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compositionComposition:DESIDUSTAT-50MG
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Prescription Medicine
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Rytstat 50 mg Tablet is used to treat anaemia associated with chronic kidney disease (CKD). It contains Desidustat, which works by stimulating the body's natural production of erythropoietin; this, in turn, promotes the production of red blood cells. This medicine may cause side effects like fever, vomiting, and peripheral oedema (swelling of the lower legs or hands). Inform your doctor if you are pregnant, breastfeeding, taking other medicines or have pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DESIDUSTAT-50MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Rytstat 50 mg Tablet

Rytstat 50 mg Tablet is a prescription medicine used to treat anaemia in adults with chronic kidney disease (CKD). Anaemia occurs when your body does not produce enough red blood cells, which can leave you feeling constantly tired, weak, and cold. This medicine helps support your body’s natural processes to generate more red blood cells and improve your energy levels.

To achieve the best results, you must take Rytstat 50 mg Tablet regularly and consistently exactly as prescribed by your doctor. You can take this medicine with or without food, but keeping a consistent routine helps maintain steady levels in your body. Along with taking your medicine, adopting certain lifestyle habits, such as eating a balanced diet and keeping your scheduled medical appointments, plays a vital role in your treatment plan.

While taking Rytstat 50 mg Tablet, some people may experience mild side effects, such as nausea, vomiting, or diarrhoea. However, you must contact your healthcare provider immediately if you experience serious symptoms, such as sudden, severe headaches, vision changes, or signs of blood clots.

Do not take this if you have uncontrolled high blood pressure or have had a severe allergic reaction to this medication in the past. Before starting treatment, it is highly important to tell your doctor if you have a history of liver problems, seizures, or heart disease so they can ensure this medicine is safe for you.

This medicine can interact with certain other treatments, such as phosphate binders, which can prevent your body from absorbing it properly. You should also consult your doctor if you are pregnant, planning to become pregnant, breastfeeding, or if you are an older adult, as specific precautions or alternative treatments may be recommended.

Uses of Rytstat 50 mg Tablet

Rytstat 50 mg Tablet is used to treat anaemia in adults with chronic kidney disease (CKD). The detailed uses of Rytstat 50 mg Tablet are as follows:

  • Anaemia in chronic kidney disease: Rytstat 50 mg Tablet is used to treat low red blood cell counts in adults with chronic kidney disease who are either on dialysis or not on dialysis. It helps elevate and maintain safe haemoglobin levels in the blood.
     

Key Benefits

Rytstat 50 mg Tablet helps treat anaemia associated with chronic kidney disease by increasing the production of healthy red blood cells. With regular use as prescribed, it helps improve oxygen delivery throughout the body, reduce symptoms of anaemia, and support a better quality of life.

  • Treats Renal Anaemia: By increasing red blood cell production, this medicine helps improve oxygen supply to the body's tissues, relieving fatigue, weakness, and reduced physical stamina associated with kidney disease.
  • Improves Energy and Daily Functioning: As haemoglobin levels improve, this medicine helps restore energy, enhance physical endurance, and make everyday activities easier to perform.
  • Convenient Oral Treatment: Available as an oral tablet, this medicine offers a convenient alternative to injectable treatments, allowing you to manage renal anaemia at home without the need for frequent injections.
Side effects of Rytstat 50 mg Tablet
  • Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
  • Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
  • Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
  • Gently massage the swollen area with firm but not painful pressure.
  • Keep the swollen area clean and moisturized to prevent injury and infection.
  • Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
  • If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
  • Rest well; get enough sleep.
  • Wear comfortable layers of clothes and get to a warm place.
  • Drink warm fluids like coffee, tea or hot chocolate.
  • Warm up using a blanket or heating pad.
  • Get plenty of fresh air.
  • Take regular sips of a cold drink.
  • Take ginger containing foods like ginger tea and ginger biscuits.
  • Do not take heavy meals at a time, take small and frequent meals.

Directions for Use

  • Rytstat 50 mg Tablet can be taken on an empty stomach, at least 1 hour before or 2 hours after meals.
  • Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.
  • Swallow it as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Rytstat 50 mg Tablet Works

Rytstat 50 mg Tablet contains desidustat, which belongs to a class of medications called hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitors. It works by gently mimicking your body’s natural response to lower oxygen levels. This action triggers your body to produce more of its own erythropoietin, which is the natural hormone that signals your bone marrow to manufacture new red blood cells. Additionally, this process helps your body absorb iron better from the food you eat and moves stored iron to where it is needed most to build new red blood cells. By improving both iron utilisation and red blood cell production, it steadily brings your haemoglobin levels back into a healthy range.
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Alcohol

Caution

Avoid consumption of alcohol with Rytstat 50 mg Tablet as it may cause serious side effects.

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Pregnancy

Caution

There is no information available about the use of Rytstat 50 mg Tablet during pregnancy. Consult your doctor if you are pregnant or suspect you are pregnant.

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Breast Feeding

Caution

Rytstat 50 mg Tablet is not recommended during breastfeeding as it is unknown if desidustat passes into breastmilk.

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Driving

Safe

Rytstat 50 mg Tablet does not alter your ability to drive or use machinery.

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Liver

Consult your doctor

There is no information available about the use of Rytstat 50 mg Tablet in patients with liver impairment. Consult your doctor if you have liver problems.

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Kidney

Safe if prescribed

Rytstat 50 mg Tablet is prescribed for the treatment of anaemia induced by chronic kidney disease. Your doctor will decide the dose of this medicine based on your disease condition.

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Children

Caution

The safety and efficacy of Rytstat 50 mg Tablet in children was not established.

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Heart

Consult your doctor

Please consult your doctor before receiving Rytstat 50 mg Tablet if you have pre-existing heart problems. Your doctor will prescribe Rytstat 50 mg Tablet if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Rytstat 50 mg Tablet to geriatric patients. Your doctor will prescribe Rytstat 50 mg Tablet if the benefits outweigh the risks.

What if I have taken an overdose of Rytstat 50 mg Tablet

If you accidentally take more than your prescribed dose, seek emergency medical care immediately. An overdose can cause your haemoglobin levels to rise too quickly, which can lead to severe high blood pressure or increase the risk of blood clots.

Diet & Lifestyle Advise

  • Check your blood pressure regularly: Because this medicine can raise your blood pressure, monitor it at home as recommended by your doctor and keep a written log of your readings.
  • Consume iron-rich foods: To help your body build new red blood cells, include iron-rich foods like leafy greens, beans, and lean meats in your diet, if permitted by your kidney specialist.
  • Stick to your kidney diet plan: Continue following any specific dietary guidelines (such as limiting sodium, potassium, or phosphorus) provided by your healthcare team.
  • Attend all scheduled blood tests: You will need frequent blood tests to monitor your haemoglobin levels. These tests are essential for your doctor to manage your treatment safely and effectively.
health query

Have a query?

How Soon It Starts Working

The time required for Rytstat 50 mg Tablet to start to work: The time required for Rytstat 50 mg Tablet to show its action is not clinically established.

The time for which the effects of Rytstat 50 mg Tablet last: The duration of action for Rytstat 50 mg Tablet is not clinically established.

What if you forget to take Rytstat 50 mg Tablet

If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose entirely and resume your regular schedule. Do not take two doses at the same time to make up for a missed one. Talk to your doctor or pharmacist if you are unsure.

Storage

• Store Rytstat 50 mg Tablet tablets at room temperature, ideally between 15°C and 30°C (59°F and 86°F). Keep the tablets in their original packaging to protect them from direct light and moisture.

Drug Warnings

  • Check your blood pressure before starting this medicine and regularly during treatment; notify your doctor immediately if your readings spike.
  • Never skip your scheduled blood tests, as they are crucial for monitoring your liver health and blood counts.
  • Be alert for signs of blood clots, such as sudden leg pain, warmth, redness, or unexplained shortness of breath.
  • Inform any surgeon, anesthesiologist, or dentist that you are taking Rytstat 50 mg Tablet before you undergo any medical procedures.
  • Do not share this medicine with anyone else, even if they have the same symptoms or kidney condition.

Drug-Drug Interactions

verifiedApollotooltip
  • Phosphate binders (such as sevelamer or calcium acetate): Taking these medications at the same time can reduce how well your body absorbs Rytstat 50 mg Tablet. Take Rytstat 50 mg Tablet at least 1 hour before or 2 hours after taking your phosphate binders.
  • Iron supplements: Certain oral iron therapies can interfere with the absorption of this medicine if swallowed at the exact same time.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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  • Calcium-fortified foods: Consuming highly fortified calcium foods or juices at the same time as your medication may lower the amount of medicine your body is able to absorb.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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FAQs

Rytstat 50 mg Tablet is used to treat anaemia associated with chronic kidney disease (CKD).
Rytstat 50 mg Tablet contains Desidustat, which works by stimulating the body's natural production of erythropoietin; this, in turn, promotes the production of red blood cells.
People who do not acquire enough iron, vitamin B12, and folic acid to create healthy red blood cells are more likely to develop anaemia. Excessive alcohol use increases your risk of anaemia.
Eating foods like red meat, beans, and peas can be beneficial if one has vitamin deficiency anaemia. In addition, items like dry fruits, dark green leafy vegetables, and seafood can supply the necessary vitamins and minerals.
Yes, Rytstat 50 mg Tablet may cause Peripheral oedema (swelling of your lower legs or hands). If symptoms persist or bother you, reach out to the doctor immediately.
The side effects of Rytstat 50 mg Tablet include vomiting, fever, abnormal physical weakness and peripheral oedema (swelling of your lower legs or hands). If these side effects persist or worsen, please consult your doctor.
Chronic kidney disease, or CKD, is an irreversible and progressive loss of kidney function. As a result, the body retains excess waste or toxins which may lead to other health problems. The symptoms include swelling of legs, shortness of breath, swelling around the eyes, weight loss, fatigue (overtiredness), decreased urine output, nausea or vomiting, especially in the morning or after eating, loss of appetite and trouble sleeping.
Your doctor may recommend a blood test to determine whether you have kidney disease. The test measures the amount of creatinine (waste product) in your blood. The doctor will use the blood test results, your gender, age, weight, and ethnic group to calculate how many millilitres of waste your kidneys should be able to filter in a minute. This calculation is known as your eGFR or estimated glomerular filtration rate. Healthy kidneys should be able to filter more than 90 mL/min. If your rate is lower than this, you may have kidney disease.
If you have diabetes, high blood pressure, heart disease, or a family history of kidney failure, you are more likely to develop kidney disease. If you have risk factors, it is advisable to get examined for kidney disease and protect your kidneys by changing your diet, lifestyle and controlling your blood glucose levels and blood pressure.
Your kidneys make erythropoietin (EPO), an important hormone that instructs your body to produce red blood cells. Kidneys fail to make enough EPO in case of kidney disease. Low EPO levels decreases red blood cell count resulting in anemia.
The risk for anemia increases when kidney disease worsens. People with CKD who also have diabetes are at a greater risk for developing anemia, likely to develop anemia earlier, and often have more severe anemia than those without diabetes. In addition, anemia with CKD is more common in people aged over 60 years.
Some of the symptoms of anemia in patients with CKD include dizziness, pale skin, fatigue (overtiredness), headache, shortness of breath, body pain, and irregular or fast heartbeats.
In patients with CKD, severe anemia can increase the risk of heart problems and strokes due to low oxygen levels in the body, which results from the decreasing level of red blood cells in the body.
Yes, you can take Rytstat 50 mg Tablet with or without food. However, try to take it the same way each time to ensure consistent absorption. Talk to your doctor or pharmacist if you need further dietary advice.
Many patients with kidney-related anaemia still need iron to help their body make new red blood cells. Your doctor will test your iron levels and prescribe an iron supplement if your body needs it.
Yes, high blood pressure is a recognised side effect of medicines that increase red blood cells. You should monitor your blood pressure regularly and report any high readings to your healthcare team.
No, Rytstat 50 mg Tablet is an oral tablet. It is not an injection. It works by stimulating your body to naturally produce its own red blood cell-stimulating hormone.
A severe headache can be a sign of a sudden spike in blood pressure. Check your blood pressure immediately if you can, and contact your doctor or seek emergency medical care right away.
This medicine is generally not recommended during pregnancy or breastfeeding as it may pose risks to the developing baby. Talk to your doctor about safer alternative treatments if you are pregnant or planning to become pregnant.
Your doctor will likely schedule blood tests every few weeks when you first start taking Rytstat 50 mg Tablet, and then periodically once your levels are stable. These tests are essential for adjusting your dose safely. Talk to your doctor for a personalised schedule.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. DrugBank Online. Db16135 Clinical & Chemical Summary. Edmonton, AB: DrugBank; 2026. [Accessed on 02 Jun. 2026]Check here
  2. National Center for Biotechnology Information (NCBI). Desidustat Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  3. National Center for Biotechnology Information (NCBI). Pmc9281218 Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  4. Dhillon S Desidustat: First Approval. Drugs. 2022;82(11):1207-1212Check here
  5. Desidustat Summary Of Product Information. [Accessed on 02 Jun. 2026]Check here
  6. Zydus Announces Phase Iv Dream Ckd Trial To Generate Real World Evidence Of Desidustat. [Accessed on 02 Jun. 2026]Check here
  7. Desidustat [Summary of Product Information]. 2022. [Accessed on 11 Mar. 2026]Check here

Country of origin

India

Manufacturer/Marketer address

Plot no 107/108,Namli block , Ranipool, East Sikkim 737135
Other Info - RYT0030
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