes.
  • Practice yoga and meditation to improve liver functioning and overall health.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

Directions for Use

  • Ruparib 300 Tablet can be taken with or without food.
  • Follow your doctor’s instructions on the dosage and timing of this medication. Try to take it at the same time each day or as recommended by a doctor for optimal results.
  • Swallow the whole tablet with a glass of water.
  • Do not break, chew or crush Ruparib 300 Tablet .

How Ruparib 300 Tablet Works

Cancer cells often rely on special helper proteins inside the body to repair themselves when their DNA gets damaged. Ruparib 300 Tablet contains rucaparib. It works by blocking these helper proteins, known as PARP (poly ADP-ribose polymerase). When these helper proteins are blocked, cancer cells, especially those that already have genetic mutations like BRCA, cannot repair their damaged DNA. As a result, the damaged DNA builds up inside the cancer cells, causing them to stop dividing and eventually die. Because normal, healthy cells have back-up repair systems, they may be less affected by this process.
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Alcohol

Consult your doctor

It is not known whether Ruparib 300 Tablet interacts with alcohol. Please consult your doctor.

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Pregnancy

Unsafe

Ruparib 300 Tablet should not be used during pregnancy as it may harm your unborn baby.

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Breast Feeding

Unsafe

Avoid breastfeeding whilst on treatment with Ruparib 300 Tablet and for at least two weeks after the last dose.

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Driving

Caution

In some cases, Ruparib 300 Tablet may cause tiredness. So, drive or operate machinery only if you are alert.

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Liver

Consult your doctor

If you have a history of liver disease, please inform your doctor before taking Ruparib 300 Tablet .

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Kidney

Consult your doctor

If you have a history of kidney disease, please inform your doctor before taking Ruparib 300 Tablet .

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Children

Unsafe

Ruparib 300 Tablet is not recommended for children as the safety and effectiveness have not been established.

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Heart

Caution

Ruparib 300 Tablet may be used in patients with heart problems, but only with close monitoring due to potential cardiovascular side effects. Your doctor will assess your heart status and adjust treatment as needed.

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Geriatrics

Caution

Ruparib 300 Tablet is considered safe for elderly patients, but doctors monitor closely for side effects and organ function. No dose adjustment is typically needed unless other health issues are present.

What if I have taken an overdose of Ruparib 300 Tablet

If you take too much of this medication, seek immediate emergency medical attention or contact a poison control centre right away.

Diet & Lifestyle Advise

  • Protect Your Skin from the Sun: Use protective clothing and a broad-spectrum sunscreen when outdoors, particularly if you develop increased sensitivity to sunlight during treatment.
  • Eat Small, Frequent Meals: If you experience nausea or reduced appetite, smaller meals throughout the day may be easier to tolerate.
  • Stay Well-Hydrated: Drink adequate fluids, particularly if you experience vomiting or diarrhoea, unless your doctor has advised you to restrict fluids.
  • Follow a Balanced Diet: Choose a varied, nutritious diet to support your overall health during cancer treatment.
     
health query

Have a query?

How Soon It Starts Working

The time required for Ruparib 300 Tablet to start to work: The time required for Ruparib 300 Tablet to show its action is not clinically established. The time for which the effects of Ruparib 300 Tablet last: The duration of action for Ruparib 300 Tablet is not clinically established.

What if you forget to take Ruparib 300 Tablet

If you miss a dose, skip the missed dose and take your next scheduled dose at your normal time. Do not take two doses at the same time to make up for a missed one.

Storage

• Store Ruparib 300 Tablet tablets at room temperature, between 20°C to 25°C (68°F to 77°F).

Drug Warnings

  • Inspect the Tablets Before Use: Do not take the tablets if they are broken, damaged, or unusually discoloured.
  • Use Effective Contraception: Ruparib 300 Tablet may harm an unborn baby. If you or your partner could become pregnant, discuss effective contraception with your doctor and follow the recommended contraception period after treatment.
  • Attend Regular Blood Tests: Your doctor may monitor your blood cell counts and liver function regularly during treatment to identify treatment-related changes early.
  • Report Symptoms of Low Blood Cell Counts: Contact your doctor if you develop persistent fever, unusual infections, unusual bruising, bleeding, or severe weakness.
  • Report New or Persistent Symptoms: Tell your doctor about persistent shortness of breath, cough, weakness, or other unusual symptoms, as rare but serious complications can occur with PARP inhibitor treatment.
     

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor about all medicines, supplements, and herbal products you are taking before starting Ruparib 300 Tablet :

  • Medicines Processed by the Liver: Ruparib 300 Tablet can affect certain liver enzymes and transport proteins, which may alter the levels or effects of other medicines. Tell your doctor or pharmacist about all prescription medicines, over-the-counter medicines, and supplements you use.
  • Blood-Thinning Medicines: If you take anticoagulants or antiplatelet medicines, inform your doctor so that potential interactions and bleeding risks can be assessed.
  • Other Anticancer Medicines: Combining Ruparib 300 Tablet with other treatments that affect bone marrow function may increase the risk of low blood cell counts and requires medical supervision.
     
RucaparibZiprasidone
Critical
RucaparibInfliximab
Severe

Drug-Drug Interactions

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RucaparibZiprasidone
Critical
How does the drug interact with Ruparib 300 Tablet:
Coadministration of Ruparib 300 Tablet and Ziprasidone may increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Ruparib 300 Tablet with Ziprasidone together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
RucaparibInfliximab
Severe
How does the drug interact with Ruparib 300 Tablet:
When Ruparib 300 Tablet is taken with Infliximab, can lead to or increase the risk or severity of developing serious infections.

How to manage the interaction:
Co-administration of Infliximab with Ruparib 300 Tablet can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience symptoms of fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in sputum, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RucaparibSotalol
Severe
How does the drug interact with Ruparib 300 Tablet:
Using sotalol together with Ruparib 300 Tablet can increase the risk or severity of irregular heart rhythms which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Although there is a possible interaction between Sotalol and Ruparib 300 Tablet, you can take these medicines together if prescribed by a doctor. If you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations consult a doctor. Do not stop using any medications without talking to a doctor.
RucaparibCladribine
Severe
How does the drug interact with Ruparib 300 Tablet:
Taking Ruparib 300 Tablet with Cladribine can increase the risk of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Cladribine and Ruparib 300 Tablet, but it can be taken if prescribed by a doctor. If you have any of these symptoms, it's important to contact a doctor right away. These symptoms include fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you urinate. Do not stop using any medications without a doctor's advice.
RucaparibPirfenidone
Severe
How does the drug interact with Ruparib 300 Tablet:
Taking Pirfenidone with Ruparib 300 Tablet can increase the risk or severity of its side effects such as liver disease or gastric problems.

How to manage the interaction:
Co-administration of Pirfenidone with Ruparib 300 Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately.
RucaparibGatifloxacin
Severe
How does the drug interact with Ruparib 300 Tablet:
Taking Gatifloxacin with Ruparib 300 Tablet can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Gatifloxacin with Ruparib 300 Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RucaparibMoxifloxacin
Severe
How does the drug interact with Ruparib 300 Tablet:
Using moxifloxacin together with Ruparib 300 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Moxifloxacin and Ruparib 300 Tablet, you can take these medicines together if prescribed by your doctor. If you notice any of these symptoms - like a fast or irregular heartbeat, severe or long-lasting diarrhea, vomiting, complications, sudden feeling dizzy or lightheaded, fainting, difficulty breathing, or feeling your heart beating fast - make sure to call your doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip

Inform your doctor about your usual diet and any foods or beverages you consume regularly while taking Ruparib 300 Tablet :
 

  • Grapefruit: Avoid grapefruit and grapefruit juice unless your doctor advises otherwise, as grapefruit may affect the metabolism of some medicines and potentially alter their effects.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

Ruparib 300 Tablet is used treat Ovarian cancer, Fallopian tube cancer, Primary peritoneal cancer and Prostate cancer.
Ruparib 300 Tablet works by blocking an enzyme that repairs damaged DNA in the cancer cells, resulting in their death. Thereby, it helps treat cancer.
Ruparib 300 Tablet may make your skin sensitive to sunlight. Therefore, avoid unnecessary or prolonged exposure to sunlight. Also, wear protective clothing and apply sunscreen.
If you experience nausea, vomiting, diarrhoea, or abdominal pain, consult your doctor, as these may be signs that Ruparib 300 Tablet is affecting your stomach or bowels.
Yes, you can take Ruparib 300 Tablet with or without food. Taking it at the same times each day is the best way to get consistent results. Talk to your doctor or pharmacist if you have questions.
If you throw up after taking your dose, do not take an additional tablet. Just wait and take your next dose at your regularly scheduled time. Talk to your doctor or pharmacist if vomiting becomes a frequent problem.
Hair loss is not a common side effect of Ruparib 300 Tablet . However, some people may experience mild hair thinning. If you notice significant hair loss, talk to your doctor or pharmacist.
Your doctor will order regular blood tests to monitor your liver function and check your blood cell levels. This helps detect any early signs of bone marrow issues or liver damage. Talk to your doctor or pharmacist for more details.
This medication can make your skin highly sensitive to sunlight, increasing your risk of severe sunburn. You should limit your time in direct sun, wear protective clothing, and use a high-SPF sunscreen. Talk to your doctor or pharmacist if you develop a sunburn or skin rash.
No, Ruparib 300 Tablet can cause serious harm to an unborn baby. Both men and women should use effective birth control during treatment and for several months afterward. Talk to your doctor or pharmacist about safe contraceptive options.
It is best to avoid or strictly limit alcohol while taking Ruparib 300 Tablet , as both alcohol and this medication can put extra strain on your liver. Talk to your doctor or pharmacist about what is safe for you.
The duration of your treatment depends on how well the medicine works for you and whether you experience any severe side effects. Your doctor will determine the appropriate length of therapy. Talk to your doctor or pharmacist to understand your specific treatment plan.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 209115S011Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. MedlinePlus. A617002 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Rucaparib Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Electronic Medicines Compendium (EMC). Pil.10027 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  5. U.S. Food and Drug Administration (FDA). 209115S003Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  6. Rucaparib [Prescribing Information]. 2024. [Accessed on 02 Jan. 2026]Check here

Country of origin

India

Manufacturer/Marketer address

A €“ 504, Shapath-4, B/S Hotel Crowne Plaza, Opp. Karnavati Club, S. G. Highway ,Ahmedabad 380 051 Gujarat
Other Info - RUP0033
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